DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and Abca2

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_006233707.2 Gene:Abca2 / 79248 RGDID:620238 Length:2435 Species:Rattus norvegicus


Alignment Length:1907 Identity:582/1907 - (30%)
Similarity:908/1907 - (47%) Gaps:409/1907 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   135 NATQL--ELDTVSKNAFAGVQF--------------DDAWANLTEND------------------ 165
            |.|.|  :|||:...|...:||              :::..|.|.|.                  
  Rat   550 NGTALLQQLDTIDNAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRK 614

  Fly   166 --PLPNDFHFALRFPAELRTATIAIANT-WLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLP 227
              .||...|:.:|..:.....|..|... |               ..|.:.||  ..|...||:.
  Rat   615 DGSLPPHVHYKIRQNSSFTEKTNEIRRAYW---------------RPGPNTGG--RFYFLYGFVW 662

  Fly   228 LQHSLSMAYLRQKSGEQDL-PNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYI 291
            :|..:..|.:....|...: |...::.:|:|.|..|..|..:..:|.|.:::|::|......::|
  Rat   663 IQDMIERAIINTFVGHDVVEPGNYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHI 727

  Fly   292 TAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALV 356
            .||||.:||||||.|||:|.:||.|||:..|:.|:||...:..::|..     .||.|::...:.
  Rat   728 VAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYG-----QVLMHSHVLIIW 787

  Fly   357 FFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTI----NSYDDLSLSSKLGWS 417
            .||.:|.|::|.|||:::..:|:|..|:|..|:|:|::|:||.:..    .::|.::...|...|
  Rat   788 LFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIAS 852

  Fly   418 LISNTAMGFGIKLILGFEGTGEGLQWSNFF-TPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQ 481
            |:|.||.|.|.|....:|..|.|:||..|. :||..||...|.|| .|::|..|:|.::..|:|.
  Rat   853 LMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAV-TMLMVDTVVYGVLTWYIEA 916

  Fly   482 VMPGSFGVPRPWNFPFTREFWCGE-REYTGVEDIPNGH--------------VEQR---DPKAFE 528
            |.||.:|:||||.||..:.:|.|. |..|.....|..|              :|.|   :.:..|
  Rat   917 VHPGMYGLPRPWYFPLQKSYWLGSGRTETWEWSWPWAHAPRLSVMEEDQACAMESRHFEETRGME 981

  Fly   529 TEPEGKHIGLQMRHLKKRFGN--KMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTS 591
            .||....:.:.:..|.|.:.|  |:.:..||:|::|:::...|||||||||||:|:|||:|||||
  Rat   982 EEPTHLPLVVCVDKLTKVYKNDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTS 1046

  Fly   592 GTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMI 656
            |:|.|.|.||||.::..|.:||:|||||||||:::|..|:.|:||:|.:..:.:.:|:.|.::.:
  Rat  1047 GSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDQLTVEEHLWFYSRLKSMAQEEIRKEMDKMIEDL 1111

  Fly   657 ELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLL 721
            ||.:|.:.....|||||||||||..|..|.::.::.|||::|:||.|||.:|||:.:.|.|||:|
  Rat  1112 ELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTIL 1176

  Fly   722 LTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKR----------------- 769
            |:||.|||||:|||||||:..|:|||.|:..|||..||.||||..|||                 
  Rat  1177 LSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGAYGDGYRLTLVKRPAEPGTSQEPGMASSPS 1241

  Fly   770 -----DDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAK--FEEMFGQLEEQSDELHLN 827
                 .:|...:|:..:.|::.......|...||||.||..|..|  ||.:|.|||...|.|||:
  Rat  1242 GRPQLSNCSEMQVSQFIRKHVASSLLVSDTSTELSYILPSEAVKKGAFERLFQQLEHSLDALHLS 1306

  Fly   828 GYGVGITSMEEVFMKVGAE----KDNTGNIKD-QHEIMNGGSGF--------------------- 866
            .:|:..|::||||:||..|    :::..::|: :.:.:.|..|.                     
  Rat  1307 SFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDALPGAEGLTAVESQAGNLARCSELAQSQA 1371

  Fly   867 -----------RGED---------------------DNESVQSDGI-----FSENRRLLQGLQLL 894
                       ||::                     |:.|:|...:     ..:..|.|:|..|.
  Rat  1372 SLQSASSVGSARGDEGAGYTDGYGDYRPLFDNLQDPDSVSLQEAEMEALARVGQGSRKLEGWWLK 1436

  Fly   895 SNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQY------ 953
            ..|:..:|:|:|....||...|..|.::|.|||.|.:.:..:.....:|.|:.:|.:||      
  Rat  1437 MRQFHGLLVKRFHCARRNSKALCSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQP 1501

  Fly   954 -----PLA-------------------------------VTVLDRS----------NVQNGTGYE 972
                 |.|                               .|.:.:|          |:.:|....
  Rat  1502 RGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPMLNLSSGESRL 1566

  Fly   973 IANKYEDLARSYGSNYGLELT-------------------------------------------- 993
            :|.::.|.........||.|:                                            
  Rat  1567 LAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPLSPDEDSLLAWNTSLPPTAGPETWTWAPS 1631

  Fly   994 ----------------GTQGF-----------------------------EDYIL---------- 1003
                            || ||                             .:|:|          
  Rat  1632 LPRLVHEPVRCTCSAQGT-GFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRLHR 1695

  Fly  1004 -------DLGKTIQVRINSRY-LVAATITESKITAWL-NNQALHTAPLTVNMVHNAI------AD 1053
                   ::.|:|...|.:|. |:...|...::...| ||:..|:.|..:|.::|||      ..
  Rat  1696 YGAITFGNIQKSIPAPIGTRTPLMVRKIAVRRVAQVLYNNKGYHSMPTYLNSLNNAILRANLPKS 1760

  Fly  1054 KLFGSSVKIQVTNAPLPYTTSTL-LSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRA 1117
            |...::..|.|||.|:..|:::| |..|..|.::  .:|..:...|.||.:.:::||:.|:.::|
  Rat  1761 KGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDV--VIAIFIIVAMSFVPASFVVFLVAEKSTKA 1823

  Fly  1118 KLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAV 1182
            |.||||.|.....:||:.::.|..:|:|.|...:|.:..|.....::.........|.||:|:::
  Rat  1824 KHLQFVSGCNPVIYWLANYVWDMLNYLVPATCCIIILFVFDLPAYTSPTNFPAVLSLFLLYGWSI 1888

  Fly  1183 LPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELF----DTKDTADILGWIFRIFP 1243
            .|.:|..|.:|..|::.:..:.::|:|.|:...:...::  :||    |.|.....|...|.|||
  Rat  1889 TPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLL--QLFEHDKDLKVVNSYLKSCFLIFP 1951

  Fly  1244 HFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGV 1308
            :::|...|.::..|.......||.|            |...:|..|.|:.  |....|.|.|.|.
  Rat  1952 NYNLGHGLMEMAYNEYINEYYAKIG------------QFDKMKSPFEWDI--VTRGLVAMTVEGF 2002

  Fly  1309 VFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQLDD-DVANERERILQMSSNELATKNLVLD 1372
            |.|.:.|:.::..:.:         .:..|..|:...|| |||:||:|:|:..::....|   ::
  Rat  2003 VGFFLTIMCQYNFLRQ---------PQRLPVSTKPVEDDVDVASERQRVLRGDADNDMVK---IE 2055

  Fly  1373 RVTKYY-----GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSL 1432
            .:||.|     |:.:||:::.|.|:..||||||||||||||:||||:||||..:.|.|:|.|.|:
  Rat  2056 NLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSV 2120

  Fly  1433 ESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQT 1497
            ..::..:.:.:|||||||||.|:||.||.|:::..|||:......|:.....:.....|..||..
  Rat  2121 LKDLLQVQQSLGYCPQFDALFDELTAREHLQLYTRLRGIPWKDEAQVVRWALEKLELTKCADKPA 2185

  Fly  1498 HAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEEC 1562
            .:||||||||||||||:||.|:.|:||||||||||.|||.|||::..:..:|:|:||||||||||
  Rat  2186 GSYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEEC 2250

  Fly  1563 EALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPA 1627
            ||:||||||||||..:|:||.|||||:|..|.::.::.:                          
  Rat  2251 EAVCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTK-------------------------- 2289

  Fly  1628 QMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQ 1692
              |.:::..|..|....:|.::|:|.:...:.:.:....:..:::|..||.....|.:|||||||
  Rat  2290 --SSQNVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEHVVGVLGIEDYSVSQ 2352

  Fly  1693 TTLEEIFLEFAKYQREDTRANQ 1714
            |||:.:|:.|||.|.::....:
  Rat  2353 TTLDNVFVNFAKKQSDNVEQQE 2374

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 65/183 (36%)
ABC2_membrane_3 <269..475 CDD:289468 77/210 (37%)
CcmA 538..843 CDD:224054 149/330 (45%)
ABC_subfamily_A 538..755 CDD:213230 110/218 (50%)
ABC2_membrane_3 913..1316 CDD:289468 115/573 (20%)
ABC_subfamily_A 1369..1587 CDD:213230 120/222 (54%)
drrA 1376..1702 CDD:130256 145/330 (44%)
Abca2XP_006233707.2 rim_protein 1..2369 CDD:130324 582/1900 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166342291
Domainoid 1 1.000 158 1.000 Domainoid score I4008
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.660

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