DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and ABCA8

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_190363.3	Gene:	ABCA8 / 823933	AraportID:	AT3G47790	Length:	901	Species:	Arabidopsis thaliana

Alignment Length:	815	Identity:	224/815 - (27%)
Similarity:	360/815 - (44%)	Gaps:	158/815 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   947 TISLTQYPLA----VTVLDRSNVQNGTGYEIANKYEDLARSY-GSNYGLELTGTQGFEDYILDLG 1006
            :|.:.|.|||    |..:...|:...:..::.|   :|.:.| ..|...::....|..|:....|
plant   186 SILIHQSPLAFPKEVNCVQGLNLWRNSSSDVNN---ELFKGYRKGNPDKKINEFAGAFDFQNTNG 247

  Fly  1007 KTIQVRI--NSRYLVAATITESKITAWLNNQALHTAPLTVNMVHNAIADKLFGSSVKI---QVTN 1066
            ..:.|.:  ||.|         |....:...||...|..||:..||..:.|.||..||   .|..
plant   248 NNLNVSVWYNSTY---------KNDTVVRPMALIRVPRLVNLASNAYLEFLKGSETKILFEYVKE 303

  Fly  1067 APLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILF------LIKERESRAKLLQFVGG 1125
            .|.|.|            .|...:|| |...:.|...|.:||      |:.|::.|.:::..:.|
plant   304 MPKPET------------KLSLDIAS-LIGPLFFTWVILLLFPVILTTLVYEKQQRLRIMMKMHG 355

  Fly  1126 VKVWTFWLSQFICDFASYIVTALIVVITIVCF----QETGLSTFGELGRYYLLLLLFGFAV---L 1183
            :....:|:       .||....||.::.::||    ...||:.| .|..|.:.|:.|...:   :
plant   356 LGDVPYWI-------VSYTYFLLISILYMLCFAIFGSLIGLNFF-RLNDYSIQLVFFFICINLQI 412

  Fly  1184 PFIYIMSLFFREPATGFARVSIVNIF-CG-MALFIVVVVMSSELFDTKDTADILGWI--FRIFPH 1244
            ...::.|..|.:..|... ::.:.:| .| :.:|:....:...||..       |||  ..::|.
plant   413 SVAFLASAMFSDVKTATV-IAYIYVFGTGLLGIFLFQFFLEDPLFPR-------GWIIAMELYPG 469

  Fly  1245 FSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVV 1309
            |||...|.::       :..|.||....|             ....|.:.|          .|:.
plant   470 FSLYRGLYEL-------SQSAFAGDYRGI-------------DGMKWRDFG----------NGMK 504

  Fly  1310 FFLIIIVLEFRLINELMFKIRQLI--------------SKPPPPPTEGQLD--------DDVANE 1352
            ....|:::|:.|:..|.:.|.|:|              ||.....::.::.        .||..|
plant   505 EVTCIMLIEWLLLLGLAYYIDQIIYSRKHPLFFLLQSTSKKKQHFSDNKISKVVVEMEKPDVCRE 569

  Fly  1353 RERILQMSSNELATKNLVLDRVTKYYG------QFMAVNQVSLCVQEVECFGLLGVNGAGKTTTF 1411
            ||::.|..........::.:.:.|.|.      |.:||..:||.:.:.||||:||.||||||:..
plant   570 REKVEQCLLKSTRDSAVLCNNLKKVYSGKDGNPQKLAVRGLSLALPQGECFGMLGPNGAGKTSFI 634

  Fly  1412 KMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRI 1476
            .||||..:.|||.|:||||.:.::|:.||..||.|||.|.|.:.|:|||.|..:..|:.::.|.:
plant   635 NMMTGIIKPSSGTAFVQGLDILTDMDRIYTTIGVCPQHDLLWEKLSGREHLLFYGRLKNLKGSVL 699

  Fly  1477 RQLSEDLAKSFG-FMKHI-DKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLW 1539
            .|..|:..:|.. |...| |||...||||.||:||.||::||||.|:|:|||:||:|||:|:.||
plant   700 TQAVEESLRSVNLFHGGIGDKQVSKYSGGMKRRLSVAISLIGSPKVVYMDEPSTGLDPASRKSLW 764

  Fly  1540 NMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNL 1604
            ::|.|.:..| :|:||:|||||.|.||.|:.|.|:|..:|||:.:.||:::....:|.:..
plant   765 DVVKRAKRKG-AIILTTHSMEEAEILCDRIGIFVDGSLQCIGNPKELKSRYGGSYVLTVTT---- 824

  Fly  1605 EALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKW 1669
                                     |:.....|::.|.....|:.......|...|.:|...||.
plant   825 -------------------------SEEHEKEVEQLVHNISTNAKKIYRTAGTQKFELPKQEVKI 864

  Fly  1670 SRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAK 1704
            ..:|..:|..:....|..:.::.||||::|::.|:
plant   865 GEVFKALEKAKTMFPVVAWGLADTTLEDVFIKVAQ 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500
		ABC2_membrane_3	<269..475	CDD:289468
		CcmA	538..843	CDD:224054
		ABC_subfamily_A	538..755	CDD:213230
		ABC2_membrane_3	913..1316	CDD:289468	85/395 (22%)
		ABC_subfamily_A	1369..1587	CDD:213230	104/225 (46%)
		drrA	1376..1702	CDD:130256	124/333 (37%)
ABCA8	NP_190363.3	ABC2_membrane_3	<247..488	CDD:289468	67/285 (24%)
		BI-1-like	367..>451	CDD:294323	17/85 (20%)
		CcmA	585..897	CDD:224054	124/341 (36%)
		ABC_subfamily_A	590..811	CDD:213230	104/221 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710