DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1801 and Abca4

DIOPT Version :9

Sequence 1:NP_728408.3 Gene:CG1801 / 33104 FlyBaseID:FBgn0031171 Length:1655 Species:Drosophila melanogaster
Sequence 2:NP_031404.1 Gene:Abca4 / 11304 MGIID:109424 Length:2310 Species:Mus musculus


Alignment Length:1958 Identity:390/1958 - (19%)
Similarity:711/1958 - (36%) Gaps:483/1958 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 ENENEQSIVSHKLQDINI---LTRMADSKREKTKYILAF---TPETTFTSEVTK-------NVA- 104
            |...:.:::...||...:   :.|....:...|:.:|.|   .|:.....::|.       |:. 
Mouse   443 EKSTQMTVIRDTLQHPTVKDFINRQLGEEGITTEAVLNFFSNGPQEKQADDMTSFDWRDIFNITD 507

  Fly   105 ----------KTLELSSTVGYESESEMQNQ----FDERTTLAGIVFNDLRDDGTPLTLSISIRFP 155
                      :.|.|.....|:.|.::..:    .:|....||:||..:....:.|...:..:..
Mouse   508 RFLRLANQYLECLVLDKFESYDDEVQLTQRALSLLEENRFWAGVVFPGMYPWASSLPPHVKYKIR 572

  Fly   156 SEFRTIAPF-LTEDRLWITRCSG-RINPGRDRAKHDKQQDIYIREGFLQLQHQIFVEWYHQLRKD 218
            .:...:... ..:||.|   .|| |.:|..|..        ||..||..||..:        .:.
Mouse   573 MDIDVVEKTNKIKDRYW---DSGPRADPVEDFR--------YIWGGFAYLQDMV--------EQG 618

  Fly   219 IVST--YPEPNVEVYNILLKAADEPC----SVMSVAQ--LPTFL-YNFIYLLPFLNIIRNVAAQV 274
            ||.:  ..||.:.||   |:....||    |.|.:..  .|.|: ..:||.:..  .::.:..:.
Mouse   619 IVKSQMQAEPPIGVY---LQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSM--TVKGIVLEK 678

  Fly   275 EDGVMVHQWHYGYSFGMQWGIKFLVLFLRMCILGVIYTIMLLAFWGFGGREGEFSGTGTIAFVCF 339
            |..:.....:.|.|..:.|...||..|..|.:     :|.||..:...||...:|.    .|:.|
Mouse   679 ELRLKETLKNQGVSNAVIWCTWFLDSFSIMAL-----SIFLLTLFIMHGRILHYSD----PFILF 734

  Fly   340 ITL--YTVEIIITGMVVAKLFANPTNAVLFALMLWLFMYAAFCIILERYW------DIHKYYVFF 396
            :.|  :....|:...:::.||:..:.|...:.:::..:|....:...  |      |:.......
Mouse   735 LFLLAFATATIMQSFLLSTLFSKASLAAACSGVIYFTLYLPHVLCFA--WQDRMTADLKTTVSLL 797

  Fly   397 ILVAF---CNCQMHF---SMSL-FRNCIEKPEMVNTIDFVLIFTSAISSALIYFLILLAIQWRMP 454
            ..|||   ....:.|   .:.| :.|..:.|...:...|:|.....:..|.:|.|:...:....|
Mouse   798 SSVAFGFGTEYLVRFEEQGLGLQWSNIGKSPLEGDEFSFLLSMKMMLLDAALYGLLAWYLDQVFP 862

  Fly   455 GT--------FL----------------SRRIVNNRPRKQQESDTTIMYLGRAPSFQN---FEFG 492
            |.        ||                .|.:....|..::..|.      ..|...|   ||..
Mouse   863 GDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEEMEDP------EHPEGMNDSFFERE 921

  Fly   493 DVGSVELMRLRHVSTSHRDSERKILKNISMRIYRGEVFVILGHIGSGKLTLLRILAGLKFPLRGN 557
            ..|.|..:.::::......|.|..:..:::..|..::...|||.|:||.|.|.||.||..|..|.
Mouse   922 LPGLVPGVCVKNLVKVFEPSGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGT 986

  Fly   558 VYIMGNPFEPNGEARRLVDFRFDEHG-LNKHLTVEQTIDYHVRLKLSPSESDRYEIERRKWLAIL 621
            |.|.|...|.|.:..|.......:|. |..||||.:.|.::.:||....|..:.|:|     |:|
Mouse   987 VLIGGKDIETNLDVVRQSLGMCPQHNILFHHLTVAEHILFYAQLKGRSWEEAQLEME-----AML 1046

  Fly   622 DQ---HVESRGVRIGKLSSGSMKLVALCCCLAGDTPIIILEEPTTQLTGREAQIFWSIVHAEKEN 683
            :.   | ..|......||.|..:.:::.....||:.:::|:|||:.:.....:..|.::...:..
Mouse  1047 EDTGLH-HKRNEEAQDLSGGMQRKLSVAIAFVGDSKVVVLDEPTSGVDPYSRRSIWDLLLKYRSG 1110

  Fly   684 RAFIIATYNVGEAEHVADRIGILSMGVLEASGTPFFLRSKFSSSVDLVIIKK------------- 735
            |..|::|:::.||:.:.|||.|:|.|.|..||||.||::.|.:...|.:::|             
Mouse  1111 RTIIMSTHHMDEADLLGDRIAIISQGRLYCSGTPLFLKNCFGTGFYLTLVRKMKNIQSQRGGCEG 1175

  Fly   736 -----------------PHVPDQPITDYINQFMQNI----EPENE----IGDSLTYRLP-VIYRP 774
                             ..:.::.:.|...|.:.::    .||.:    ||..|.:.|| ..::.
Mouse  1176 VCSCTSKGFSTRCPTRVDEITEEQVLDGDVQELMDLVYHHVPEAKLVECIGQELIFLLPNKNFKQ 1240

  Fly   775 RLQKLLIHLEIDRKM--LGIENVRVVGAELSDIYMTLVTSFRLQQQMI--------------PDV 823
            |....|.. |::..:  ||:.:..:....|.:|::.:..........:              |..
Mouse  1241 RAYASLFR-ELEETLADLGLSSFGISDTPLEEIFLKVTEDAGAGSMFVGGAQQKREQAGLRHPCS 1304

  Fly   824 TQTFKYQVVSQ-------------------------------KQLTKQRMRAMFYKKMIHT---- 853
            ..|.|.:..:|                               .:|..|.::|:..|:..||    
Mouse  1305 APTEKLRQYAQAPHTCSPGQVDPPKGQPSPEPEDPGVPFNTGARLILQHVQALLVKRFHHTIRSR 1369

  Fly   854 ----APNVWPIIMIFTSFVLIAII------------------------------ARLSVLLDM-- 882
                |..|.|...:|.:.:|..|:                              ..|.||.|:  
Mouse  1370 KDFVAQIVLPATFVFLALMLSIIVPPFGEFPALTLHPWMYGHQYTFFSMDEPNNEHLEVLADVLL 1434

  Fly   883 ----------------------------PKERQNSIHI--------------------------- 892
                                        |....|..|:                           
Mouse  1435 NRPGFGNRCLKEEWLPEYPCINATSWKTPSVSPNITHLFQKQKWTAAHPSPSCKCSTREKLTMLP 1499

  Fly   893 -------GFREPE------DVVKYLPNLKDCGYID------IRSAVK----VNKKKSVGVS---- 930
                   |...|:      :|::.|.|.....|:.      |||::|    ||:::..|:|    
Mouse  1500 ECPEGAGGLPPPQRTQRSTEVLQDLTNRNISDYLVKTYPALIRSSLKSKFWVNEQRYGGISIGGK 1564

  Fly   931 ---RTFDDDS---FVCEKGSYRN------NLRKKNELRSFGAVESDGDEHLNGYISQDMFHSAPM 983
               .....::   |:...|...|      ......|:..| ....:..:::..:.:...:|:...
Mouse  1565 LPAIPISGEALVGFLSGLGQMMNVSGGPVTREASKEMLDF-LKHLETTDNIKVWFNNKGWHALVS 1628

  Fly   984 MLNLLQNVILRLSYPMQTDLVVLVENHPLPTQLSQKINVLDNKIAHIHV------PLVVGCII-- 1040
            .||:..|.|||.|.|...|    .|.:.: |.:||.:|:...:::.|.|      .:|..|:|  
Mouse  1629 FLNVAHNAILRASLPRDRD----PEEYGI-TVISQPLNLTKEQLSDITVLTTSVDAVVAICVIFA 1688

  Fly  1041 -PLTVSVFVIPLVEEEIYDVRFLQHMAGLGLKVFWGINLFWDWFTFFVYSVIIVVIMSLMGIGGF 1104
             ....:.||:.|::|.:...:.||.::|:....:|..|..||...:.|.:.::|.|.       .
Mouse  1689 MSFVPASFVLYLIQERVTKAKHLQFISGVSPTTYWLTNFLWDIMNYAVSAGLVVGIF-------I 1746

  Fly  1105 GFYENA--------IMVVLLTTFGLAALPLTYLVSMF--VNKSIVRAFLVSVLLQGVSGLVLYII 1159
            ||.:.|        .:|.||..:|.|.:|:.|..|..  |..:...|...:.|..|::...:..:
Mouse  1747 GFQKKAYTSPDNLPALVSLLMLYGWAVIPMMYPASFLFEVPSTAYVALSCANLFIGINSSAITFV 1811

  Fly  1160 YWDVANSNTIFFYAA------------CMSPG---FSLLDGVSNVYAQNLEQAICIDKCEATDSC 1209
            .....|:.|:..:.|            |:..|   .:|...|::||||..|              
Mouse  1812 LELFENNRTLLRFNAMLRKLLIVFPHFCLGRGLIDLALSQAVTDVYAQFGE-------------- 1862

  Fly  1210 TEENMNEVVPNCKFDTFFKWAAPG------ILPPILYMVLSALI--FLMLIFWIELHRREKKFHT 1266
             |.:.|.          |:|...|      .:..::|.:|:.||  ...|..||....||..|. 
Mouse  1863 -EYSANP----------FQWDLIGKNLVAMAIEGVVYFLLTLLIQHHFFLTRWIAEPAREPVFD- 1915

  Fly  1267 SRDLRKMRTATYPFDDGDVADVKQKIAEADNTKAKQSVFLVDQV-EARVPAAGKRIHTVSFALNK 1330
                          :|.|||:.:|::....|   |..:..:::: :....::...:..:...:..
Mouse  1916 --------------EDDDVAEERQRVMSGGN---KTDILKLNELTKVYSGSSSPAVDRLCVGVRP 1963

  Fly  1331 YMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYVRGLDFKYDLESIHTYMGYSPQHRGLLNELTP 1395
            ....|:.|...:||:...:.|.|......|:..|.|......:..:|..|||.||...:.:.||.
Mouse  1964 GECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTSISDVHQNMGYCPQFDAIDDLLTG 2028

  Fly  1396 REHIRLLCMIRGVPEAKIGEKMHDLCLM-LNMTGWMHRKCSLLTAEKRHKLKIALALVAYNKILV 1459
            |||:.|...:||||..:| ||:.:..:. |.::.:..|.....:...:.||..|:||.....:|:
Mouse  2029 REHLYLYARLRGVPSKEI-EKVANWGIQSLGLSLYADRLAGTYSGGNKRKLSTAIALTGCPPLLL 2092

  Fly  1460 LDEPTCGMPATTRREIWNILRYIRYCGKTIIFATNDELECKILADFIILFQDSEMLAIGSLQYLR 1524
            |||||.||....||.:||.:..|...|:.::..::...||:.|...:.:........:|::|:|:
Mouse  2093 LDEPTTGMDPQARRMLWNTIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGTFQCLGTIQHLK 2157

  Fly  1525 YKYSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLHNRSELVGRLNNWFKFYVPVGHIV 1589
            ||:..|:.:.::       :...:::|..|:..:.:|.......|....|.::..:|.||...: 
Mouse  2158 YKFGDGYIVTMK-------IKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHHSMLQFQVPSSSL- 2214

  Fly  1590 YSFLYGAMEKNKLRLNVSDYCIYQADM----MSVVAQVQET--------------RAQL--KHHL 1634
             :.::..:..:|..|.:.:|.:.|..:    ::...|..||              :|:|  |...
Mouse  2215 -ARIFQLLISHKDSLLIEEYSVTQTTLDQVFVNFAKQQTETYDLPLHPRAAGASWQAKLEEKSGR 2278

  Fly  1635 VQTEGPLP 1642
            :||:.|||
Mouse  2279 LQTQEPLP 2286

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1801NP_728408.3 ABC2_membrane_3 <246..379 CDD:289468 26/137 (19%)
ABC2_membrane_4 <293..448 CDD:289500 33/169 (20%)
EcfA2 499..717 CDD:224047 63/221 (29%)
P-loop_NTPase 500..721 CDD:304359 66/224 (29%)
ABC2_membrane_3 <972..1254 CDD:289468 71/323 (22%)
EcfA2 1307..1521 CDD:224047 53/215 (25%)
P-loop_NTPase 1324..1524 CDD:304359 54/200 (27%)
Abca4NP_031404.1 rim_protein 1..2271 CDD:130324 382/1941 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 891..910 3/24 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1311..1344 1/32 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2266..2310 8/21 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838460
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.750

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