DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and Abca14

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	XP_038957098.1	Gene:	Abca14 / 365362	RGDID:	1561491	Length:	1691	Species:	Rattus norvegicus

Alignment Length:	1777	Identity:	648/1777 - (36%)
Similarity:	968/1777 - (54%)	Gaps:	200/1777 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KFVLLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHS 73
            :|::|||||:.|:....:.:|:|::|     :.|:.|.||.      ||..:::......:...
  Rat    19 QFLVLLWKNFLLKSRKVFGLVVEIIL-----IFLLFVWTLT------VRRISKKKFIPAMIFNP- 71

  Fly    74 LHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNP-VLKKLVEEAWQSLGKN-KI--CESE 134
                      |.|..|....:|     |::.|.|.|.:. ..:.:.|...:.|..| |:  ..||
  Rat    72 ----------IPLTLPGFLNQN-----FDYELAYVPSDSNAARNITEMVKKDLNFNFKVQGFSSE 121

  Fly   135 NATQ--LELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRF-----------PAELRTATI 186
            .:.:  ::.:..:::..|.:.||..:.  |.|:|||....::|||           |:|.:..|
  Rat   122 ESFEKYIKYEDKAEHVLAAIVFDHKFK--TSNEPLPLQVKYSLRFGRMYDPENVLKPSERQKET- 183

  Fly   187 AIANTWLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSG---EQDLPN 248
                .|.|..|||::...||||..::||| .|||:|||||.:|||:..|.:...||   |....|
  Rat   184 ----EWNTSILFPSVPSLGPRNVLENDGG-NPGYIREGFLLVQHSVDKAIMMHHSGRAAEAMFAN 243

  Fly   249 --VVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNW 311
              :..:|:|:||:|.|..|.....:....||.:|......|...|..||||:|||...::||||.
  Rat   244 TTIYARRFPYPAFIHDNFLWTFIVMFPWTILFTFTQMALDIIGTIMLEKEKRLKEYQLMVGLSNA 308

  Fly   312 LHWTAWFVKSFIMLTISAILIA--ILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMA 374
            :.|.::|:...:|..|...|:.  :.:||....   |..|::...:.|:.:.:.:||:...||::
  Rat   309 MLWVSYFITFLLMYFIIICLLCGILFLKITHER---VFQHSDPLFIAFYFLCFAISSMLLGFMIS 370

  Fly   375 TFFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGE 439
            |||:|||.|.::.|.:.|:.:.||....:.||..|||.||...||:|||:.||..||...|..|.
  Rat   371 TFFNRASLATSIAGFLHFLTFFPYLIVFSLYDQTSLSGKLALCLITNTALAFGTDLICKLEMKGH 435

  Fly   440 GLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCG 504
            |.||.||.|.|:.||.|||..::.|.|.|..:|.::..||:.|.||.:|||:||||...:.:|.|
  Rat   436 GAQWYNFATKVNPDDDLTLAHIIGMFLFSAFLYGLVAWYVDAVFPGKYGVPKPWNFFLQKTYWFG 500

  Fly   505 E----REYTGVEDIPNGHVEQRDPKAF-ETEPEGKHIGLQMRHLKKRFGNK----MVVKGLSMNM 560
            |    ||.:.|.|:|        |..| |.||.....|:|::||.|.|..|    |.||.||:|:
  Rat   501 EPALSREESQVSDLP--------PSDFMEPEPVDLEAGIQIQHLYKEFTLKNSTLMAVKDLSLNL 557

  Fly   561 FEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEM 625
            :|.:|||||||||||||||:|:|||::.||.|...|:|.||.:::...|.|||:|||.::||..:
  Rat   558 YEGQITVLLGHNGAGKTTTLSILTGLYLPTKGKVYISGYDISSDMVQVRKSLGLCPQDDLLFPLL 622

  Fly   626 SVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVV 690
            :||.|:.|:..:||:......:|:.:.|....|..|:|..|..||||||||||:..||.||||||
  Rat   623 TVSEHLYFYCVIKGISSTNRPREIHRMLTSFGLLQKSNTMSKDLSGGMKRKLSIIIALIGDTKVV 687

  Fly   691 LCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLK 755
            :.|||:|||||.:||.:|||||..|..||:|||||.|||||||||||||:..|.|||.|:|.|||
  Rat   688 ILDEPTSGMDPVSRRAIWDLLQHYKKDRTILLTTHHMDEADVLGDRIAILVMGVLKCCGSSLFLK 752

  Fly   756 KQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQ 820
            |.||.||.|:.||..|.:..:::.|:..|||..:.|.::.||||:.||...:.:|.|:|..|||:
  Rat   753 KLYGVGYHLVIVKTPDSDDGKISQLIKNYIPTAEMETNVAAELSFILPKEHTHRFAELFTDLEER 817

  Fly   821 SDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQHEIMNGGSGFR--GEDDNESVQ------- 876
            .:||.::|:||.:|:|:|||.||    .|..::|...||....|...  ..::||::.
  Rat   818 QEELGISGFGVSMTTMDEVFFKV----SNLADLKLNTEIAQSASTVNPSTSENNENMNVPRNFER 878

  Fly   877 -------SDGIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILII 934
                   ||..|:      .|..|...|::||.:|:.:::|||..|||:|             ::
  Rat   879 SGYSGRYSDSSFN------AGWPLYMQQFRAMFIKRVMFSWRNWKLLLLQ-------------LL 924

  Fly   935 KTQG-TFQELKPITISLTQYPLAVTVLDRSNVQNGTGYEIANKYEDLARSYGSNYGLELTGTQ-- 996
            ..|| |:..:|.|..|:.:.|..|..|::.. :....:.::.. ..|.:....|..:.|...:
  Rat   925 ALQGLTYVLIKGIGFSVPKEPARVMDLEQYG-ETTVPFSVSGD-PPLTQKLTKNLEIMLKDKKQK 987

  Fly   997 ------GFEDYILDLGKTIQVRINSRYLVAATITESKITAWLNNQALHTAPLTVNMVHNAIADKL 1055
                  |.:||:|.....|...|.: :.:..|..|...|.|.||:|.|.:||:::::.|.|...|
  Rat   988 VHEVQGGVQDYLLTNKDCIYSCIVA-FSLDVTRKEKTFTFWFNNEAYHASPLSLSILDNIIFKYL 1051

  Fly  1056 FGSSVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRAKLL 1120
            .|....|.|:|.|.|...:...|:..:.:  |.|:..||.|.|...:|.:.|..:.||.|:||.:
  Rat  1052 SGPDATITVSNKPQPQPFTKGRSEERSAS--GIQIVFNLLFGMSIFTSGFCLMTVTERVSKAKHI 1114

  Fly  1121 QFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRY---YLLLLLFGFAV 1182
            |||.||....||||..:.|...:.|..   |:.::.|..|.:....|...:   .|:|:|||:::
  Rat  1115 QFVSGVYTLNFWLSALLWDLIIHFVAC---VLLLLVFLYTDVHILLENYNFLDTMLILMLFGWSI 1176

  Fly  1183 LPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELF-DTK-DTADILGWIFRIFPHF 1245
            :||||::|.::......:.::.:.|...|....||..|:  ||. |.| .|.:::.....:.|.:
  Rat  1177 IPFIYLLSFWYNNSTNAYIKIFVFNHCLGFMSIIVDAVV--ELIPDIKTSTKNLILNSLLLLPIY 1239

  Fly  1246 SLAMSLNKVYTNTATRNACAKAGALPPILLC--ELVPQCCNLKPYFAWEEPGVLPETVYMAVTGV 1308
            :..||:.|.|:....|..|:..|:|.....|  ||.        .::.::..:......||.||:
  Rat  1240 NFGMSIFKYYSIQEIRKLCSSLGSLNTFSGCQHELT--------VYSMDKRAIGRHVTAMAATGL 1296

  Fly  1309 VFFLIIIVLE----------FRL----INELMFKIRQLISKPPPPPTEGQLDDDVANERERILQM 1359
            ::||.||:||          :|.    |.::.:|.|  :||.....:|   |:||.||||.|||.
  Rat  1297 IYFLFIILLETTSWNLKAFIYRYVLFGIYKIFYKAR--MSKELSGDSE---DEDVQNERETILQH 1356

  Fly  1360 SSNELATKNLVLDRVTKYYGQF---MAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERIS 1421
            |.:.| ...:::.::.|.|.:.   :||..:||.:|:.|||||||:||||||||||::||:|..:
  Rat  1357 SWHSL-NSTVLIKKLIKIYFKIPPTLAVRNISLTIQKEECFGLLGLNGAGKTTTFKILTGEEIAT 1420

  Fly  1422 SGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKS 1486
            ||..:::|.|:..|:..:...||||||||||||.:|.||:|.::..:.|:.|:.||....:|.|.
  Rat  1421 SGDVFIEGYSITRNILKVRSKIGYCPQFDALLDYMTSREILTMYARVWGIPENNIRSYVNNLLKM 1485

  Fly  1487 FGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKS 1551
            .......:|..:..||||||:||||||::|:.||::||||:|||||.|||.|||.|.|.|:|||.
  Rat  1486 LYLKPQAEKFIYTLSGGNKRRLSTAIAIMGNSSVVFLDEPSTGMDPLARRMLWNAVIRTRESGKV 1550

  Fly  1552 IVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGY 1616
            |::|||||||||||||||||||.|:..|:||.|||||||.....:.||                :
  Rat  1551 IIITSHSMEECEALCTRLAIMVQGKLVCLGSPQHLKNKFGNIYTMNIK----------------F 1599

  Fly  1617 ARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRD 1681
            ....|:..|      :|:   |.::...:|.|.|::|.||||.:|||.....|.::||::|..::
  Rat  1600 KTGTDDDVV------QDL---KNYIAEVFPGSDLKQENQGILNYYIPSKDNSWGKVFGILEKAKE 1655

  Fly  1682 QLNVEDYSVSQTTLEEIFLEFA 1703
            ..|:||||:||.|||::||.||
  Rat  1656 DYNLEDYSISQITLEQVFLTFA 1677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	63/181 (35%)
		ABC2_membrane_3	<269..475	CDD:289468	75/207 (36%)
		CcmA	538..843	CDD:224054	159/308 (52%)
		ABC_subfamily_A	538..755	CDD:213230	121/220 (55%)
		ABC2_membrane_3	913..1316	CDD:289468	109/418 (26%)
		ABC_subfamily_A	1369..1587	CDD:213230	117/220 (53%)
		drrA	1376..1702	CDD:130256	155/328 (47%)
Abca14	XP_038957098.1	rim_protein	<100..1681	CDD:130324	624/1669 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342300
Domainoid	1	1.000	176	1.000	Domainoid score	I3511
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1134	1.000	Inparanoid score	I207
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		mtm8956
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910