DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and Abca1

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_038965774.1 Gene:Abca1 / 313210 RGDID:631344 Length:2263 Species:Rattus norvegicus


Alignment Length:1927 Identity:632/1927 - (32%)
Similarity:974/1927 - (50%) Gaps:348/1927 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 HKWQMVIELVLPAIFSLL-----LVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRSSYLGKL 83
            |..:.:.|.:.|.|::.:     :.||||::|:  :|...:.|:.|..|:.....         :
  Rat   410 HDLEGMWEELSPQIWTFMESSQEMDLVRTMLDS--RGNDQFWERKLDGLDWTAQD---------I 463

  Fly    84 IALIAPNR---RRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICESENATQLE----- 140
            :|.:|.|.   :..||  |.:.:...::..|..::.:          ::..|..|..:||     
  Rat   464 MAFLAKNPEDVQSPNG--SVYTWREAFNETNQAIQTI----------SRFMECVNLNKLEPIPTE 516

  Fly   141 -------LDTVSKNAF-AGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRL 197
                   ::.:.:..| ||:.|.....:..|   ||:...:.:|         :.|.|...|.::
  Rat   517 VRLINKSMELLDERKFWAGIVFTGITPDSVE---LPHHVKYKIR---------MDIDNVERTNKI 569

  Fly   198 FPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQDLPNVVMKRYPFPAYIFD 262
            .......|||.:..:|    ..|:..||..||..:..|.:|..:|.:....|.:::.|:|.|:.|
  Rat   570 KDGYWDPGPRADPFED----MRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYVQQMPYPCYVDD 630

  Fly   263 PLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTI 327
            ..|..||..|.|.:.|::||....|.|.|..|||.:|||.|:||||.|.:.|.:||:.|.|.|.:
  Rat   631 IFLRVMSRSMPLFMTLAWIYSVAVIIKSIVYEKEARLKETMRIMGLDNGILWFSWFISSLIPLLV 695

  Fly   328 SAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWF 392
            ||.|:.|::|:.     .:|.:::.:.:..||.::.|.:|..||:::|.|||.:.|||..|:|:|
  Rat   696 SAGLLVIILKLG-----DLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRTNLAAACGGIIYF 755

  Fly   393 IAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLT 457
            ..|:||...:...|.:..|.|:..||:|..|.|||.:....||..|.|:||.|.|.....:|...
  Rat   756 TLYLPYVLCVAWQDYVGFSIKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFKSPVEEDGFN 820

  Fly   458 LGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTGVEDIPNGHVEQR 522
            |...:.|||....||.::..|:|.|.||.:|:||||.||.|:.:|.||.  ...:..|....:..
  Rat   821 LTTSVSMMLFDTFIYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEE--IDEKSHPGSSQKGA 883

  Fly   523 DPKAFETEPEGKHIGLQMRHLKK--RFGNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTG 585
            .....|.||....:|:.:::|.|  |.|.|:.|.||::|.:|.:||..|||||||||||:|:|||
  Rat   884 SEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTG 948

  Fly   586 MFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVA 650
            :||||||||.|.|.|||:.:...|.:||:|||||||||.::|..||.|::|:|||..|.|:.|:.
  Rat   949 LFPPTSGTAYILGKDIRSEMNSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEME 1013

  Fly   651 KYLKMIEL-EDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQE 714
            :....:.| ..|....:|:|||||:|||||..|..|.:|||:.|||::|:||.:||.:|:||.:.
  Rat  1014 QMALDVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY 1078

  Fly   715 KVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRD------DCE 773
            :.|||::|:||.|||||:|||||||:..|:|.|.|:|.|||.|.|:||.|..||:|      .|.
  Rat  1079 RQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCR 1143

  Fly   774 -----------------------------------TNEVTA---LLNKYIPGLKPECDIGAELSY 800
                                               |.:|:|   |:.|::...:...|||.||:|
  Rat  1144 NSSSTVSCLKKVVPELPAAGQSGGRGGEVQRLVALTQDVSAISNLIRKHVSEARLVEDIGHELTY 1208

  Fly   801 QLPDSASAK--FEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAE--------------KDN 849
            .||..|:.:  |.|:|.:::::..:|.::.||:..|::||:|:||..|              :.|
  Rat  1209 VLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRN 1273

  Fly   850 TGNIKDQHEIMNGGSGFRGED---------DNESVQSD---GIFSENRRLLQGLQLLSNQWKAML 902
            .....|:...::   .|..:|         |.||.::|   |:..:....|:|.:|...|:.|:|
  Rat  1274 RRAFGDKQSCLH---PFTEDDAVDPNDSDLDPESRETDLLSGMDGKGSYQLKGWKLTQQQFVALL 1335

  Fly   903 LKKFLYTWRNKLLLLIQNIMPVFFVVVTI---LIIKTQGTFQELK-------------------- 944
            .|:.|...|::.....|.::|..||.:.:   ||:...|.:..|:                    
  Rat  1336 WKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPNLELQPWMYNEQYTFVSNDAPED 1400

  Fly   945 --------------------------PITISL------TQYPLAVTVLD---RSN---------- 964
                                      |.|..|      |..|:..|::|   ..|          
  Rat  1401 MGTQELLNALTKDPGFGTRCMEGNPIPNTPCLVGEEDWTTGPVPQTLMDLFQNGNWTMKNPSPSC 1465

  Fly   965 ---------------------------------VQNGTG-----YEIANKYEDLARS-------- 983
                                             :||.||     |.:....:.:|:|        
  Rat  1466 QCSSDKIKKMLPVCPPGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTYVQIIAKSLKNKVWVN 1530

  Fly   984 ---YGS-NYGLE----LTGTQGFEDYILDLGKTIQVRINS---RYL------VAATITESKITAW 1031
               ||. :.|:.    |..:|...:.|..:.|.:::..:|   |:|      :....|::.:..|
  Rat  1531 EFRYGGFSLGVSDSQALPPSQEVNNAIKQMKKLLKLTKDSSADRFLSSLGRFMTGLDTKNNVKVW 1595

  Fly  1032 LNNQALHTAPLTVNMVHNAI--ADKLFG---SSVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLA 1091
            .||:..|.....:|:::|||  |:...|   |...|...|.||..|...|........::...::
  Rat  1596 FNNKGWHAISSFLNVINNAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVS 1660

  Fly  1092 SNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVC 1156
            ..:.|.|.||.:.:::|||:||.|:||.|||:.|||...:|||.|:.|..:|:|.|.:|||..:|
  Rat  1661 ICVIFAMSFVPASFVVFLIQERVSKAKHLQFICGVKPVIYWLSNFVWDMCNYVVPATLVVIIFIC 1725

  Fly  1157 FQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVM 1221
            ||:....:...|....|||||:|:::.|.:|..|..|:.|:|.:..::.||:|.|:...:...|:
  Rat  1726 FQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVL 1790

  Fly  1222 SSELFDT---KDTADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGA---LPPILLCELVP 1280
              |||..   .|..|||..:|.|||||.|...|..:..|.|..:|..:.|.   :.|:       
  Rat  1791 --ELFTNNKFNDINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPL------- 1846

  Fly  1281 QCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQL 1345
                     :|:..|  .....|||.||||||:.:::::|      |.||....|...||...: 
  Rat  1847 ---------SWDLVG--RNLFAMAVEGVVFFLVTVLIQYR------FFIRPRPVKARLPPLNDE- 1893

  Fly  1346 DDDVANERERILQ-MSSNELATKNLVLDRVTKYYGQFM--AVNQVSLCVQEVECFGLLGVNGAGK 1407
            |:||..||:|||: ...|::    |.:..:||.|.:..  ||:::.:.:...|||||||||||||
  Rat  1894 DEDVRRERQRILEGGGQNDI----LEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGK 1954

  Fly  1408 TTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQ 1472
            |:||||:|||..::.|.|.:...|:.||::.:::.:||||||||:.:.|||||.|..|.:||||.
  Rat  1955 TSTFKMLTGDTAVTRGDALLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHLEFFALLRGVP 2019

  Fly  1473 ESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQ 1537
            |..:.::.|...:..|.:|:.:|....||||||||||||||:||.|.|::||||||||||.|||.
  Rat  2020 EKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNKRKLSTAIALIGGPPVVFLDEPTTGMDPKARRF 2084

  Fly  1538 LWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRR 1602
            |||....|...|:|:||||||||||||||||:||||||.|:|:||.|||||:|..|..:.:    
  Rat  2085 LWNCALSIIKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVV---- 2145

  Fly  1603 NLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGV 1667
                    |::|.   ||            |:..|:||....:|.|:|:|:::.:|.:.:|.:..
  Rat  2146 --------RIAGS---NP------------DLKPVQEFFGLAFPGSVLKEKHRNMLQYQLPSSLS 2187

  Fly  1668 KWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQRED 1709
            ..:|||.::..::.:|::||||||||||:::|:.|||.|.:|
  Rat  2188 SLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDD 2229

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 68/179 (38%)
ABC2_membrane_3 <269..475 CDD:289468 77/205 (38%)
CcmA 538..843 CDD:224054 151/353 (43%)
ABC_subfamily_A 538..755 CDD:213230 116/219 (53%)
ABC2_membrane_3 913..1316 CDD:289468 132/544 (24%)
ABC_subfamily_A 1369..1587 CDD:213230 121/219 (55%)
drrA 1376..1702 CDD:130256 153/327 (47%)
Abca1XP_038965774.1 rim_protein 1..2238 CDD:130324 632/1927 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 158 1.000 Domainoid score I4008
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.830

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