Protein Alignment CG1801 and abt-2

DIOPT Version :9

• Sequence 1: NP_728408.3
• Gene: CG1801 / 33104
• FlyBaseID: FBgn0031171
• Length: 1655
• Species: Drosophila melanogaster
• Sequence 2: NP_490949.3
• Gene: abt-2 / 171782
• WormBaseID: WBGene00000020
• Length: 2146
• Species: Caenorhabditis elegans
• Alignment Length: 1861
• Identity: 375/1861 - (20%)
• Similarity: 696/1861 - (37%)
• Gaps: 432/1861 - (23%)

  Fly    31 VIMVLVIFLNPIAHSKRLLYTTTENENEQSIVSHK----------LQDINILTRMADSKREKTKY 85
            |:..|.|.|..|.|.:.||||...:..|.....|.          |..|.:.....:....:|.:
 Worm   438 VVDRLNIPLRDIEHLRNLLYTYPSDALEFQDRLHASDLWPASQKLLHFIKVYKNGQNQLNTRTIH 502

  Fly    86 IL---AFTPET------TFTSEVTKNVAK-----TLELSSTVGYESESEMQN--QFDERTTLAGI 134
            ..   .|.|.:      |:|..:|:...|     .|:....|..|.|.|...  ..|......||
 Worm   503 FFLEHLFAPSSDEYSFGTYTKNITEIANKYTGCFLLDRFRFVTDEKELETNAVCLMDTHQYFTGI 567

  Fly   135 VFNDLRDDGTPLT--LSISIR-FPSEFRTIAPFLTEDRLWITRCSGRINP-GRDRAKHDKQQDIY 195
            ||| :..:.|...  .:..|| :|....:...|:          ..:.|| .||:...|.:   |
 Worm   568 VFN-IDSNATEFDGFTTYKIRHYPEMVDSTTSFM----------DSKSNPFSRDKPLIDLK---Y 618

  Fly   196 IREGFLQLQHQIFVEWYHQLRKDIVSTYPEPNVEVYNILLKAADE--PCSVMSVAQLPTFLYNFI 258
            |..||..||..|......:|     :...:.|:.||     |..|  ||:|.....:..|:..|:
 Worm   619 ITFGFSFLQESIDRAIMSEL-----TNQTDANLGVY-----AQQEPYPCTVKDTFNVALFMPLFL 673

  Fly   259 ---YLLPFLNIIRNVAAQVEDGVMVHQWHYGYSFG---MQWGIKFLVL-FLRMCILGVI------ 310
               ::.|...:::|:..:.|..:.......|....   :.||:..||| |:.:.|:.:|
 Worm   674 LISFIFPSALLVKNIVYEKEQKIKEQMRAMGLGDAVHFISWGLISLVLNFISVLIISIISKVAKI 738

  Fly   311 -----YTIMLLAFWGFGGREGEFSGTGTIAFVCFITLYTVEIIITGMVVAKLFANPTNAVLFALM 370
                 ||::|                    ||..:.|::  .|...:..:.||.|...|.....:
 Worm   739 FDYTDYTLLL--------------------FVLILFLFS--SIAMSIFFSTLFTNANIATAATCV 781

  Fly   371 LWLFMYAAFCII-LERYWDIHKYYVFFIL--VAFCNCQMHFSMSLFRNCIEKP------EMVNTI 426
            ||...:..|.:: .:|........:..||  .|..:|   |.:....|.:|:.      ||.|.:
 Worm   782 LWFVFFIPFQLLRTDRISSPTFNRISLILPPTAMGHC---FKLLESFNAMERATWSDLWEMNNPV 843

  Fly   427 --------DFVLIFTSAISSALIYFLILLAIQWRMPGTFLSRR--------------IVNNRPR- 468
                    ..:|:..:|:...|.:::..:|     ||.|..|:              :..||..
 Worm   844 LGISVELCMIMLVVDTAVFLILAWYISAVA-----PGDFGVRQPLWFPFTLKYWAPGLYKNRVEF 903

  Fly   469 -KQQESDTTIMYLGRAPSFQNFEFGDVGSVELMRLRHVSTSHR--DSERKILKNISMRIYRGEVF 530
             ..:..||       .|:..:|   |.....|....|:::..:  ::..|.|..:::|:|.|::.
 Worm   904 VDDEHFDT-------IPNSDSF---DSEPTNLTLAVHINSMSKVYENGTKALDCLNLRLYEGQIT 958

  Fly   531 VILGHIGSGKLTLLRILAGLKFPLRGNVYIMGNPFEPNGEARRLVDFR--FDEHG-LNKHLTVEQ 592
            .:|||.|:||.|.:.||.||..|..|...|.......  :.||:.|..  ..:|. |..||||.:
 Worm   959 GLLGHNGAGKTTTMSILCGLYAPSSGTAKIYQRDIRT--DLRRVRDVLGICPQHNVLFSHLTVSE 1021

  Fly   593 TIDYHVRLKLSPSESDRYEIERRKWLAILDQHVESRGVRIGKLSSGSMKLVALCCCLA--GDTPI 655
            .:.....||..|......:::.    .:....:..:..::....||.||. .||..:|  |.:..
 Worm  1022 QLRLFAALKGVPDSELTSQVDE----ILASVSLTEKANKLASTLSGGMKR-RLCIGIAFIGGSRF 1081

  Fly   656 IILEEPTTQLTGREAQIFWSIVHAEKENRAFIIATYNVGEAEHVADRIGILSMGVLEASGTPFFL 720
            :||:|||..:.....:..|.::...||.|..:::|:::.||:.::|||.|||....:    |..|
 Worm  1082 VILDEPTAGVDVTARKDIWKLLQRNKEGRTILLSTHHMDEADVLSDRIAILSQDFEK----PDLL 1142

  Fly   721 RSK---FSSSVDLVIIKKPHVPDQPITDYINQFMQNIEPENEIGDSLTYRLPVIY---------- 772
            ..|   |.....|::.:            ||..:::         ..|:...||.
 Worm  1143 DGKRLIFQHFYALLVCR------------INYTLKS---------KRTFLFQVIIPLFLLALAEL 1186

  Fly   773 ---------RPRLQKLLIHLEIDRKMLG------------IENVRVVGAELSDIYMTLV----TS 812
                     ||.|...:..|.::..::|            .||     :..:||...:.    |.
 Worm  1187 FVLLQVSTARPDLMVSMPPLPLETSIMGNHSDFYVNSWDTAEN-----STANDILHAMFSSPGTG 1246

  Fly   813 FRLQQQMIPDVTQTFKYQVVSQ--------------------KQLTKQRMRAMF-YKKMIHTAPN 856
            .|..:.:..|:..|.:.:::.:                    .:...|.::..| |.:.|..|..
 Worm  1247 PRCAKDVPNDLLDTMRRELMFRNRYGFGRNKPAPGVDKDSVDNEYQCQNIQGEFDYTEDISNATY 1311

  Fly   857 VWPII-----------------------------MIF-------TSFVLIAIIARLS-------- 877
            ..||.                             .||       |.|.||...|:|:
 Worm  1312 NAPIYCGCEDFGWNCTLEDWKWNETNWLRLNTTDRIFDLTGRNLTQFRLITRFAQLANTTAPFFL 1376

  Fly   878 ---VLLDMPKERQNSIHIGFREPEDVVK--YLPNLKDCGYIDIRSAVKVNKKKSVGVS----RTF 933
               .|..:.:..|:...|      |..|  :|..:|     ||..::::....:.|:.    :..
 Worm  1377 GGFSLGHVNQRAQSQADI------DTSKRGWLETIK-----DIAQSMRIINLNTTGIEPATPKVL 1430

  Fly   934 DDDSFVCEKGSYRNNLRKKNELRSFGAVESDGDEHLNGYISQDMFHSAPMMLNLLQNVILRL-SY 997
            |..:.........|:|.:..::|          |::..:.:..::...|:..|:|.|.:||. .|
 Worm  1431 DPFAQNITLNQVVNDLLQNLDVR----------ENVKVWFNNKIWPGFPIASNILSNALLRQEDY 1485

  Fly   998 PMQ-TDLVVLVENHPLPTQLSQKINVLDNK---------IAHIHVPLVVGCIIPLTVSVFVIPLV 1052
            .:. .||.:|..|||:...:||   .||..         :..|.:.|:|..:||   :.|.:.||
 Worm  1486 AIDPEDLGILTMNHPMNKTISQ---TLDQNALKFTQALAVFRITILLLVLSMIP---AGFTVYLV 1544

  Fly  1053 EEEIYDVRFLQHMAGLGLKVFWGINLFWDWFTFFVYSVIIVVIMSLM-----------GIGGFG- 1105
            |:.|.:...||.:.||....:|..:..:|   ..||:::|:|||.:.           |...|.
 Worm  1545 EDRICEALHLQLVGGLRKVTYWVTSYLYD---MVVYTLVIIVIMLIYLCFRVSDFTADGATFFAF 1606

  Fly  1106 ---FYENAIMVVLLT-----TFGLAALPLTYLV--SMFVNKSIVRAFLV----SVLLQGVSGLVL 1156
               |:.:.:..:|..     .|.:|||....:.  |.||  .||.|..|    |:::|..|
 Worm  1607 LLLFFVHGMSTILYAYVFQKAFSVAALSFVLIAIGSYFV--GIVCALTVIMLESLMVQDPS---- 1665

  Fly  1157 YIIYWDVANSNTIFFYAACMSPGFSLLDGVSNVYAQNLEQAICIDKCEATDSCTEENMN--EVVP 1219
                  :..::|:......:.|.::|  |::      :.:.:.|.:..|..|...:.||  :::.
 Worm  1666 ------LIPAHTVCSIVFLVLPQYNL--GIA------IFRGLMIYQVRAIGSNFLQQMNRPDMIN 1716

  Fly  1220 NCKFDTFFKWAAPG--ILPPILYMVLS--ALIFLMLIFWIELHRREKKFHTSRDLRKMRTATYPF 1280
            .....:...:...|  |:...::::::  .|||..:..:..:.:||:....:..||:..|.
 Worm  1717 QLPLPSLLAFDQMGIHIMCLFIHVIIATICLIFSQMDEFGFVRKRERNLTDAMMLREPSTC---- 1777

  Fly  1281 DDGDVADVKQKIAEADNTKAKQSVFLVDQVEARVPAAGKRIHTVSFALNKYMSMGIFGPRNSGKS 1345
            ||.||...:|::.......:.....:|..:..........:..:|||:......|:.|...:||:
 Worm  1778 DDEDVVKERQRVDAIPMDSSDNHALIVRNLAKAYNPELLAVKGISFAVEPGECFGLLGLNGAGKT 1842

  Fly  1346 HLMRQLVGQRGFAFGEIYVRGLDFK----YDLESIHTYMGYSPQHRGLLNELTPREHIRLLCMIR 1406
            .....|..:.....|.|.::.....    .|:.:.. .:||.||...|..:|:.||:::....||
 Worm  1843 TTFAMLTAKIRPGHGSIEMQNTRINTGSFSDVRNFQ-QLGYCPQFDALNMKLSTRENLKFYARIR 1906

  Fly  1407 GVPEAKIGEKMHDLCLMLNMTGWMHRKCSLLTAEKRHKLKIALALVAYNKILVLDEPTCGMPATT 1471
            |:...:|...:..|.:.|::..:.:.:.|.|:...|.||.:|:|||:...::.||||:.||...:
 Worm  1907 GIVPTQIDSIIDRLLIALHLRPYANTQTSSLSGGNRRKLSVAVALVSQPSLIFLDEPSAGMDPGS 1971

  Fly  1472 RREIWNILRYIRYCGKTIIFATNDELECKILADFIILFQDSEMLAIGSLQYLRYKYSHGFYLEVR 1536
            ::.:|.::..:...||.::..::...||:.|...|.:.....:..:|..|:|:.||..|..|.::
 Worm  1972 QQFLWKVIERLCKSGKAVVLTSHSMEECEALCTRIAIMDRGRIRCLGGKQHLKSKYGKGSMLTMK 2036

  Fly  1537 LIRDGATLAESEENLRKDVENLAKF-------VNFLHNRSELVGRLNNWFKFYVPVGHIVYSFLY 1594
            :.:|        || .|::..:.:.       |..:|..:..:         ::..|....:.:.
 Worm  2037 MGKD--------EN-AKEIAGIMRSKLGDGSRVEAIHCSTIFI---------HIEQGTASVARVL 2083

  Fly  1595 GAMEKNKLRLNVSDYCIYQADMMSVVAQVQET--RAQLKHH 1633
            ..:.:.|...:|.|:.:.|:.:.:|...:.|:  .::..||
 Worm  2084 EIVNQVKKMYDVDDFTLTQSTLDNVFQSIAESDNLSEEGHH 2124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	27/150 (18%)
		ABC2_membrane_4	<293..448	CDD:289500	36/183 (20%)
		EcfA2	499..717	CDD:224047	59/224 (26%)
		P-loop_NTPase	500..721	CDD:304359	59/227 (26%)
		ABC2_membrane_3	<972..1254	CDD:289468	71/324 (22%)
		EcfA2	1307..1521	CDD:224047	49/217 (23%)
		P-loop_NTPase	1324..1524	CDD:304359	49/203 (24%)
abt-2	NP_490949.3	rim_protein	39..2117	CDD:130324	373/1852 (20%)
		ABC_subfamily_A	929..1134	CDD:213230	57/211 (27%)
		ABC_subfamily_A	1802..2024	CDD:213230	50/222 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920