DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and ABCA4

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_001319703.1	Gene:	ABCA4 / 823929	AraportID:	AT3G47750	Length:	937	Species:	Arabidopsis thaliana

Alignment Length:	1024	Identity:	252/1024 - (24%)
Similarity:	408/1024 - (39%)	Gaps:	292/1024 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRS 77
            |..||.|.|..:.|..|..:|:|....:|||.::.|.||:        ..|..|.......:|::
plant    16 LFRKNLTYQKRNIWSNVRLIVIPFYLCVLLVGIQVLFDTQ--------VNNSADNRCGCRCIHKN 72

  Fly    78 SYLGKLIALIAPNRRRKNGGFSKFEFILCYS--------------PVNPVLK------KLVEEAW 122
            .. ||.        .||:.|       |.||              |:.|:|:      :||:.|.
plant    73 GD-GKC--------ERKSCG-------LQYSSLTQASFCAFPNPPPLLPLLQIPRPETRLVDPAR 121

  Fly   123 QSLGKNKIC------ESENATQLELDTVSKN----AFAGVQFDDAWANLTEN------------- 164
            .|..:...|      ...|.|..|  |:|:|    :||....|....||..|
plant   122 SSCRRTGSCPVTILVTGNNHTLGE--TLSRNLLSTSFAVNSSDHFLRNLAYNVLGTISEADYTNY 184

  Fly   165 -DP-----LP-----------NDFHFALR-----FPAELRTATIAIANTWLTMRLFPTIDLTGPR 207
             ||     ||           .:..|:.|     |..|:|  .:...|.|              |
plant   185 LDPGIHSDLPIFQIRPYCTPTTNLSFSFRQPPITFHKEVR--CVQGLNLW--------------R 233

  Fly   208 N---EGDDDGGIPPGYLREG--------------------------------------------- 224
            |   |.:|:  |..|| |:|
plant   234 NNSVEVNDE--IFKGY-RQGNHEEIINEVAAAYDLLDTDRNKFNVTIWYNSSYKGNFKVQDRRVK 295

  Fly   225 FLPLQHSLSM---AYLRQKSGEQDLPNVVMKRYPFPAYIFD-----PLLEGM-----SSIMSLII 276
            ::.:..|::|   ||||            ..|.|....:||     |..|.|     :|::..|.
plant   296 YVRVPRSVNMVSNAYLR------------FLRGPGTKMLFDFVKEMPKQESMLRVDIASVIGPIF 348

  Fly   277 L---LSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWT---AWFVKSFIMLTISAILIAIL 335
            |   :..::|  .|...:..||::.|:.:||:.||.:..:|.   |:|      |.||.:.|..|
plant   349 LTWVIVLLFP--VILNSLVYEKQQHLRIIMKMHGLGDGPYWMITYAYF------LAISTLYIICL 405

  Fly   336 VKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWF----IAYI 396
            :....:..:......:::....|..:.|...|...|::::.||:..||:....|..|    :...
plant   406 MIFGSAIGLKFFRFNDYSIQFIFYFLCINLQISIAFLVSSAFSKVETASVAAYLYVFGSGLLGGF 470

  Fly   397 PYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGT--------------GEGLQWSNFF 447
            .:.|.:.     .||...||..:.....||.:     :.|.              .:|::| .:|
plant   471 LFQFMLE-----GLSFPRGWIFVMELYPGFSL-----YRGLYEFSQYALKRQLNGSDGMKW-KYF 524

  Fly   448 TPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTGVE 512
            :..::|:      |..::::...:.:|...|:::|   |.....|:.|
plant   525 SDSAMDE------VFYIIIIEWFLALIAAYYMDRV---SSSAKDPFLF----------------- 563

  Fly   513 DIPNGHVEQRDPKAFETEPEGKHIGLQMR---------------------------HLKK----R 546
             :.|...:...|:....:..|..:.::|.                           .|||    |
plant   564 -LKNLIKKSPSPQRHSLQRLGSSVSVEMEKLDVVEERAKVEQLMLESSTSHAIVCDKLKKVYPGR 627

  Fly   547 FGN--KMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGAR 609
            .||  ||.|.|||:.:...|...:||.||||||:.|:|:||:..||||||::...||..:::...
plant   628 DGNPPKMAVGGLSIAVPPGECFGMLGPNGAGKTSFINMMTGLVKPTSGTALVESLDICQDMDKVY 692

  Fly   610 MSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIEL--EDKANVASSKLSGG 672
            .|:|:||||::|::.::...|:.|:.|:|.|:|..:.|.:.:.||.:.|  |..|:..:.|.|||
plant   693 TSMGVCPQHDLLWETLTGREHLLFYGRLKNLKGSDLNQAIEESLKSVNLSREGVADKPAGKYSGG 757

  Fly   673 MKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRI 737
            |||:|||..:|.|..|||..||||:|:||::||.||..::..|....::||||.|:||:.|.||:
plant   758 MKRRLSVAISLIGSPKVVYMDEPSTGLDPASRRSLWTAIKGAKKHTAIILTTHSMEEAEFLCDRL 822

  Fly   738 AIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQL 802
            .|..||.|:|.|....||.:||..|.|......:.| .:|..|:....|..|....|.....:::
plant   823 GIFVDGRLQCVGNPKELKARYGGSYVLTMTTSSEHE-KDVEMLIQDVSPNAKKIYHIAGTQKFEI 886

  Fly   803 PDSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVG--AEKDN 849
            |.. ..:..|:|..:|:......:..:|:..|::|:||:||.  |:..|
plant   887 PKD-EVRIAELFQAVEKAKGNFRVFAWGLADTTLEDVFIKVARTAQASN 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	43/199 (22%)
		ABC2_membrane_3	<269..475	CDD:289468	43/229 (19%)
		CcmA	538..843	CDD:224054	117/339 (35%)
		ABC_subfamily_A	538..755	CDD:213230	96/251 (38%)
		ABC2_membrane_3	913..1316	CDD:289468
		ABC_subfamily_A	1369..1587	CDD:213230
		drrA	1376..1702	CDD:130256
ABCA4	NP_001319703.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710