Protein Alignment Abca3 and Abca12

DIOPT Version :10

• Sequence 1: NP_608445.2
• Gene: Abca3 / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Sequence 2: NP_780419.2
• Gene: Abca12 / 74591
• MGIID: 2676312
• Length: 2595
• Species: Mus musculus
• Alignment Length: 1734
• Identity: 524/1734 - (30%)
• Similarity: 854/1734 - (49%)
• Gaps: 254/1734 - (14%)

  Fly   140 ELDTVSKNAFAGVQ-FDDAWANLTEN-------DP----LPNDFHFALRFPAELRTATIAIANTW 192
            |::||::..:...: |......|..|       ||    ||....:.:|.  .|:||.
Mouse   935 EMETVAEQLYKSNELFGSVIFKLPSNGSLHRGFDPEKVSLPPIVRYTIRM--SLKTAQ------- 990

  Fly   193 LTMRLFPT-IDLTGPRNEGDDDGGIPPGYLR---EGFLPLQHSLSMAYLRQKSG--EQDLPNVVM 251
             |.|...| |...||.|.        |.:.:   ..|:.||.|:..|.:..::|  .|::. |.:
Mouse   991 -TTRSIRTKIWAPGPHNS--------PSHNQIYGRAFIYLQDSIERAIIELQTGRNSQEVA-VQV 1045

  Fly   252 KRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTA 316
            :..|:|.::.|..|..:|..:.::::::::.......|.:..||:.:|.|.||:||:::..|:.|
Mouse  1046 QAVPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFA 1110

  Fly   317 WFVKS--FIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSR 379
            |.::|  |:::|| ||||.||...|      :|...|...|..:...|..|.|...::::.||:.
Mouse  1111 WLIESIGFLLVTI-AILIVILKFGN------ILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNN 1168

  Fly   380 ASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWS 444
            .:.||.:..||:.||:.|:...:...|:||...|:..||:|.||..:..:.|..:|..|.||||.
Mouse  1169 TNIAALIGSLIYVIAFFPFIVLVTVEDELSYVIKVFMSLLSPTAFSYASQYIARYEEQGVGLQWE 1233

  Fly   445 NFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFW-----CG 504
            |.:.....|||.:.|.:..::|....||..|..||..|.||::|:..||.||....:|     |.
Mouse  1234 NMYKSPVQDDTTSFGWLCCLILADSFIYFFIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCA 1298

  Fly   505 EREYTGVEDI--PNGHVEQRDPKAFET----------EPEGK--HIGLQMRHLKKRFGNKMVVKG 555
            |.::.....:  .|..::..:|.|.:|          |||.|  .:|:.:..:.|.:|:|..|:.
Mouse  1299 EVKHEKSNGLMFTNIMMQNTNPSASKTSPDCAFPSNIEPEPKDLQVGVALHGVTKIYGSKTAVEN 1363

  Fly   556 LSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNV 620
            |::|.:|..||.|||.||||||||||||||:|..|:||..:.|.||:|::...|.::|:|.||:|
Mouse  1364 LNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGATAGTIFVYGKDIKTDLNTVRKNMGVCMQHDV 1428

  Fly   621 LFDEMSVSNHIRFFSRMK--GLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCAL 683
            ||..::...|:..:..:|  ......:.:||.:.||...|....:.....||||||||||:..||
Mouse  1429 LFSYLTTKEHLLLYGSIKVPHWTKTQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIAL 1493

  Fly   684 CGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQ 748
            .|.::||:.||||:|:||.:||.:||::.:.|..||::|:||.:|||:||.||||.:..|.|:|.
Mouse  1494 IGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCC 1558

  Fly   749 GTSFFLKKQYGSGYRLICVKRDD--------CETNEVTALLNKYIPGLKPECDIGAELSYQLP-- 803
            |:.|:||:.:|.||.|...|:..        |:|..|||::..::|....:.|||.||.|.||
Mouse  1559 GSPFYLKEAFGDGYHLTLTKKKSPNLDTNAICDTVAVTAMIQSHLPEAYLKEDIGGELVYVLPPF 1623

  Fly   804 -DSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQH----EIMNGG 863
             ...|..:..:...|::...:|::..||:..|::||||:.:..:...:.|:..:|    ::.|..
Mouse  1624 STKVSGAYLSLLRALDKGMGKLNIGCYGISDTTVEEVFLNLTKDSQKSSNMSLEHLTQRKVGNPS 1688

  Fly   864 SGFRGEDDNESVQS-------DGIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNI 921
            :......|:.||.|       |.:.:.:.: |:|..||..:..|:|:|:|.:|.||...|:.|.|
Mouse  1689 ANGTSTPDDLSVSSSNFTDRDDKVLTRSEK-LEGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVI 1752

  Fly   922 MPVFFVVVT---------------ILIIKT-QGT------FQELKPITISLT----QYP-LAVTV 959
            :|:.||...               |:|..: .||      :....|.|..|.    .:| :....
Mouse  1753 LPIVFVATAMGLGTLRDSSNSYPEIMISPSIYGTSEQTAFYANFDPSTSGLVSALWNFPGIDNVC 1817

  Fly   960 LDRSNVQ----------NGTGYEI-----------------ANKYEDLARSYGSNYGLELTGTQG 997
            |:.|::|          |.:|..|                 .|.:....|:|.|.....||| :.
Mouse  1818 LNTSDLQCLKKDDLGKWNTSGEAIDNFGVCSCSDNVQECPKFNYHPPHRRTYSSQVIYNLTG-KH 1881

  Fly   998 FEDYILDLGKTIQVRINSRY----------------LVAATITESKITAWLNNQALHTAPLTVNM 1046
            .|:|::   .|....:..||                :.|.....:....|.:.:..|:.|..:|.
Mouse  1882 MENYLI---TTANHFVQKRYGGWSFGMKLTNDLRFDVTAVPDNRTLAKVWYDPEGYHSLPAYLNS 1943

  Fly  1047 VHNAI----ADKLFGSSVKIQVTNAPLP-------YTTSTLLSQLSTGNNLGTQLASNLCFCMCF 1100
            ::|.:    ..:...:...|.:.:.|.|       .|.|:|:..|         :|.::......
Mouse  1944 LNNFLLRVNMSEYDAARHGIIMYSHPYPGVQDQEQATISSLIDIL---------VALSILMGYSV 1999

  Fly  1101 VSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTF 1165
            .::.::.::::|.:::||.||.:.|:.|..:|::.||.|...|:|.....:..|..|:.....:.
Mouse  2000 TTASFVTYIVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGVIAIFKLPAFYSG 2064

  Fly  1166 GELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKD 1230
            ..||...|||||||:|...::|:::..|.|....|.....||:|.|:.   .:|.:|...|.:|:
Mouse  2065 NNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGIN---SIVSLSVVYFLSKE 2126

  Fly  1231 ---------TADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLK 1286
                     .::.|..||.|||.|.....|.::....|..:.....|...|             .
Mouse  2127 KPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQAVLDFLKAYGVEYP-------------S 2178

  Fly  1287 PYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQLDDDVAN 1351
            ..|..::.|.:  .|.:...|.:|||:.:::...||.:|....|:..|.|.....:.  |:||..
Mouse  2179 ETFEMDKLGAM--FVALVSQGTMFFLLRLLINEWLIKKLRLFFRKFTSSPIMETVDE--DEDVRA 2239

  Fly  1352 ERERILQMSSNELATKNLV-LDRVTKYY----GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTF 1411
            ||.|:    .:..|..:|| |.|:||.|    .:.:|||.:||.:...|||||||||||||||.|
Mouse  2240 ERFRV----ESGAAEFDLVQLHRLTKTYQLIHKKIIAVNNISLGIPAGECFGLLGVNGAGKTTIF 2300

  Fly  1412 KMMTGDERISSGAAYVQGLSLE-SNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESR 1475
            ||:|||...|||...::..|.. .:::|...::|||||.|||.|.:|..|.|..:..:.|:.|..
Mouse  2301 KMLTGDIIPSSGNILIRNKSGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKD 2365

  Fly  1476 IRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWN 1540
            |:.....|.:....|.:.|:.|...|.|.|||||||:|:||.||::.||||::||||.::|.||.
Mouse  2366 IKDTVHKLLRRLHLMAYKDRSTSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWR 2430

  Fly  1541 MVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLE 1605
            ::.....:..|::||||||||||||||||||||||.|:||||.||:|::|.:|..:|:.::.|
Mouse  2431 IISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGRFQCIGSLQHIKSRFGRGFTVKVHLKNN-- 2493

  Fly  1606 ALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWS 1670
                                     :..::.:.:|::..:|.:.|::::..:|.:::|:|....:
Mouse  2494 -------------------------KVSMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVA 2533

  Fly  1671 RIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAK----YQREDT 1710
            .||.|:|:|:..||:.::.||||||||:|:.|||    |:..||
Mouse  2534 NIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYENVDT 2577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abca3	NP_608445.2	rim_protein	<137..1708	CDD:130324	522/1730 (30%)
Abca12	NP_780419.2	rim_protein	7..>86	CDD:130324
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..143
		rim_protein	749..2569	CDD:130324	521/1724 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1672..1703		6/30 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2575..2595		2/3 (67%)