DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and CG8908

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:NP_611464.3 Gene:CG8908 / 37293 FlyBaseID:FBgn0034493 Length:1626 Species:Drosophila melanogaster


Alignment Length:1807 Identity:494/1807 - (27%)
Similarity:871/1807 - (48%) Gaps:303/1807 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 VLLLW----KNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQ 71
            :.|||    |....|:::....||.:|.|.:..|:........:.:::....|...|:|      
  Fly    14 ICLLWLVICKTARFQFSNTLTSVIIIVGPIVVFLVYAATALFREPQEETSVKYPPVNIT------ 72

  Fly    72 HSLHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICESE-- 134
                                       :|..:|. |||.|.||..::|:....|   |...|:  
  Fly    73 ---------------------------TKVPYIY-YSPENLVLAAVIEDVVHDL---KAVGSKAF 106

  Fly   135 -NATQLELDTVSKN--AFAGVQFDDAWANLTENDPLPNDFHFALRFPAELR-TATIAIANTWLTM 195
             :|::|....:.|:  .:.|::|||:::::.|   ||.:....||||..|| ...:...||.:..
  Fly   107 ASASELNKALIGKDTYGYVGIEFDDSFSDINE---LPINVTVGLRFPLHLRKNPKMVWDNTSILK 168

  Fly   196 RLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQDLPNVVMKRYPFPAYI 260
            .....:|.                |..||||.:|..||.|.:|.|:....||.|:::.||..|.:
  Fly   169 HSKMDVDY----------------YQVEGFLVVQAKLSEALIRAKNEAVVLPEVILQHYPDVAEV 217

  Fly   261 FDPLLEGMSSIMSL--IILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFI 323
                 :.:.:.::|  ::.|.......|:.:.|..|:...|::::::||:..|::|.:||:.:|:
  Fly   218 -----DRLDNRVALGGVLFLPVTISAAYLAQMIVMERRDHLRDMLELMGVRAWIYWLSWFLVAFL 277

  Fly   324 MLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTG 388
            :|:|..:.:.:|:|  |    ...:.::.:.::|||::|.:..:...||:::|||..........
  Fly   278 LLSIPTVFMVLLLK--W----RYFSLSDSSLVLFFLLVYNLEVLTSAFMISSFFSDTVGVQVAIV 336

  Fly   389 LIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVD 453
            ::..|..:|:...:..|.. :|...:...|..|:::..|::..:..|....||.|:..|.....|
  Fly   337 IVHLIGCLPWRLLLMGYVP-TLPRTIFVCLFLNSSLAMGLQQFIKSENLRLGLHWTYLFERTDWD 400

  Fly   454 DTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTGVEDIPNGH 518
            :.:.||.:::.||..|::.:::..|:||:....   .|.|.||....|||.              
  Fly   401 EFVHLGPILLFMLFGCLLRILVLAYMEQLRSYQ---NRKWYFPVQPSFWCR-------------- 448

  Fly   519 VEQRDPKAFETEPEGKHIGL-------QMRHLKKRFGNKMVVKGLSMNMFEDEITVLLGHNGAGK 576
             ..|.|::.:.:.||:..|:       :.|:::|.|...:.||.|::|.::|||||.||||.:||
  Fly   449 -WNRRPRSDDFDVEGQETGIRGHPLIVRARNIEKVFNEWIAVKDLNLNFYQDEITVFLGHNDSGK 512

  Fly   577 TTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLR 641
            :|.:.:|.|...|::|...|||.|:.||...||.|:.||||.||||::::...|::|:.|:|||.
  Fly   513 STILMLLAGFLRPSAGEITINGYDLATNQRKARQSMCICPQPNVLFEKVNARWHLQFYCRLKGLN 577

  Fly   642 GKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQ 706
            .:....|..|||::..|:|.||.....|..|:||.|.:||.|||::|::|.|||.:.|||:.|..
  Fly   578 RQEASAETDKYLEIGRLQDFANTKVKNLPSGIKRMLMLCCNLCGNSKILLLDEPGTSMDPAMRSN 642

  Fly   707 LWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSG--YRLICVKR 769
            :||||::|:.||.:::.||.|:||:|:.|:|.::||.::...||:.||.:..|:|  |.|||.|.
  Fly   643 MWDLLRRERKGRCIIMATHNMNEAEVVADQIVVLCDAQVIGYGTTGFLTQIAGTGSSYLLICTKM 707

  Fly   770 DDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQSDELHLNGYGVGIT 834
            |.|...|||..|....|.:|...:....::|:||.....::..:|.:|||...||:|....|...
  Fly   708 DTCIVAEVTNFLQIRFPDIKLHNEFSIYVTYELPTKYVQQYAALFLELEEALGELNLAEISVCAP 772

  Fly   835 SMEEVFMKVGAEKDNTGNIKDQHEIMNGGSGFRG-----------EDDNESVQSDGIFSENRRLL 888
            ::..||:::|.|...:.|.....::::..|....           |||                 
  Fly   773 TLGSVFLQMGEEMRQSWNRISSFDLLSSPSPMLSLLNLLPTFEVREDD----------------- 820

  Fly   889 QGLQLLSNQWKAMLLKKFLYTWRNK----LLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITIS 949
             |.....|||:|::.||.|:|.|::    :::....|:.:..:..:|.|........||  :...
  Fly   821 -GRVKCCNQWRAIVEKKRLFTLRHQKFYCMIIATPIIICLLIISFSIFIFLVDHHLSEL--LVTD 882

  Fly   950 LTQYPLAVTVLDRSNVQNGTGYEIANKYEDLARSYGSN---YGLELTGTQG--FEDYILDLGKTI 1009
            |:.||.||.|:| |..:       .|::|   |.|.:|   .|..:..|.|  .:||:|...::.
  Fly   883 LSIYPKAVFVID-SPAE-------GNRFE---RHYMANVIGQGGTVRSTSGTPIDDYLLAEMESD 936

  Fly  1010 QVRINSRYLVAATI--TESKITAWLNNQALHTAPLTVNMVHNAIADKLFGSSVKIQVTNAPLPYT 1072
            ||::...:|..||.  ..:.|.||.||:..|.:.|::.:|:.||..:|  :.:.|::.|.|...|
  Fly   937 QVKVQHTFLAGATFDSNANSIIAWSNNKLKHGSALSMGLVYAAIGQEL--AKLDIRIVNKPYQDT 999

  Fly  1073 TSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFI 1137
            ....:..|...:.:  :.|..:...:...::|:.:..|.||.|:.:..||..|:...|:|||...
  Fly  1000 VQQAVRGLIYASTI--EFAVLVFHYLVLGTAIFAVLPIVERRSKVQHQQFSSGMSRSTYWLSHLS 1062

  Fly  1138 CDFASYI--VTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGF 1200
            .|:..||  :..||||..|         |.|.:....:.||.|||:.:.|.|::.|...:....|
  Fly  1063 WDYCFYIAMILPLIVVAGI---------TIGSVLPVIVQLLAFGFSAISFTYLLCLMSNDFGKMF 1118

  Fly  1201 ARVSIVNIFCGMALFI--------VVVVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTN 1257
            :.:..:|:...:||||        ..|:.|               :..:.||:||          
  Fly  1119 SIILYINMIGVLALFIHPKSPQTRYAVIES---------------VLLVHPHYSL---------- 1158

  Fly  1258 TATRNACAKAGALPPILLCELVPQCCNL-----KPYFAWEEPGVLPETVYMAVTGVVFFLIIIVL 1317
                                    ||.:     ...|:.::   ||   |:..:|..:..|::  
  Fly  1159 ------------------------CCGMYEAIRMSTFSLKQ---LP---YLIFSGAAYLTIVV-- 1191

  Fly  1318 EFRLINELMFKIRQLISKPPPPPTEGQLDDDVANERERILQMSSNELATKNLVLDRVTKYYGQFM 1382
             |..:...:..:.:.|......|:....|.:|...|.|:..:::...|...|:|..::|.||.|:
  Fly  1192 -FAWVPRRLNYVFKSIRNEKIYPSYKDEDKEVDKMRRRLAYLTTAHYAFFPLILKNLSKRYGSFV 1255

  Fly  1383 AVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCP 1447
            ||..::|.:...||.||||.||:||::.|:|:.|.|.|:.|:.:::|.||::......:.:|:||
  Fly  1256 AVRSLTLDLNPFECVGLLGRNGSGKSSIFRMIVGMESITVGSIHIKGYSLKTRPKDASRHVGFCP 1320

  Fly  1448 QFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAI 1512
            :...||..:||::.||..|::.|::...|:.|...||:.|..:.|::|:...||.|.||||..|:
  Fly  1321 RELMLLSFMTGKDALRFCCLINGIRREYIKSLVASLAECFELVPHMNKRISTYSNGTKRKLMIAM 1385

  Fly  1513 AVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEF 1577
            ..: :||::.|||||.|:|..|:.::|:::..||..|:||:||:|::||||.|||.:.||.:|..
  Fly  1386 GTL-APSLMCLDEPTAGVDMHAKYEIWSILDGIRQGGRSILLTTHNLEECEFLCTNVGIMDHGSL 1449

  Fly  1578 KCIGSTQHLKNKFSKGLILKIKV---------RRN------------------------------ 1603
            .|.||...||::|:.|:.:|:|:         |.|                              
  Fly  1450 LCYGSLSRLKHRFNMGIFVKVKMGTRAEMDDERDNWMQITMMPPNDSEMGSTVGARRMMLAHLLR 1514

  Fly  1604 -----LEALRQARLSGGYARNPDEQTVPAQMSQR-DIDA----VKEFVETEYPNSILQEE--YQG 1656
                 :|.::::|.|   ...||  |..::::.| |.:|    ::|..:.::|.|.:.|:  |:|
  Fly  1515 HHNPPVEPVKKSRTS---RAQPD--TTNSELNMRKDYEALLQELEEVFKKDHPYSTVSEKYSYRG 1574

  Fly  1657 ILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQRE 1708
            ::||.||...:|||.||..||:.:|::.:..||||.||.:::|::|.:.|.:
  Fly  1575 MITFCIPRGQIKWSAIFEYMENLKDEMQILYYSVSHTTFQDVFMKFVRKQNQ 1626

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 37/181 (20%)
ABC2_membrane_3 <269..475 CDD:289468 45/207 (22%)
CcmA 538..843 CDD:224054 122/313 (39%)
ABC_subfamily_A 538..755 CDD:213230 93/223 (42%)
ABC2_membrane_3 913..1316 CDD:289468 96/428 (22%)
ABC_subfamily_A 1369..1587 CDD:213230 86/217 (40%)
drrA 1376..1702 CDD:130256 126/376 (34%)
CG8908NP_611464.3 ABC2_membrane_3 69..394 CDD:289468 88/392 (22%)
LivG 471..686 CDD:223488 90/214 (42%)
ABC_subfamily_A 474..691 CDD:213230 93/216 (43%)
ABC2_membrane_3 845..1192 CDD:289468 96/430 (22%)
NatA 1242..1461 CDD:226927 88/219 (40%)
ABC_subfamily_A 1242..1459 CDD:213230 86/217 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45451233
Domainoid 1 1.000 97 1.000 Domainoid score I371
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 228 1.000 Inparanoid score I138
Isobase 1 0.950 - 0 Normalized mean entropy S3774
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 1 1.000 - - otm51427
orthoMCL 1 0.900 - - OOG6_100045
Panther 1 1.100 - - P PTHR19229
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X215
1110.850

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