Protein Alignment CG1801 and abca5

DIOPT Version :9

• Sequence 1: NP_728408.3
• Gene: CG1801 / 33104
• FlyBaseID: FBgn0031171
• Length: 1655
• Species: Drosophila melanogaster
• Sequence 2: NP_001135599.1
• Gene: abca5 / 100216156
• XenbaseID: XB-GENE-1012902
• Length: 1639
• Species: Xenopus tropicalis
• Alignment Length: 1800
• Identity: 377/1800 - (20%)
• Similarity: 705/1800 - (39%)
• Gaps: 376/1800 - (20%)

  Fly     4 SKGLLFKRYIRIELNLWRRTLFEIVALVIMVLVIFLNPIAHSKRLLYTTTENENEQSIVSHKLQD 68
            :|.||:|.|: |:....|.::.||:..:|..|:          .||:.:..   |||  .|....
 Frog    14 TKTLLYKNYL-IKCRTKRDSIQEILYPIIWWLI----------SLLWASMV---EQS--KHYEAM 62

  Fly    69 INILTRMADSKREKTKYILAFTPETTFTSEVTKNVAKTLELSSTV--GYESESEMQ---NQFDER 128
            .|.|....|....: ..|:.:|||:..|..:....|....|:...  .|..|..|:   :.|:|.
 Frog    63 PNTLLGGLDGPSSR-HLIIGYTPESNITQHIMAMTASECYLTDITFKPYLDEEHMKTASSSFEEH 126

  Fly   129 TTLAGIVFNDLRDDGTPLTLSISIRF-----PSEFRTIAPFLTED-RLWITRCSGRINPGRDRAK 187
              ..|:||::        .:|..:||     |.....:.|  .|| .||....|.
 Frog   127 --FVGVVFDN--------AMSYKLRFSVYSVPDSTLYMTP--REDCHLWNCEASE---------- 169

  Fly   188 HDKQQDIYIREGFLQLQHQI----------FVEWYHQLRKDIVSTYPEPNVEVYNILLKAADEPC 242
                   |....|..||..|          :..| .:|:........|..|.|.:....|.....
 Frog   170 -------YFYSTFTYLQACIDSSMIKMKTNYSAW-EELKSTRAVIMGEQEVIVVDTFYHALMSVF 226

  Fly   243 SVMSVAQLPTFLYNFIYLLPFLNIIRNVAAQVEDGVMVHQWHYGYSFGMQWGIKFLVLFLRMCIL 307
            .||:.:.|.       |.:.|. ::.....:|::.:.:...| ..:|.:.|.:.:....|   ::
 Frog   227 LVMAFSPLG-------YSVAFY-VVFEKEKKVKEFMKLMGLH-DTAFWLPWVLLYTGFIL---VI 279

  Fly   308 GVIYTIMLLAFWGFGGREGEFSGTGTIAFVCFI--TLYTVEIIITGMVVAKLFANP--TNAVLFA 368
            .::..::...|:.|         :.:..|:.|:  .||.:.:::..:::|.||.|.  ..|::|.
 Frog   280 SLVMAVVATTFFPF---------SKSNCFLIFLLYALYGISLVLFALMLAPLFKNSKRAGAIVFL 335

  Fly   369 LMLWLFMYAAFCIILERYWDIHKYYVFFILVAFCNCQMHFSMSLFRNCIEKPEMVNTIDF----- 428
            ..|.|.....|.::.|   |..|.:|:| ...||.|.....::         ::::..||
 Frog   336 STLALGAVGIFIVLKE---DFPKSFVWF-FSPFCQCTFMIGIA---------QVLHLEDFQRGAQ 387

  Fly   429 -----------VLIFTSAISSALIYFLILLAIQWRMPGTFLSRR--IVNNRP-----RKQQESDT 475
                       |:.|...:..:::|.|:...:...:||.:..|:  ....:|     ||::..:.
 Frog   388 FTHLKDGPYPLVITFIFLVVDSVMYLLLATYLDQVLPGEYGLRQSPFFFLKPSYWSKRKKRYGEL 452

  Fly   476 TIMYLGRAPSFQNFEFGDVGSVEL-----MRLRHVSTSHR--DSERKILKNISMRIYRGEVFVIL 533
            ...|..||....  |..:..|.||     :|:..:..|.|  :..|..|:.::..||.|::..::
 Frog   453 NESYFDRAVDMS--EVIEPVSAELHGKEAIRICCICKSFRKNNKPRNALQGLTFDIYEGQITALV 515

  Fly   534 GHIGSGKLTLLRILAGLKFPLRGNVYIMGN---PFEPNGEARRL------VDFRFDEHGLNKHLT 589
            ||.|:||.||:.||.||..|..|...:.|:   ..:...||.::      .|..||.      ||
 Frog   516 GHSGTGKTTLMNILCGLCPPTEGFATVYGHRVTDIDEIQEASKMTGICQQTDIFFDV------LT 574

  Fly   590 VEQTIDYHVRLKLSPSESDRYEIERRKWLAILD----QHVESRGVRIGKLSSGSMKLVALCCCLA 650
            ||:.:  |:...|...:....|.|..|.|..||    :|..:|     .||.|..:.:::...:.
 Frog   575 VEENL--HIFASLRGIDEKTKEQEINKILFDLDMQALKHNHAR-----TLSIGQKRKLSVAIAVL 632

  Fly   651 GDTPIIILEEPTTQLTGREAQIFWSIVHAEKENRAFIIATYNVGEAEHVADRIGILSMGVLEASG 715
            |:..:::|:|||..:........|.::...|.....:.:|:.:.||:.:|||..::|.|.|:..|
 Frog   633 GNPKVLLLDEPTAGMDSCSRHTVWDLLKKRKGKHVTVFSTHCMEEADILADRKAVISQGSLKCIG 697

  Fly   716 TPFFLRSKFSSSVDLVI-IKKPHVPDQPITDYINQFMQNIEPENEIGDSLTYRLPVIYRPRLQKL 779
            :..||:||:.....|.: ||||...| .::..|.|.:.......:..:||.|.||:....:...|
 Frog   698 SSLFLKSKWGVGYRLSMDIKKPCDVD-ALSSLITQHISGASLMQQSENSLLYSLPLKDVSKFPGL 761

  Fly   780 LIHLEIDRKMLGIENVRVVGAELSDIYMTLVTSFRLQQ----------------QMIPDVTQ-TF 827
            ...|: ....|||....|....|.|::..|.|...:.|                :.:.|:.| ..
 Frog   762 FSALD-SGSDLGIITYGVSATTLEDVFFKLETEAEIDQTDGIFNQRNLEDEGKWKSMEDIEQGLL 825

  Fly   828 KYQV------VSQKQLTKQRMRAM--FYKKMIHTAPNVWPIIMIFTSFVLI-------------A 871
            :..:      |:...|.||::.|:  .:.:.:|.....:..:.:...|.|:             .
 Frog   826 ELSLESSPCSVTGSALWKQQVAAVAKLHFRNLHRESKSFRCVCLCLLFFLVPQLTLYFLGLSYHQ 890

  Fly   872 IIARLSVLLDM----PKERQNSIHIGFREPEDVVKYLPNLKDCGYIDIRSAVKVNKKKSVGVSRT 932
            .:|.:.:..||    ||::.:             |:|.:|.      ::::...|..:.:|
 Frog   891 SLAPIRLSADMYFSHPKQKSH-------------KFLTSLL------LQNSTGTNLDELLG---- 932

  Fly   933 FDDDSFVCEKGSYRNNLRKKNELRSFGAVESDGDEH---LNGYIS-----------QDMFHSAPM 983
                        ..|:.:.|.:|.: |:.......|   ||.::|           ..|.||.|:
 Frog   933 ------------NLNSQKIKVDLIN-GSDYMSASPHNAALNVFLSGKHYTYEAIFNSSMVHSLPV 984

  Fly   984 MLNLLQNVILRLSYPMQTDLVVLVENHPLPTQLSQKINVLDNKIAHIHVPLVVGCIIPLTVSVFV 1048
            ::|.:.|.:||   .:..:..:.|.|.|...........||......::.::.|          :
 Frog   985 LINTISNSLLR---QLGVNESIEVWNSPFYQDFLHTSYGLDFYFLIAYLGIMTG----------M 1036

  Fly  1049 IPLVE-EEIYDVRFLQH----MAGLGLKVFWGINLFWDWFTFFVYSVIIVVIMSLMGI-GGFGFY 1107
            :|.:. |..|:.:...:    ||||....:|......|...||:  :::.::.|::.. .|...:
 Frog  1037 LPYIAMENAYNHKVKAYSQLKMAGLYPSAYWVGQAVVDIPLFFL--MLLFMVGSMLAFKSGIDLH 1099

  Fly  1108 ENAIMVVLLTTFGL--AALPLTYLVSM---FVNK-----SIVRAFLVSVLLQGVSGLVLYIIYWD 1162
            ...::.::....|.  |.:.|||:||.   .:|.     |::.|...|:.:..:...:.:
 Frog  1100 AGTVLAMIFCLIGYVPAVVLLTYVVSFTYKLINDTRQWWSLIFAVTASISIIIIEAAIFF----- 1159

  Fly  1163 VANSNT-----IFFYAACMSPGFSLLDGVSNVYAQNLEQAICIDKCEATDSCTEENMNEVVPNCK 1222
             |:|.|     :||  :...|.:.||..::           |..|.         :.|....:.|
 Frog  1160 -ASSVTVTRLHVFF--SIFFPVYPLLGCLT-----------CFIKM---------SRNLAHSDVK 1201

  Fly  1223 FDTFFKWAAPGILPPILYMVLSALIFLMLIFWIELH------RREKKFHT-SRDLRKMRTATYPF 1280
            ..|........:..|.::.    |||.:::.::|:.      |::..|.: ::..:..:.|..|.
 Frog  1202 GLTQLGRLLVAVFAPYVHF----LIFFLILRYLEMKYGGRSIRKDPVFRSQTKKTKPWKFAEVPE 1262

  Fly  1281 D-DGDVADVKQKIAE--ADNTKAKQSVFLVDQVEARVPAAGKRI----------HTVSFALNKYM 1332
            | |.||...:.::.|  |.:...|..| ||..:.......||.|          :.|||.:.|..
 Frog  1263 DEDEDVKVERARVGEYMAPDCNEKPMV-LVSGLHKEQDQTGKTILGKAMRKLVVNNVSFCVRKGE 1326

  Fly  1333 SMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYV-------RGLDFKYDLESIHTYMGYSPQHRGLL 1390
            ::|:.||..:|||.|:..:|||.....|:|.:       .||       |...::|||||.....
 Frog  1327 TVGLVGPNGAGKSTLLNMMVGQSELNAGQILMGDPAAGEPGL-------SPPRFLGYSPQTNYFW 1384

  Fly  1391 NELTPREHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTGWMHRKCSLLTAEKRHKLKIALALVAYN 1455
            .|:..:||:.....|:|:....:.|....:...|::...:......|:...:.||..||:::...
 Frog  1385 PEIKLQEHLETYGAIKGMGSNVLKEVTRRIVETLDLKDHLQEPAKKLSVGNQRKLSFALSMLGNP 1449

  Fly  1456 KILVLDEPTCGMPATTRREIWNILR-YIRYCGKTIIFATNDELECKILADFIILFQDSEMLAIGS 1519
            .|::|:||:.||....::.:|.::| .::...:..:..|:...|.:.:.|.:.:....::..|||
 Frog  1450 DIVLLEEPSTGMDPKNKQIMWKVIRTTLKGKEQAAVITTHSMEEAEAICDRVAIMVSGQLRYIGS 1514

  Fly  1520 LQYLRYKYSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLHNRSELVGRLNNWFKFYVP 1584
            :|:|:.|:...|.||::|  |....:::.|.|.|::  |..|.|..|..|     .::...:.||
 Frog  1515 VQHLKSKFGRYFSLELKL--DTRARSQNVEFLHKEI--LQIFPNASHQES-----FSSLMSYKVP 1570

  Fly  1585 VGHI-VYSFLYGAMEKNKLRLNVSDYCIYQADMMSV---VAQVQE 1625
            ...: ..|..:..:|:.|...|:.:|...||.:..|   :|:.||
 Frog  1571 KEDVESLSQTFSKLEQVKQMYNIEEYIFSQATLEQVFIELAKEQE 1615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	22/136 (16%)
		ABC2_membrane_4	<293..448	CDD:289500	31/174 (18%)
		EcfA2	499..717	CDD:224047	62/237 (26%)
		P-loop_NTPase	500..721	CDD:304359	62/235 (26%)
		ABC2_membrane_3	<972..1254	CDD:289468	56/313 (18%)
		EcfA2	1307..1521	CDD:224047	54/231 (23%)
		P-loop_NTPase	1324..1524	CDD:304359	51/207 (25%)
abca5	NP_001135599.1	rim_protein	<87..1616	CDD:130324	352/1709 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010