DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and abca4b

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_021322694.1 Gene:abca4b / 555506 ZFINID:ZDB-GENE-050517-4 Length:2327 Species:Danio rerio


Alignment Length:2012 Identity:618/2012 - (30%)
Similarity:954/2012 - (47%) Gaps:421/2012 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 WNHKWQMVIELVL-----PAIFSLLLVLVRTLVDTE--QKGVRYYNE---------QNLTDLNLL 70
            ||....:|:..:|     ||:..::.....|..:.|  ||..:.:.|         ||...:|::
Zfish   387 WNSVKPLVMGKILYTPDSPAVRKIIKSANTTFEELERLQKIGKVWEELGPQLWDFFQNSIQMNMI 451

  Fly    71 QHSLHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPV--------------LKKLVEEA 121
            :.:|...:.:..|      :||.:...||..: ||.:....|.              :.:|.::|
Zfish   452 RDTLRNPTVMDFL------DRRLRETEFSTKD-ILNFLHNGPEGERFMNMTSFDWSDVFRLADQA 509

  Fly   122 WQSLGKNKICES---------EN-ATQLELDTVSKNAF-AGVQFDDAWANLTENDPLPNDFHFAL 175
            .:...:...|.|         || .|...|..:.:|.| ||:.|.|.:....|   ||....|.:
Zfish   510 IRMFNRYSECISLDKFVGHMDENLMTHQALHLLGENKFWAGLVFMDMYPWTIE---LPRHVKFKI 571

  Fly   176 RFPAELRTATIAIANTWLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQK 240
            |...:....|..|.:.:..         .|||.:..:|    ..|:..||..||..:....|:..
Zfish   572 RMDIDAVERTNKIKDRYWD---------PGPRADPVED----HRYIWGGFAYLQDLIEHGILKLH 623

  Fly   241 SGEQDLP-NVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMK 304
            :| .|.| .|.:::.|:|.|:.|..:..::....:.::|::||..:.:.|.|..|||.:|||.:|
Zfish   624 TG-HDWPLGVYLQQMPYPCYVDDMFMLTLNRCFPIFMVLAWIYSVSMVVKSIVLEKEMRLKETLK 687

  Fly   305 IMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICF 369
            .||:||.:.|..||:.||||:|.|..|:..:|...     .||.::|...|..||:.:.|::|..
Zfish   688 AMGVSNGVIWYTWFIDSFIMMTASTALLTGIVMAG-----KVLNYSNPIILFLFLLTFTVATIMQ 747

  Fly   370 CFMMATFFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGF 434
            ||:|:.||::|:.|||.:|:|:|..|:|:.|.....|.::...||..||:|..|.|||.:.:..:
Zfish   748 CFLMSVFFNKANLAAACSGIIYFTLYLPHIFCFAWQDRITKDMKLAVSLLSPVAFGFGTEYLSRY 812

  Fly   435 EGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTR 499
            |..|.||||.|..|.....|..:....:.|||:..|:|.::..|::.|.||.:|:.||:.||...
Zfish   813 EEQGLGLQWDNIGTSPLEGDEYSFFTSIRMMLLDAVLYGVLAWYLDNVFPGQYGIGRPFYFPLQS 877

  Fly   500 EFWCG----------------EREYTGVEDIPNG-------------------HVEQRDPKA--- 526
            .:|..                |......||:..|                   |.|:|:...   
Zfish   878 SYWLKPSPPSETSNAVPEKPLENHVEKQEDVEYGGLSPEHRECNGSRNSKHCKHKEKRERMEKER 942

  Fly   527 --------------------------FETEPEGKHIGLQMRHLKKRFG--NKMVVKGLSMNMFED 563
                                      ||.|||...||:.::.|.|.:.  ::..|..|:||.:|.
Zfish   943 EREEQLKMQEEIQQEEIQQWYCENPFFEPEPESLLIGVSVQDLVKMYNRYSRPAVDCLNMNFYES 1007

  Fly   564 EITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVS 628
            :||..|||||||||||:|:|||:||||||||.|.|.||||.::..|.|||:|||||:||..::|.
Zfish  1008 QITSFLGHNGAGKTTTLSILTGLFPPTSGTAYIYGRDIRTEMDAIRQSLGMCPQHNILFKHLTVE 1072

  Fly   629 NHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCD 693
            .||.|:|.|||...|..||||...|:.:.|..|.:..:..|||||:|||||..|..|.::||:.|
Zfish  1073 EHILFYSLMKGREHKEAEQEVENMLEDLGLPHKRDEEAQNLSGGMQRKLSVAMAFVGGSRVVILD 1137

  Fly   694 EPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQY 758
            ||:||:||.:||.:||||.:.:.|||::|:||.|||||:|.||:||:..|:|.|.|:..|||..:
Zfish  1138 EPTSGVDPYSRRSIWDLLLKYRTGRTVILSTHHMDEADLLSDRVAIISKGKLHCSGSPLFLKNCF 1202

  Fly   759 GSGYRLICVKR--------DDCE-------------------------------TNEVTALLNKY 784
            |.|:.|..|:|        ::|:                               ...:|.|::.:
Zfish  1203 GVGFYLTLVRRMKDQRKKENECDCASECSCTCSTCTRYKEESQALQPERVLDGNVESITTLIHHH 1267

  Fly   785 IPGLKPECDIGAELSYQLPDSA--SAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGA-- 845
            :|..|....||.|::|.||:..  ...:..:|.:|||...::.|:.:|:..||:||:|:||.|  
Zfish  1268 VPEAKLIEMIGQEMTYLLPNKGFKYRAYASLFRELEETLGDMGLSSFGISDTSLEEIFLKVTADG 1332

  Fly   846 EKDNTGNIKDQHEIM--NGGSGFR-----GEDDN---ESVQSDGIFSENR--RLLQGLQLLSNQW 898
            |..|:....:|..:.  ..|:||.     .||.|   .|::||.  ||.|  |.::|..|:..|:
Zfish  1333 EAANSSVTPEQWMLQQRKNGNGFMKDTGLAEDANGVGASLESDS--SEGRASRQVKGFSLVLKQF 1395

  Fly   899 KAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTI---LIIKTQGTFQ------------------- 941
            .|:|:|:|.:..|:....|.|.::|..||::.:   :|:...|.:.                   
Zfish  1396 HALLVKRFHHATRSHKDFLAQIVLPASFVLIALVFTMIVPPFGEYPCLTLTPWMYGPQFTFISNE 1460

  Fly   942 -------------------------------------------ELKPIT---------------- 947
                                                       |:.|::                
Zfish  1461 QPSHPKMKHFIQTLLKDPGMGTRCMANQPLENIFTCLNSSSDWEVPPVSPEVSNILSSPEWDSRN 1525

  Fly   948 ----------ISLTQYPLAVT-----------------VLDRSNVQNGTGY-----------EIA 974
                      :.||..|:...                 :||.:| :|.:.|           .:.
Zfish  1526 PSPSCECSTDLKLTMLPMCPAGAGGLPPRQRKEPTGDILLDMTN-RNISDYLVKTYTKLIKTSLK 1589

  Fly   975 NKYEDLARSYGSNYGLELTG--------TQGFEDYILDLGKTIQVRINSRYLVAA---------- 1021
            :||....:.||   |:.:.|        .:..::....||:.:.:| ..||..:|          
Zfish  1590 SKYWVNEQRYG---GISVGGRLPILDVDPEEIQNIFSQLGRMMNIR-GGRYSKSAMDELETFLHY 1650

  Fly  1022 TITESKITAWLNNQALHTAPLTVNMVHNAIADKLF-----GSSVKIQVTNAPLPYTTSTLLSQLS 1081
            ..:|..:..|.||:..|.....:|:.:|||.....     .|...|...|.||..|...|.....
Zfish  1651 MESEYNVKVWYNNKGWHAMASFLNVANNAILRAYLPPHANPSDYGITAINHPLNLTKEQLSEVTV 1715

  Fly  1082 TGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVT 1146
            ...::...:|..:.|.|.|:.:.::|:||:||.::||.||||.||....:|.:.|..|..:|.|:
Zfish  1716 LTTSVDAVVAICVIFAMSFIPASFVLYLIQERVTKAKHLQFVSGVSPLVYWFANFFWDMLNYSVS 1780

  Fly  1147 ALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCG 1211
            ..:||...|.|.:...::...|.....||.|:|::|.|.:|.:|..|..|:|.:..:|.:|:|.|
Zfish  1781 TAMVVAIFVGFDKKCYTSPTNLPALIALLCLYGWSVTPMMYPLSYMFNVPSTAYVSLSCINLFIG 1845

  Fly  1212 MALFIVVVVMSSELFDTKDTA----DILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAG---A 1269
            :....:..::  |||:...:.    ::|..:..:||||.|...|..:..|.|..:..|:.|   :
Zfish  1846 INSSAITFIL--ELFENNRSLLMFNEVLKKVLLVFPHFCLGRGLIDMAMNQAVTDVYARFGEEFS 1908

  Fly  1270 LPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLIS 1334
            :.|                |.|...|  .....|||.|.|:|:      |.|:.:..|.:...||
Zfish  1909 MDP----------------FRWNFVG--KNLFCMAVEGFVYFI------FNLLIQYKFFLHHWIS 1949

  Fly  1335 KPPPPPTEGQL-----DDDVANERERILQMSSNELATKN--LVLDRVTKYYGQFM--AVNQVSLC 1390
                  ..|..     |||||.|||||.:..:     ||  |::..::|.|.:..  ||:::.:.
Zfish  1950 ------DYGMSLGTDEDDDVAQERERIYKGGN-----KNDILLIRDLSKTYRRRKRPAVDKICVG 2003

  Fly  1391 VQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDD 1455
            |...|||||||||||||||||||:|||..::||...|.|.|:.||:..:::.:||||||||:.:.
Zfish  2004 VPAGECFGLLGVNGAGKTTTFKMLTGDTDVTSGELSVAGYSILSNILDVHQNMGYCPQFDAIDEL 2068

  Fly  1456 LTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSV 1520
            |||||.|.::..|||:.||.|.:::|...:..|..::.......||||||||||||||:||.|.:
Zfish  2069 LTGREHLYLYARLRGIPESEISRVAEWGIQKLGLSEYAGNCAGTYSGGNKRKLSTAIAMIGCPPL 2133

  Fly  1521 IYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQH 1585
            :.||||||||||.:||.||..:..|...|:::|||||||||||||||||||||||.|||:|:.||
Zfish  2134 VLLDEPTTGMDPHSRRFLWTAILSIIRDGRAVVLTSHSMEECEALCTRLAIMVNGTFKCLGTIQH 2198

  Fly  1586 LKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSIL 1650
            ||.||..|.::.:|::.....|           :||  .|||:          .|:::.:|..|.
Zfish  2199 LKYKFGGGYVVTMKIKAAKPGL-----------SPD--LVPAE----------SFMDSSFPGCIQ 2240

  Fly  1651 QEEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQ--REDT 1710
            :|::...|.:.|....:  :|:|.|:.:|:::||:||||||||||:::|:.|||.|  .:||
Zfish  2241 REKHYNTLQYEIAAASL--ARVFQLVLTNKERLNIEDYSVSQTTLDQVFVNFAKQQSGEDDT 2300

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 64/179 (36%)
ABC2_membrane_3 <269..475 CDD:289468 74/205 (36%)
CcmA 538..843 CDD:224054 142/347 (41%)
ABC_subfamily_A 538..755 CDD:213230 113/218 (52%)
ABC2_membrane_3 913..1316 CDD:289468 111/551 (20%)
ABC_subfamily_A 1369..1587 CDD:213230 119/219 (54%)
drrA 1376..1702 CDD:130256 153/327 (47%)
abca4bXP_021322694.1 AAA 1..2315 CDD:333001 618/2012 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170582264
Domainoid 1 1.000 139 1.000 Domainoid score I4737
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
87.660

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