DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and PDR12

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_015267.1	Gene:	PDR12 / 856049	SGDID:	S000005979	Length:	1511	Species:	Saccharomyces cerevisiae

Alignment Length:	1242	Identity:	230/1242 - (18%)
Similarity:	417/1242 - (33%)	Gaps:	436/1242 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   619 NVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELED--------KANVASSKLSGGMKR 675
            |:|.:|..:       .|::.: .:.:..:..|.:...|:.|        ...:.|.:|..|::.
Yeast    53 NILSNEEGI-------ERLESM-ARVISHKTKKEMDSFEINDLDFDLRSLLHYLRSRQLEQGIEP 109

  Fly   676 KLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLL-----LTTHFMDEADVLGD 735
                     ||:.:...:..:.|:|.||...    ...|::.|.:.     |.:.|..::||...
Yeast   110 ---------GDSGIAFKNLTAVGVDASAAYG----PSVEEMFRNIASIPAHLISKFTKKSDVPLR 161

  Fly   736 RIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSY 800
            .|...|.|.:: .|...|:..:.|:|    |.....|.:.|.:.|:           |:..|.||
Yeast   162 NIIQNCTGVVE-SGEMLFVVGRPGAG----CSTFLKCLSGETSELV-----------DVQGEFSY 210

  Fly   801 QLPDSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAE------------------- 846
            ...|.:     ||..:.:         ||.:....::..|.|:..:
Yeast   211 DGLDQS-----EMMSKYK---------GYVIYCPELDFHFPKITVKETIDFALKCKTPRVRIDKM 261

  Fly   847 --KDNTGNIKDQ----------------HEIMNGGSGFRGEDDNESV-----QSDGIFSENRRLL 888
              |....||:|.                ::.:.|.||  ||....|:     .:..|:|.: ...
Yeast   262 TRKQYVDNIRDMWCTVFGLRHTYATKVGNDFVRGVSG--GERKRVSLVEAQAMNASIYSWD-NAT 323

  Fly   889 QGLQLLSNQWKAMLLKKFLYTWRNKLLLLI----QNIMPVFFVVVTIL----------IIKTQGT 939
            :||...:....|..::.......|..::.|    :||..: |...|:|          ..|..|.
Yeast   324 RGLDASTALEFAQAIRTATNMVNNSAIVAIYQAGENIYEL-FDKTTVLYNGRQIYFGPADKAVGY 387

  Fly   940 FQEL---KPITISLTQYPLAVTVLDRSNVQNGT-----GYE---------------IANKYEDLA 981
            ||.:   ||..::..::..:|||    :.:|.|     |||               .:..|::|.
Yeast   388 FQRMGWVKPNRMTSAEFLTSVTV----DFENRTLDIKPGYEDKVPKSSSEFEEYWLNSEDYQELL 448

  Fly   982 RSYGSNYGLELTGTQGFEDY-----------ILDLGKTIQV----RINSRYLV------------ 1019
            |:|              :||           .||:.|..::    |.||:|:|
Yeast   449 RTY--------------DDYQSRHPVNETRDRLDVAKKQRLQQGQRENSQYVVNYWTQVYYCMIR 499

  Fly  1020 -------AATITESKITAWLNNQALHTAPLTVNMVHNAIADKLFGSSVKIQVTNAPLPYTT--ST 1075
                   .:|.|:..::::|      ...|.:..:.:.|.||...::.........|.|..  ::
Yeast   500 GFQRVKGDSTYTKVYLSSFL------IKALIIGSMFHKIDDKSQSTTAGAYSRGGMLFYVLLFAS 558

  Fly  1076 LLSQLSTGNNLGTQ--LASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFIC 1138
            :.|....||:..::  :..:..:.|..:|:..:..:|.|..::...:..:..:..|..::.....
Yeast   559 VTSLAEIGNSFSSRPVIVKHKSYSMYHLSAESLQEIITEFPTKFVAIVILCLITYWIPFMKYEAG 623

  Fly  1139 DFASYIVTALIV------VITIVC-FQETGLSTFGELGRYYLLLLLFGFAVLPF----IYIMSLF 1192
            .|..||:..|.|      :...|. ..::|:......|.:.|:|.::...|||.    .:|..|.
Yeast   624 AFFQYILYLLTVQQCTSFIFKFVATMSKSGVDAHAVGGLWVLMLCVYAGFVLPIGEMHHWIRWLH 688

  Fly  1193 FREPAT--------------------------GFARVSIVNIFCGMA------------------ 1213
            |..|.|                          |:..:||.|..|..|
Yeast   689 FINPLTYAFESLVSTEFHHREMLCSALVPSGPGYEGISIANQVCDAAGAVKGNLYVSGDSYILHQ 753

  Fly  1214 ---------------------LFIVVVVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTN 1257
                                 ..:..|::|..|...:...|:|.:.....|.    :........
Yeast   754 YHFAYKHAWRNWGVNIVWTFGYIVFNVILSEYLKPVEGGGDLLLYKRGHMPE----LGTENADAR 814

  Fly  1258 TATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLI 1322
            ||:|....:|...|.:.|.:::.:    |..|.|
Yeast   815 TASREEMMEALNGPNVDLEKVIAE----KDVFTW------------------------------- 844

  Fly  1323 NELMFKIRQLISKPPPPPTEGQLDDDVANERERILQMSSNELATKNLVLDRVTKYYGQFMAVNQV 1387
            |.|.:.|          |.:|                     ||:.|:.|    .:|.
Yeast   845 NHLDYTI----------PYDG---------------------ATRKLLSD----VFGY------- 867

  Fly  1388 SLCVQEVECFGLLGVNGAGKTTTFKMMTGDERIS----SGAAYVQGLSLESNMNSIYKMIGYCPQ 1448
               |:..:...|:|.:||||||...::.  :||:    :|...|....|.::.|   :..||..|
Yeast   868 ---VKPGKMTALMGESGAGKTTLLNVLA--QRINMGVITGDMLVNAKPLPASFN---RSCGYVAQ 924

  Fly  1449 FDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHI----DKQTHAYS-------G 1502
            .|..:.:|:.||.||....||       :|.|..|.:.:.:::.|    ..|.:|.:       |
Yeast   925 ADNHMAELSVRESLRFAAELR-------QQSSVPLEEKYEYVEKIITLLGMQNYAEALVGKTGRG 982

  Fly  1503 GN---KRKLSTAIAVIGSPS-VIYLDEPTTGMDPAARRQLWNMVCRIR---DSGKSIVLTSHS-- 1558
            .|   ::|||..:.::..|| :::|||||:|:|   .:..|::|..:|   |||:||:.|.|.
Yeast   983 LNVEQRKKLSIGVELVAKPSLLLFLDEPTSGLD---SQSAWSIVQFMRALADSGQSILCTIHQPS 1044

  Fly  1559 ---MEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEAL-----RQARLSGG 1615
               .|:.:.|   |.:...|:....|.                 :..|.|.|     ||:.:..|
Yeast  1045 ATLFEQFDRL---LLLKKGGKMVYFGD-----------------IGPNSETLLKYFERQSGMKCG 1089

  Fly  1616 YARNPDE 1622
            .:.||.|
Yeast  1090 VSENPAE 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500
		ABC2_membrane_3	<269..475	CDD:289468
		CcmA	538..843	CDD:224054	43/236 (18%)
		ABC_subfamily_A	538..755	CDD:213230	27/148 (18%)
		ABC2_membrane_3	913..1316	CDD:289468	90/553 (16%)
		ABC_subfamily_A	1369..1587	CDD:213230	64/244 (26%)
		drrA	1376..1702	CDD:130256	71/279 (25%)
PDR12	NP_015267.1	3a01205	89..1468	CDD:273362	223/1198 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	105	1.000	Inparanoid score	I1418
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050