DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and ABCG1

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	XP_024307909.1	Gene:	ABCG1 / 9619	HGNCID:	73	Length:	786	Species:	Homo sapiens

Alignment Length:	767	Identity:	160/767 - (20%)
Similarity:	273/767 - (35%)	Gaps:	234/767 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 SIMSLIIL--LSFIYPC-TYITKYITAEKEKQLKEVMKIMGLSNWLHW----------TAWFVKS 321
            |:.:.|:|  |..:.|. |::::|..|.:...          ..|::|          .||.:::
Human     7 SVCTAILLARLWCLVPTHTFLSEYPEAAEYPH----------PGWVYWLQMAVAPGHLRAWVMRN 61

  Fly   322 FIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAV 386
            .:...|.:.....|.    .|:.||||....||....:.:..::|           ::..::..|
Human    62 NVTTNIPSAFSGTLT----HEEKAVLTVFTGTATAVHVQVAALAS-----------AKLESSVFV 111

  Fly   387 TGLIWFIAYIPYSFTINSYDDLSLSSK-------LGWSLI----SNTAMGFGIKLILGFEGTGEG 440
            |..:        |..|.:..|.:|..|       .|.|::    ||..:          :.:...
Human   112 TDCV--------SCKIENVCDSALQGKRVPMSGLQGSSIVIMPPSNRPL----------KASAAS 158

  Fly   441 LQWSNFFTPVSVD-DTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRP--WNFPFTREFW 502
            ..||     |.|. ....||.|.|.               .:|:..:.|..|.  |.||
Human   159 CTWS-----VQVQGGPHHLGVVAIS---------------GKVLSAAHGAGRAYGWGFP------ 197

  Fly   503 CGEREYTGVEDIPNGHVEQRDPKAFETEPEGKHIGLQMRHLKKRFGNKMVVKGLSMNMFEDEITV 567
                               .||                    ...|.|.::||:|......|:..
Human   198 -------------------GDP--------------------MEEGYKTLLKGISGKFNSGELVA 223

  Fly   568 LLGHNGAGKTTTISML-----TGMFPPTSGTAIING--SDIR--TNIEGARMSLGICPQHNVLFD 623
            ::|.:||||:|.:::|     |||    .|..:|||  .|:|  ..:....|...:...|..:.:
Human   224 IMGPSGAGKSTLMNILAGYRETGM----KGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQE 284

  Fly   624 EMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTK 688
            .|.||.|::...:.:|.|     :.|.:.|..:.|...||..:..||||.:::|::...|..:..
Human   285 AMMVSAHLKLQEKDEGRR-----EMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPP 344

  Fly   689 VVLCDEPSSGMDPSARRQLWDLLQ-QEKVGRTLLLTTHFMDEADV--LGDRIAIMCDGELKCQGT 750
            |:..|||:||:|.::..|:..|:: ..:.||:::.|.| ...|.:  |.|::.::..|:
Human   345 VMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH-QPSAKLFELFDQLYVLSQGQ------ 402

  Fly   751 SFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAEL-SYQLP-----DSASAK 809
                           ||.|     .:|..|    :|.|:   |:|... :|..|     :.||.:
Human   403 ---------------CVYR-----GKVCNL----VPYLR---DLGLNCPTYHNPADFVMEVASGE 440

  Fly   810 FEEMFGQL-----EEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIK---DQHEIMNGGSGF 866
            :.:...:|     |...|..|....|........::.:...|...|..:|   .....|.|...|
Human   441 YGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSF 505

  Fly   867 RGEDDNE----------SVQSDGIFSENR-------RLLQGLQLL--SNQWKAMLLKK-FLYTWR 911
            ......:          |:..|.:.:..|       .||.||..|  .|:.|.:|... ||:.
Human   506 SASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFF-- 568

  Fly   912 NKLLLLIQNIMPVFFVVVTILIIKTQ-GTF-QELKPITISLTQYPLAVTVLD 961
            :.|.|:...:||      |:|....: |.| :|......||..|.||.|:.|
Human   569 SMLFLMFAALMP------TVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMAD 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	33/187 (18%)
		ABC2_membrane_3	<269..475	CDD:289468	41/229 (18%)
		CcmA	538..843	CDD:224054	76/327 (23%)
		ABC_subfamily_A	538..755	CDD:213230	58/228 (25%)
		ABC2_membrane_3	913..1316	CDD:289468	16/51 (31%)
		ABC_subfamily_A	1369..1587	CDD:213230
		drrA	1376..1702	CDD:130256
ABCG1	XP_024307909.1	3a01204	202..786	CDD:273361	111/464 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910