DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and Abca14

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	XP_017167760.1	Gene:	Abca14 / 67928	MGIID:	2388708	Length:	1719	Species:	Mus musculus

Alignment Length:	1794	Identity:	638/1794 - (35%)
Similarity:	964/1794 - (53%)	Gaps:	195/1794 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KFVLLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHS 73
            :|.:|||||:.|:..:...:|:|::|     :.|:.|.||.      ||..:::  |.:
Mouse     8 QFSVLLWKNFLLKSRNVVGLVVEIIL-----IFLLFVWTLT------VRRISKK--TSI------ 53

  Fly    74 LHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSP-VNPVLKKLVEEAWQSLGKN-KI--CESE 134
               |..:...|.|..|....:|     |::.|.|.| .:...:.:.|...:.|..| |:  ..||
Mouse    54 ---SDVIFNPILLTLPKFLNEN-----FDYELAYVPSESNAARNITEMVKKDLNFNFKVQGFPSE 110

  Fly   135 NATQLELDTVSKNA--FAGVQFDDAWANLTENDPLPNDFHFALRF-----PAEL-RTATIAIANT 191
            .:.:..:...:|:|  .|.:.||..:.  |.|:.||....::|||     |..| :.:.......
Mouse   111 ESFERYIKYENKDAHVLAAIVFDHKFK--TSNERLPLQVKYSLRFGRIYDPENLFQPSKYQKEIE 173

  Fly   192 WLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGE--QDL---PNVVM 251
            |.|..|||::...||||..::||| .|||:|||||.:|||:..|.:...||.  :|:   ..:..
Mouse   174 WNTSTLFPSVPSLGPRNFLENDGG-NPGYIREGFLIVQHSVDKAIMMYHSGRAAEDIFANTTIYA 237

  Fly   252 KRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLK---------------- 300
            :|:|.||:|.|..|....::....||.:|......|...|..||||:||
Mouse   238 ERFPHPAFIHDSFLWTFIAMFPWTILFTFTQMALVIVGTIMLEKEKRLKLTYMYAYVPRVCLFPA 302

  Fly   301 --------------------EVMKIMGLSNWLHWTAWFVKSFIMLTISAILIA--ILVKINWSED 343
                                |...::||||.:.|.::|:...:|..|...|:.  :.:||....
Mouse   303 KNRRGCWIPGMEVTDGCEHPEYQLMVGLSNAMLWVSYFITFLLMYFIIICLLCGILFLKITHER- 366

  Fly   344 VAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTINSYDDL 408
              |..|::...:.|:.:.:.|||:...|:::|.|::||.|.::.|.:.|:.:.||....:.||.:
Mouse   367 --VFQHSDPLFIAFYFMCFAVSSVLLGFLISTLFNKASLATSIAGFLHFLTFFPYLILYHKYDQI 429

  Fly   409 SLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYM 473
            |||.||...||:|||:.||..||...|..|.|.||:||.|.|:.||.|||..::.|.|.|..:|.
Mouse   430 SLSGKLALCLITNTALAFGTDLICKLEMKGHGAQWNNFATKVNADDDLTLAHIIGMFLFSAFLYG 494

  Fly   474 IICLYVEQVMPGSFGVPRPWNFPFTREFWCGE----REYTGVEDIPNGHVEQRDPKAFETEPEGK 534
            ::..|::.|.||::|||:||||...:.:|.||    ||.:.|.|:.:...       .|.||.|.
Mouse   495 LVAWYLDAVFPGTYGVPKPWNFFLQKAYWFGEPALSREESQVSDLLSSDF-------MEPEPVGL 552

  Fly   535 HIGLQMRHLKKRF----GNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAI 595
            ..|::::||.|.|    ...|.|..||:|::|.:|||||||||||||||:|:|||::.||.|...
Mouse   553 VAGIRIQHLYKEFILKNSTLMAVNDLSLNLYEGQITVLLGHNGAGKTTTLSILTGLYLPTRGKVY 617

  Fly   596 INGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELED 660
            |:|.||.:::...|.|||:|||.::||..::||.|:.|:..:||:..:...:|..:.|....|..
Mouse   618 ISGYDISSDMVQIRKSLGLCPQDDLLFPMLTVSEHLHFYCVIKGIPLQNQSRETNRMLTSFGLLQ 682

  Fly   661 KANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTH 725
            ::|..|..||||||||||:..||.||||||:.|||:|||||.:||..|||||..|..||:|||||
Mouse   683 QSNTMSKDLSGGMKRKLSIIIALIGDTKVVILDEPTSGMDPVSRRATWDLLQHYKKDRTILLTTH 747

  Fly   726 FMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKP 790
            .|||||||||||||:..|.|||.|:|.||||.||.||.|:.||..|....::..|:..|||..|.
Mouse   748 HMDEADVLGDRIAILVMGILKCCGSSLFLKKLYGVGYHLVIVKTPDSNDEKIFQLIKNYIPTAKM 812

  Fly   791 ECDIGAELSYQLPDSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKD 855
            |.::.||||:.||...:.:|.|:|..|||:.:||.::|:||.:|:|:|||.||    .|..::|.
Mouse   813 ETNVAAELSFILPKEHTHRFAELFTDLEEKQEELGISGFGVSMTTMDEVFFKV----SNLEDLKL 873

  Fly   856 QHEIMNGGS--GFRGEDDNESVQSDGIFSE---NRRLLQ-----GLQLLSNQWKAMLLKKFLYTW 910
            ..||....|  .....:||:::.....|..   :||.|.     |..|...|::||.:|:.:::|
Mouse   874 NTEIAPSASIVSQSSNEDNQNMNVPRNFERPGYSRRHLDSSFNAGWSLYIQQFRAMFIKRVMFSW 938

  Fly   911 RNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITI-SLTQYPLAVTVLDRSNVQNGTGYEIA 974
            |...|||:|.:.   .:.:..|:||........:|..: .|.||...:.....|...|.|  :|.
Mouse   939 RYWKLLLLQLLA---LLGLMYLLIKGISFSVPKEPARVMDLEQYGETIVPFSVSGDPNLT--QIL 998

  Fly   975 NK-YEDLARSYGSNYGLELTGTQG-FEDYILDLGKTIQVRINSRYLVAATITESKITAWLNNQAL 1037
            .| .|.:.::...    ::...|| .::|:|.....|...|.: :.:..|..|.....|.||:|.
Mouse   999 TKNLETMLKAKKQ----KIHEVQGDMKNYLLTSKDCIYSCIVA-FSLDVTTEEKTFIFWFNNEAY 1058

  Fly  1038 HTAPLTVNMVHNAIADKLFGSSVKIQVTNAPLPY-TTSTLLSQLSTGNNLGTQLASNLCFCMCFV 1101
            |.|||:::::.|.|...|.|....|.|:|.|.|. .|....::.|..   |.|:..||.|.|...
Mouse  1059 HAAPLSLSILDNIIYKYLSGPDATITVSNNPQPQRVTKDKSNERSIS---GIQIVFNLLFGMSIF 1120

  Fly  1102 SSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFG 1166
            :|.:.|..:.||.|:||.:|||.||....||||..:.|...:.|..   |:.:|.|..|.:...
Mouse  1121 TSGFCLMTVTERVSKAKHIQFVSGVYTLNFWLSALLWDLIIHFVAC---VLLLVVFLYTDVDIL- 1181

  Fly  1167 ELGRYYLL-----LLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELF 1226
             |.:|:.|     |:|||::::||||::|.::......:.::.:.|...|....||..|:.. :.
Mouse  1182 -LEKYHFLDTMFILMLFGWSIIPFIYLLSFWYNNSTNAYIKIFVFNHCLGFISIIVDAVVQI-IP 1244

  Fly  1227 DTK-DTADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFA 1290
            |.| .|.:::.....:.|.::..||:.|.|.....|..|:..|.:..|..|:  .|..:: |.::
Mouse  1245 DIKTSTKNLILNSMLLLPIYNFGMSIYKYYNIHEIRKLCSSLGYINTIPSCK--SQIIDI-PIYS 1306

  Fly  1291 WEEPGVLPETVYMAVTGVVFFLIIIVLE----------FRL----INELMFKIRQLISKPPPPPT 1341
            ..:..:......||.||:::|::||:||          :|.    |..:.:|.|  :|:.....:
Mouse  1307 MNQKAIGRHVTAMAATGLIYFILIILLETTSWNLKIFIYRYVLFGIYRIFYKAR--MSEELSGYS 1369

  Fly  1342 EGQLDDDVANERERILQMSSNELATKNLVLDRVTKYY--GQFMAVNQVSLCVQEVECFGLLGVNG 1404
            |   ::||.||||.||......|.:..|:.:.:..|:  ...:||..:|:.:|:.|||||||:||
Mouse  1370 E---EEDVQNERETILNHPWRSLNSTVLIKELIKIYFKIPPTLAVRNISVAIQKEECFGLLGLNG 1431

  Fly  1405 AGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLR 1469
            ||||||||::||:|..:||..:::|.|:..|:..:...:|||||||||||.:|.||:|.::..:.
Mouse  1432 AGKTTTFKILTGEEIATSGDVFIEGYSITRNILKVRSKVGYCPQFDALLDYMTSREILTMYARVW 1496

  Fly  1470 GVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAA 1534
            |:.|:.||...::|.|........||..:..||||||:||||||::|:.:|::||||:|||||.|
Mouse  1497 GIPENSIRAYVDNLLKMLYLKPQADKFIYTLSGGNKRRLSTAIAIMGNSTVVFLDEPSTGMDPLA 1561

  Fly  1535 RRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIK 1599
            ||.|||.|.:.|:|||.|::|||||||||||||||||||.|:|.|:||.|||||||.....:.||
Mouse  1562 RRMLWNAVIKTRESGKVIIITSHSMEECEALCTRLAIMVQGKFVCLGSPQHLKNKFGNIYTMTIK 1626

  Fly  1600 VRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPL 1664
                            :..:.|:.||      :|:   |:|:...:|.|.|::|.||||.:|||.
Mouse  1627 ----------------FKTDTDDNTV------QDL---KDFIAEVFPGSDLKQENQGILNYYIPS 1666

  Fly  1665 TGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFA 1703
            ....|.::||::|..::..|:||||:||.|||::||.||
Mouse  1667 KNNSWGKVFGILEKAKEDYNLEDYSISQITLEQVFLTFA 1705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	61/217 (28%)
		ABC2_membrane_3	<269..475	CDD:289468	73/243 (30%)
		CcmA	538..843	CDD:224054	156/308 (51%)
		ABC_subfamily_A	538..755	CDD:213230	117/220 (53%)
		ABC2_membrane_3	913..1316	CDD:289468	110/412 (27%)
		ABC_subfamily_A	1369..1587	CDD:213230	115/219 (53%)
		drrA	1376..1702	CDD:130256	154/327 (47%)
Abca14	XP_017167760.1	rim_protein	<128..1709	CDD:130324	604/1647 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838510
Domainoid	1	1.000	180	1.000	Domainoid score	I3485
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1133	1.000	Inparanoid score	I220
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		mtm8719
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770