DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and ABCA11

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_001332171.1	Gene:	ABCA11 / 836291	AraportID:	AT5G61690	Length:	953	Species:	Arabidopsis thaliana

Alignment Length:	975	Identity:	255/975 - (26%)
Similarity:	427/975 - (43%)	Gaps:	183/975 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WDKFVLLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQ 71
            :.:|..|..||..|.|.:|....:::.....|.||:..:...:.........|  :|:||..|
plant    11 YQQFTALFGKNLLLSWRNKRATCLQIFSSFFFILLIFCIEEAMKASDASSSAY--KNITDPTL-- 71

  Fly    72 HSLHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICESENA 136
                          |::|........|  |..:.||..|           |          |.|.
plant    72 --------------LVSPPILPCEDKF--FVKLPCYDFV-----------W----------SGNN 99

  Fly   137 TQLELDTVSKNAFAGVQFDDAWANLTEND--PLPNDFHFALRFPAELRTATIAIANTWLTMRLFP 199
            ::...|.||             |.:..|.  |:|.:...:.:.|.|:        :|||   |..
plant   100 SRRVTDIVS-------------AIMANNPGRPIPTNKVQSFKEPDEV--------DTWL---LSH 140

  Fly   200 TIDLTG-----PRNEGDDDGGIPPGYLREG------------FLPLQHSLSMAYLRQKSGEQDLP 247
            .:.:.|     .||......|:......|.            .:|||.:......|...|:   |
plant   141 PLQVPGALHFVERNASVISYGVQTNSSSESKRGQTEDPTFKFLVPLQVAAEREIARSLLGD---P 202

  Fly   248 N----VVMKRYPFPAYIFDPLLEGMSSIMSLIILLSF-IYPCTYITKYITAEKEKQLKEVMKIMG 307
            |    :..|.:..||.|.:  .....|:|..:..|:| ::........:..|||.:|::.|.:||
plant   203 NFGWGLGFKEFARPAIITE--TTSALSVMGPVFFLAFSMFGFVLQLGALVTEKELKLRQAMTMMG 265

  Fly   308 LSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFL-IIYIVSSICFCF 371
            :.:..:|.:|.....|:..:|::.: :|..:.:..|..:   .|...|||.| :::..:.|...|
plant   266 VYDSAYWLSWLTWEGILTLVSSLFL-VLFGMIFRFDFFL---KNSFVLVFLLFLLFQFNMIGLAF 326

  Fly   372 MMATFFSRASTAAAVTGLIWFIAYI---------PYSFTINSYDDLSLSSKLGWSLISNTAMGFG 427
            .:::..|::|:|..|..|::.|.:|         |||   :||   ::|.::.|||........|
plant   327 ALSSIISKSSSATTVGFLVFLIGFITQFVSATGFPYS---SSY---AVSRRVMWSLFPPNTFSAG 385

  Fly   428 IKLILGFEGT--GEGLQWSNFFTPVSVDDT--LTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFG 488
            :||:|....|  ..|:.|||.........|  :::..:...:|.:.:.:.::.:|.:.::|.:.|
plant   386 LKLLLDATSTPKSSGISWSNRAVCEGGQATCVISINIIYQWLLGTFLFWFVLAIYFDNIIPNASG 450

  Fly   489 VPRPWNFPFTREFWCGEREYTGVEDIPNG-------------HVEQRDPKAFETEPEGK------ 534
            |.:|..:.....:|.|:    |...:..|             |....|....|.|.|.|
plant   451 VRKPIFYFLAPGYWTGK----GGNKVEEGSIFSCVGSVPLVEHNTPNDKDVLEEETEVKQQAMDG 511

  Fly   535 ----HIGLQMRHLKKRFGNKM--------------VVKGLSMNMFEDEITVLLGHNGAGKTTTIS 581
                :|.:|:..|.|.:....              .||||.||:.:|::..|||.||||||||||
plant   512 IADPNIAVQIHGLAKTYPGTTKLGCCKCTKTSPFHAVKGLWMNIAKDQLFCLLGPNGAGKTTTIS 576

  Fly   582 MLTGMFPPTSGTAIINGSDIRTN--IEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKA 644
            .|||:.|.|.|.|:|.|..||::  |...|..:|:|||.::|:|.:|...|:..|:.:|||...:
plant   577 CLTGINPVTGGDALIYGDSIRSSVGISNIRKMIGVCPQFDILWDALSSEQHLHLFASIKGLPPAS 641

  Fly   645 VEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWD 709
            ::....|.|..::|...|.|.:...||||||:|||..||.||.|:|..|||::||||..||.:||
plant   642 IKSTAEKLLADVKLTGAAKVRAGSYSGGMKRRLSVAVALIGDPKLVFLDEPTTGMDPITRRHVWD 706

  Fly   710 LLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCET 774
            ::|:.|.||.::||||.|:|||:|.|||.||..|.|:|.|||..||.::|:|:.......::...
plant   707 IIQESKKGRAIILTTHSMEEADILSDRIGIMAKGRLRCIGTSIRLKSRFGTGFVATVSFIENKND 771

  Fly   775 NEVTA-----LLNKYIP---GLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQSDELHLNGYGV 831
            |.:..     .|.|:..   .::|..:..|.:::.:|..........|.:|:.:..|..::...:
plant   772 NNIGVGASHEPLKKFFKEHLKVEPTEENKAFMTFVIPHDKENLLTGFFEELQNRESEFGISDIQL 836

  Fly   832 GITSMEEVFMKVG--AEKDNT---GNIKDQHEIMNG-------GSGFRGEDDNESVQS-DGIFSE 883
            |:.::||||:.:.  ||.::.   ||:... |:.:|       |:.|.|..|.|:.:: .|:..|
plant   837 GLATLEEVFLNIARQAELESATAEGNMVTL-ELASGISLEIPVGARFVGIPDTENAENPSGVMVE 900

Fly 884 883
plant 901 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	47/190 (25%)
		ABC2_membrane_3	<269..475	CDD:289468	51/220 (23%)
		CcmA	538..843	CDD:224054	121/328 (37%)
		ABC_subfamily_A	538..755	CDD:213230	103/232 (44%)
		ABC2_membrane_3	913..1316	CDD:289468
		ABC_subfamily_A	1369..1587	CDD:213230
		drrA	1376..1702	CDD:130256
ABCA11	NP_001332171.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820