DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and abca3b

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	XP_009297489.1	Gene:	abca3b / 564344	ZFINID:	ZDB-GENE-050517-2	Length:	1703	Species:	Danio rerio

Alignment Length:	1767	Identity:	678/1767 - (38%)
Similarity:	1025/1767 - (58%)	Gaps:	142/1767 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WDKFVLLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQ 71
            |.:|.||||||:..|.......::|:.||.:||.:|:::|      || |.:.|..|.|
Zfish     4 WQQFGLLLWKNYIQQKRQILVTLVEIALPLLFSAILIVLR------QK-VSFTNYPNAT------ 55

  Fly    72 HSLHRSSY-LGKLIALIAPNRRRKNGGFSKFEFILCYSPVN-PVLKKLVEEAWQSLG---KN-KI 130
               |..|: |..|..|:...:.:           |.|.|.| .|::::.::..|:|.   || :.
Zfish    56 ---HYQSFPLNGLPPLLCYQQLQ-----------LAYVPANASVVQQIAQDVQQNLQSCIKNVRG 106

  Fly   131 CESENATQ--LELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIAN--- 190
            .|:|...:  ::.|..|....|.:.|:..:::  :::|||....:.|||....|.|.....:
Zfish   107 FETEEQFEEFVKTDPESGKILAAIVFEHPFSH--DDEPLPLQVSYHLRFTYSPRNAPAREKSELN 169

  Fly   191 -----TWLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQH----SLSMAYLRQKS-GEQD 245
                 .|.|:.|||...:.|||.:.|..|| .|||.|||||.:|:    ::.|||.|..: ...|
Zfish   170 PNNDMDWHTLSLFPLFQMPGPREQHDPHGG-TPGYYREGFLQVQYAVDRAIMMAYNRSAAMALFD 233

  Fly   246 LPNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSN 310
            ...|::.|:|:||:|:|..:..:.:.:.|:::|||.|....|.:.:..|||::|||.|::|||||
Zfish   234 QTQVLLSRFPYPAFIYDVFILAIQNQLPLLLVLSFTYTALNIVRAVVQEKERKLKEYMRMMGLSN 298

  Fly   311 WLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMAT 375
            ||||:|||:..|:.|:||...:.:|..:..|.:.||||:::.|.:..||:::.:|:|.|.||::.
Zfish   299 WLHWSAWFLMFFLFLSISIFFVTVLFCVKVSPNGAVLTYSDPTLVFVFLLVFAISTINFSFMISV 363

  Fly   376 FFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEG 440
            |||||:.|||..|.|:|::|:||.|....||.||.:.|:...||||.||..|.:||..|||.|.|
Zfish   364 FFSRANVAAAAGGFIYFLSYLPYVFLWPRYDLLSHAQKVSACLISNVAMAMGAQLIGMFEGKGTG 428

  Fly   441 LQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGE 505
            :||.|.|..|:|||..:|..|:.::|:..::|.::..|||.|.||.:|||:||.|.....:||..
Zfish   429 IQWHNLFEAVTVDDDFSLAQVIGLLLLDALLYGLVAWYVEAVFPGEYGVPQPWYFFILPSYWCSS 493

  Fly   506 REYTGVEDIPNGHVEQRDPKA--FETEPEGKHIGLQMRHLKKRF--GNKM--VVKGLSMNMFEDE 564
            .....:::..:....::..|.  .|.||.|...|::::.|.|.|  |||.  .|:.|::||||.:
Zfish   494 PRVAFLKEKEDEEDAEKASKGEFMEEEPAGLVAGVKIKRLAKVFKVGNKSKEAVRDLTLNMFEGQ 558

  Fly   565 ITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSN 629
            |||||||||||||||:|||||:|||:||.|.|||.||..::...|.|||:||||:||||.::|..
Zfish   559 ITVLLGHNGAGKTTTLSMLTGLFPPSSGRAYINGYDICQDMALIRRSLGLCPQHDVLFDNLTVRE 623

  Fly   630 HIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDE 694
            |:.|::::||...:.:..||.:.::::.||||.|.....||||||||||:..||.||:|||:.||
Zfish   624 HLLFYTQLKGYPREKIPGEVDRIIRILNLEDKRNAKCKTLSGGMKRKLSIGIALIGDSKVVMLDE 688

  Fly   695 PSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYG 759
            |:|||||||||..|||||.||.|||:|||||||||||:||||||||..|||:|.|:..|||.:||
Zfish   689 PTSGMDPSARRATWDLLQGEKRGRTILLTTHFMDEADLLGDRIAIMASGELQCCGSPLFLKNKYG 753

  Fly   760 SGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQSDEL 824
            :||.::.||...|..:|:|.|::.|:|....|...||||||.||..::::||.:|.:||...|||
Zfish   754 AGYHMVIVKDAFCNVSEITRLVHMYVPDATLESSAGAELSYILPKESTSRFELLFAELEMNRDEL 818

  Fly   825 HLNGYGVGITSMEEVFMKVGAEKDNTGNIKD--------QHE------IMNGGSGFRG------- 868
            .:..||..:|:|||||::||...|::.:|:.        |||      .|:..|...|
Zfish   819 GIASYGASVTTMEEVFLRVGKLVDSSLDIQAIQLPALQYQHERRSHDWTMDDSSSISGMTDVTDF 883

  Fly   869 EDDNESVQSDGIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILI 933
            .|....:..||   .|.:|..|.:|...|:.||.||:.||:|||..:::.|.::|:.|.|:.:::
Zfish   884 TDSCTMISEDG---SNIKLNTGARLYMQQFYAMFLKRALYSWRNWKVMVAQFLVPLIFTVLALVV 945

  Fly   934 IKTQGTFQELKPITISLTQY-----PLAVTVLDRSNVQNGTGYEIANKYEDLARSYGSNYGLELT 993
            .::..:......:.::|.||     |:|        |:...|...:...|.......|...:...
Zfish   946 ARSLPSSHSSPQLRLALKQYGQTHVPVA--------VEANAGPLASLLAEIYTTQLPSQNAIAAP 1002

  Fly   994 GTQGFEDYILDLGKTIQVRINSRYLVAATITESKITAWLNNQALHTAPLTVNMVHNAIADKLFGS 1058
            ....|.:|:|...:......|...:|.|....|.:..:.|||..||....:.:|.||:...|.|.
Zfish  1003 NITDFSEYVLYNAQREGGAFNEHCVVGAAFRSSDVIGYFNNQGYHTPATALMLVDNALFKLLAGP 1067

  Fly  1059 SVKIQVTNAPLPYTTS-TLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQF 1122
            :..||..|.|:|...| |..||||. :..|..:|.||.:.|..::|.:.|.|:.||..::|.:|.
Zfish  1068 NASIQTGNDPMPRNVSETAQSQLSE-SQTGFAIAINLMYGMASLASTFALLLVSERSVKSKHVQQ 1131

  Fly  1123 VGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIY 1187
            |.||.:..||.|..:.|..::::..|::::....|..........|.....||||:|:||:|.:|
Zfish  1132 VSGVYLTNFWFSALLWDLINFLLPCLLMLVVFRVFSVKAFVAQNHLVDVLFLLLLYGWAVIPLMY 1196

  Fly  1188 IMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKDTADILGWIFRIFPHFSLAMSLN 1252
            :||..|...||.:.|::|.||..|.|.|:.|.:|:....:....:.:|..:|.|||::.|.||..
Zfish  1197 LMSFLFSTAATAYTRLTIFNIISGTATFLAVTIMTIPELNLLHLSHLLDKVFLIFPNYCLGMSFT 1261

  Fly  1253 KVYTNTATRNACAKAGALPPILLCELVPQCCNL---KPYFAWEEPGVLPETVYMAVTGVVFFLII 1314
            :.|.|......|..:.      |.:.:.:..|:   ..||:.|||||....|.:::.||||.:::
Zfish  1262 EFYQNYEMITFCTSSP------LAKYICKYYNITYQMNYFSMEEPGVGRFLVALSLQGVVFIILL 1320

  Fly  1315 IVLEFRLINELMFKIRQ-----LISKPPPPPTEGQLDDDVANERERILQMSS--NELATKNLVLD 1372
            .::|.|.|..|:...|:     |:::....|.    |.|||.||:|:|:...  ..:....||:.
Zfish  1321 FLIELRCIRLLLNLCRRRKKALLLAEEALQPE----DRDVAEERKRVLECQPVVESMVGSPLVVQ 1381

  Fly  1373 RVTKYY--GQ-FMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLES 1434
            .::|.|  || .:||:::||.|.:.|||||||.|||||||||||:||||.|:||.|::.|.|:.:
Zfish  1382 ELSKMYSGGQSLLAVDRLSLAVGKGECFGLLGFNGAGKTTTFKMLTGDESITSGDAFIDGYSILT 1446

  Fly  1435 NMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHA 1499
            ::..:.:.|||||||||:||.:||||.|.::..|||:.|..:....|::.:|.....|.||...:
Zfish  1447 DVKKVQQRIGYCPQFDAVLDHMTGRETLSMYARLRGIPEKYVTACVENVLRSLLLEPHADKLVRS 1511

  Fly  1500 YSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEA 1564
            ||||||||||..:|:||.|.||:||||:|||||.|||.||:.:.|.|:|||:|::||||||||||
Zfish  1512 YSGGNKRKLSAGMALIGGPPVIFLDEPSTGMDPVARRLLWDAITRTRESGKAIIITSHSMEECEA 1576

  Fly  1565 LCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQM 1629
            ||||||:||||:|||:||.||||:||..|..|..|||                       |..::
Zfish  1577 LCTRLAVMVNGQFKCLGSPQHLKSKFGSGYTLLAKVR-----------------------VETEL 1618

  Fly  1630 SQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTT 1694
            .:.|:...|:|:|:.:|.|:|::|:||::.:::....:.|:::||::|:.:::.::|||.|||.:
Zfish  1619 EESDLQLFKDFIESTFPGSLLKDEHQGMVHYHLTDKTLTWAQVFGVLETAKEKYSIEDYCVSQIS 1683

  Fly  1695 LEEIFLEFAKYQ 1706
            ||::||.||::|
Zfish  1684 LEQVFLSFAQFQ 1695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	77/179 (43%)
		ABC2_membrane_3	<269..475	CDD:289468	89/205 (43%)
		CcmA	538..843	CDD:224054	170/308 (55%)
		ABC_subfamily_A	538..755	CDD:213230	131/220 (60%)
		ABC2_membrane_3	913..1316	CDD:289468	111/411 (27%)
		ABC_subfamily_A	1369..1587	CDD:213230	127/220 (58%)
		drrA	1376..1702	CDD:130256	159/328 (48%)
abca3b	XP_009297489.1	AAA	1..>95	CDD:333001	32/117 (27%)
abca3b	XP_009297489.1	AAA	<122..1695	CDD:333001	638/1620 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582229
Domainoid	1	1.000	197	1.000	Domainoid score	I3064
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37437
Inparanoid	1	1.050	1146	1.000	Inparanoid score	I205
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm25386
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	LDO	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910