DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abca3 and abca4b

DIOPT Version :10

Sequence 1:NP_608445.2 Gene:Abca3 / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_021322694.1 Gene:abca4b / 555506 ZFINID:ZDB-GENE-050517-4 Length:2327 Species:Danio rerio


Alignment Length:2011 Identity:617/2011 - (30%)
Similarity:955/2011 - (47%) Gaps:419/2011 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 WNHKWQMVIELVL-----PAIFSLLLVLVRTLVDTE--QKGVRYYNE---------QNLTDLNLL 70
            ||....:|:..:|     ||:..::.....|..:.|  ||..:.:.|         ||...:|::
Zfish   387 WNSVKPLVMGKILYTPDSPAVRKIIKSANTTFEELERLQKIGKVWEELGPQLWDFFQNSIQMNMI 451

  Fly    71 QHSLHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPV--------------LKKLVEEA 121
            :.:|...:.:..|      :||.:...||..: ||.:....|.              :.:|.::|
Zfish   452 RDTLRNPTVMDFL------DRRLRETEFSTKD-ILNFLHNGPEGERFMNMTSFDWSDVFRLADQA 509

  Fly   122 WQSLGKNKICES---------EN-ATQLELDTVSKNAF-AGVQFDDAWANLTENDPLPNDFHFAL 175
            .:...:...|.|         || .|...|..:.:|.| ||:.|.|.:....|   ||....|.:
Zfish   510 IRMFNRYSECISLDKFVGHMDENLMTHQALHLLGENKFWAGLVFMDMYPWTIE---LPRHVKFKI 571

  Fly   176 RFPAELRTATIAIANTWLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQK 240
            |...:....|..|.:.:..         .|||.:..:|    ..|:..||..||..:....|:..
Zfish   572 RMDIDAVERTNKIKDRYWD---------PGPRADPVED----HRYIWGGFAYLQDLIEHGILKLH 623

  Fly   241 SGEQDLP-NVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMK 304
            :| .|.| .|.:::.|:|.|:.|..:..::....:.::|::||..:.:.|.|..|||.:|||.:|
Zfish   624 TG-HDWPLGVYLQQMPYPCYVDDMFMLTLNRCFPIFMVLAWIYSVSMVVKSIVLEKEMRLKETLK 687

  Fly   305 IMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICF 369
            .||:||.:.|..||:.||||:|.|..|:..:|...     .||.::|...|..||:.:.|::|..
Zfish   688 AMGVSNGVIWYTWFIDSFIMMTASTALLTGIVMAG-----KVLNYSNPIILFLFLLTFTVATIMQ 747

  Fly   370 CFMMATFFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGF 434
            ||:|:.||::|:.|||.:|:|:|..|:|:.|.....|.::...||..||:|..|.|||.:.:..:
Zfish   748 CFLMSVFFNKANLAAACSGIIYFTLYLPHIFCFAWQDRITKDMKLAVSLLSPVAFGFGTEYLSRY 812

  Fly   435 EGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTR 499
            |..|.||||.|..|.....|..:....:.|||:..|:|.::..|::.|.||.:|:.||:.||...
Zfish   813 EEQGLGLQWDNIGTSPLEGDEYSFFTSIRMMLLDAVLYGVLAWYLDNVFPGQYGIGRPFYFPLQS 877

  Fly   500 EFWCG----------------EREYTGVEDIPNG-------------------HVEQRDPKA--- 526
            .:|..                |......||:..|                   |.|:|:...   
Zfish   878 SYWLKPSPPSETSNAVPEKPLENHVEKQEDVEYGGLSPEHRECNGSRNSKHCKHKEKRERMEKER 942

  Fly   527 --------------------------FETEPEGKHIGLQMRHLKKRFG--NKMVVKGLSMNMFED 563
                                      ||.|||...||:.::.|.|.:.  ::..|..|:||.:|.
Zfish   943 EREEQLKMQEEIQQEEIQQWYCENPFFEPEPESLLIGVSVQDLVKMYNRYSRPAVDCLNMNFYES 1007

  Fly   564 EITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVS 628
            :||..|||||||||||:|:|||:||||||||.|.|.||||.::..|.|||:|||||:||..::|.
Zfish  1008 QITSFLGHNGAGKTTTLSILTGLFPPTSGTAYIYGRDIRTEMDAIRQSLGMCPQHNILFKHLTVE 1072

  Fly   629 NHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCD 693
            .||.|:|.|||...|..||||...|:.:.|..|.:..:..|||||:|||||..|..|.::||:.|
Zfish  1073 EHILFYSLMKGREHKEAEQEVENMLEDLGLPHKRDEEAQNLSGGMQRKLSVAMAFVGGSRVVILD 1137

  Fly   694 EPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQY 758
            ||:||:||.:||.:||||.:.:.|||::|:||.|||||:|.||:||:..|:|.|.|:..|||..:
Zfish  1138 EPTSGVDPYSRRSIWDLLLKYRTGRTVILSTHHMDEADLLSDRVAIISKGKLHCSGSPLFLKNCF 1202

  Fly   759 GSGYRLICVKR--------DDCE-------------------------------TNEVTALLNKY 784
            |.|:.|..|:|        ::|:                               ...:|.|::.:
Zfish  1203 GVGFYLTLVRRMKDQRKKENECDCASECSCTCSTCTRYKEESQALQPERVLDGNVESITTLIHHH 1267

  Fly   785 IPGLKPECDIGAELSYQLPDSA--SAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGA-- 845
            :|..|....||.|::|.||:..  ...:..:|.:|||...::.|:.:|:..||:||:|:||.|  
Zfish  1268 VPEAKLIEMIGQEMTYLLPNKGFKYRAYASLFRELEETLGDMGLSSFGISDTSLEEIFLKVTADG 1332

  Fly   846 EKDNTGNIKDQHEIM--NGGSGFR-----GEDDN---ESVQSDGIFSENR--RLLQGLQLLSNQW 898
            |..|:....:|..:.  ..|:||.     .||.|   .|::||.  ||.|  |.::|..|:..|:
Zfish  1333 EAANSSVTPEQWMLQQRKNGNGFMKDTGLAEDANGVGASLESDS--SEGRASRQVKGFSLVLKQF 1395

  Fly   899 KAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTI---LIIKTQGTFQ------------------- 941
            .|:|:|:|.:..|:....|.|.::|..||::.:   :|:...|.:.                   
Zfish  1396 HALLVKRFHHATRSHKDFLAQIVLPASFVLIALVFTMIVPPFGEYPCLTLTPWMYGPQFTFISNE 1460

  Fly   942 -------------------------------------------ELKPIT---------------- 947
                                                       |:.|::                
Zfish  1461 QPSHPKMKHFIQTLLKDPGMGTRCMANQPLENIFTCLNSSSDWEVPPVSPEVSNILSSPEWDSRN 1525

  Fly   948 ----------ISLTQYPLAVT-----------------VLDRSNVQNGTGY-----------EIA 974
                      :.||..|:...                 :||.:| :|.:.|           .:.
Zfish  1526 PSPSCECSTDLKLTMLPMCPAGAGGLPPRQRKEPTGDILLDMTN-RNISDYLVKTYTKLIKTSLK 1589

  Fly   975 NKYEDLARSYGSNYGLELTG--------TQGFEDYILDLGKTIQVRINSRYLVAA---------- 1021
            :||....:.||   |:.:.|        .:..::....||:.:.:| ..||..:|          
Zfish  1590 SKYWVNEQRYG---GISVGGRLPILDVDPEEIQNIFSQLGRMMNIR-GGRYSKSAMDELETFLHY 1650

  Fly  1022 TITESKITAWLNNQALHTAPLTVNMVHNAIADKLF-----GSSVKIQVTNAPLPYTTSTLLSQLS 1081
            ..:|..:..|.||:..|.....:|:.:|||.....     .|...|...|.||..|...|.....
Zfish  1651 MESEYNVKVWYNNKGWHAMASFLNVANNAILRAYLPPHANPSDYGITAINHPLNLTKEQLSEVTV 1715

  Fly  1082 TGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVT 1146
            ...::...:|..:.|.|.|:.:.::|:||:||.::||.||||.||....:|.:.|..|..:|.|:
Zfish  1716 LTTSVDAVVAICVIFAMSFIPASFVLYLIQERVTKAKHLQFVSGVSPLVYWFANFFWDMLNYSVS 1780

  Fly  1147 ALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCG 1211
            ..:||...|.|.:...::...|.....||.|:|::|.|.:|.:|..|..|:|.:..:|.:|:|.|
Zfish  1781 TAMVVAIFVGFDKKCYTSPTNLPALIALLCLYGWSVTPMMYPLSYMFNVPSTAYVSLSCINLFIG 1845

  Fly  1212 MALFIVVVVMSSELFDTKDTA----DILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAG---A 1269
            :....:..::  |||:...:.    ::|..:..:||||.|...|..:..|.|..:..|:.|   :
Zfish  1846 INSSAITFIL--ELFENNRSLLMFNEVLKKVLLVFPHFCLGRGLIDMAMNQAVTDVYARFGEEFS 1908

  Fly  1270 LPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLIS 1334
            :.|                |.|...|  .....|||.|.|:|:      |.|:.:..|.:...||
Zfish  1909 MDP----------------FRWNFVG--KNLFCMAVEGFVYFI------FNLLIQYKFFLHHWIS 1949

  Fly  1335 KPPPPPTEGQL-----DDDVANERERILQ-MSSNELATKNLVLDRVTKYYGQFM--AVNQVSLCV 1391
                  ..|..     |||||.|||||.: .:.|::    |::..::|.|.:..  ||:::.:.|
Zfish  1950 ------DYGMSLGTDEDDDVAQERERIYKGGNKNDI----LLIRDLSKTYRRRKRPAVDKICVGV 2004

  Fly  1392 QEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDL 1456
            ...|||||||||||||||||||:|||..::||...|.|.|:.||:..:::.:||||||||:.:.|
Zfish  2005 PAGECFGLLGVNGAGKTTTFKMLTGDTDVTSGELSVAGYSILSNILDVHQNMGYCPQFDAIDELL 2069

  Fly  1457 TGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVI 1521
            ||||.|.::..|||:.||.|.:::|...:..|..::.......||||||||||||||:||.|.::
Zfish  2070 TGREHLYLYARLRGIPESEISRVAEWGIQKLGLSEYAGNCAGTYSGGNKRKLSTAIAMIGCPPLV 2134

  Fly  1522 YLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHL 1586
            .||||||||||.:||.||..:..|...|:::|||||||||||||||||||||||.|||:|:.|||
Zfish  2135 LLDEPTTGMDPHSRRFLWTAILSIIRDGRAVVLTSHSMEECEALCTRLAIMVNGTFKCLGTIQHL 2199

  Fly  1587 KNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQ 1651
            |.||..|.::.:|::.....|           :||  .|||:          .|:::.:|..|.:
Zfish  2200 KYKFGGGYVVTMKIKAAKPGL-----------SPD--LVPAE----------SFMDSSFPGCIQR 2241

  Fly  1652 EEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQ--REDT 1710
            |::...|.:.|....:  :|:|.|:.:|:::||:||||||||||:::|:.|||.|  .:||
Zfish  2242 EKHYNTLQYEIAAASL--ARVFQLVLTNKERLNIEDYSVSQTTLDQVFVNFAKQQSGEDDT 2300

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Abca3NP_608445.2 rim_protein <137..1708 CDD:130324 586/1852 (32%)
abca4bXP_021322694.1 rim_protein 1..2315 CDD:130324 617/2011 (31%)

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