DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and CG6052

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster

Alignment Length:	1738	Identity:	806/1738 - (46%)
Similarity:	1127/1738 - (64%)	Gaps:	88/1738 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VTNWDKFVLLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLN 68
            |.:|||..||:||||.||||.|.|:|..||||.:|..|::::|.:|..|:.....|...:::|||
  Fly    16 VGDWDKLKLLMWKNWILQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDEIRYPTVSISDLN 80

  Fly    69 LLQHSLHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEA---WQSLGKNKI 130
            |..    |...||..|.       .:||..:.....|||:|.||:...:|...   .:.||....
  Fly    81 LYM----RMVPLGNRIL-------HENGSLNIPRNFLCYTPNNPINSAIVGATAIRLRLLGTRAY 134

  Fly   131 CESENATQLELDTVSKNAFAGVQFDDAWANLTENDP-LPNDFHFALRFPAELRTATIAIANTWLT 194
               :.|..:|.|.|..|..|||||:|. .|:..||. .|.:.:::||||:||||....|.:||.|
  Fly   135 ---DTALHMEQDMVLHNFLAGVQFEDN-ENVNTNDAGYPLNLNYSLRFPSELRTMQGPIIDTWRT 195

  Fly   195 MRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQD--LPNVVMKRYPFP 257
            .|||.:.|.:|.||..|:|||:|.||:||||||:||:|:|::|...||..|  :|.:.::|:|:.
  Fly   196 SRLFLSYDTSGSRNRLDNDGGVPVGYIREGFLPIQHALTMSWLALASGVTDTGIPAIHLQRFPYR 260

  Fly   258 AYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSF 322
            ||.:|.||.|:..::..:||||||||.:.:|||:|:|||.||||:||::|:.|||||.||||||:
  Fly   261 AYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGVHNWLHWVAWFVKSY 325

  Fly   323 IMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVT 387
            |||.:...||..|:.:.:...|||||.:::..::.||..|:|:|:|.|||:|..||:||||:||.
  Fly   326 IMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLFSKASTASAVA 390

  Fly   388 GLIWFIAYIPYSFTINSYDDLSLSSKLGWSLI-SNTAMGFGIKLILGFEGTGEGLQWSNFFTPVS 451
            .:.||:.||||||....|:.|||.|||..||| ||:|:||||.:|:.:||||||:.|.|.|.|||
  Fly   391 AIFWFLTYIPYSFGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTGEGITWRNMFHPVS 455

  Fly   452 VDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTGVEDIPN 516
            .||:|||..:::.|....::::.||||||||.||.:||||.|||...:.:|   |:|     :|:
  Fly   456 TDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYW---RQY-----VPS 512

  Fly   517 GHVEQRDPKAFETEPEG----------KHIGLQMRHLKKRFGNKMVVKGLSMNMFEDEITVLLGH 571
            .::    ..:|:|...|          :.:|:|:.:|:|.:|....|||:|:.|..:||||||||
  Fly   513 LNI----VPSFQTILHGSAKAKSCRRAREVGIQLFNLQKNYGKLKAVKGISLKMHRNEITVLLGH 573

  Fly   572 NGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSR 636
            |||||||||:|:||:..|||||||:||.||||::..||.|||||||:|:||.||||.:||.|||:
  Fly   574 NGAGKTTTINMITGIVKPTSGTAIVNGYDIRTHLAKARESLGICPQNNILFKEMSVRDHIIFFSK 638

  Fly   637 MKGLRG-KAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMD 700
            :||:|| ||||.||.||:.|::|:||:.||:..||||||||||:||||||:.|||||||||||:|
  Fly   639 LKGIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGID 703

  Fly   701 PSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLI 765
            .:.||.||||||.||.|||:|||||:|||||||||||||:.:|:|:||||||:|||::|:||.|:
  Fly   704 AAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLV 768

  Fly   766 CVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQSDELHLNGYG 830
            |:.:..|:...||.|:.||:|.:|||..:|.||:|:||...|.||.|:...|:|:..:|.|.|||
  Fly   769 CIMQSGCDVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEYSKKFAELLQDLDEKCAQLQLVGYG 833

  Fly   831 VGITSMEEVFMKVGAEKDNTGNIKDQHEIMNGGSG--FRGEDDNESVQSDGIFSENRRLLQGLQL 893
            :...::|:|||.|..:|          .:..|..|  ..|..|.:.:..|....|.||:.:....
  Fly   834 LSGATLEDVFMAVNTDK----------RVQGGAEGPPVDGSIDFKELVFDSKTREKRRIRRCFMF 888

  Fly   894 LSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQYPLAVT 958
                |:|:.||||..|.||..||.||.::|:..:.:|||..:....:.||..:.||:.||..|..
  Fly   889 ----WQALFLKKFYTTTRNYWLLGIQLVLPIAVMALTILNSRGGRIYYELPAMPISINQYSSAYV 949

  Fly   959 VLDRSNVQNGTGYEIANKYEDLARSYGSNYGLELTGTQGFEDYILDLGKTIQVRINSRYLVAATI 1023
            ||: .|..:.|. .:|:.|......|.....|..||...||||||........||:..:|...|:
  Fly   950 VLE-DNTTDKTS-SLADAYSKHLEHYARRCTLLRTGDLKFEDYILSHDVNHSRRIDFHFLAGLTV 1012

  Fly  1024 TESKITAWLNNQALHTAPLTVNMVHNAIADKLFGSSVKIQVTNAPLPYTTSTLLSQLSTGNNLGT 1088
            :|:....||||:.|||||||:|::|||:|.||.|......|||.||||:..|...:|:.|..||.
  Fly  1013 SENNFIVWLNNKPLHTAPLTLNLLHNALAIKLLGQDASTYVTNEPLPYSDDTRTLRLNKGQVLGA 1077

  Fly  1089 QLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVIT 1153
            :::.||...|||:::.|.:.:|:|||:|||||||:.||.|..:|.|..:.|:..::::||..::|
  Fly  1078 EISINLSLTMCFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILT 1142

  Fly  1154 IVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVV 1218
            |..|:|.|..|..:|.||:.:||:|||..:...|..|..|.:.||||.|:||:|...|..||::.
  Fly  1143 IAAFKEIGYITPLDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMGTGLFLMF 1207

  Fly  1219 VVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAG--ALPPILLCELVPQ 1281
            :.::.|.|..||.|:.|.|.||:.||:|||.|.:.::.....|..|:..|  .||..|.|..||.
  Fly  1208 MTLNFEAFQLKDVAEKLAWYFRLSPHYSLASSTHSIHIGYNIRRGCSIGGIRKLPKQLRCRNVPI 1272

  Fly  1282 CCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQL- 1345
            ||::..|:.|.:||||.|..||.:.|...||:|::.:.::.|.:..|:....||  ....||..
  Fly  1273 CCDIPGYYGWRKPGVLVEITYMIMLGSTLFLLIVMHDAKVCNLIAEKLGNCFSK--RKRVEGGTS 1335

  Fly  1346 --DDDVANERERILQMSSNELATKNLVLDRVTKYYGQFMAVNQVSLCVQEVECFGLLGVNGAGKT 1408
              :|.|..|:..:.:|.::......|::.:::|.|...:||..:|..|...|||||||:||||||
  Fly  1336 IENDSVVAEQRVVREMINSGRKDVPLLVYKISKRYRSKLAVKAISFHVPHAECFGLLGINGAGKT 1400

  Fly  1409 TTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQE 1473
            :||||:.|||:|:||.||:.|.::.:  :.:|:.||||||||||.:||||||.|.|:|:|||||.
  Fly  1401 STFKMLAGDEKITSGEAYIDGTNIST--HKVYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQR 1463

  Fly  1474 SRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQL 1538
            ..:..:...||.||||.||:||||..|||||:|||||||:|:|:|||:||||||:||||||||||
  Fly  1464 RHVTPICWGLAISFGFAKHMDKQTKHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQL 1528

  Fly  1539 WNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRN 1603
            |.::..||.:|||||||||||:||||||:||||||:|||||:||.|.|||:||||||||:||:..
  Fly  1529 WQIIGLIRTAGKSIVLTSHSMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHK 1593

  Fly  1604 LEALRQARLSGGYARNPDEQTVP------------AQMSQRD-IDAVKEFVETEYPNSILQEEYQ 1655
            .:..:  |:....:.:.|::::.            .:.||.| |..|..|:..|.|::.|:|||.
  Fly  1594 KKTFQ--RVVEDSSSSNDKKSISETDLKFLQMASVMESSQADRILKVNRFISKEIPDAELKEEYN 1656

  Fly  1656 GILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFA 1703
            |::|:|||.:.. .|:||.|:|:|..:||:|||.:.||.||||||:||
  Fly  1657 GLITYYIPHSKT-LSKIFQLLETNSHKLNIEDYLIMQTRLEEIFLDFA 1703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	95/180 (53%)
		ABC2_membrane_3	<269..475	CDD:289468	106/206 (51%)
		CcmA	538..843	CDD:224054	187/305 (61%)
		ABC_subfamily_A	538..755	CDD:213230	148/217 (68%)
		ABC2_membrane_3	913..1316	CDD:289468	159/404 (39%)
		ABC_subfamily_A	1369..1587	CDD:213230	137/217 (63%)
		drrA	1376..1702	CDD:130256	187/338 (55%)
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	19/32 (59%)
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	755/1591 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450239
Domainoid	1	1.000	144	1.000	Domainoid score	I1483
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	716	1.000	Inparanoid score	I123
Isobase	1	0.950	-	0	Normalized mean entropy	S3774
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm25386
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	P	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
	11	10.850