Protein Alignment ABCA and CG34120

DIOPT Version :9

• Sequence 1: NP_608445.2
• Gene: ABCA / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Sequence 2: NP_001285513.1
• Gene: CG34120 / 318066
• FlyBaseID: FBgn0083956
• Length: 1998
• Species: Drosophila melanogaster
• Alignment Length: 1685
• Identity: 383/1685 - (22%)
• Similarity: 701/1685 - (41%)
• Gaps: 355/1685 - (21%)

  Fly   118 VEEAWQSLGKNKICESENATQLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELR 182
            :||:.......|:  |.:|:..|..|:|.::..||..::.... ||...:..|
  Fly   513 LEESGDEKAAPKV--SASASDHEATTISPSSLDGVTTEEVRVT-TEQTVVSGD------------ 562

  Fly   183 TATIAIANTWLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQDLP 247
                            |  ||...:||     .:.....|:|...|......:....|..:.::.
  Fly   563 ----------------P--DLLLLKNE-----DVLKRSKRQGLFDLLGGFGGSGDANKKNKFEVD 604

  Fly   248 NV--VMKRYPFPAYIFDPLLEGM---SSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMG 307
            |:  ..|::|:||::.|....|:   ..:....:|...::....:.:.|.. :|.:...:|:.||
  Fly   605 NMQFYTKQFPYPAFLNDVFKRGLYLAQGVQVAYLLGLVVFVALSVRERIWM-RESRNSMLMRSMG 668

  Fly   308 LSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFM 372
            |.......||.:.||:.|   .::.|::..:.:|.  .:|.:.|:..::|:.:.:.:..|.||:|
  Fly   669 LKAHSELVAWALMSFLEL---CVIFALISGVLYSG--GILGYTNWFFMMFYCLSFGLCLISFCYM 728

  Fly   373 MATFFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGT 437
            ...||:.|:..|..:.|::||:..|:...:.....||:.......|...||...|...::..|..
  Fly   729 CTNFFNSANIGAVASALLFFISLCPFIIVLMFDAKLSVFESFLVDLSFTTAFAKGWGELIRMELQ 793

  Fly   438 GEGLQWSNFFTPVSVDDTLTLG-------AVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNF 495
            .|||         :|...:.:|       ..::|.|:..::|.:|.|..::       ..:..|:
  Fly   794 QEGL---------TVRHLIQVGPARSECAMALLMFLLDLLLYAVIGLAYQR-------YKKTDNY 842

  Fly   496 PFTREFWCGEREYTGVEDIPNGHVEQRDPKAFETEPEGKHIGLQMRHLKKRFGNKMVVKGLSMNM 560
            .|.                          |...::.:|| :|..:.::.|.:|:|..|..||::.
  Fly   843 SFV--------------------------KVSRSQLDGK-LGASLVNVSKLYGSKCAVSNLSLDF 880

  Fly   561 FEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEM 625
            ..::::.|||.|||||:|.|.:|||....:||..::.|..          .:|:|.|.|:|...:
  Fly   881 ARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAGEH----------QVGVCWQDNILIPTL 935

  Fly   626 SVSNHIRFFSRMK----GLRG-KAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCG 685
            :...|::.::::|    |..| :.:..|||:.|:.:......:..|.:||||.:|:|.|..|...
  Fly   936 TAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQSLNFGKHESYPSWQLSGGYRRRLCVAIAFIA 1000

  Fly   686 DTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGT 750
            ...||:.|||.:|:|..||:.:|.|:::.:.||.::..|||||||..|.|.:.||.:|.:..|.:
  Fly  1001 SPSVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLVIMRNGRIIAQHS 1065

  Fly   751 SFFLKKQYGSGY--RLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDS--ASAKFE 811
            ...|::...|.|  ||.|     .:...||.::.| ...|.|:..:....:...|.|  .:|.:.
  Fly  1066 RDSLQRLCTSNYSIRLRC-----ADATGVTFVIQK-AQQLLPQTQVTHSGAADYPHSLTINASYA 1124

  Fly   812 EMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKD----NTGNIKDQHEIMNGGSGFRGEDDN 872
            |            ||....|....:.:..:..|:..|    .:.:::.:.|.:|.    .|||..
  Fly  1125 E------------HLTPGAVEFLELLQSQVTAGSISDVELTTSSSLEQEFEQLNR----NGEDAG 1173

  Fly   873 ESVQSDGIFSENRRLLQGLQLLSN-------QWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVT 930
            ....:    |:...::.|..::::       |::.::.|:..:..||..|||...::|..|.:..
  Fly  1174 PRRPA----SDRSGVVAGPAMITDEPPTACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCA 1234

  Fly   931 ILII--KTQGTFQELKPITISLTQYPLAVTVLDRSNVQNGTGYEIANKYEDLARSYGSNYG---L 990
            :..:  :.:..|..:.|::.||  ||.....|..   :..|.:  :.|.....|:...:.|   :
  Fly  1235 MWFVSYRLEDDFDTVLPLSRSL--YPQTAQFLSH---ERATSF--SEKLYPQLRTSCDHLGECRV 1292

  Fly   991 ELTGTQGFEDYILDLGKTIQVRINSRYLVAATITESKITAWLNNQALHTAPLTVNMVHN-AIADK 1054
            ..|..|.: |::|:.......|....|    .:..|..|.|.||:..|:....:|.::: .:...
  Fly  1293 FNTSQQSY-DWVLNSWGEYSERRYGGY----GLNGSGATVWYNNKGYHSMMAWLNDLNSELLRTT 1352

  Fly  1055 LFGSSVKIQVTNAP-----LPYTTSTLLSQLSTGNNLGTQLASNLCFCMCFVS-SIYILFLIKER 1113
            :..|...|...|.|     ...:||::|.|...|:.:...|   :.|.:...| |:|   |:.||
  Fly  1353 MNDSESSILTLNEPWKLGFAELSTSSILRQAGDGSMVFILL---IAFGLVVASGSVY---LVNER 1411

  Fly  1114 ESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTF-------GELGRY 1171
            .:..||.|.:.||...|:||...:.|:...::..::.::.|:.|   |:..|       |.:|
  Fly  1412 VNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMF---GMPVFVDRQQLVGIIG-- 1471

  Fly  1172 YLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCG--------MALFIVV-VVMSSELFD 1227
              |.|.|.||.:|.:::....|.:     :.::||:|||.        |.:.::: ||.....:|
  Fly  1472 --LSLAFSFACVPSVHVAEKIFSD-----SSIAIVSIFCANLIVPLVTMGIILILGVVGDGPAWD 1529

  Fly  1228 TKDTADILGWIFRIFPHFSLA---MSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYF 1289
              |....|...|.|||..:|.   :.|.|.|                   :..||.:..::..|
  Fly  1530 --DWRHALNQAFLIFPIHALGDGFLELCKNY-------------------MVALVFRRYDIDSY- 1572

  Fly  1290 AWEEPGVLPETVY------MAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQLDDD 1348
              :.|  |...:.      :.:.||...:|.:::|:.|:..|..::.:|            ||..
  Fly  1573 --KHP--LASDLLGRHFTALLLVGVAALIINVLIEWHLLRRLWQRVERL------------LDCT 1621

  Fly  1349 VANERERILQM--------------SSNELATKNLVLDRVTKYYGQFMAVNQVSLCVQEVECFGL 1399
            ...|.:::.|:              :...:..:||.|.....:|    ||..|:..||..|||||
  Fly  1622 YRRELDKLGQLKLVNIQSIFKSCVDTGEAVRAENLWLAYRRGHY----AVRNVNFSVQRGECFGL 1682

  Fly  1400 LGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIY---KMIGYCPQFDALLDDLTGREV 1461
            ||.|||||:|.||::||              .|:.::..||   ..|.||||.:.|...||..|.
  Fly  1683 LGKNGAGKSTIFKLLTG--------------QLQPDVGQIYFEQPGISYCPQSNPLDPLLTTTEC 1733

  Fly  1462 LRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEP 1526
            :|.:..|||:::  :.|..:.:..::....:.|.|....||||:|||:.|:...|....:.:|||
  Fly  1734 IRFYGRLRGIRD--LDQFLDRVLDTYELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEP 1796

  Fly  1527 TTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFS 1591
            |:.|||..|..::..:.::..:.:::||||||:.|.|.||.|:|::..|:.....|.|.||::
  Fly  1797 TSDMDPVTRDMVYATIEQLLLARRAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSE-- 1859

  Fly  1592 KGLILKIKVRRNLEALRQARLSGGYAR-----NPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQ 1651
                                 .|||..     .|.:|.:.::...:.:...::.
  Fly  1860 ---------------------HGGYYAVTCFCGPAQQAILSRSLNQRLPGARDL----------- 1892

  Fly  1652 EEYQGILTFYI-----------PLTGVKWSRIFGLMESNRDQ-LNVEDYSVSQTTLEEIF 1699
            :.|...|.|.:           ||.    |.:|.::   .|. :||..:|:|:...|.:|
  Fly  1893 QHYAHSLRFLVRVRSPGSLGDAPLL----SELFAIL---CDVCVNVARFSLSRCRFETVF 1945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	40/182 (22%)
		ABC2_membrane_3	<269..475	CDD:289468	44/212 (21%)
		CcmA	538..843	CDD:224054	88/313 (28%)
		ABC_subfamily_A	538..755	CDD:213230	70/221 (32%)
		ABC2_membrane_3	913..1316	CDD:289468	95/439 (22%)
		ABC_subfamily_A	1369..1587	CDD:213230	76/220 (35%)
		drrA	1376..1702	CDD:130256	95/344 (28%)
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468	31/144 (22%)
		ABC_subfamily_A	859..1073	CDD:213230	71/223 (32%)
		drrA	865..1162	CDD:130256	90/324 (28%)
		ABC2_membrane_3	1230..1601	CDD:289468	91/426 (21%)
		Mem_trans	1436..>1552	CDD:304621	30/129 (23%)
		ABC_subfamily_A	1651..1857	CDD:213230	77/225 (34%)
		drrA	1666..1945	CDD:130256	93/335 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451224
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I138
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm46598
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	P	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.800