DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and ABCA9

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_001330984.1	Gene:	ABCA9 / 836295	AraportID:	AT5G61730	Length:	950	Species:	Arabidopsis thaliana

Alignment Length:	913	Identity:	232/913 - (25%)
Similarity:	397/913 - (43%)	Gaps:	160/913 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KFVLLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVR------TLVDTEQKGVRYYNEQNLTDL 67
            :|..|..||..|.|.:|....:.|.....|.||:..:.      .|..|..|        |:||.
plant    13 QFTALFKKNLLLSWRNKRATCLHLFSSFFFILLIFSIEESSKASDLTSTRHK--------NVTDP 69

  Fly    68 NLLQHSLHRSSYLGKLIAL-IAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKIC 131
            .             .|::| |.|...:.......|:|:                 |......::.
plant    70 K-------------ALVSLPILPCEDKFFVRLPCFDFV-----------------WSGNQSRRVT 104

  Fly   132 ESENATQLE-----LDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANT 191
            :..:|....     :.|....:|...:..|||. ::....:....||.      .:.||:
plant   105 DIVSAIMANNPGRPIPTNKVQSFTKPEEVDAWF-MSHPSQVTGALHFV------EKNATV----- 157

  Fly   192 WLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQDLP-NVVMKRYP 255
             ::..:.........|...:|     |.:  :..:|||.:......|...|:.... :...|.:.
plant   158 -ISYGIQTNSSSEKKRGRRED-----PTF--KFLVPLQIAAEREIARSLIGDPKFSWDFGFKEFA 214

  Fly   256 FPA----------YIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSN 310
            .||          |:..|:.....|:...::.|.          .:..|||.:|:|.|..||:..
plant   215 RPAIGGEVIISAFYLMGPVFFLAFSMFGFVLQLG----------SVVTEKELKLREAMTTMGVYE 269

  Fly   311 WLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMAT 375
            ..:|.:|.:...|:..:|::.: :|..:.:..:..:........|:|||..:  :.|...|.:::
plant   270 SAYWLSWLIWEGILTFVSSLFL-VLFGMMFQFEFFLKNSFVLVFLLFFLFQF--NMIGLAFALSS 331

  Fly   376 FFSRASTAAAVTGLIWFIAYI---------PYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLI 431
            ..|::|:|..|..|::.:.:|         |||   ::|   |:.|::.|||........|::|:
plant   332 IISKSSSATTVGFLVFLVGFITQIVTTAGFPYS---SAY---SIGSRVIWSLFPPNTFSAGLQLL 390

  Fly   432 LGFEGTG----EGLQWSNFFTPVSVDDT--LTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVP 490
            |  |.|.    .|:.||........:.|  :|...:.|.::.:...:.::.||.:.::|.:.||.
plant   391 L--EATSSPGDSGISWSERAICAGGESTCVITTNKIYIWLVGTFFFWFVLALYFDNIIPNASGVR 453

  Fly   491 RPWNFPFTREFWCGEREYTGVED----------IPNGHVEQRDPKAFETE-------PEGK---H 535
            :...:.....:|.| :|...||:          .|..|:...|....|.|       .:|:   :
plant   454 KSIFYFLKPSYWTG-KEGNKVEEGSICSCIGSVPPVEHITPEDEDVLEEEILVKQQAMDGRVDPN 517

  Fly   536 IGLQMRHLKKRFGNKM--------------VVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGM 586
            |.:|:..|.|.:....              .||||.||:.:|::..|||.||||||||||.|||:
plant   518 IAVQIHGLAKTYPGTTKLGCCKCTKTSPFHAVKGLWMNIAKDQLFCLLGPNGAGKTTTISCLTGI 582

  Fly   587 FPPTSGTAIINGSDIRTNI--EGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEV 649
            .|.|.|.|.|.|:.||:::  ...|..:|:|||.::|:|.:|...|:..|:.:|||...:::...
plant   583 NPVTGGDAKIYGNSIRSSVGMSNIRKMIGVCPQFDILWDALSSEEHLHLFASIKGLPPSSIKSIA 647

  Fly   650 AKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQE 714
            .|.|..::|...|.:.:...||||||:|||..||.||.|:|..|||::||||..||.:||::|:.
plant   648 EKLLVDVKLTGSAKIRAGSYSGGMKRRLSVAIALIGDPKLVFLDEPTTGMDPITRRHVWDIIQES 712

  Fly   715 KVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGY----RLICVKRDDCETN 775
            |.||.::||||.|:|||:|.|||.||..|.|:|.|||..||.::|:|:    ..|..|:|...
plant   713 KKGRAIILTTHSMEEADILSDRIGIMAKGRLRCIGTSIRLKSRFGTGFVATVSFIENKKDGAP-- 775

  Fly   776 EVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVF 840
            |......|....::|..:..|.:::.:|.......:..|.:|:::..|..:....:|:.::||||
plant   776 EPLKRFFKERLKVEPTEENKAFMTFVIPHDKEQLLKGFFAELQDRESEFGIADIQLGLATLEEVF 840

  Fly   841 MKV 843
            :.:
plant   841 LNI 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	43/198 (22%)
		ABC2_membrane_3	<269..475	CDD:289468	47/220 (21%)
		CcmA	538..843	CDD:224054	121/324 (37%)
		ABC_subfamily_A	538..755	CDD:213230	101/232 (44%)
		ABC2_membrane_3	913..1316	CDD:289468
		ABC_subfamily_A	1369..1587	CDD:213230
		drrA	1376..1702	CDD:130256
ABCA9	NP_001330984.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820