DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and PDR10

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_014973.1	Gene:	PDR10 / 854506	SGDID:	S000005855	Length:	1564	Species:	Saccharomyces cerevisiae

Alignment Length:	1373	Identity:	259/1373 - (18%)
Similarity:	458/1373 - (33%)	Gaps:	457/1373 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   534 KHIGLQMRHLKKRFGNK------------MVVKGLSMNMFEDEITVLLGHNGAGKTT---TISML 583
            |::.:..|.:.:|..::            .::|.:...:...|:.|:||..|||.||   :||:.
Yeast   165 KYLKMSWRCISRRLFHRTHGKSEDNDSGFQILKPMDGCINPGELLVVLGRPGAGCTTLLKSISVN 229

  Fly   584 TGMFPPTSGTAI-ING---SDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRG-- 642
            |..|..:..|.| .||   .:|:.:..|   .:....:.::....::|...:...:|:|..|.
Yeast   230 THGFKISPDTIITYNGFSNKEIKNHYRG---EVVYNAESDIHIPHLTVFQTLYTVARLKTPRNRI 291

  Fly   643 KAVEQEV-AKYLKMIELE--DKANVASSK--------LSGGMKRKLSVC-CALCGDTKVVLCDEP 695
            |.|:::. ||::..:.:.  ..::.|.:|        :|||.::::|:. .::|| :|....|..
Yeast   292 KGVDRDTFAKHMTEVAMATYGLSHTADTKVGNDFVRGVSGGERKRVSIAEVSICG-SKFQCWDNA 355

  Fly   696 SSGMDPSARRQLWDLLQQE----KVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKK 756
            :.|:|.:...:....|:.:    |...|:.:.....|..| |.|::.::.||.....|.|...||
Yeast   356 TRGLDSATALEFIKALKTQATITKSAATVAIYQCSKDAYD-LFDKVCVLYDGYQIFFGPSKQAKK 419

  Fly   757 QY-GSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQ 820
            .: ..||  :|.:|      :.||
Yeast   420 YFQRMGY--VCPER------QTTA----------------------------------------- 435

  Fly   821 SDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKD----QHEIMNGGSGFRGEDDNESVQSDGIF 881
                   .|...|||..|             .|||    :|.||...:.:       .:....|.
Yeast   436 -------DYLTSITSPSE-------------RIKDKDMVKHGIMIPQTAY-------EMNQYWIQ 473

  Fly   882 SENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPI 946
            ||..:.||           :.:.|.|.|..::....|:|..          |.|.....:...|.
Yeast   474 SEEYKQLQ-----------VQVNKHLDTDSSQQREQIKNAH----------IAKQSKRARPSSPY 517

  Fly   947 TISLTQYPLAVTVLDRSNVQNGTGYEIANKYEDLARSYGSNYGLELTGTQGFEDYILDLGKTIQV 1011
            |:|.......:.:.|...::|....::.......|.:.       :.|:..:|
Yeast   518 TVSFFLQVKYILIRDIWRIKNDPSIQLFTVLSHAAMAL-------ILGSMFYE------------ 563

  Fly  1012 RINSRYLVAATITESKITAWLNNQALHTAPLTVNMVHNAIADKLFGSSVKIQVTNAPLPYTTSTL 1076
                 .:::.|.|    |.:....|:..|     ::.||     |.|.::|.......|.|....
Yeast   564 -----VMLSTTTT----TFYYRGAAIFFA-----ILFNA-----FSSLLEIFSLYETRPITEKHK 609

  Fly  1077 LSQL---------STGNNLGTQLASNLCFCMCFVSSIYILFLIK-ERESRAKLLQFVGGVKVWTF 1131
            ...|         ||.:::.|:||:.:.|      :|...|||. :|::.|....|
Yeast   610 TYSLYRPSADAFASTFSDVPTKLATAVTF------NIPYYFLINLKRDAGAFFFYF--------- 659

  Fly  1132 WLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYY------LLLLLFGFAVLPFIYIMS 1190
                            ||.:||:...... ....|.:.:..      ..:||..||:.
Yeast   660 ----------------LINIITVFAMSHL-FRCIGSVSKTLPQAMVPASVLLLAFAMY------- 700

  Fly  1191 LFFREPATGFA--RVSIVNIFCGMALFIVVVVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNK 1253
                   ||||  ||.::    |.:.:|..:...|.||::....:..|   |.||......|...
Yeast   701 -------TGFAIPRVQML----GWSKWISYINPLSYLFESLMINEFHG---RNFPCAQYIPSGPN 751

  Fly  1254 VYTNTATRNACAKAGALPP---ILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIII 1315
            ....|.....|:..|::|.   :...:.:......:....|...|:       .:..::||| .:
Yeast   752 YVNATGDEVTCSALGSIPGNNYVSGDDFIQTNYGYRHKNKWRSVGI-------GLAYIIFFL-FL 808

  Fly  1316 VLEFRLINE--------LMF--------KIRQLIS--KPPPPPTEGQLDDDVANERERILQMSSN 1362
            .|.|...||        |:|        |.:.::|  |....||..      .::.|:.::|::|
Yeast   809 YLFFCEYNEGAKQNGEMLVFPHSVVKKMKKKGIVSEKKKKNQPTLS------TSDAEKDVEMNNN 867

  Fly  1363 ELAT------------------------------------------------------KNLVLDR 1373
            ..||                                                      |||..|.
Yeast   868 SSATDSRFLRDSDAAIMGNDKTVAKEHYSSPSSSASQSNSFSKSDDIELSKSQAIFHWKNLCYDI 932

  Fly  1374 VTKYYGQFMAVNQVSLCVQEVECFGLLGVNGAGKT---------TTFKMMTGDERISSGAAYVQG 1429
            ..| .|:...::.|...|:......|:|.:|||||         ||..::|||       .:|.|
Yeast   933 PIK-NGKRRILDNVDGWVKPGTLTALIGASGAGKTTLLDCLAERTTMGLITGD-------VFVDG 989

  Fly  1430 LSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLS---EDLAKSFGFMK 1491
            ...:   .|..:.||||.|.|..|...|.||.||....||...:..|.:..   |::.:......
Yeast   990 RPRD---QSFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQADDVSIEEKDKYVEEVIEVLEMKL 1051

  Fly  1492 HIDKQTHAYSGG----NKRKLSTAIAVIGSPS-VIYLDEPTTGMDPAARRQLWNMVCRIRDSGKS 1551
            :.|........|    .:::|:..:.:...|. :::|||||:|:|.........::.::...|::
Yeast  1052 YADAIVGVPGEGLNVEQRKRLTIGVELAAKPKLLVFLDEPTSGLDSQTAWSTCQLMKKLASRGQA 1116

  Fly  1552 IVLTSHS-----MEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQAR 1611
            |:.|.|.     |:|.:    ||..:..|     |.|.:. .:..||....|..   .||
Yeast  1117 ILCTIHQPSALLMQEFD----RLLFLQEG-----GQTVYF-GELGKGCKTMINY---FEA----- 1163

  Fly  1612 LSGGYARNPDEQTVPAQ-------------MSQ------RDIDAVKE------FVETEYP----- 1646
             .|.:...||..  ||:             .||      ||.:..:|      ::|.|.|
Yeast  1164 -HGAHKCPPDAN--PAEWMLEIVGAAPGTHASQDYFAIWRDSEEYREMQKELDWMERELPKRTEG 1225

  Fly  1647 -NSILQEEYQGILTFYIPLTGVK------------WSRIFGLMESNRDQLNVEDYSVSQTTLEEI 1698
             ::..|:|:.....:.|.|...:            ||:.|                  .|.:.|:
Yeast  1226 SSNEEQKEFATSTLYQIKLVSYRLFHQYWRTPFYLWSKFF------------------STIVSEL 1272

  Fly  1699 FLEFAKYQ 1706
            |:.|..::
Yeast  1273 FIGFTFFK 1280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500
		ABC2_membrane_3	<269..475	CDD:289468
		CcmA	538..843	CDD:224054	66/342 (19%)
		ABC_subfamily_A	538..755	CDD:213230	53/253 (21%)
		ABC2_membrane_3	913..1316	CDD:289468	72/423 (17%)
		ABC_subfamily_A	1369..1587	CDD:213230	59/239 (25%)
		drrA	1376..1702	CDD:130256	85/390 (22%)
PDR10	NP_014973.1	3a01205	110..1556	CDD:273362	259/1373 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	105	1.000	Inparanoid score	I1418
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050