DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and Abca12

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:NP_780419.2 Gene:Abca12 / 74591 MGIID:2676312 Length:2595 Species:Mus musculus


Alignment Length:1734 Identity:524/1734 - (30%)
Similarity:854/1734 - (49%) Gaps:254/1734 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 ELDTVSKNAFAGVQ-FDDAWANLTEN-------DP----LPNDFHFALRFPAELRTATIAIANTW 192
            |::||::..:...: |......|..|       ||    ||....:.:|.  .|:||.       
Mouse   935 EMETVAEQLYKSNELFGSVIFKLPSNGSLHRGFDPEKVSLPPIVRYTIRM--SLKTAQ------- 990

  Fly   193 LTMRLFPT-IDLTGPRNEGDDDGGIPPGYLR---EGFLPLQHSLSMAYLRQKSG--EQDLPNVVM 251
             |.|...| |...||.|.        |.:.:   ..|:.||.|:..|.:..::|  .|::. |.:
Mouse   991 -TTRSIRTKIWAPGPHNS--------PSHNQIYGRAFIYLQDSIERAIIELQTGRNSQEVA-VQV 1045

  Fly   252 KRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTA 316
            :..|:|.::.|..|..:|..:.::::::::.......|.:..||:.:|.|.||:||:::..|:.|
Mouse  1046 QAVPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFA 1110

  Fly   317 WFVKS--FIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSR 379
            |.::|  |:::|| ||||.||...|      :|...|...|..:...|..|.|...::::.||:.
Mouse  1111 WLIESIGFLLVTI-AILIVILKFGN------ILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNN 1168

  Fly   380 ASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWS 444
            .:.||.:..||:.||:.|:...:...|:||...|:..||:|.||..:..:.|..:|..|.||||.
Mouse  1169 TNIAALIGSLIYVIAFFPFIVLVTVEDELSYVIKVFMSLLSPTAFSYASQYIARYEEQGVGLQWE 1233

  Fly   445 NFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFW-----CG 504
            |.:.....|||.:.|.:..::|....||..|..||..|.||::|:..||.||....:|     |.
Mouse  1234 NMYKSPVQDDTTSFGWLCCLILADSFIYFFIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCA 1298

  Fly   505 EREYTGVEDI--PNGHVEQRDPKAFET----------EPEGK--HIGLQMRHLKKRFGNKMVVKG 555
            |.::.....:  .|..::..:|.|.:|          |||.|  .:|:.:..:.|.:|:|..|:.
Mouse  1299 EVKHEKSNGLMFTNIMMQNTNPSASKTSPDCAFPSNIEPEPKDLQVGVALHGVTKIYGSKTAVEN 1363

  Fly   556 LSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNV 620
            |::|.:|..||.|||.||||||||||||||:|..|:||..:.|.||:|::...|.::|:|.||:|
Mouse  1364 LNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGATAGTIFVYGKDIKTDLNTVRKNMGVCMQHDV 1428

  Fly   621 LFDEMSVSNHIRFFSRMK--GLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCAL 683
            ||..::...|:..:..:|  ......:.:||.:.||...|....:.....||||||||||:..||
Mouse  1429 LFSYLTTKEHLLLYGSIKVPHWTKTQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIAL 1493

  Fly   684 CGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQ 748
            .|.::||:.||||:|:||.:||.:||::.:.|..||::|:||.:|||:||.||||.:..|.|:|.
Mouse  1494 IGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCC 1558

  Fly   749 GTSFFLKKQYGSGYRLICVKRDD--------CETNEVTALLNKYIPGLKPECDIGAELSYQLP-- 803
            |:.|:||:.:|.||.|...|:..        |:|..|||::..::|....:.|||.||.|.||  
Mouse  1559 GSPFYLKEAFGDGYHLTLTKKKSPNLDTNAICDTVAVTAMIQSHLPEAYLKEDIGGELVYVLPPF 1623

  Fly   804 -DSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQH----EIMNGG 863
             ...|..:..:...|::...:|::..||:..|::||||:.:..:...:.|:..:|    ::.|..
Mouse  1624 STKVSGAYLSLLRALDKGMGKLNIGCYGISDTTVEEVFLNLTKDSQKSSNMSLEHLTQRKVGNPS 1688

  Fly   864 SGFRGEDDNESVQS-------DGIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNI 921
            :......|:.||.|       |.:.:.:.: |:|..||..:..|:|:|:|.:|.||...|:.|.|
Mouse  1689 ANGTSTPDDLSVSSSNFTDRDDKVLTRSEK-LEGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVI 1752

  Fly   922 MPVFFVVVT---------------ILIIKT-QGT------FQELKPITISLT----QYP-LAVTV 959
            :|:.||...               |:|..: .||      :....|.|..|.    .:| :....
Mouse  1753 LPIVFVATAMGLGTLRDSSNSYPEIMISPSIYGTSEQTAFYANFDPSTSGLVSALWNFPGIDNVC 1817

  Fly   960 LDRSNVQ----------NGTGYEI-----------------ANKYEDLARSYGSNYGLELTGTQG 997
            |:.|::|          |.:|..|                 .|.:....|:|.|.....||| :.
Mouse  1818 LNTSDLQCLKKDDLGKWNTSGEAIDNFGVCSCSDNVQECPKFNYHPPHRRTYSSQVIYNLTG-KH 1881

  Fly   998 FEDYILDLGKTIQVRINSRY----------------LVAATITESKITAWLNNQALHTAPLTVNM 1046
            .|:|::   .|....:..||                :.|.....:....|.:.:..|:.|..:|.
Mouse  1882 MENYLI---TTANHFVQKRYGGWSFGMKLTNDLRFDVTAVPDNRTLAKVWYDPEGYHSLPAYLNS 1943

  Fly  1047 VHNAI----ADKLFGSSVKIQVTNAPLP-------YTTSTLLSQLSTGNNLGTQLASNLCFCMCF 1100
            ::|.:    ..:...:...|.:.:.|.|       .|.|:|:..|         :|.::......
Mouse  1944 LNNFLLRVNMSEYDAARHGIIMYSHPYPGVQDQEQATISSLIDIL---------VALSILMGYSV 1999

  Fly  1101 VSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTF 1165
            .::.::.::::|.:::||.||.:.|:.|..:|::.||.|...|:|.....:..|..|:.....:.
Mouse  2000 TTASFVTYIVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGVIAIFKLPAFYSG 2064

  Fly  1166 GELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKD 1230
            ..||...|||||||:|...::|:::..|.|....|.....||:|.|:.   .:|.:|...|.:|:
Mouse  2065 NNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGIN---SIVSLSVVYFLSKE 2126

  Fly  1231 ---------TADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLK 1286
                     .::.|..||.|||.|.....|.::....|..:.....|...|             .
Mouse  2127 KPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQAVLDFLKAYGVEYP-------------S 2178

  Fly  1287 PYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQLDDDVAN 1351
            ..|..::.|.:  .|.:...|.:|||:.:::...||.:|....|:..|.|.....:.  |:||..
Mouse  2179 ETFEMDKLGAM--FVALVSQGTMFFLLRLLINEWLIKKLRLFFRKFTSSPIMETVDE--DEDVRA 2239

  Fly  1352 ERERILQMSSNELATKNLV-LDRVTKYY----GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTF 1411
            ||.|:    .:..|..:|| |.|:||.|    .:.:|||.:||.:...|||||||||||||||.|
Mouse  2240 ERFRV----ESGAAEFDLVQLHRLTKTYQLIHKKIIAVNNISLGIPAGECFGLLGVNGAGKTTIF 2300

  Fly  1412 KMMTGDERISSGAAYVQGLSLE-SNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESR 1475
            ||:|||...|||...::..|.. .:::|...::|||||.|||.|.:|..|.|..:..:.|:.|..
Mouse  2301 KMLTGDIIPSSGNILIRNKSGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKD 2365

  Fly  1476 IRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWN 1540
            |:.....|.:....|.:.|:.|...|.|.|||||||:|:||.||::.||||::||||.::|.||.
Mouse  2366 IKDTVHKLLRRLHLMAYKDRSTSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWR 2430

  Fly  1541 MVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLE 1605
            ::.....:..|::||||||||||||||||||||||.|:||||.||:|::|.:|..:|:.::.|  
Mouse  2431 IISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGRFQCIGSLQHIKSRFGRGFTVKVHLKNN-- 2493

  Fly  1606 ALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWS 1670
                                     :..::.:.:|::..:|.:.|::::..:|.:::|:|....:
Mouse  2494 -------------------------KVSMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVA 2533

  Fly  1671 RIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAK----YQREDT 1710
            .||.|:|:|:..||:.::.||||||||:|:.|||    |:..||
Mouse  2534 NIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYENVDT 2577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 53/181 (29%)
ABC2_membrane_3 <269..475 CDD:289468 63/207 (30%)
CcmA 538..843 CDD:224054 126/317 (40%)
ABC_subfamily_A 538..755 CDD:213230 95/218 (44%)
ABC2_membrane_3 913..1316 CDD:289468 101/492 (21%)
ABC_subfamily_A 1369..1587 CDD:213230 112/223 (50%)
drrA 1376..1702 CDD:130256 134/330 (41%)
Abca12NP_780419.2 ABC2_membrane_3 <1006..1267 CDD:289468 78/276 (28%)
NosY <1108..1269 CDD:224196 54/167 (32%)
ZnuC 1346..1570 CDD:224046 97/223 (43%)
ABC_subfamily_A 1350..1565 CDD:213230 95/214 (44%)
ABC2_membrane_3 <1913..2174 CDD:289468 60/272 (22%)
CcmA 2253..2567 CDD:224054 140/340 (41%)
ABC_subfamily_A 2254..2477 CDD:213230 111/222 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838439
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 1 1.100 - - O PTHR19229
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.740

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