DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and abca1a

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:NP_001296394.1 Gene:abca1a / 558924 ZFINID:ZDB-GENE-031006-12 Length:2268 Species:Danio rerio


Alignment Length:1930 Identity:624/1930 - (32%)
Similarity:967/1930 - (50%) Gaps:368/1930 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 ELVLPAIFSLL-----LVLVRTLVDTEQKGVRYYN------EQNLTDLNLLQHSLHRSSYLGKLI 84
            |.:.|.|::.:     :.|||||:. .....|::|      |..:.|:         |.:|.|  
Zfish   422 EEMRPKIWNFMENSEEMDLVRTLLQ-NNASARFFNAKLSGTEWRVEDV---------SRFLSK-- 474

  Fly    85 ALIAPNRRRKNG-----------------GFSKFEFILCYSPVNPVL--KKLVEEAWQSLGKNKI 130
               :....|.:|                 ..|:|...:....:.||.  ::||.::.:.|...|.
Zfish   475 ---SSEDTRPHGTAYTWREVFNETDQAIQTISRFMECVNLDKLEPVANEERLVNKSMRLLDDRKF 536

  Fly   131 CESENATQLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTM 195
                              :||:.|.|..:|.::   ||.:.::.:|         :.|.|...|.
Zfish   537 ------------------WAGIVFPDMQSNTSD---LPLNVNYKIR---------MDIDNVERTN 571

  Fly   196 RLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQDLPNVVMKRYPFPAYI 260
            ::.......|||.:..:|    ..|:..||..||..:....:|..:|.::...|.:::.|:|.|:
Zfish   572 KIKDGYWDPGPRADPFED----LRYIWGGFTYLQDVIEHGIIRALTGSKEKTGVYIQQMPYPCYV 632

  Fly   261 FDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIML 325
            .|..|..||..|.|.:.|:::|....|.|.:..|||.:|||.|:||||.|.:.|.:||:.|.|.|
Zfish   633 DDIFLRVMSRSMPLFMTLAWMYSVAIIIKGVVYEKEARLKETMRIMGLDNGILWLSWFISSLIPL 697

  Fly   326 TISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLI 390
            .|||.|:.:::|:.     .:|.:::...:..||..:.|.:|..||:::|.||||:.|||..|:|
Zfish   698 LISAALLVLILKMG-----NLLPYSDPGVIYLFLSSFAVVTIMQCFLISTLFSRANLAAACGGII 757

  Fly   391 WFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDT 455
            :|..|:||...:...:.:...:|:..||:|..|.|||.:....||..|.|:||||..:....:|:
Zfish   758 YFTLYLPYVLCVAWQNYVGFGAKIVVSLLSPVAFGFGCEYFALFEEQGVGIQWSNLLSSPMQEDS 822

  Fly   456 LTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTG-VEDIPNGHV 519
            ..|...:.:||...|:|.::..|:|.|.||.:|:||||.||||:.:||||:  .| ...:|:...
Zfish   823 YNLTTSICLMLFDSVLYAVMTWYIEAVFPGQYGIPRPWYFPFTKSYWCGEK--CGWTTSVPSNRK 885

  Fly   520 EQRDPKAFETEPEGKHIGLQMRHLKKRFGN-KMVVKGLSMNMFEDEITVLLGHNGAGKTTTISML 583
            |..:....|.||.....|:.:.:|.|.:.| |:.|.||::..:|.:||..|||||||||||:|:|
Zfish   886 ENAEAVCIEEEPAHIDPGVYIENLMKIYSNGKVAVDGLTLGFYEGQITSFLGHNGAGKTTTMSIL 950

  Fly   584 TGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQE 648
            ||:||||||||.|.|.||||::...|.:||:||||||||..::|..||.|::|:|||..:.|:.|
Zfish   951 TGLFPPTSGTAYIQGKDIRTDLNAIRQNLGVCPQHNVLFSMLTVEEHIWFYARLKGLSAEKVKSE 1015

  Fly   649 VAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQ 713
            :.:.:..:.|..|....|::|||||:|||||..|..|.:|||:.|||::|:||.|||.:||||.:
Zfish  1016 MEQIVMDLGLPHKRTSRSNQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYARRGIWDLLLK 1080

  Fly   714 EKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRD------DC 772
            .:.|||::|:||.|||||:|||||||:..|:|.|.|:|.|||.|.|:||.|..||:|      .|
Zfish  1081 YRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKTQLGTGYYLTLVKKDFDLSASSC 1145

  Fly   773 ETNEVTA----------------------------------------LLNKYIPGLKPECDIGAE 797
            .|:..|.                                        ::.|::|..:...|:|.|
Zfish  1146 RTSSSTVSYSKGSLKKDDSVSESSSDAGLGSDHESETTTIDISLISNVIFKHVPTARLVEDLGHE 1210

  Fly   798 LSYQLP-DSA-SAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKD----- 855
            ::|.|| :|| ...|.|:|.:::::..:|.::.||:..|::||:|:||..:........|     
Zfish  1211 ITYVLPYESAKDGAFVELFHEIDDRLTDLSISSYGISDTTLEEIFLKVAEDCGVDAETSDGTLPA 1275

  Fly   856 ----QHEIMNGGSGFR-----------GEDDNESVQS---DGIFSENRRLLQGLQLLSNQWKAML 902
                :|...:..|..:           .|.|.||.::   ||...:....::|..|...|:.|:|
Zfish  1276 RRNRRHAFGDHQSCLKPFTEDDFDFNDSEGDPESRETDWLDGADGKGSYQVKGWSLKRQQFVALL 1340

  Fly   903 LKKFLYTWRNKLLLLIQNIMPVFFVVVTI---LIIKTQGTFQE--LKP----------------- 945
            .|:.||..|::.....|.::|..||.:.:   ||:...|.:..  |:|                 
Zfish  1341 WKRLLYARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLALEPSMYEEQFTFISNDAPED 1405

  Fly   946 ------------------------------------------ITISLTQY--------------- 953
                                                      :|.|:...               
Zfish  1406 RHTNRLLDALKDSPAYTDQCTDGKNTASRSCPIKDGEWLVPEVTESIEAIFLNGNWSMENPSPLC 1470

  Fly   954 ----------------------PLAVTVLDRSNVQNGTGYEIANKYEDLARSYGS---------- 986
                                  |..:.|.....:||.:|..|:   :.|.::|..          
Zfish  1471 ECSCEGRKKMLPECPPGAGGLPPPQIKVTHDETLQNLSGRNIS---DYLVKTYAQIIGKSLKNKL 1532

  Fly   987 -----NYG---LELTGTQGFE--DYILDLGKTIQVRIN-------SRYL------VAATITESKI 1028
                 .||   |....||...  |.:.|....|:.|.:       .|:|      :....|.:.:
Zfish  1533 WVNEFRYGGFSLGARNTQALPPGDELTDAISHIRSRFSLESGTAADRFLGSLSTFIRGLDTNNNV 1597

  Fly  1029 TAWLNNQALHTAPLTVNMVHNAI-----ADKLFGSSVKIQVTNAPLPYTTSTL--LSQLSTGNNL 1086
            ..|.||:..|:....:|:::||:     ...|..|...|...|.||..|...|  ::.::|    
Zfish  1598 KIWFNNKGWHSIGSFLNVMNNAVLRANLPPGLDRSKFGINAFNHPLNLTKEQLSHVALMTT---- 1658

  Fly  1087 GTQLASNLC--FCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALI 1149
            ...:..::|  |.|.||.:.:::|||:||.::||.:||:.||:.:.:||:.|:.|..:|||.|.:
Zfish  1659 SVDVLVSICVIFAMSFVPASFVVFLIQERVNKAKHMQFISGVQPFLYWLANFVWDMCNYIVPATL 1723

  Fly  1150 VVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMAL 1214
            |:|..||||:....:...|....|||||:|:::.|.:|..|.||:.|:|.:..::.|||..|:..
Zfish  1724 VIIIFVCFQQEAYVSSTNLPVLALLLLLYGWSITPLMYPASFFFKIPSTAYVVLTSVNILIGING 1788

  Fly  1215 FIVVVVMSSELFDTKDTA---DILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLC 1276
            .:...|:  |||.:.:..   |||..:|.|||||.|...|..:..|.|..:|..:.|.       
Zfish  1789 SVSTFVL--ELFGSNEIGGINDILKNVFLIFPHFCLGRGLIDMVKNQAMADALERFGE------- 1844

  Fly  1277 ELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPT 1341
                  ...:...||:..|  .....||:.||:||.|.:::::|    ...|.|.|.:|..|   
Zfish  1845 ------NRFRSPLAWDMVG--KNLFAMAIEGVIFFSITVLIQYR----FCIKARSLSTKLKP--- 1894

  Fly  1342 EGQLDDDVANERERILQMSSNELATKNLVLDRVTKYY--GQFMAVNQVSLCVQEVECFGLLGVNG 1404
            .|:.|:|||.||:|||.....   |..|.|.::||.|  .|..||:::.:.:...||||||||||
Zfish  1895 IGEEDEDVARERQRILGGGGQ---TDILELRQLTKVYKRKQKPAVDRLCVGIPPGECFGLLGVNG 1956

  Fly  1405 AGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLR 1469
            ||||:||||:|||..::||.||:.|.|:.:.::.:::.:||||||||:.|.|||||.|..:.:||
Zfish  1957 AGKTSTFKMLTGDSVVTSGEAYLAGNSVLTEIDEVHQNMGYCPQFDAINDLLTGREHLEFYAILR 2021

  Fly  1470 GVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAA 1534
            ||.|..:.::::...:..|.||::||...:|||||.||||||:|:||.|.|::||||||||||.|
Zfish  2022 GVPEKEVCKVADWGIRKLGLMKYVDKAAGSYSGGNMRKLSTAMALIGGPPVVFLDEPTTGMDPKA 2086

  Fly  1535 RRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIK 1599
            ||.|||.:..|...|:|:||||||||||||||||:||||||.|:|:||.|||||||..|..:.: 
Zfish  2087 RRALWNCILSIIKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNKFGDGYTIIL- 2150

  Fly  1600 VRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPL 1664
                       |::|...|               ::.|.||:|.|.|.|.|:|:::.:|.:.:..
Zfish  2151 -----------RVAGADPR---------------LEPVMEFIERELPGSTLKEKHRNMLQYQLSS 2189

  Fly  1665 TGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQRED 1709
            :....:|||.::..|::||::||||||||||:::|:.|||.|.::
Zfish  2190 SLTSLARIFNILSKNKEQLHIEDYSVSQTTLDQVFVNFAKDQSDE 2234

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 65/179 (36%)
ABC2_membrane_3 <269..475 CDD:289468 73/205 (36%)
CcmA 538..843 CDD:224054 148/353 (42%)
ABC_subfamily_A 538..755 CDD:213230 115/217 (53%)
ABC2_membrane_3 913..1316 CDD:289468 124/548 (23%)
ABC_subfamily_A 1369..1587 CDD:213230 123/219 (56%)
drrA 1376..1702 CDD:130256 156/327 (48%)
abca1aNP_001296394.1 rim_protein 1..2233 CDD:130324 624/1927 (32%)
ABC_subfamily_A 904..1122 CDD:213230 115/217 (53%)
ABC_subfamily_A 1919..2139 CDD:213230 123/219 (56%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 168 1.000 Domainoid score I3783
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.830

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