DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and ABCA13

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	XP_011513432.1	Gene:	ABCA13 / 154664	HGNCID:	14638	Length:	5059	Species:	Homo sapiens

Alignment Length:	1897	Identity:	395/1897 - (20%)
Similarity:	710/1897 - (37%)	Gaps:	423/1897 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 EIVALVIMVLV-IFLNPIAHSKRLLYTTTENENEQSIVSHKLQDINILTRMADSKREKTKYILAF 89
            ||:.|....|| .||.||.|.| :|||....|..:.|                   :|..|
Human  3296 EILQLPNGALVWTFLKPILHGK-ILYTPNTPEINKVI-------------------QKANY---- 3336

  Fly    90 TPETTFTSEVTKNVAKT-LELSSTVGYESESEMQNQFDE---RTTLAGIVFNDLRDDGTPLTLSI 150
               |.:..:..|.:::| ||:||........:|.||..|   ...:...|.|.|..|...||..:
Human  3337 ---TFYIVDKLKTLSETLLEMSSLFQRSGSGQMFNQLQEALRNKFVRNFVENQLHIDVDKLTEKL 3398

  Fly   151 SI-----------RFPSEFRTIAPFLTEDRLWITRCSGRINPGRDRAKHD------KQQDIYIRE 198
            ..           .....||.:...|..    ::.|   :...|.:|...      |..::..:.
Human  3399 QTYGGLLDEMFNHAGAGRFRFLGSILVN----LSSC---VALNRFQALQSVDILETKAHELLQQN 3456

  Fly   199 GFL-----------------------QLQHQIFVEWYHQLRKDIVST-----YPEPNVEV----Y 231
            .||                       .:.:.|.....:.:|.|:|..     :|: |:..    |
Human  3457 SFLASIIFSNSLFDKNFRSESVKLPPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQ-NLPADGFKY 3520

  Fly   232 N-------------ILL----KAADEPCSVMSVAQLP-----TFLYNFIYLLPFLNIIR---NVA 271
            |             |:|    :.|.||.:....|..|     .||.|..:..|.:.::.   :||
Human  3521 NYVFAPLQDMIERAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVSVA 3585

  Fly   272 AQV-----EDGVMVHQWHYGYSFGMQWGIKFLVLFL-RMCILGVIYTIMLLAFWGFGGREGEFSG 330
            :.|     |..:.:.:  |....|:...|.||..|| .|.:|.:....:.:..    ...|.|:.
Human  3586 SMVRKLVYEQEIQIEE--YMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVL----KTSGIFAH 3644

  Fly   331 TGTIAFVCFITLYTVEIIITGMVVAKLFANPTNAVLFALMLWLFMYAAFCIILERYWDIHKYYVF 395
            :.|.....|:..:.:.:::...:::..|:....|.|...::::..:..:.::|.    :|....|
Human  3645 SNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLV----LHNQLSF 3705

  Fly   396 FILVAFCNCQ-MHFSMSLF--------RNCIEKPEMVNTID----------FVLIFTSAISSALI 441
            ......|... ..|...:|        ...|:...|...::          ::::|.|:     :
Human  3706 VNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWVCWMILFDSS-----L 3765

  Fly   442 YFLILLAIQWRMPGTFLSRR----------------IVNNRPRKQQESDTTIMYL-----GRAPS 485
            |||....:...:||||..|:                :|..|   |....:::.:.     .:..|
Human  3766 YFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKR---QYFLSSSLFFFNENFDNKGSS 3827

  Fly   486 FQNFEFGDVGSVELMRLRHVSTSHRDSERKILKNISMRIYRGEVFVILGHIGSGKLTLLRILAGL 550
            .||.|....||...:.|..| |...:..:.:::::|:..||.::..:||..|:||.|::.:|.||
Human  3828 LQNREGELEGSAPGVTLVSV-TKEYEGHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGL 3891

  Fly   551 KFPLRGNVYIMGNPFEPNGEARRL-------VDFRFDEHGLNKHLTVEQTI--------DYHVRL 600
            ..|..|.:.|.|...:.:....|:       .|...|...:.:||.:..:|        :.|.::
Human  3892 HPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQV 3956

  Fly   601 KLSPSESDRYEIERRKWLAILDQHVESRGVRIGKLSSGSMKLVALCCCLAGDTPIIILEEPTTQL 665
            ..:..:.|..:          .||.::|.     ||.|..:.::|.....|.:..::|:|||:.:
Human  3957 NQTLQDVDLTQ----------HQHKQTRA-----LSGGLKRKLSLGIAFMGMSRTVVLDEPTSGV 4006

  Fly   666 TGREAQIFWSIVHAEKENRAFIIATYNVGEAEHVADRIGILSMGVLEASGTPFFLRSKFSSSVDL 730
            ........|.|:...:|.|..|..|:::.|||.::||:.:|..|.|...|.||.|:..:...:.|
Human  4007 DPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRL 4071

  Fly   731 VIIKKPHVPDQP-------ITDYINQFMQNIEPENEIGDSLTYRLPV-IYRPRLQKLLIHLEIDR 787
            .:.::|.|.:..       :|..|..::.....::..|..|||.:|. ..:..|:.|...|:.:.
Human  4072 TLTRQPSVLEAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENL 4136

  Fly   788 KMLGIENVRVVGAELSDIYMTLV------------TSFRLQQQMIPDVTQTF-----KYQVVSQK 835
            ..|.:....:....|.::::.|:            |...||..........:     :...|...
Human  4137 HQLHLTGYGISDTTLEEVFLMLLQDSNKKSHIALGTESELQNHRPTGHLSGYCGSLARPATVQGV 4201

  Fly   836 QLTKQRMRAMFYKKMIHT--------APNVWPIIMIFTSFVLIAIIARLSVLLDMPKERQNSIHI 892
            ||.:.::.|:..:::..|        |..:.|::.:..:..|..:   ..:..:.|..|....|
Human  4202 QLLRAQVAAILARRLRRTLRAGKSTLADLLLPVLFVALAMGLFMV---RPLATEYPPLRLTPGH- 4262

  Fly   893 GFREPE------------DVVKYLPNLKDCGYIDIRSAVKVNKKKSVGVSRT--FD----DDSFV 939
             ::..|            |:.:.|  |:.....|:..|....::|:....||  |.    .||..
Human  4263 -YQRAETYFFSSSGGDNLDLTRVL--LRKFRDQDLPCADLNPRQKNSSCWRTDPFSHPEFQDSCG 4324

  Fly   940 CEKGSYRN---------------NL------------RKKNELR--SFG---AVESDGDEHLNGY 972
            |.|...|:               ||            .:|..|.  |||   ..|:.|   .||.
Human  4325 CLKCPNRSASAPYLTNHLGHTLLNLSGFNMEEYLLAPSEKPRLGGWSFGLKIPSEAGG---ANGN 4386

  Fly   973 IS-----------QDMFHSAPMMLNLLQNVILRLSYPMQTD---LVVLVENHPLPTQLSQKINVL 1023
            ||           |..|||.|..||.|.|:||....|...|   ..:.:.:||....|..:..:|
Human  4387 ISKPPTLAKVWYNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYGGALLNEDKIL 4451

  Fly  1024 DNKIAHIHVPLVVGCIIPLTVSVFVIPL----VEEEIYDVRFLQHMAGLGLKVFWGINLFWDWFT 1084
            :: |....|.|   ||: |..|:....:    |.:.:...:.|||::|||.:::|..|..:|...
Human  4452 ES-IRQCGVAL---CIV-LGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLF 4511

  Fly  1085 FFVYSVIIVVIMSLMGIGGFGFYEN-AIMVVLLTTFGLAALPLTYLVSMFVNKSIVRAFLVSVLL 1148
            :.|...:.|.::....:..|.|.:| |...:||:.||.|.||..||:|...:.|.| ||:..|.|
Human  4512 YLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDV-AFISYVSL 4575

  Fly  1149 QGVSGLVLYIIYWDVANSNTIFFYAACMSPGFSLLDGVSNVYAQNLEQAICIDKCEAT---DSCT 1210
            ..:.||...:|        ||.       |  .||..:|.  |:||:....:.|...|   ..|.
Human  4576 NFIFGLCTMLI--------TIM-------P--RLLAIISK--AKNLQNIYDVLKWVFTIFPQFCL 4621

  Fly  1211 EENMNEVVPN-CKFDTFFKWAAPGILPPI-------LYMVLSALIFLMLIFWIELH---RREKKF 1264
            .:.:.|:..| .|:|....:.....:.|.       :::.|::...::|:..:.||   .|..:.
Human  4622 GQGLVELCYNQIKYDLTHNFGIDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLLRWPRG 4686

  Fly  1265 HTSRDLRKMRTATYPFDDGDVADVKQKIAEADNT--------------KAKQSVFLVDQVEARVP 1315
            |::     ::.......|.||...::::.|....              :..|::..|..:...:|
Human  4687 HST-----LQGTVKSSKDTDVEKEEKRVFEGRTNGDILVLYNLSKHYRRFFQNIIAVQDISLGIP 4746

  Fly  1316 AAGKRIHTVSFALNKYMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYVR-GLDFKYDLESIHT- 1378
                          |....|:.|...:|||...:.|.|:.....|...:| .:....||.|..|
Human  4747 --------------KGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTA 4797

  Fly  1379 --YMGYSPQHRGLLNELTPREHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTGWMHRKCSLLTAEK 1441
              .:||.||...|...||..||:...|.:||:|...|.|...||...|::.....:..:..:...
Human  4798 GVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGT 4862

  Fly  1442 RHKLKIALALVAYNKILVLDEPTCGMPATTRREIW-NILRYIRYCGKTIIFATNDELECKILADF 1505
            :.||..|||||....||:||||:.||...::|.:| .|::.:|. |...:..::...||:.|...
Human  4863 KRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVRE-GCAAVLTSHSMEECEALCTR 4926

  Fly  1506 IILFQDSEMLAIGSLQYLRYKYSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLHNRSE 1570
            :.:..:.....:||.|:::.::..|:.::|.|.::........::|:.....:           :
Human  4927 LAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKLYFPGI-----------Q 4980

  Fly  1571 LVGRLNNWFKFYVPVGHIVYSFLYGAMEKNKLRLNVSDYCIYQADMMSV----VAQVQE------ 1625
            ..|:..|..:::||......:.|:..:|.||..||:..|.|.|..:..|    .::.|:
Human  4981 FKGQHLNLLEYHVPKRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQQTLQSTL 5045

  Fly  1626 ---TRAQLKHHL 1634
               |.:...|||
Human  5046 DPSTDSHHTHHL 5057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	26/146 (18%)
		ABC2_membrane_4	<293..448	CDD:289500	27/174 (16%)
		EcfA2	499..717	CDD:224047	54/232 (23%)
		P-loop_NTPase	500..721	CDD:304359	56/235 (24%)
		ABC2_membrane_3	<972..1254	CDD:289468	80/311 (26%)
		EcfA2	1307..1521	CDD:224047	59/218 (27%)
		P-loop_NTPase	1324..1524	CDD:304359	58/204 (28%)
ABCA13	XP_011513432.1	rim_protein	3068..5049	CDD:130324	391/1887 (21%)
		ABC_subfamily_A	3842..4062	CDD:213230	56/235 (24%)
		ABC_subfamily_A	4719..4945	CDD:213230	61/240 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148364
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850