DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and ABCA10

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_001364250.1	Gene:	ABCA10 / 10349	HGNCID:	30	Length:	1543	Species:	Homo sapiens

Alignment Length:	1673	Identity:	340/1673 - (20%)
Similarity:	659/1673 - (39%)	Gaps:	314/1673 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 VAKTLELSSTVGYESESEMQNQFDER-TTLAGIVFNDLRDDGTPLTLSISIRFPSEFRTIAPFLT 166
            :|..::..:.:|...|..|..:..:: ..:.|::|:|        |.|..::|...:|  .|.:.
Human     6 LASFMKGRTVIGTPDEETMDIELPKKYHEMVGVIFSD--------TFSYRLKFNWGYR--IPVIK 60

  Fly   167 EDRLWITRCSGRINPGRDRAKHDKQQDI------YIREGFLQLQHQIFVEWYHQLRKDIVSTYPE 225
            |...:...|         .|.|.   :|      |..:||:..|..|
Human    61 EHSEYTEHC---------WAMHG---EIFCYLAKYWLKGFVAFQAAI------------------ 95

  Fly   226 PNVEVYNILL--KAADEPCSVMSV-AQLPTFL---------YNFIYLLPFLNII----RNVAAQV 274
             |..:..:..  ...:|..||:.: .::|.|:         ::|..|:.|.:.|    .|||.
Human    96 -NAAIIEVTTNHSVMEELTSVIGINMKIPPFISKGEIMNEWFHFTCLVSFSSFIYFASLNVAR-- 157

  Fly   275 EDG----VMVHQWHYGYSFGMQWGIKFL-VLFLRMCILGVIYTIMLLAFWGFGGREGEFSGTGTI 334
            |.|    :|........:|.:.||:.:: .:|:....:.::.|.:.:.|           .||.:
Human   158 ERGKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVITSIPIVF-----------HTGFM 211

  Fly   335 AFVCFITLYTVEIIITGMVVAKLFANPTNAVLFALMLWLFMYAAFCIILERYWDIHKYYVFFILV 399
            ......:||.:.:|....:::.|...|..|.|...:..:|.......:|.|...:...:|..:|.
Human   212 VIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWGCLGFTVLYRQLPLSLGWVLSLLS 276

  Fly   400 AFC---------NCQMHFSMSLFRN-CIEKPEMVNTIDFVLIFTSAISSALIYFLILLAIQWRMP 454
            .|.         :...:.|..:|.: ..:..:|:.|. |:|.|     ..|.|.:..|..:..:|
Human   277 PFAFTAGMAQITHLDNYLSGVIFPDPSGDSYKMIATF-FILAF-----DTLFYLIFTLYFERVLP 335

  Fly   455 --------------GTFLSR------RIVNNRPRKQQESDTTIMYLGRAPSFQNFEFGDVGSVEL 499
                          .:|.|:      .|..|....:..||.:...:  :|.|.        ..|.
Human   336 DKDGHGDSPLFFLKSSFWSKHQNTHHEIFENEINPEHSSDDSFEPV--SPEFH--------GKEA 390

  Fly   500 MRLRHVSTSHRDSERKI--LKNISMRIYRGEVFVILGHIGSGKLTLLRILAGLKFPLRGNVYIMG 562
            :|:|:|...:.....|:  |:.|...||.|::..||||.|:||.|||.||:||.....|:..|..
Human   391 IRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYN 455

  Fly   563 ---NPFEPNGEARRLV------DFRFDEHGLNKHLTVEQTIDYHVRLK-LSPSESDRYEIERRKW 617
               :......|.|:.:      :|:||      .|||.:.:....::| :.|.|.:: |::|
Human   456 TQLSEITDMEEIRKNIGFCPQFNFQFD------FLTVRENLRVFAKIKGIQPKEVEQ-EVKR--- 510

  Fly   618 LAILDQHVES-RGVRIGKLSSGSMKLVALCCCLAGDTPIIILEEPTTQLTGREAQIFWSIVHAEK 681
             .|::..::| :.:...|||.|..:.:.|...:.||..:::|:|||..|........||::...|
Human   511 -IIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHK 574

  Fly   682 ENRAFIIATYNVGEAEHVADRIGILSMGVLEASGTPFFLRSKFSSSVDLVIIKKPHVPDQPITDY 746
            .:|..:.:|..:.||:.:|||...||.|.|:.:|:..||:.|:.....|.:.:......:.||..
Human   575 VDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSL 639

  Fly   747 INQFMQNIEPENEIGDSLTYRLPVIYRPRLQKLLIHLEIDR-KMLGIENVRVVGAELSDIYMTL- 809
            |.|.:.:.:...|..:.|.|.||:....:...|  :.::|: ...||.|..|....|:::::.|
Human   640 IKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDL--YSDLDKCSDQGIRNYAVSVTSLNEVFLNLE 702

  Fly   810 ------VTSFRLQQQMIPDVTQT------FKYQVVSQKQLTKQRMRAMFYKKMIHTAPNVWPIIM 862
                  ...|.:.:|....||:.      .:..:.|..:..|....|..:::.|:....:..:.:
Human   703 GKSAIDEPDFDIGKQEKIHVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKL 767

  Fly   863 -----IFTSFVLIAIIARLSVLLD--MPKERQNSIHIGFREPEDVVKYLPNLKDCGYIDIRSAVK 920
                 .....:|:..||.:.::|:  |.|..:.: |.....|.   .|..:|:......:.|.:.
Human   768 RRERRALLCLLLVLGIAFIPIILEKIMYKVTRET-HCWEFSPS---MYFLSLEQIPKTPLTSLLI 828

  Fly   921 VNKKKSVGVSRTFDD-------DSFVCEKGSYRNNLRKKNELRSF-GAVESDGDE---HLNGYIS 974
            ||...|     ..:|       ...|.|...:||  |..::..|: ||:...||:   ..:...:
Human   829 VNNTGS-----NIEDLVHSLKCQDIVLEIDDFRN--RNGSDDPSYNGAIIVSGDQKDYRFSVACN 886

  Fly   975 QDMFHSAPMMLNLLQNVILRL-SYPMQTDLVVLVENHPLPTQLSQKINVLDNKI--AHIHVPLVV 1036
            ....:..|:::.::.|.::.: ::   |:|:.:..     |..|:...|||...  ..|.:.|:.
Human   887 TKKLNCFPVLMGIVSNALMGIFNF---TELIQMES-----TSFSRDDIVLDLGFIDGSIFLLLIT 943

  Fly  1037 GCIIPLTVSVFV-IPLVEEEIYDVRFLQHMAGLGLKVFWGINLFWDWFTFF--VYSVIIVVIMSL 1098
            .|:.|     |: :..:.:...:|:....::||....:|......|...:|  ::|:.::.....
Human   944 NCVSP-----FIGMSSISDYKKNVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIF 1003

  Fly  1099 MGIGGFGFYENAIMVVLLTTFGLAA--LPLTYLVSMFVNK----SIVRAFLVSVLLQGVSGLVLY 1157
            :   ||......:.|:::...|.|.  :.|||::|....|    :...:|...::|..||.:::.
Human  1004 L---GFQLSWELMFVLVVCIIGCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFIILICVSTIMVS 1065

  Fly  1158 IIYWDVANSNTIFFYAACM--SPGFSLLDGVSNVYAQNLEQAICIDKCEATDSCTEENMNEVVPN 1220
            ..|   ...|.|.    ||  .|.|:||.     |...|.|   :|.....|| .:..:|||...
Human  1066 TQY---EKLNLIL----CMIFIPSFTLLG-----YVMLLIQ---LDFMRNLDS-LDNRINEVNKT 1114

  Fly  1221 CKFDTFFKWAAPGILPPILYMVLSALIFLMLI------FWIELHRREKKFHTSRDLRKMRTATYP 1279
                         ||...|...|.::|||.:|      :..|:..::..|..|...|:    |:|
Human  1115 -------------ILLTTLIPYLQSVIFLFVIRCLEMKYGNEIMNKDPVFRISPRSRE----THP 1162

  Fly  1280 ------FDDGDVADVKQKIAEA-------------------DNTKAKQSVFLVDQVEARVPAAGK 1319
                  .:|.||...:.:.|.|                   :..:.|:|.|...:.:.
Human  1163 NPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFSTRKKKI------- 1220

  Fly  1320 RIHTVSFALNKYMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYVRG--LDFKYDLESIHTYMGY 1382
            .|..|||.:.|...:|:.|...:|||..::.:.|......|.:.::|  ...:...::...::||
Human  1221 AIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSLKFLGY 1285

  Fly  1383 SPQHRGLLNELTPREHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTGWMHRKCSLLTAEKRHKLKI 1447
            .||...|..:||.:||:.|...::|:.:......:..|...|.:...:......|:...:.||..
Human  1286 CPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTLSEGIKRKLCF 1350

  Fly  1448 ALALVAYNKILVLDEPTCGMPATTRREIWNILR-YIRYCGKTIIFATNDELECKILADFIILFQD 1511
            .|:::....:::||||..||....::::|.||: .::...:..:..|:...|.:.:.|.:.:...
Human  1351 VLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVS 1415

  Fly  1512 SEMLAIGSLQYLRYKYSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLHNRSELVGRLN 1576
            ..:..|||:|:|:.|:...:.||:::...            ..||.|...:..|..::....|.:
Human  1416 GTLRCIGSIQHLKNKFGRDYLLEIKMKEP------------TQVEALHTEILKLFPQAAWQERYS 1468

  Fly  1577 NWFKFYVPVGHI-VYSFLYGAMEKNKLRLNVSDYCIYQADMMSVVAQV 1623
            :...:.:||..: ..|..:..:|..|...|:.:|.:.||.:..|..::
Human  1469 SLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEEYSLSQATLEQVFLEL 1516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	28/151 (19%)
		ABC2_membrane_4	<293..448	CDD:289500	29/165 (18%)
		EcfA2	499..717	CDD:224047	67/230 (29%)
		P-loop_NTPase	500..721	CDD:304359	68/233 (29%)
		ABC2_membrane_3	<972..1254	CDD:289468	61/301 (20%)
		EcfA2	1307..1521	CDD:224047	45/216 (21%)
		P-loop_NTPase	1324..1524	CDD:304359	45/202 (22%)
ABCA10	NP_001364250.1	rim_protein	<37..1520	CDD:130324	336/1642 (20%)
ABCA10	NP_001364250.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1153..1177		7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148337
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750