DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and ABCA10

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_001318860.1	Gene:	ABCA10 / 836296	AraportID:	AT5G61740	Length:	909	Species:	Arabidopsis thaliana

Alignment Length:	965	Identity:	237/965 - (24%)
Similarity:	402/965 - (41%)	Gaps:	204/965 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WDKFVLLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLT------ 65
            |.:...||.||.|.|..|.|..:..:::|.:..|.|:.::.|:|     |......:||
plant    10 WAQANALLRKNLTYQRRHIWTNIRLVLVPLLLCLFLLGIQLLLD-----VVVNKAADLTKCGSQD 69

  Fly    66 DLNLLQHSLHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKI 130
            |.::....:.....|..|:.:..|..|..:|||..:..:                      .:|.
plant    70 DFSIGDCPIPNPPLLPPLLQIPEPESRAVSGGFFSYNDL----------------------PDKS 112

  Fly   131 CESENATQLEL----------DTVSKNAFAG---VQFDDAWANLTEN--------------DP-L 167
            |.......:.:          ..:|.|.|.|   |...|..::|..|              || :
plant   113 CRKTGTCPVTILLTGNNHSLGQALSGNMFGGSFAVNSSDLLSSLAYNVLGSTLALGTNNYADPGI 177

  Fly   168 PNDF-------------HFALRFPAELRTATIAI------------------ANTW------LTM 195
            .:||             .:.|.| .::.||...:                  ...|      :|.
plant   178 ESDFPIYSIQSQCSPNSTWPLSF-GKIHTAVTCLQGLSLWRNNSVEVNDELFKGNWKGNPERMTN 241

  Fly   196 RLFPTIDLTG-PRNEGD----------DDGGIPPGYLREGFLP-LQHSLSMAYLRQKSGE----- 243
            .:....||.. .||..|          ||....| .:|   :| |.:.:|.|||:...|.
plant   242 EIAAAYDLLNTDRNNFDVTIWYNSTNIDDPSRAP-LVR---VPRLLNLVSNAYLKFLKGPGTRIL 302

  Fly   244 ----QDLPNVVMKRYPFPAYIFDPL-LEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVM 303
                :::|....|.....|.:..|| ...:..::..:||.|.:|           ||:::|:.:|
plant   303 FEFVKEVPKHQTKFNLDIASMLGPLFFTWVVLLLFPVILTSLVY-----------EKQERLRIIM 356

  Fly   304 KIMGLSNWLHWT---AWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVS 365
            |:.||....:|.   |:|      ||:|...:..||....:..:......:::....|..|::..
plant   357 KMHGLGIGPYWMISYAYF------LTLSMFYVISLVIFGSAIGLRYFRLNDYSVQFIFYFIFVNL 415

  Fly   366 SICFCFMMATFFSRASTAAAV-------TGLIWFIAY--IPYSFTINSYDDLSLSSKLGWSLISN 421
            .|.|.|:.::.||:..||..|       :||:....:  :..|.|......|:|....|:||..
plant   416 QISFAFLASSIFSKVKTATVVAYTLVFASGLLGMFLFGELLESPTFPEKGILALELYPGFSLFR- 479

  Fly   422 TAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPG- 485
                 |:.....:...|.|::|.:.       ....:..:..:|.|...:.:|:...::.:...
plant   480 -----GLYEFAQYASRGNGMKWKDL-------KESGMDKLFYLMSVEWFVILIVAYSIDLLSSSG 532

  Fly   486 ---------SFGVPRPWNFPFTREFWCGEREYTG--VEDIPNGHVEQRDPKAFETEPEGK--HIG 537
                     |..:|.|          ..:|:.:.  :.|:....|.|...|..:...||.  | .
plant   533 RSPFVFFKKSSSLPSP----------SVQRQNSENVLIDMEKTDVTQEREKVEKLRKEGTTGH-A 586

  Fly   538 LQMRHLKKRF----GN--KMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAII 596
            :...:|||.:    ||  |:.|:||.:::...|...:||.||||||:.|:|:||:..||||||::
plant   587 IVCDNLKKVYPGSDGNPPKLAVRGLYLDVPSGECFGMLGPNGAGKTSFINMMTGLLKPTSGTALV 651

  Fly   597 NGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELED- 660
            .|.||..::.....|:|:||||::|:..::...|:.|:.|:|.::|.|:.|.|.:.||.:.|.|
plant   652 QGLDICKDMNKVYTSMGVCPQHDLLWGTLTGREHLLFYGRLKNIKGSALMQAVEESLKSVSLFDG 716

  Fly   661 -KANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTT 724
             .|:..:.|.||||||:|||..:|.|:.|||..||||:|:||::|:.||.::|:.|....::|||
plant   717 GVADKPAGKYSGGMKRRLSVAISLIGNPKVVYMDEPSTGLDPASRKDLWTVIQRAKQNTAIILTT 781

  Fly   725 HFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYI-PGL 788
            |.|:||:.|.||:.|..||.|:|.|....||.:||..|  :.......|..|....:.|:| |..
plant   782 HSMEEAEFLCDRLGIFVDGGLQCVGNPKELKGRYGGSY--VFTMTTSVEHEEKVERMVKHISPNS 844

  Fly   789 KPECDIGAELSYQLPDSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKV 843
            |....:.....:::| .......::|..:|:...:..:..:|:..|::|:||.||
plant   845 KRVYHLAGTQKFEIP-KQEVMIADVFFMVEKVKSKFTVFAWGLADTTLEDVFFKV 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	42/192 (22%)
		ABC2_membrane_3	<269..475	CDD:289468	44/217 (20%)
		CcmA	538..843	CDD:224054	113/313 (36%)
		ABC_subfamily_A	538..755	CDD:213230	94/224 (42%)
		ABC2_membrane_3	913..1316	CDD:289468
		ABC_subfamily_A	1369..1587	CDD:213230
		drrA	1376..1702	CDD:130256
ABCA10	NP_001318860.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710