Protein Alignment ABCA and abca8

DIOPT Version :9

• Sequence 1: NP_608445.2
• Gene: ABCA / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Sequence 2: XP_031749971.1
• Gene: abca8 / 549630
• XenbaseID: XB-GENE-1005441
• Length: 1619
• Species: Xenopus tropicalis
• Alignment Length: 1824
• Identity: 476/1824 - (26%)
• Similarity: 828/1824 - (45%)
• Gaps: 368/1824 - (20%)

  Fly    13 LLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLV-----RTLVDTEQKGVRYYNEQNLTDLNLLQH 72
            |.|||..|:|..||..::|.:....|.|:::|:     .|.|..|      ||..
 Frog    17 LFWKNLLLKWRRKWHTILEWLQNLAFVLVMLLISVMGLSTFVQLE------YNSP---------- 65

  Fly    73 SLHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQS--LGKNKICESEN 135
                :..||:|.|:...|           .|.:.|...:|..:.::|:..:|  :...|:.|..:
 Frog    66 ----AEVLGRLDAVDRSN-----------NFKVGYVYTSPTSRDIMEKVAKSIIIPGIKVQEYSD 115

  Fly   136 ATQLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLFPT 200
            ...| ||.::..|..||.|.|             .|.:.:|:|..    .||..|.:     |..
 Frog   116 EGNL-LDDMTNKAVVGVTFVD-------------KFSYHIRYPIN----NIAYPNDY-----FAF 157

  Fly   201 IDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGE---QDLPNVVMKRYPFPAYIFD 262
            :....|.::    ...|..|....||.||.|:..|.:...|..   .::.:||..|
 Frog   158 MGFCAPGSQ----ACYPTYYWSRQFLSLQASIDSAIIELTSNHSVWDNMASVVTVR--------- 209

  Fly   263 PLLEGMSSIMSLIILLSFIY--PCTYI------TKYITAEKEKQLKEVMKIMGLSNWLHWTAWFV 319
             :...::|......:.:||:  |..|:      :.|||.|: ::::|::|:|.|.:...|.:|.:
 Frog   210 -MKSTVASFRQYFHIGTFIFLMPMCYVSLMYLLSLYITRER-REMRELLKMMRLKDLAFWLSWGL 272

  Fly   320 KSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAA 384
            .....:.|.|.|:.::.|      ..|...:::..::|..:.|.::.:.|.||::..| |:..|.
 Frog   273 LYLFYILILANLMTLVTK------AFVFVQSSYGIIMFLFVFYGIALMSFTFMLSALF-RSPRAT 330

  Fly   385 AVTGLIWFIA-YIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFT 448
            |:.|  :||. ::.....:....|...:..:..|:....|...|:...:..|...:|:    :|:
 Frog   331 AIAG--FFITLFLSALGLVLLRKDFPQALAVLLSIFPQFAFAVGLTESVHMESDLQGV----YFS 389

  Fly   449 PVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGER---EYTG 510
            .::.|.:..|.: .|.:.:..:.||.:.||.|:|:....|:.....|.....:|..::   ..|.
 Frog   390 DMAGDSSHVLSS-FISLALDSIFYMGLTLYFEKVLADKHGLKYEPFFFMKSSYWSKKKLSPVLTQ 453

  Fly   511 VEDIPNGHVEQRDPKAFETEP---EGKHIGLQMRHLKKRF----GNKMVVKGLSMNMFEDEITVL 568
            .||  :|  |....:.||..|   .||. .:::..:.|::    .|...::||.:|::|.:||.|
 Frog   454 TED--SG--ESSMGEFFERVPIDLHGKE-AIRINKVMKKYCDQDKNIEALRGLDLNIYEGQITAL 513

  Fly   569 LGHNGAGKTTTISMLTGMFPPTSGTAIING---SDIRTNIEGARMSLGICPQHNVLFDEMSVSNH 630
            |||:||||||.:::|:|:.|.:.|:|.:..   ||:: ::|..:...|.|||.:|.|:.::|..:
 Frog   514 LGHSGAGKTTLLNILSGLCPASDGSATVYSYKLSDMQ-HLEEIKKRTGFCPQSDVKFNPLTVKEN 577

  Fly   631 IRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEP 695
            :..|:::||:..|.::.:|.|.|..:::.|..||.:..||||.:|||::..||.||.:|:|.|||
 Frog   578 LTVFAKIKGIPRKQIKHKVQKVLSDLQMNDIENVEADNLSGGQRRKLTLGIALLGDPQVLLLDEP 642

  Fly   696 SSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGS 760
            ::|:||.:|..:|.:|::.|..|..|.:|.||||||:|.||.|::.:|.|||.|:|.|||:::|.
 Frog   643 TAGLDPCSRHHIWTILKENKADRVTLFSTQFMDEADILADRKAVISNGRLKCVGSSLFLKRKWGI 707

  Fly   761 GYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQSDELH 825
            ||.|.......|:...:|:::.:::|..|.......||:|.||......|.::|         ||
 Frog   708 GYHLRMQVSPTCDVELMTSIIKQHVPDAKLTAQNEEELTYTLPFENMDAFPDLF---------LH 763

  Fly   826 LNG--------YGVGITSMEEVFMKVGAEKDNTGNI-KDQHEIMNGGSG--------FRGEDDNE 873
            |:|        |||.:|::::||:|:..|    |.| |..:.:.:..||        ..|.:|:.
 Frog   764 LDGQVGNSIVNYGVSMTTLDDVFLKLEGE----GEIEKGDYGVFSPDSGAPEDKDCFSAGMEDSL 824

  Fly   874 SVQSDGIFSENRRLLQGLQLLSNQWKA------MLLKKFLYTWRNKLLLLIQNIMPVFFVVVTIL 932
            .:.||    .....|.||.|...|..|      :.||....|:|:.|:||...|:|   :::|.:
 Frog   825 LLMSD----SGSATLSGLSLWRQQVLAIARVRLLKLKHDSKTFRSILILLALFIIP---IIMTTI 882

  Fly   933 IIKTQGTFQELKPITISLT-----QYPLAVTVLDRSNVQNGTGYEIANKYEDLARSYGSNYGLEL 992
            :||   .|.  |.||..||     |:|                       ||....|.::..:..
 Frog   883 VIK---IFH--KVITWELTPSLYFQHP-----------------------EDRFHRYYTDLQIYN 919

  Fly   993 TGTQGFEDYILDLGK---TIQVRINSRYLVAATITESKI-----------TAWLNNQALHTAPLT 1043
            ......||::..|.:   .:|| :|..|.:..|.....|           |...|.:|.:..|:.
 Frog   920 NTGSSIEDFLGALKEQNIAVQV-VNGEYDMETTFYRGAIEVSQATKGYGFTIVGNPKAQNALPVL 983

  Fly  1044 VNMVHNAIADKLFGSSVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILF 1108
            ||::.||:. .:|.|:..|:|.|.|:   |..|:....:               :.|.|...:|.
 Frog   984 VNIISNALL-MIFNSTEHIRVWNHPV---TEYLVEDFES---------------VTFYSGFMLLL 1029

  Fly  1109 L------------IKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETG 1161
            .            |::|..:|:....:.|:....:|..|.:.|...|.:...::|..:..|....
 Frog  1030 FASGLAPHFAMSSIEDRRIKARTQLRISGIFPSAYWFGQALVDVPLYWILLFLMVAILFSFNSQV 1094

  Fly  1162 LSTF--------GELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVV 1218
            :.:|        |.:|        :|.||:.::|::|..|   ..|.:.....:||..::.||.:
 Frog  1095 IFSFVPAIILITGVIG--------YGAAVVLYVYVISFVF---GRGKSHHDGWSIFFVISAFIPM 1148

  Fly  1219 VVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCC 1283
            :     |.|...|..:....|.:.|                       |..|..|:.|
 Frog  1149 I-----LLDVVSTYAVGITFFLLLP-----------------------ASTLSGIIRC------- 1178

  Fly  1284 NLKPYF----AWEEPGVLPETVYMAVTGVVFFLIII-VLE----FRLINELMFKIRQLISKPPPP 1339
             :..|.    ..|:..:|  .::.....:|.|.:|: |||    .|.:...:| .|:.:.|....
 Frog  1179 -IDVYHFDRSTLEDEHLL--YLFFPFLHIVIFSVILWVLERVFGMRSLKTNLF-YRKKVQKNQEE 1239

  Fly  1340 PTEGQLDDDVANERERILQMSS--NELATKNLVL-DRVTKYY-----------GQFMAVNQVSLC 1390
            ..| ..|::|..||||: :|||  |.:..|.::: |.:.|.|           .:..|...:|.|
 Frog  1240 LGE-DTDEEVLAERERV-KMSSTTNNMEEKPIIIVDSLRKEYKVKKGKSFFKKNKKAATKNISFC 1302

  Fly  1391 VQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYK---MIGYCPQFDAL 1452
            |::.|..||||.|||||||:..|:.|:.|.::|...:.|...:.:.||.|.   .:|||||.:.|
 Frog  1303 VRKGEVLGLLGPNGAGKTTSIYMLAGEIRPTAGEVLLCGTDPDKSQNSQYDPTGSLGYCPQDNPL 1367

  Fly  1453 LDDLTGREVLRIFCMLRGVQ----ESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIA 1513
            ..:||.::.|.|:..::|::    |:.|:::||.|.    ..:|::|.....|.|..||:..||:
 Frog  1368 WPNLTVKQHLEIYAAVKGLKKKDAETAIKRVSEALE----LKEHLEKAARKLSAGVSRKVCFAIS 1428

  Fly  1514 VIGSPSVIYLDEPTTGMDPAARRQLWNMV-CRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEF 1577
            ::|:|:::.||||:||:||..:::||..: ...|:..:..:||:|.|||.||:|.|:||||:|:.
 Frog  1429 MLGNPNIVLLDEPSTGLDPKGQQRLWRAIRSAFRNKDRGAILTTHYMEEAEAVCDRVAIMVSGKL 1493

  Fly  1578 KCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVE 1642
            :||||.|.||:||.||.:|:|||:                            :...:|.:...:.
 Frog  1494 RCIGSIQQLKSKFGKGYLLEIKVK----------------------------NSNQVDQIHNEII 1530

  Fly  1643 TEYPNSILQEEYQGILTFYIPLTGVK-WSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQ 1706
            ..:|::..|:.:..:|.:.||:..|: .|:.|..:|..:...|:|:||.||.||.::|:|..|.|
 Frog  1531 QIFPHAARQDRFSSLLVYKIPVENVQSLSKAFLDLEEAKRAYNIEEYSFSQPTLTQVFIELTKEQ 1595

  Fly  1707 -RED 1709
             |||
 Frog  1596 ERED 1599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	36/188 (19%)
		ABC2_membrane_3	<269..475	CDD:289468	44/214 (21%)
		CcmA	538..843	CDD:224054	113/319 (35%)
		ABC_subfamily_A	538..755	CDD:213230	86/223 (39%)
		ABC2_membrane_3	913..1316	CDD:289468	86/446 (19%)
		ABC_subfamily_A	1369..1587	CDD:213230	84/237 (35%)
		drrA	1376..1702	CDD:130256	112/345 (32%)
abca8	XP_031749971.1	rim_protein	<225..1601	CDD:130324	418/1548 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010