DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and Abca15

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_796187.2	Gene:	Abca15 / 320631	MGIID:	2388709	Length:	1668	Species:	Mus musculus

Alignment Length:	1767	Identity:	593/1767 - (33%)
Similarity:	943/1767 - (53%)	Gaps:	161/1767 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VTNWD--KFVLLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTD 66
            :.:|:  |.:||||||:||:......:|.|:||..:.|::|:..|.|:..::....|:.:|.::.
Mouse     1 MASWESRKLLLLLWKNFTLKRRKFGTLVSEIVLVLLLSIVLLTTRHLLSIKKIEALYFPDQPIST 65

  Fly    67 LNLLQHSLHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVN-PVLKKLVEEAWQSLGKN-K 129
            :    .|..|:|..                  |.:.:.|.|.|.| .|::.:|:.....|..: |
Mouse    66 V----PSFFRASVT------------------SFYPWELAYVPSNIMVVENIVKNVKNDLNLHMK 108

  Fly   130 ICESENATQLE---LDTV-SKNAFAGVQFDDAWANLTENDPLPNDFHFALRF---PAELRTATIA 187
            :....:.:..|   ..|| |:|..|.:.|...:||  .:||||....:.|||   ...:.:....
Mouse   109 VIGFPSESDFEDYARSTVNSRNILAAIVFGHNFAN--SSDPLPKKVKYYLRFSDIKKNINSGAYY 171

  Fly   188 IANTWLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGE------QDL 246
            ..:||||..||.::.|.||||..:.||| .|||:.||||.:||:|..|.:....|.      .|:
Mouse   172 QGDTWLTKFLFHSLRLVGPRNPYEADGG-SPGYITEGFLAVQHALDKAIMLHHGGADAAALFNDI 235

  Fly   247 PNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNW 311
             ::.::|:|:|||..|......::.:.|.:..:|.:....:...|..|||.:|||...::||.||
Mouse   236 -SLFIQRFPYPAYYHDYFYLFATTFIPLTVACTFFFNHYVLVWSIVWEKENRLKEYQLMIGLRNW 299

  Fly   312 LHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATF 376
            :.|.|:|. :|:.|....|::..:|.....|...:..:.:.|.:..||:.|.:|||.|.||::|.
Mouse   300 MFWVAYFF-TFLCLYFINIIVMCMVLFVKIEPAPIFQYNDPTLVFIFLLFYAISSIFFSFMVSTL 363

  Fly   377 FSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGL 441
            |::.|.|.::...::|:.|.|......|::.:....||.||...|..|.||.:.::..:....|:
Mouse   364 FNKVSLAMSLGSFLFFLTYFPAVAMHQSFERMPSKQKLIWSFDFNVGMAFGFRFLVNTDAKKTGM 428

  Fly   442 QWSNFFTPVSVD-DTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGE 505
            :|||.|  :|.| |:.....|:.|:|....||.::..|:|.|.||.:|||:||||.....:|.||
Mouse   429 KWSNIF--LSTDSDSFLFAYVLGMLLADAFIYGLVAWYIEAVFPGEYGVPKPWNFFLMHSYWFGE 491

  Fly   506 REYTGVEDIPNGHVEQRDPKAFETEPEGKHIGLQMRHLKKRF----GNKMVVKGLSMNMFEDEIT 566
            .....:|  .....|:.:.|.||.||.....|:|::||.|.|    ..|:.:|.||:|::|.::|
Mouse   492 PPQQKLE--ITQFYERVESKYFEAEPTDLTAGIQIKHLHKVFQKNNTTKVAIKDLSLNLYEGQVT 554

  Fly   567 VLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHI 631
            ||||||||||:||:|:|:|::|||||.|.::|.||..:::..|.|||:|||.|:|||.::||.|:
Mouse   555 VLLGHNGAGKSTTLSILSGLYPPTSGEAYVHGEDISQHMDQVRNSLGLCPQQNLLFDHLTVSEHL 619

  Fly   632 RFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPS 696
            .|:.|:||:..|...:|....|....|.:|.:..|..|||||||||::..||.|.:||.:.|||:
Mouse   620 YFYCRIKGVPQKMYLEETNNMLSAFNLMEKCDAFSKSLSGGMKRKLAIIIALIGGSKVAILDEPT 684

  Fly   697 SGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSG 761
            |||||::||..||:||..|..||:|||||:||||||||||||||..|.|:|.|:|.|||:.||.|
Mouse   685 SGMDPASRRSTWDILQTYKQNRTILLTTHYMDEADVLGDRIAIMVRGTLRCCGSSVFLKRLYGVG 749

  Fly   762 YRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQSDELHL 826
            ..|:.||...|:..|::.|::.|:|....|.::|.|||:.||...:.:||.:|..|||..:.|.:
Mouse   750 SHLVMVKEPYCDIAEISKLIHSYVPTATLETNVGNELSFILPKEYTHRFEALFTALEENQENLGI 814

  Fly   827 NGYGVGITSMEEVFMKVGAEKDNTGNIKDQHEIMNGGSGFRGEDDNESVQSDG-----IFSENRR 886
            :.:||.||:|||||:||...:|:..:|:.......|..|    :.|..|:|.|     ..||::.
Mouse   815 SSFGVSITTMEEVFLKVSNLEDSKTDIEATQSPSVGSKG----NKNGDVESSGRVGFPTQSEDQN 875

  Fly   887 LL--QGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITIS 949
            ::  .|..|...|::||.:|:.:|.|||...:|:|.:   ..::.|.|::|:. .|:..|...::
Mouse   876 IVFNTGCSLYLQQFRAMFMKRLMYNWRNWRGILVQIL---GLIISTFLLLKSH-EFRYKKIRQMN 936

  Fly   950 LTQYPLAV---TVLDRSNVQNGTGYEIANKYEDLARSYGSNYGLELTGTQGFEDYILDLGKTIQV 1011
            |.:|...:   ::..:||:.:.....:.|..:.      .|:  :|...||      ||.|.::.
Mouse   937 LDEYGQTIVPFSIWGKSNLTSSLLTHLENMLKP------GNH--QLKEVQG------DLLKYLEG 987

  Fly  1012 RINSRYL--VAATI----TESKITAWLNNQALHTAPLTVNMVHNAIADKLFGSSVKIQVTNAPLP 1070
            .....:|  :|.:|    ....:|...||:|.|:..|::.::.|.:...|.||...|.|.|.|.|
Mouse   988 NDECVHLCVIALSIKVVANRVNLTVLFNNEAYHSPSLSLTVLDNILFMSLSGSDASITVFNKPQP 1052

  Fly  1071 YTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQ 1135
                :...:...|:..|..:|..:...|..:.|.:.:..:.||.::.|.:||:.||.:..:|||.
Mouse  1053 ----SPQRKEWPGSTDGKIVAFKIQLGMALLVSGFCILTVTERHNKTKHMQFLSGVSILVYWLSA 1113

  Fly  1136 FICDFASYIVT-ALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATG 1199
            .:.|...:.:: ..::|:...|..:..::.:..|.. .|:|.|||::.:|..|::|..|.:..:.
Mouse  1114 LVFDLIIFFISCCFLLVMFKYCKFDIYVTDYHILDT-MLILTLFGWSAIPLTYLLSFLFSKSNSA 1177

  Fly  1200 FARVSIVNIFCGMALFIVVVVMSSEL--FDTKDTADILGWIFRIFPHFSLAMSLNKVYTNTATRN 1262
            :..:.:.....|....::..::.:.:  ..:..|...|.....:||.::|...:::.......:.
Mouse  1178 YINLLVFCYLSGTLSLLMDTIIEARISTIMSNSTQTFLLNALLLFPMYNLGKCISEYTVIYRKKM 1242

  Fly  1263 AC-AKAGALPPILLCELVPQCCN---LKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLIN 1323
            .| .:..||..:       .|.|   .|..::.::|.:....:.|::.|.||.|:|...|
Mouse  1243 LCIQQKNALKYL-------NCSNKHTKKNIYSLKKPMLGKYLIAMSIAGFVFLLLIFFWE----- 1295

  Fly  1324 ELMFKIRQLI---------SKPPPPPTEGQL-----DDDVANERERILQMSSNELATKNLVLDRV 1374
            .:.:|::..|         .|..|.....:|     |:||.|||..||......|....|:.: :
Mouse  1296 NISWKVKMFIHQHIYFGACKKYKPDIISKELSGTSEDNDVENERREILYQPEKFLNCPVLIKE-L 1359

  Fly  1375 TKYYGQ---FMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNM 1436
            ||.|.:   .:||..:||.:||..||||||.|||||||||:::||:...::|..::.|:||..|:
Mouse  1360 TKIYFKSPLILAVKNISLAIQERACFGLLGFNGAGKTTTFQILTGENIPTAGDVFIDGISLTKNI 1424

  Fly  1437 NSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYS 1501
            ..:...|||||||||||:.:||.|::.::..:.|:.|.:|:...:....|.....|.:.....||
Mouse  1425 VKVRSKIGYCPQFDALLEYMTGWEIMIMYARIWGISEHQIQPYVKKYLNSLDLESHANSLISTYS 1489

  Fly  1502 GGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALC 1566
            .||||:||||||.:|.||||:||||:|||||.|||.||:.|.:||:|||:|::||||||||||||
Mouse  1490 EGNKRRLSTAIATMGKPSVIFLDEPSTGMDPRARRLLWDTVIKIRESGKAIIITSHSMEECEALC 1554

  Fly  1567 TRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQ 1631
            |||:|||.|...|:||.|:|||||....|||.||:                            |.
Mouse  1555 TRLSIMVRGRLTCLGSPQYLKNKFGNIYILKAKVK----------------------------SG 1591

  Fly  1632 RDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLE 1696
            ..:|..|.|:...:|.|.||:|.||||.:.||.....|.::||::|..::|.|:||||:||.||:
Mouse  1592 ETLDEFKNFITLTFPGSELQQENQGILNYCIPRKNNSWGKVFGILEKAKEQYNLEDYSISQITLD 1656

  Fly  1697 EIFLEFAKYQRE 1708
            ::||.||...|:
Mouse  1657 QVFLSFADQDRK 1668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	52/179 (29%)
		ABC2_membrane_3	<269..475	CDD:289468	60/206 (29%)
		CcmA	538..843	CDD:224054	152/308 (49%)
		ABC_subfamily_A	538..755	CDD:213230	116/220 (53%)
		ABC2_membrane_3	913..1316	CDD:289468	84/418 (20%)
		ABC_subfamily_A	1369..1587	CDD:213230	112/220 (51%)
		drrA	1376..1702	CDD:130256	151/328 (46%)
Abca15	NP_796187.2	ABC2_membrane_3	144..464	CDD:289468	100/324 (31%)
		ABC2_membrane	<267..383	CDD:304374	35/116 (30%)
		CcmA	522..831	CDD:224054	152/308 (49%)
		ABC_subfamily_A	522..743	CDD:213230	116/220 (53%)
		ABC2_membrane_3	<1009..1231	CDD:289468	49/226 (22%)
		CcmA	1354..1648	CDD:224054	144/322 (45%)
		ABC_subfamily_A	1354..1575	CDD:213230	112/221 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838478
Domainoid	1	1.000	180	1.000	Domainoid score	I3485
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1133	1.000	Inparanoid score	I220
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		mtm8719
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810