DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and ABCA12

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_001318859.1	Gene:	ABCA12 / 836292	AraportID:	AT5G61700	Length:	917	Species:	Arabidopsis thaliana

Alignment Length:	961	Identity:	247/961 - (25%)
Similarity:	413/961 - (42%)	Gaps:	188/961 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WDKFVLLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNE--QNLT---- 65
            |.:...||.||.|.|..|.|..|..:::|....|:|:.::.::|...|||...:.  .|:|
plant    10 WTQANALLRKNLTYQRKHIWTNVRLILVPLFLCLILLAIQQVLDALMKGVSDMSNCGGNVTLPGG 74

  Fly    66 ------------DLNLLQHSLHRS------SY--------------------------LGKLIAL 86
                        .|.:.||.| ||      ||                          |||.:
plant    75 ICPIPNPPSLPPMLQIPQHEL-RSVKTDFFSYKDLPDKLCRETGSCPVTILFTGDKLPLGKAL-- 136

  Fly    87 IAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKI-----------------CESE 134
                    :.......|::..|.:.|.|...|..:.::.|::..                 |.:.
plant   137 --------SANIFSTSFVVNSSDLLPTLANNVLGSTEAAGEDNYEDPGIASDLPIYSIQPSCSAN 193

  Fly   135 NATQLELDTVSKNAFAGVQFDDAWAN--LTENDPLPNDFHFALR-FPAELRTATIAIANTWLTMR 196
            :...|.|..: :.|...||....|.|  :..||.|   |..:.| .||.:....:|..:...|.|
plant   194 STWPLSLGQI-QTAVKCVQGLCLWRNNSVEVNDEL---FKGSWRGNPAGMPNEIVAAYDLMSTDR 254

  Fly   197 LFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSL-SMAYLRQKSGE---------QDLPNVVM 251
              ...::|...|...:|.......|:...:|...:| |.|||:...|.         :::|....
plant   255 --KNFNVTIWYNSTYNDEFATGQALKLVRVPRSINLISNAYLKFLKGPGTRILFEFLKEVPKEET 317

  Fly   252 KRYPFPAYIFDPL-LEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWT 315
            |.....|.:..|| ...:..::..:||.|.:|           ||:::|:.:||:.||.:..:|.
plant   318 KMNQDIASLLGPLFFTWVVLLLFPVILTSLVY-----------EKQERLRIIMKMHGLGDGPYWM 371

  Fly   316 ---AWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFF 377
               |:|      ||||.:.:..||....:..:......:::....|..||....|...|::::.|
plant   372 ISYAYF------LTISMLYVISLVGFGSAIGLKYFRRNDYSIQFVFYFIYSNLQISLAFLVSSIF 430

  Fly   378 SRASTAAAV-------TGLIWFIAYIPYSFTINSYDDLSLSSKL--GWSLISNTAMGFGIKLILG 433
            |:..|...:       |||:....:.....|.:..::..|:.:|  |:||..      |:.....
plant   431 SKVKTVTVIAYILVYGTGLLGSFLFQKMIETQSFPEEWILAMELYPGFSLYR------GLYEFSQ 489

  Fly   434 FEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFT 498
            :...|.|::|.:      :.|: .:|.|..:|.|...:.:|:..|::||              ||
plant   490 YASRGNGMKWQD------LSDS-GMGEVFCIMSVEWFLALIVAYYIDQV--------------FT 533

  Fly   499 ---REFWCGEREYTGVEDIPNGHVEQR-DPKAFETEPEGKHIGLQMR------------------ 541
               ..|:.....:.....:|.....|| |.|....:.: ||...|.|
plant   534 SGKHPFFFLVNLFKSPSSLPRRPTVQRLDSKRVFIDMD-KHDVTQERESVQKLRNEGSTGHAILC 597

  Fly   542 -HLKK----RFGN--KMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGS 599
             :|||    |.||  ||.|:||.:::...|...:||.||||||:.|||:||:..|:||||::.|.
plant   598 DNLKKVYPGRDGNPPKMAVRGLYLSVSSGECFGMLGPNGAGKTSFISMMTGLLKPSSGTALVQGL 662

  Fly   600 DIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELED--KA 662
            ||..::.....|:|:||||::|::.::...|:.|:.|:|.::|..:.|.|.:.||.:.|.|  ..
plant   663 DICKDMNKVYTSMGVCPQHDLLWETLTGREHLLFYGRLKNIKGSDLTQAVEESLKSVSLYDGGVG 727

  Fly   663 NVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFM 727
            :..:...||||||:|||..:|.|:.|||..||||:|:||::|:.||:::::.|....::||||.|
plant   728 DKPAGNYSGGMKRRLSVAISLIGNPKVVYLDEPSTGLDPASRKNLWNVIKRAKQNTAIILTTHSM 792

  Fly   728 DEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPEC 792
            :||:.|.||:.|..||.|:|.|.|..||.:||..| :..:........||..|:....|..|...
plant   793 EEAEFLCDRLGIFVDGGLQCIGNSKELKSRYGGSY-VFTMTTSSKHEEEVERLVESVSPNAKKIY 856

  Fly   793 DIGAELSYQLPDSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKV 843
            .:.....::|| ....:..|:|..:|:......:..:|:..|::|:||:||
plant   857 HLAGTQKFELP-KQEVRIAEVFRAVEKAKANFTVFAWGLADTTLEDVFIKV 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	41/192 (21%)
		ABC2_membrane_3	<269..475	CDD:289468	46/217 (21%)
		CcmA	538..843	CDD:224054	115/331 (35%)
		ABC_subfamily_A	538..755	CDD:213230	95/243 (39%)
		ABC2_membrane_3	913..1316	CDD:289468
		ABC_subfamily_A	1369..1587	CDD:213230
		drrA	1376..1702	CDD:130256
ABCA12	NP_001318859.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.710