DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and ABCA7

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	XP_024307083.1	Gene:	ABCA7 / 10347	HGNCID:	37	Length:	2151	Species:	Homo sapiens

Alignment Length:	1915	Identity:	402/1915 - (20%)
Similarity:	677/1915 - (35%)	Gaps:	548/1915 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 VAKTLELSSTVGYESESEMQNQ----FDERTTLAGIVFNDLRDDGTPLT----------LSISIR 153
            |.:.|.|.......||:.:.::    ..|....||:||....|...|..          :.|.||
Human   403 VTECLSLDKLEAAPSEAALVSRALQLLAEHRFWAGVVFLGPEDSSDPTEHPTPDLGPGHVRIKIR 467

  Fly   154 FPSEFRTIAPFLTEDRLWITRCSGRINPGRDRAKHDKQQDI-YIREGFLQLQHQIFVEWYHQLRK 217
            ...:..|....: .||.|        :||   ...|...|: |:..||:.||
Human   468 MDIDVVTRTNKI-RDRFW--------DPG---PAADPLTDLRYVWGGFVYLQ------------- 507

  Fly   218 DIVS-------TYPEPNVEVYNILLKAADEPCSVMSV------AQLPTFL-YNFIY--LLPFLNI 266
            |:|.       :...|...:|   |:....||.|..|      ..||.|| ..:||  .|....:
Human   508 DLVERAAVRVLSGANPRAGLY---LQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAV 569

  Fly   267 IRNVAAQVEDGVMVHQWHYGYSFGMQWGIKFLVLFLRMCILGVIYTIMLLAFWGFGGREGEFSGT 331
            :|....::.|.:.        :.|:...:.:|..|| .|:...:.:..||......|....:|..
Human   570 VREKETRLRDTMR--------AMGLSRAVLWLGWFL-SCLGPFLLSAALLVLVLKLGDILPYSHP 625

  Fly   332 GTIAFVCFITLYTVEIIITGMVVAKLFANPTNAVLFALMLWLFMYAAFCIILERYWDIHKYYVFF 396
            |.:  ..|:..:.|..:....:::..|:...             .||.|..| .|:.::..||..
Human   626 GVV--FLFLAAFAVATVTQSFLLSAFFSRAN-------------LAAACGGL-AYFSLYLPYVLC 674

  Fly   397 IL------------------VAF-CNCQMHFSMSLFRNCIEKPEMVN-----TIDFVLIFTSA-- 435
            :.                  ||| ..|:   |::|.....|..:..|     |.|   :|:.|
Human   675 VAWRDRLPAGGRVAASLLSPVAFGFGCE---SLALLEEQGEGAQWHNVGTRPTAD---VFSLAQV 733

  Fly   436 ----ISSALIYFLILLAIQWRMPG--------TFLSRRI--VNNRPRKQQESDTTIM----YLGR 482
                :..|.:|.|....::...||        .|..||.  ...||.|......|.:    .:..
Human   734 SGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPAPCPTPLDPKVLVEE 798

  Fly   483 APSFQNFEFGDVGSVELMRLRHVSTSHRDSERKILKNISMRIYRGEVFVILGHIGSGKLTLLRIL 547
            ||.         |....:.:|.:......|.:..|:.:|:..|:|.:...|||.|:||.|.|.||
Human   799 APP---------GLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSIL 854

  Fly   548 AGLKFPLRGNVYIMGNPFEPNGEARRLVDFRFDEHGLNKHLTV---------EQTIDYHV----R 599
            :||..|..|:.:|:|:            |.|.....:..||.|         ..|:|.||    |
Human   855 SGLFPPSGGSAFILGH------------DVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGR 907

  Fly   600 LK-LSPS----ESDRYEIERRKWLAILDQ--HVESRGVRIGKLSSGSMKLVALCCCLAGDTPIII 657
            || ||.:    |.||          :|..  .|..:.|:...||.|..:.:::.....|.:.::|
Human   908 LKGLSAAVVGPEQDR----------LLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVI 962

  Fly   658 LEEPTTQLTGREAQIFWSIVHAEKENRAFIIATYNVGEAEHVADRIGILSMGVLEASGTPFFLRS 722
            |:|||..:.....:..|.::...:|.|..|::|:::.|||.:.||:.:::.|.|...|:|.|||.
Human   963 LDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRR 1027

  Fly   723 KFSSSVDLVIIKKPHVP----DQPITDY-----INQFMQNIEPENEIGDSLTYRLPVIYRP--RL 776
            ...|...|.:: |..:|    ::..||.     ..|..:|....:.:|......|...:.|  ||
Human  1028 HLGSGYYLTLV-KARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARL 1091

  Fly   777 QKLLIH--------------------LEIDRKMLGIENVRVVGAELSD-----IYMTLV------ 810
            .:.|.|                    .|:|.:   :..:|:.|..:||     |::.:|
Human  1092 VEELPHELVLVLPYTGAHDGSFATLFRELDTR---LAELRLTGYGISDTSLEEIFLKVVEECAAD 1153

  Fly   811 --------------------TSFRLQQQ-------------MIPDVTQTFKYQVVSQKQ---LTK 839
                                .:.||:..             ..|:..|......|.:.|   ||:
Human  1154 TDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAVGRVQGWALTR 1218

  Fly   840 QRMRAMFYKKMIHT--------APNVWPIIMIFTSFVLIAII--------ARLSVLL-------- 880
            |:::|:..|:.:..        |..|.|.:.:..:.|...|:        .|||..:
Human  1219 QQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTMYGAQVSFF 1283

  Fly   881 --DMPKER--------------------QNSIHIGFREPE---DVVKYLPN-------------- 906
              |.|.:.                    |:|.| .|..||   :|.|.|.:
Human  1284 SEDAPGDPGRARLLEALLQEAGLEEPPVQHSSH-RFSAPEVPAEVAKVLASGNWTPESPSPACQC 1347

  Fly   907 --------LKDC----------------GYID-------------------IRSAVK----VNKK 924
                    |.||                |.:.                   :|..:|    ||:.
Human  1348 SRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEV 1412

  Fly   925 KSVGVSRTFDDDSFVC--EKGSYRNNLRKKNELRSF------GAVES------------DGDEHL 969
            :..|.|....|.....  |.|      |...||.:.      ||::.            |..:.|
Human  1413 RYGGFSLGGRDPGLPSGQELG------RSVEELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSL 1471

  Fly   970 NGYISQDMFHSAPMMLNLLQNVILRLSYPMQTDLVVLVENHPLPTQLSQKINVLDNKIAHIHVPL 1034
            ..:.:...:||....:|...|.|||...|            |.|.:.:..|..|::.:......|
Human  1472 KIWFNNKGWHSMVAFVNRASNAILRAHLP------------PGPARHAHSITTLNHPLNLTKEQL 1524

  Fly  1035 VVGCIIPLTVSV----------------FVIPLVEEEIYDVRFLQHMAGLGLKVFWGINLFWDWF 1083
            ..|.::..:|.|                |.:.|:||.:...:.||.|.||...::|..|..||..
Human  1525 SEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMC 1589

  Fly  1084 TFFVYSVIIVVIMSLMGIGGFGFYENA--------IMVVLLTTFGLAALPLTYLVSMF------- 1133
            .:.|.:.|:|:|.       ..|.:.|        .:::||..:|.:..||.|..|.|
Human  1590 NYLVPACIVVLIF-------LAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTA 1647

  Fly  1134 ------------VNKSIVRAFLVSVL----LQGVSGLVLYIIYWDVANSNTIFFYAACMSPGFSL 1182
                        :|.|:. .|::.:.    ||.||.::..:.         :.|...|:..|  |
Human  1648 YVVLTCINLFIGINGSMA-TFVLELFSDQKLQEVSRILKQVF---------LIFPHFCLGRG--L 1700

  Fly  1183 LDGVSNVYAQNLEQAICIDKCEATDSCTEENMNEVVPNCKFDTFFKWAAPGILPPILYMVLSALI 1247
            :|.|.|   |.:..|.                 |.:.:.:|.:..:|...|  ..:|.||:...:
Human  1701 IDMVRN---QAMADAF-----------------ERLGDRQFQSPLRWEVVG--KNLLAMVIQGPL 1743

  Fly  1248 FLMLIFWIELHRRE--KKFHTSRDLRKMRTATYPF---DDGDVADVKQKIAEADNTKAKQSVFLV 1307
            ||:....:: ||.:  .::...|.    |..:.|.   :|.|||..::::.:.    |.|...||
Human  1744 FLLFTLLLQ-HRSQLLPQYSVPRP----RVRSLPLLGEEDEDVARERERVVQG----ATQGDVLV 1799

  Fly  1308 DQVEARVPAAGKRIHTVS---FALNKYMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYVRGLDF 1369
            .:...:| ..|:|:..|.   ..:......|:.|...:||:...|.:.|....:.||..:.|...
Human  1800 LRNLTKV-YRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSV 1863

  Fly  1370 KYDLESIHTYMGYSPQHRGLLNELTPREHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTGWMHRKC 1434
            ..:..:.|..|||.||...:...||.|||:.||..:||||||::.:........|.::.:..|..
Human  1864 AREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPA 1928

  Fly  1435 SLLTAEKRHKLKIALALVAYNKILVLDEPTCGMPATTRREIWNILRYIRYCGKTIIFATNDELEC 1499
            ...:...:.||..|||||....::.|||||.||..:.||.:||.|..:...|::::..::...||
Human  1929 GTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEEC 1993

  Fly  1500 KILADFIILFQDSEMLAIGSLQYLRYKYSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNF 1564
            :.|...:.:..:.....:||.|:|:.:::.|..|.:|:     ..|.|:.        .|.||..
Human  1994 EALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRV-----PAARSQP--------AAAFVAA 2045

  Fly  1565 LHNRSEL----VGRLNNWFKFYVPV-GHIVYSFLYGAMEKNKLRLNVSDYCIYQADMMSVVAQVQ 1624
            ....:||    .|||    :|.:|. |....:.::|.:..:.....|.|:.:.|..:..|.....
Human  2046 EFPGAELREAHGGRL----RFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFS 2106

  Fly  1625 ETRAQLKHHLVQTEGPLPLDTT----SPKK 1650
            :.:.:.:....|.|..:.:|..    .||:
Human  2107 KDQGKDEDTEEQKEAGVGVDPAPGLQHPKR 2136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	24/141 (17%)
		ABC2_membrane_4	<293..448	CDD:289500	34/184 (18%)
		EcfA2	499..717	CDD:224047	64/237 (27%)
		P-loop_NTPase	500..721	CDD:304359	66/240 (28%)
		ABC2_membrane_3	<972..1254	CDD:289468	68/328 (21%)
		EcfA2	1307..1521	CDD:224047	60/216 (28%)
		P-loop_NTPase	1324..1524	CDD:304359	57/202 (28%)
ABCA7	XP_024307083.1	rim_protein	1..2114	CDD:130324	397/1891 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750