DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Abca3 and abca4a

DIOPT Version :10

Sequence 1:NP_608445.2 Gene:Abca3 / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:NP_001428973.1 Gene:abca4a / 798993 ZFINID:ZDB-GENE-050517-3 Length:2306 Species:Danio rerio


Alignment Length:1932 Identity:597/1932 - (30%)
Similarity:931/1932 - (48%) Gaps:384/1932 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 QNLTDLNLLQHSLHRSSYLGKLIALIAPNRRRKNGGFS---------------------KFEFIL 105
            |:...:|:|:.|:...:.:..:      |:..:|..|:                     .|::..
Zfish   443 QDSVQINMLRDSIRNPTVMDHI------NKGLRNAAFTGQHILNFLYSGPEEDREQDMPNFDWRN 501

  Fly   106 CYSPVNPVLKKLVEEAWQSLGKNK---ICESENATQLELDTVSKNAF-AGVQFDDAWANLTENDP 166
            .::..:.|: :|:....:.|..:|   |.:.:..|...|:.:.:..| ||:.|.|.::..|:   
Zfish   502 IFNLTDQVI-RLINRYGECLVLDKFSSISDEDQLTHRALNLLEEGKFWAGLVFVDMYSWTTK--- 562

  Fly   167 LPNDFHFALRFPAELRTATIAIANTWLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHS 231
            :|......:|...::...|..|.:.:..         .|||.:..||    ..|:..||..||..
Zfish   563 VPPHVKVKIRMDIDVVERTNKIKDRYWD---------PGPRADPMDD----LRYIWGGFAYLQDM 614

  Fly   232 LSMAYLRQKSGEQDLPNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKE 296
            :....::..:|::....|.:::.|:|.|:.|..:..::....:.::|:::|..:...|.|..|||
Zfish   615 IEHGIIKTHTGKEWPLGVYLQQMPYPCYVDDLFMLTLNRCFPIFMVLAWVYSVSMTVKSIVLEKE 679

  Fly   297 KQLKEVMKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLII 361
            .:|||.:|.||::|.:.|..||:.:|.|:..|..|:.:::.     ...||.::|...|..||:.
Zfish   680 MRLKETLKAMGVTNRVLWCTWFIDTFFMMASSTALLTLIIM-----GGKVLNYSNPIILFLFLLT 739

  Fly   362 YIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGF 426
            :..::|..||:|:.||::|:.|||.:|:|:|..|:|:.......|.::...|:..||:|..|.||
Zfish   740 FTTATIMQCFLMSVFFNKANLAAACSGIIYFTLYLPHVVCFAWQDRITKDMKIMASLMSQVAFGF 804

  Fly   427 GIKLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPR 491
            |.:.:..:|..|.||||.|..|.:...|..:....:|||.|..|:|.::..|::.|.||.:|:.|
Zfish   805 GTEYLSRYEEQGLGLQWDNIQTSLLEGDEFSFLNSIIMMAVDTVLYGVLAWYLDSVFPGQYGIGR 869

  Fly   492 PWNFPFTREFWCGERE-------------------YTGVEDIPNGHVEQRDPKA----------- 526
            |..||....:|....|                   ....:|....|.....|..           
Zfish   870 PCYFPIQPSYWLNRPEPLKQVPGKPTVEKPAFDNLVNNTDDQAKNHTAPEKPPEPPGSCKHGDIR 934

  Fly   527 ------------------------------FETEPEGKHIGLQMRHLKKRF--GNKMVVKGLSMN 559
                                          ||.||.|...|:.:.:|.|.|  .::..|.|||:.
Zfish   935 EKLEREKLQKRIVEEEINRSMSTDSSGKVFFEPEPSGLVAGVCVENLYKVFSGSSRPAVDGLSLT 999

  Fly   560 MFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDE 624
            .:|.:||..|||||||||||:|:||||||||||||.|.|.||||:::..|.|||:|||||::|..
Zfish  1000 FYEGQITAFLGHNGAGKTTTMSVLTGMFPPTSGTAYIYGKDIRTDMDAIRKSLGMCPQHNIIFHH 1064

  Fly   625 MSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKV 689
            |:|:.||.|:|.:||......:.||...|:.:.|..|.|..:..|||||:|||||..|..|..||
Zfish  1065 MTVAEHILFYSLLKGRPLPEAQLEVENMLEDLGLPHKRNEEAQNLSGGMQRKLSVAMAFVGGAKV 1129

  Fly   690 VLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFL 754
            |..|||:||:||.:||.:||||.:.:.||||:|:||.|||||:|.||:||:..|.|.|.|:..||
Zfish  1130 VFLDEPTSGVDPYSRRSIWDLLLKYRAGRTLILSTHHMDEADLLSDRVAIISQGRLYCCGSPLFL 1194

  Fly   755 KKQYGSGYRLICVKR-----------------DDC-------------------------ETN-- 775
            |...|:|:.|..|:|                 |||                         |.|  
Zfish  1195 KNCLGAGFYLTLVRRIKEQPAPVRKEGQCDCTDDCSCKCSLCTKFKASDTEKPRVSERQMEGNIE 1259

  Fly   776 EVTALLNKYIPGLKPECDIGAELSYQLPDSA--SAKFEEMFGQLEEQSDELHLNGYGVGITSMEE 838
            .:|||::.::|..:....||.||::.||..|  ...:..:|.:|||...::.|:.:||..||:||
Zfish  1260 SITALVHHHVPEARLIEVIGQELTFLLPSRAFKHRSYASLFRELEETLADMGLSSFGVSDTSLEE 1324

  Fly   839 VFMKVGAEKD----NTGNIKDQHEIMNGGSGFRGEDDNESVQSDGIFSENR--RLLQGLQLLSNQ 897
            ||:||.|:.:    ||.:..|           |...:.:|..::.|..|.|  :.::|..|:..|
Zfish  1325 VFLKVTADGEAAHINTASDTD-----------RSHANGQSNSANVISKEGRGSQQVKGFFLVVKQ 1378

  Fly   898 WKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQYPLAVTVLDR 962
            :.|:|:|:|.:|.|:....|.|.::|..||.::::.......|.|...:|:|...|....|....
Zfish  1379 FFALLIKRFHHTTRSGKDFLAQIVLPASFVFISLMFTLIVPPFGEYPSLTLSPWMYGRQFTFFSN 1443

  Fly   963 SNVQ------------NGTGY----------------EIANKYE------------------DLA 981
            ..:|            |..|:                .|..::|                  |::
Zfish  1444 EQMQSPDMRYFGEVLLNRPGFGTRCMVDEPLEEYPCNNITTEWEMPLVNPMLIEMLSNSEWTDIS 1508

  Fly   982 RSYGSNYG-------------------------------LELTGTQGFEDYILDLGKT----IQV 1011
            .|......                               ::||| :...||::   ||    |:.
Zfish  1509 PSPSCQCSTPNKLTMLPVCPEGAGGLPPPQRIQSTGDMLMDLTG-RNISDYLV---KTYPNLIRT 1569

  Fly  1012 RINSRYLV---------------------------AATI-------------------------- 1023
            .:.|:|.|                           ||.|                          
Zfish  1570 SLKSKYWVNEQRYGGISVGGRLPVLNLDPKSIQNAAAQIGRLLNVTGGRYSKLALDEFATFLRYM 1634

  Fly  1024 -TESKITAWLNNQALHTAPLTVNMVHNAIADKLFGSSVK-----IQVTNAPLPYTTSTLLSQLST 1082
             ||:.:..|.||:..|.....:|:.:|||........|.     |...|.||..|...|......
Zfish  1635 ETENNVKVWFNNKGWHAMVAFMNVANNAILRANLPPGVDLNEYGITAINHPLNLTKEQLSEVTVL 1699

  Fly  1083 GNNLGTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTA 1147
            ..::...:|.|:.|.|.||.:.::|:||:||.::||.||||.||....:|.:.|..|..:|.|:|
Zfish  1700 TTSVDAVVAINVIFAMSFVPAGFVLYLIQERVTQAKHLQFVSGVSPLVYWTANFFWDMINYSVSA 1764

  Fly  1148 LIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGM 1212
            .:||...:.|.:...::.|.|.....||:|:|::|.|.:|.||..|..|:|.:..:|.:|:|.|:
Zfish  1765 AMVVGIFIAFDKKCYTSPGNLQALIALLMLYGWSVTPMMYPMSYIFNVPSTAYVSLSCINLFIGI 1829

  Fly  1213 ALFIVVVVMSSELFDTKDTA----DILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPI 1273
            ....:..::  :|||:.:..    .:|.....:||||.|...|..:..|.|..:..|:.|     
Zfish  1830 NSSAITFIL--DLFDSTEALYKCNQVLKKALLVFPHFCLGRGLIDMAMNQAVMDVYARFG----- 1887

  Fly  1274 LLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLIS--KP 1336
                   :..:|.| |:|:..|  ....:|||.|.|:|::.|::::|      |.:...:|  |.
Zfish  1888 -------EDFSLDP-FSWDFVG--ENLTFMAVEGFVYFILNILIQYR------FFLDHWMSDFKK 1936

  Fly  1337 PPPPTEGQLDDDVANERERILQ-MSSNELATKNLVLDRVTKYYGQFM-AVNQVSLCVQEVECFGL 1399
            ||...|   |.|||.|||||.: .|||::..   :.|....|.|.|. ||:::.:.|...|||||
Zfish  1937 PPITDE---DVDVAKERERIYKGGSSNDILQ---IKDLSKTYTGTFRPAVDRICVGVSPGECFGL 1995

  Fly  1400 LGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRI 1464
            ||||||||||||||:|||..::||.|.|.|.|:.:|:..:::.:||||||||:.|.|||||.|.:
Zfish  1996 LGVNGAGKTTTFKMLTGDIDVTSGEADVAGYSILTNILDVHQNMGYCPQFDAIDDLLTGREHLHL 2060

  Fly  1465 FCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTG 1529
            :..||||.||.|.:::|...:..|..::.......||||||||||||||:||.|:::.|||||||
Zfish  2061 YARLRGVPESEISRVAEWGIQKLGLSEYAGCTAGTYSGGNKRKLSTAIAMIGCPALLLLDEPTTG 2125

  Fly  1530 MDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGL 1594
            |||.:||.|||.:..:...|:::|||||||||||||||||||||||.|||:|:.||||.||..|.
Zfish  2126 MDPHSRRFLWNSIMSVIQGGRAVVLTSHSMEECEALCTRLAIMVNGTFKCLGTIQHLKYKFGDGY 2190

  Fly  1595 ILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILT 1659
            ::.:|:       |.|::.          .||      |::..:.|:|:.:|..|.:|::...|.
Zfish  2191 VVTMKI-------RAAKVG----------AVP------DLNPAEAFMESTFPGCIQREKHYNTLQ 2232

  Fly  1660 FYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQ 1706
            :.|..:.:  ::||.::.:|::.||:||||||||||:::|:.|||:|
Zfish  2233 YEIASSSL--AKIFQVVLANKEMLNIEDYSVSQTTLDQVFVNFAKHQ 2277

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Abca3NP_608445.2 rim_protein <137..1708 CDD:130324 584/1833 (32%)
abca4aNP_001428973.1 None

Return to query results.
Submit another query.