DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and abca4

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:NP_001011033.1 Gene:abca4 / 496442 XenbaseID:XB-GENE-1000810 Length:2359 Species:Xenopus tropicalis


Alignment Length:1977 Identity:602/1977 - (30%)
Similarity:937/1977 - (47%) Gaps:451/1977 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 DTEQKGVRYYNEQNLTDLNLLQHSLHR-SSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPV 113
            |...:|...|:.:|:  .|:..|::.. :.|:|.|.             ..|||           
 Frog   488 DERPEGQVNYDWRNI--FNITDHAIRLFNQYMGCLT-------------LDKFE----------- 526

  Fly   114 LKKLVEEAWQSLGKNKICESENATQLELDTVSKNAF-AGVQFDD--AWANLTENDPLPNDFHFAL 175
                        |.:   :..:.|...|..:.:|.| ||:.|.|  .|.|     .||:...:.:
 Frog   527 ------------GHD---DESHLTHHALYLLEENKFWAGLVFLDMFPWTN-----TLPSHVKYKI 571

  Fly   176 RFPAELRTATIAIANTWLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQK 240
            |...:....|..|.:.:..         .|||.:..:|    ..|:..||..||..:....::.:
 Frog   572 RMDIDAVEKTNKIKDRYWD---------PGPRADPVED----MRYIWGGFAYLQDMIDHGIIKSQ 623

  Fly   241 SGEQDLPNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKI 305
            :..:....:.:::.|:|.::.|..:..::....:.::|::||..:.:.|.|..|||.:|||.||.
 Frog   624 TSTEVPAGIYLQQMPYPCFVDDVFMITLNRCFPIFMVLAWIYSISMLVKDIVLEKELRLKETMKN 688

  Fly   306 MGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFC 370
            ||::|.:.|...|:.||.::|.|.||:.:::.:.     .||.::|...|..||:.:.:::|...
 Frog   689 MGVTNDVIWLTRFIDSFTVMTTSTILLTVVIVVG-----GVLHYSNPIILFCFLMAFTIATIMQA 748

  Fly   371 FMMATFFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFE 435
            |:|:.|||:|:.|||.:|:|:|..|:|:.......|.:::..|...|.:|..|.|||.:.:..:|
 Frog   749 FLMSVFFSKANLAAACSGVIYFTLYLPHILCFAWQDRMTIKLKTLASFLSPVAFGFGTEYLSRYE 813

  Fly   436 GTGEGLQWSNF-FTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTR 499
            ..|.||||.|. .:|:..|:...|.:: .|||:...||..:..|::.|.||.:|:|:||.|||..
 Frog   814 EQGLGLQWGNIRKSPMEGDEYSFLFSI-FMMLLDAFIYWTLAWYIDHVFPGEYGIPKPWYFPFLA 877

  Fly   500 EFWCG-EREYTGVED-----------IPNGHVEQRD--PKA------------------------ 526
            .:||. |.|:.|..|           |...|:|..|  |:|                        
 Frog   878 TYWCKFEHEFGGDADSIETELSIHEHIEENHIEPTDNQPEALPDGVKEEAEKSVKQDDIIVNKDS 942

  Fly   527 -------------------------------------------FETEPEGKHIGLQMRHLKKRFG 548
                                                       ||.||.|...|:.::.|.|.:.
 Frog   943 SACKHKVKKEKEQEEKQRKDEQEKERNDKDDMKDGFTYIGNPFFEPEPPGMVPGVYIQDLVKVYE 1007

  Fly   549 N--KMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMS 611
            |  |..|..:::..:|.:||..|||||||||||:|::||:|||||||..:.|.||:|:::..|.|
 Frog  1008 NTYKPAVDRMNITFYEGQITAFLGHNGAGKTTTLSIITGLFPPTSGTVWVRGRDIQTHMDSIRQS 1072

  Fly   612 LGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRK 676
            ||:|||||:||..::|..||.|::::||...|..|::....|:.:.:..|.|..:..|||||:||
 Frog  1073 LGMCPQHNILFRHLTVEEHILFYAQLKGKSRKQAERQAEVMLEDMGIPHKRNDEAQNLSGGMQRK 1137

  Fly   677 LSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMC 741
            |||..|..|::|||:.|||:||:||.:||.:||||.:.:.|||::|:||.|||||:|||||||:.
 Frog  1138 LSVALAFVGESKVVVLDEPTSGVDPYSRRSIWDLLLKYRSGRTIILSTHHMDEADLLGDRIAIVS 1202

  Fly   742 DGELKCQGTSFFLKKQYGSGYRLICVKR----------------DDC------------------ 772
            .|:|.|.|:..|||..:|:|:.|..|:|                .||                  
 Frog  1203 QGKLFCSGSPLFLKNCFGTGFYLTLVRRMRNIKDTGKKDSASCQSDCSCPCSSCTPKVKENLLEQ 1267

  Fly   773 ----ETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFE---EMFGQLEEQSDELHLNGYG 830
                :.:.:|.|::.::|..|....||.||.|.|| |...||.   .:|.:|||...:|.|:.:|
 Frog  1268 ELDGDVSGLTELIHHHVPEAKLLESIGQELIYLLP-SKDFKFRAYASLFRELEETLGDLGLSSFG 1331

  Fly   831 VGITSMEEVFMKVGAEK--------------------------------DNTGN----IKDQHEI 859
            :..|.:||:|:||.|:.                                ||.|.    .||.|..
 Frog  1332 ISDTPLEEIFLKVTADSVTGTETPEEWMLQQRKSRTSLGVDNQTTVINIDNKGQESSIRKDSHHC 1396

  Fly   860 MNGGSGFRGEDDNESV---QSDGIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNI 921
                   :.|.:..::   ::||   ...|.::|.:||..|:.|:::|:|.:..|:......|.:
 Frog  1397 -------KAEKNPPNINDREADG---RGSRQIKGTELLQQQFNALIIKRFKHATRSHKDFFAQIV 1451

  Fly   922 MPVFFVVVTI---LIIKTQGTFQEL---------------------------------------- 943
            :|..||::.:   ||:...|.:..|                                        
 Frog  1452 LPASFVLLALVFTLIVPPFGEYPSLTLHPWIYGQQFVFFSNEQPGNEQMATFSNAFLNSPGLGTR 1516

  Fly   944 ----KP------------------ITISLTQYPL-----------AVTVLDRSN----------- 964
                :|                  ::.|:|...|           :.|...||.           
 Frog  1517 CMKDQPLSKKYQCTNTSNEWTMPAVSPSVTNMLLSQEWTRDNPSPSCTCSSRSKLMMLPECPEGA 1581

  Fly   965 ---------------VQNGTGYEIAN----KYEDLARS-----YGSN---YG-------LELTGT 995
                           :|:.|...|::    .|.||.||     |..|   ||       |.:...
 Frog  1582 GGRPPPQRIQPSSEIIQDLTERNISDFLLKTYPDLIRSSMKSKYWVNEQRYGGISVGGKLPVLHV 1646

  Fly   996 QGFE--DYILDLGKTIQVRINS---------RYLVAATITESKITAWLNNQALHTAPLTVNMVHN 1049
            :|.:  .:...:|:...|...:         :..:....||..|..|.||:..|:..:.:|:.:|
 Frog  1647 KGGDIVSFFSQVGQMTNVTAGTTTKAISQELQTFLQNLETEDNIKVWFNNKGWHSMVIFINVANN 1711

  Fly  1050 AI------ADK---LFGSSVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIY 1105
            ||      |||   .||    |...|.||..|...|........::...:|..:.|.|.|:.:.:
 Frog  1712 AILRANLGADKDPEEFG----ITTMNHPLNLTKDQLSEVTVLTTSVDVVVAICVIFAMSFIPASF 1772

  Fly  1106 ILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGR 1170
            :|:||:||.|.||.||||.||....:||:.|..|..:|.::..:|||..:.|.:...::...|..
 Frog  1773 VLYLIQERVSNAKHLQFVSGVTPAIYWLTNFAWDIINYAISVAMVVIIFIAFDKKAYTSSSNLPA 1837

  Fly  1171 YYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKDTA--- 1232
            ...||..:|:||:|.:|..|..|..|:|.:..:|.:|:|.|:....:..::  :||:...:.   
 Frog  1838 LIALLFFYGWAVIPMMYPASYLFNVPSTAYVALSCINLFIGINSSAITFIL--DLFENNRSLLKF 1900

  Fly  1233 -DILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGV 1296
             :.|..:..|||||.|...|..:..|.|..:..|:.|..             ::...|.||   .
 Frog  1901 NEKLKDLLLIFPHFCLGRGLIDLAMNQAVTDVYARFGEE-------------HVSNPFQWE---F 1949

  Fly  1297 LPETVY-MAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQLDDDVANERERILQ-M 1359
            |...:: |||.|||:|.:.::::.|......|      |:||....||: |:|||.||:|::: .
 Frog  1950 LGRNIFAMAVEGVVYFTLNLLIQHRFFFSTWF------SEPPKGLVEGE-DEDVAQERQRVIKGG 2007

  Fly  1360 SSNELATKNLVLDRVTKYY--GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISS 1422
            ..|::    |.|..:||.|  .|..||:::.:.|:..|||||||||||||||||||:|||.:::|
 Frog  2008 GKNDI----LKLKELTKTYPGKQSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDIQVTS 2068

  Fly  1423 GAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSF 1487
            |.|.|.|.|:..::..:::..||||||||:.|.|||||.|:::..||||.|..|..:::...:..
 Frog  2069 GDASVAGYSILQDIADVHQNSGYCPQFDAIDDLLTGREHLQLYGRLRGVPEDEIDMVADWGIEKL 2133

  Fly  1488 GFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSI 1552
            |..|:.|..|..||||||||||||||:||.|.|:.||||||||||.:||.|||.:..|...|:::
 Frog  2134 GLGKYADNLTGTYSGGNKRKLSTAIALIGCPPVVLLDEPTTGMDPQSRRFLWNSIVSIIKEGRAV 2198

  Fly  1553 VLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYA 1617
            |||||||||||.|||||||||.|.|||:|:.||||.||..|.|:.:|||.:         ..|.|
 Frog  2199 VLTSHSMEECEVLCTRLAIMVKGTFKCLGTIQHLKYKFGDGYIVTMKVRAS---------KPGLA 2254

  Fly  1618 RNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQ 1682
            .:|              ..|::|::|.:|.|:.:|::..:|.:  .|:....:|:|.|:.||:|.
 Frog  2255 PDP--------------GPVEKFIQTNFPGSVQREKHYNMLQY--QLSSSSLARVFQLLISNKDS 2303

  Fly  1683 LNVEDYSVSQTTLEEIFLEFAKYQRED 1709
            ||:|:||||||||:::|:.|||.|.||
 Frog  2304 LNIEEYSVSQTTLDQVFVNFAKQQTED 2330

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 56/179 (31%)
ABC2_membrane_3 <269..475 CDD:289468 68/206 (33%)
CcmA 538..843 CDD:224054 140/347 (40%)
ABC_subfamily_A 538..755 CDD:213230 106/218 (49%)
ABC2_membrane_3 913..1316 CDD:289468 121/548 (22%)
ABC_subfamily_A 1369..1587 CDD:213230 124/219 (57%)
drrA 1376..1702 CDD:130256 159/327 (49%)
abca4NP_001011033.1 rim_protein 1..2347 CDD:130324 602/1977 (30%)
ABC2_membrane 604..>778 CDD:304374 52/178 (29%)
ABC_subfamily_A 997..1216 CDD:213230 106/218 (49%)
ABC_subfamily_A 2013..2233 CDD:213230 124/219 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 160 1.000 Domainoid score I3998
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.930

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