DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and Abca6

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:NP_671751.2 Gene:Abca6 / 76184 MGIID:1923434 Length:1624 Species:Mus musculus


Alignment Length:1843 Identity:435/1843 - (23%)
Similarity:798/1843 - (43%) Gaps:398/1843 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRS 77
            ||.|....:|..|.:.::|..:|.|..|.:.|.                                
Mouse    15 LLHKILLKKWRRKRESLLEWSIPIIIGLHMGLF-------------------------------- 47

  Fly    78 SYLGKLIAL--IAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICESENATQL- 139
            |||.:.|.:  :.|........|:....::.|:|::.:.:       |.:.|.....:...|:: 
Mouse    48 SYLARNIQVLEVPPQDLGSLNEFNGSSLVVVYTPISNITQ-------QIMNKTTFAPTMKGTRII 105

  Fly   140 ------ELDTVSKNAF---AGVQFDDAWA------NLTENDPLPNDFHFALRFPAELRTATIAIA 189
                  :||.|..:..   .||.|:|:::      .:..|..|..|.                :|
Mouse   106 GVPSIEDLDEVLLHNIPDALGVIFNDSFSYQLKVLRMYGNPFLKEDL----------------LA 154

  Fly   190 NTWLT-MRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGE------QDLP 247
            :.|.| .:.|.::.                .|...||:.||.:::...:...:..      ..:.
Mouse   155 HCWDTHSQAFCSLS----------------KYWERGFVALQTAINAGIIEVTTNHSVMEELMSID 203

  Fly   248 NVVMKRYPF-PAYIFDPLLEGMSSIMSLIILL---SFIYPCTYITKYITAEKEKQLKEVMKIMGL 308
            .:.||..|| |..:.|      ..|..|..||   ||||   :.:..:|.|: ||.|||||:|||
Mouse   204 GINMKTLPFIPRDLSD------YEIFILFCLLYFSSFIY---FASSNVTKER-KQCKEVMKVMGL 258

  Fly   309 SNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMM 373
            .:...|.:|.:.....:.|.:|.|||::.   |..:.::|  .|..:.....:|.:|.|...|:|
Mouse   259 QDSAFWLSWGLIYVGFIFIISIFIAIIIT---STQIIMMT--GFLVIFTLFFLYGLSLIAVTFLM 318

  Fly   374 ATFFSRASTAAAVTGLI-------WFIAYIPYSFTINSYDDLSLSSKLGW--SLISNTAMGFGIK 429
            |....:    |.:|.||       |...    .||:...:   |...|.|  |:.|..|...|:.
Mouse   319 AVLLQK----AVLTNLIVLFFTLFWGCV----GFTVLHKE---LPPSLEWVLSIFSPFAFTSGMA 372

  Fly   430 LILGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVP-RPW 493
            .::..:....|:.:     |....::..:.||..::....::|:::.||.::::  .:|.. |..
Mouse   373 KVIFQDYNLNGVVF-----PDPSGESYVMIAVFFILAFDSLLYLVLALYFDKIL--LYGAEHRSA 430

  Fly   494 NFPFTREFWCG----------EREYTGVEDIPNG-HVEQRDPKAFETEPEGKHIGLQMRHLKKRF 547
            ...|.....|.          ||:..  .::|:. :.|..||     |.:||. .:::|::||.:
Mouse   431 PLFFLNPTSCFRKTANRNKVIERDLD--PELPSDEYFEPVDP-----EYQGKE-AIRIRNIKKEY 487

  Fly   548 ----GNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAII---NGSDIRTNI 605
                |....:|||.::::|.:||.:|||:||||::.:::|:|::.||:|:..:   |.||:: ::
Mouse   488 KGKSGKVKALKGLFLDIYESQITAILGHSGAGKSSLLNILSGLYVPTAGSVTVYNKNLSDMQ-DL 551

  Fly   606 EGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLS 670
            :..|.::|:||||||.||.::|..::..|:::||:..:.|||||.:.|..:::::..:..:..||
Mouse   552 KEIRKAIGVCPQHNVQFDALTVKENLTLFAKIKGILPQDVEQEVQQILSELDMQNIRDDLAEHLS 616

  Fly   671 GGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGD 735
            .|.||||:...|..||.:::|.|||:.|:||.:|:::|..|::.:....:|.:|.||||||:|.|
Mouse   617 EGQKRKLTFGIATVGDPQILLLDEPTVGLDPFSRQRIWGFLKERRADHVILFSTQFMDEADILAD 681

  Fly   736 RIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSY 800
            |..::.:|.|||.|:|.|||:::|.||.|.....:.|::..:|:.:|.:||..|.:.....:|.|
Mouse   682 RKVLIANGALKCTGSSVFLKRKWGLGYHLSLFMDETCDSERLTSFINHHIPYAKLKAKTKEKLVY 746

  Fly   801 QLPDSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQHEIMNGGSG 865
            .||...:::|.|.|..|::.|.: .|..|.|.::::.:||:.:..|.....:.:.:..       
Mouse   747 ILPLERTSEFPEFFSDLDKYSGQ-GLMSYEVSMSTLNDVFLNLEGEPSTKQDFEKRET------- 803

  Fly   866 FRGEDDNESVQSDGI----FSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNK------LLLLIQN 920
               ..|:||:....:    .|:.:..:..:.|...|..|:...:.|...|.:      ||||...
Mouse   804 ---ATDSESLNDMEVAYPSLSQVQETVSTMSLWRMQVCAIARLRILKLKRERKAFLIILLLLGIA 865

  Fly   921 IMP--VFFVVVTILIIKTQGTFQE----LKPITISLTQYP--LAVTVLDRSNVQNGTGYEIANKY 977
            ::|  :.:|...:|.:|....|:.    |.|     .|.|  |..::|..:|.:        :..
Mouse   866 LLPLVIEYVANALLEVKNNWEFKTDLYFLSP-----GQLPQGLRTSLLVINNTE--------SNI 917

  Fly   978 EDLARSY-GSNYGLELTGTQGFEDYILDLGKTIQVRINSRYLVAATITESKITAWLNNQALHTAP 1041
            ||..:|. ..|..||:   ..||    :...|..:..|...:|:....:.:.:|..|.:.||..|
Mouse   918 EDFLQSLKHQNIVLEV---DDFE----NRNATNSLSYNGAIIVSGRQKDYRFSAVCNTKRLHCFP 975

  Fly  1042 LTVNMVHNAIADKLFGSS---VKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSS 1103
            :.:|::.|.|...|..:.   :|..:.:   |:...           :.|.:.....|.:|.:.|
Mouse   976 ILMNVISNGILHMLNHTQYIRIKEDIFS---PFIVL-----------VWTGIQETCLFILCVICS 1026

  Fly  1104 I---YILFLIKERESRAKLLQFVGGVKVWTFWLSQFICD------------FASYIVTAL----- 1148
            :   ..:..:.:.:.:|....::.|:....:|..|.:.|            |.||....|     
Mouse  1027 LSPHIAMSSVSDYKKKADSQLWISGLYPSAYWCGQAVVDISLFSGMLLTSYFTSYTSKLLNIDMT 1091

  Fly  1149 ------IVVITIVCFQETGLSTFGELGRYYLLLLLFG-------FAVLPFIYIMSLFFREPATG- 1199
                  ::|:.:.|.......|       |::..:||       ...:.|:.::::.|.:.|.| 
Mouse  1092 SEIVFSVIVLALGCAASLVFLT-------YVISFVFGKRKKNSTLWSICFLLVIAITFEKVANGP 1149

  Fly  1200 ------FARVSIVNIFCGMALFIVVVVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTNT 1258
                  .:...:|..|....|.:|:.:.:.:.:..          |....|...|:.|       
Mouse  1150 FNEALVISATMLVPSFALNGLLVVLEMRAYQYYIE----------FEEIKHGLSAVDL------- 1197

  Fly  1259 ATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFR--- 1320
                           |||        |.||                :..::|..::..||.:   
Mouse  1198 ---------------LLC--------LIPY----------------IHTLLFIFVLRCLELKYGK 1223

  Fly  1321 --LINELMFKIRQLISKPPPPPTEGQLDDDVANERERILQMSSNELATKNLVLDRV-------TK 1376
              :..:.:|:|.....|..|.|.| .:|:|...:.||:  .:|:.|:|.||....|       .:
Mouse  1224 NVVRRDPIFRIAPQSLKAQPNPEE-PIDEDENVQAERL--RTSDALSTPNLDEKPVIIASCLHKE 1285

  Fly  1377 YYGQ----------FMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGL- 1430
            |.||          .|||..||.||.:.|..||||.:||||:::.:|:.|..:.::|...::.| 
Mouse  1286 YAGQKKHCCSRRTRNMAVRNVSFCVNKGEILGLLGPDGAGKSSSIRMIAGITKPTAGQVELKRLS 1350

  Fly  1431 SLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGV-QESRIRQLSEDLAKSFGFMKHID 1494
            |...:........|||||.:.|..:||.:|.|.::..::|: :|..:..:|. |..:......::
Mouse  1351 SAVGHQGDSRAEFGYCPQENGLWPNLTVKEHLELYAAVKGLRKEDAVVAISR-LVNALKLHDQLN 1414

  Fly  1495 KQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMV-CRIRDSGKSIVLTSHS 1558
            .|......|..|||...::::|:..|:.||||:||:|.:.:.|:|..: ..::|:.|.::|::|.
Mouse  1415 VQVQNLVAGATRKLCFVLSILGNSPVLILDEPSTGLDVSGKHQVWQAIQAVVKDNEKGVLLSTHD 1479

  Fly  1559 MEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQ 1623
            :.|.||||.|.||||:|..:|||..||||.||.:..:|:::|:                      
Mouse  1480 LAEAEALCDRAAIMVSGRLRCIGPIQHLKRKFGQDYVLELRVK---------------------- 1522

  Fly  1624 TVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGV-KWSRIFGLMESNRDQLNVED 1687
                .:||..:  |...:...:|.:..|:....:||:.:|:|.| ..|:.|..:|:.:...::||
Mouse  1523 ----DVSQEPL--VHREILKLFPQAARQDRCFSLLTYKLPVTDVHPLSQAFHKLEAVKHGFDLED 1581

  Fly  1688 YSVSQTTLEEIFLEFAKYQREDT 1710
            ||:||.||:.:.||.:|.|...|
Mouse  1582 YSLSQCTLDRVILELSKEQELGT 1604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 54/192 (28%)
ABC2_membrane_3 <269..475 CDD:289468 55/217 (25%)
CcmA 538..843 CDD:224054 109/311 (35%)
ABC_subfamily_A 538..755 CDD:213230 83/223 (37%)
ABC2_membrane_3 913..1316 CDD:289468 76/460 (17%)
ABC_subfamily_A 1369..1587 CDD:213230 76/237 (32%)
drrA 1376..1702 CDD:130256 102/339 (30%)
Abca6NP_671751.2 rim_protein <169..1600 CDD:130324 398/1612 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838447
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.650

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