Protein Alignment ABCA and Abcg1

DIOPT Version :9

• Sequence 1: NP_608445.2
• Gene: ABCA / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Sequence 2: NP_445954.2
• Gene: Abcg1 / 85264
• RGDID: 620294
• Length: 666
• Species: Rattus norvegicus
• Alignment Length: 629
• Identity: 126/629 - (20%)
• Similarity: 244/629 - (38%)
• Gaps: 174/629 - (27%)

  Fly   513 DIPNGHVEQRD-----PKAFETEPEGKHIGLQMRHLK---------KRFGNKMVVKGLSMNMFED 563
            |:.|||:::.|     .:.|.:.|....:.::.:.|.         ::.|.|.::||:|......
  Rat    47 DLLNGHLKKVDNNFTEAQRFSSLPRRAAVNIEFKDLSYSVPEGPWWRKKGYKTLLKGISGKFNSG 111

  Fly   564 EITVLLGHNGAGKTTTISML-----TGMFPPTSGTAIING--SDIR--TNIEGARMSLGICPQHN 619
            |:..::|.:||||:|.:::|     |||    .|..:|||  .|:|  ..:....|...:...|.
  Rat   112 ELVAIMGPSGAGKSTLMNILAGYRETGM----KGAVLINGMPRDLRCFRKVSCYIMQDDMLLPHL 172

  Fly   620 VLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALC 684
            .:.:.|.||.|::...:.:|.|     :.|.:.|..:.|...||..:..||||.:::|::...|.
  Rat   173 TVQEAMMVSAHLKLQEKDEGRR-----EMVKEILTALGLLPCANTRTGSLSGGQRKRLAIALELV 232

  Fly   685 GDTKVVLCDEPSSGMDPSARRQLWDLLQ-QEKVGRTLLLTTHFMDEADV--LGDRIAIMCDGELK 746
            .:..|:..|||:||:|.::..|:..|:: ..:.||:::.|.| ...|.:  |.|::.::..|:
  Rat   233 NNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIVCTIH-QPSAKLFELFDQLYVLSQGQ-- 294

  Fly   747 CQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAEL-SYQLPDSASAKF 810
                               ||.|         ..::..:|.|:   |:|... :|..|  |....
  Rat   295 -------------------CVYR---------GKVSNLVPYLR---DLGLNCPTYHNP--ADFVM 326

  Fly   811 EEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQHEIMNGGSG--------FR 867
            |...|:..:|:..|                  |.|.::...:...:.|:  ||.|        ..
  Rat   327 EVASGEYGDQNSRL------------------VRAVREGMCDSDYKREL--GGDGDVNPFLWHRP 371

  Fly   868 GEDDNESVQSDGIFSEN---------RR---------LLQGLQLLSNQWKAMLLKKFLYTWRNKL 914
            .|:|:.|::....||.:         :|         :|..|::.|:....:|:........|:.
  Rat   372 AEEDSASMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEA 436

  Fly   915 LLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQYPLAVTVLDRSNVQNGTGYEIANKYED 979
            ..::.|...:||.::.::       |..|.|..::   :||.::|..|.::         |.:..
  Rat   437 KKVLSNSGFLFFSMLFLM-------FAALMPTVLT---FPLEMSVFLREHL---------NYWYS 482

  Fly   980 LARSYGSNYGLELTGTQGFEDYILDLGKTIQVRINSRYLVAATITESKITAWLNNQ--------- 1035
            |...|                    |.||:   .:..:.:...:....|..|:.:|
  Rat   483 LKAYY--------------------LAKTM---ADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVL 524

  Fly  1036 --ALHTAPLTVNMVHNAIADKLFGSSVKIQVTNAPLPYTTSTLL 1077
              ||.|   ..::|..::...:..:|..:||.....|.|...:|
  Rat   525 FAALGT---MTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVL 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500
		ABC2_membrane_3	<269..475	CDD:289468
		CcmA	538..843	CDD:224054	73/326 (22%)
		ABC_subfamily_A	538..755	CDD:213230	59/237 (25%)
		ABC2_membrane_3	913..1316	CDD:289468	29/176 (16%)
		ABC_subfamily_A	1369..1587	CDD:213230
		drrA	1376..1702	CDD:130256
Abcg1	NP_445954.2	3a01204	60..666	CDD:273361	121/616 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000