DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and Abca4

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_001101191.1	Gene:	Abca4 / 310836	RGDID:	1309445	Length:	2290	Species:	Rattus norvegicus

Alignment Length:	1931	Identity:	601/1931 - (31%)
Similarity:	940/1931 - (48%)	Gaps:	371/1931 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VRTLVDT-EQKG--VRYYNE------------QNLTDLNLLQHSLHRSSYLGKLIALIAPNRRRK 94
            ||.||.. |:.|  :.|:.|            |:.|..:.:...|.......:.|....||..|:
  Rat   405 VRKLVKAWEEVGPQIWYFFEKSTQMAVIRDTLQHPTVKDFINRQLGEEGITTEAILNFFPNGPRE 469

  Fly    95 N--GGFSKFEFILCYS-------PVNPVLKKLVEEAWQSLGKNKICESENATQLELDTVSKNAF- 149
            |  ...:.|::...::       ..|..|:.||.:.::|..     :....||..|..:.:|.|
  Rat   470 NQADDMTSFDWRDIFNITDRFLRLANQYLECLVLDKFESYD-----DEVQLTQRALSLLEENRFW 529

  Fly   150 AGVQFDD--AWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLFPTIDLTGPRNEGDD 212
            |||.|.|  .|.:     .||....:.:|...::...|..|.:.:..         :|||.:..:
  Rat   530 AGVVFPDMYPWTS-----SLPPHVKYKIRMDIDVVEKTNKIKDRYWD---------SGPRADPVE 580

  Fly   213 DGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQDLPNVVMKRYPFPAYIFDPLLEGMSSIMSLIIL 277
            |.    .|:..||..||..:....:|.::..:....|.:::.|:|.::.|..:..::....:.::
  Rat   581 DF----RYIWGGFAYLQDMVEQGIVRSQTPAEPPIGVYLQQMPYPCFVDDSFMIILNRCFPIFMV 641

  Fly   278 LSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSE 342
            |::||..:...|.|..|||.:|||.:|..|:||.:.|..||:.||.::::|..|:.:.:...
  Rat   642 LAWIYSVSMTVKGIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTLFIMHG--- 703

  Fly   343 DVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTINSYDD 407
              .:|.:::...|..||:.:..::|..||:.:||||:||.|||.:|:|:|..|:|:.......|.
  Rat   704 --RILHYSDPFILFLFLLAFATATIMQCFLFSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDR 766

  Fly   408 LSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIY 472
            ::...|...||:|..|.|||.:.::.||..|.||||||........|..:....|.|||:...:|
  Rat   767 MTADLKTTVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGKSPLEGDEFSFLLSMKMMLLDAALY 831

  Fly   473 MIICLYVEQVMPGSFGVPRPWNFPFTREFW-----CGEREYTGVEDIPNGHVEQRDPK-----AF 527
            .::..|::||.||.:|.|.||.|.....:|     |..||...:|.......|..||:     .|
  Rat   832 GLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEEIEDPEYPEDSFF 896

  Fly   528 ETEPEGKHIGLQMRHLKKRF--GNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPT 590
            |.|..|...|:.:::|.|.|  |::..|..|::..:|::||..|||||||||||:|:|||:.|||
  Rat   897 ERELPGLVPGVCVKNLVKVFEPGSRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPT 961

  Fly   591 SGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKM 655
            |||.:|.|.||..:::..|.|||:|||||:||..::|:.||.|::::||...:....|:...|:.
  Rat   962 SGTVLIGGKDIEISLDAVRQSLGMCPQHNILFHHLTVAEHILFYAQLKGRSWEEARLEMEAMLED 1026

  Fly   656 IELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTL 720
            ..|..|.|..:..|||||:|||||..|..||:|||:.|||:||:||.:||.:||||.:.:.|||:
  Rat  1027 TGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDSKVVVLDEPTSGVDPYSRRSIWDLLLKYRSGRTI 1091

  Fly   721 LLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVK--------RDDCE---- 773
            :::||.|||||:|||||||:..|.|.|.||..|||..:|:|:.|..|:        |..||
  Rat  1092 IMSTHHMDEADLLGDRIAIISQGRLYCSGTPLFLKNCFGTGFYLTLVRKMKNIQSQRCGCEGACS 1156

  Fly   774 --------------------------TNEVTALLNKYIPGLK-PECDIGAELSYQLPDS--ASAK 809
                                      ..|:|.|:..::|..| .|| ||.||.:.||:.  ....
  Rat  1157 CTSKGFSARCPARVDEITEEQVLDGDVKELTDLVYHHVPEAKLVEC-IGQELIFLLPNKNFKQRA 1220

  Fly   810 FEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDN----TGNIKDQHEIMNGGSGFR--- 867
            :..:|.:|||...:|.|:.:|:..|.:||:|:||..:.::    .|..:.:.|    .:|.|
  Rat  1221 YASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSESGSKFVGGTQQKRE----HTGLRHPC 1281

  Fly   868 -------------------GEDD------NESVQSDGI-FSENRRL-LQGLQLLSNQWKAMLLKK 905
                               |:.|      :...:..|| |:...|| ||.:|       |:|:|:
  Rat  1282 SAPVEKHRQHAQASHTCSPGQVDPPKGQPSPEPEDPGIPFNTGARLILQHVQ-------ALLVKR 1339

  Fly   906 FLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQY----------------- 953
            |.:..|::...:.|.::|..||.:.:::......|.|...:|:....|
  Rat  1340 FHHAVRSRKDFVAQIVLPATFVFLALMLSIIVPPFGEFPALTLHPWMYGHQFTFFSMDEPNNEHL 1404

  Fly   954 -PLAVTVLDRSNVQN-------------------------------------------------- 967
             .||..:|:|....|
  Rat  1405 EVLADVLLNRPGFGNRCLKEEWLPEYPCGNATSWKTPSVSPNITHLFQKQKWTAAHPSPACKCST 1469

  Fly   968 ------------GTG---------------YEIANK---------YEDLARS------------Y 984
                        |.|               .::.|:         |..|.||            |
  Rat  1470 REKLIMLPECPEGAGGLPPPQRIQRSTEVLQDLTNRNISDYLVKTYPALIRSSLKSKFWVNEQRY 1534

  Fly   985 GSNYGLELTGT--------QGFEDYILDLGKTIQV------RINSRYL---VAATITESKITAWL 1032
            |   |:.:.|.        :....::.|||:.:.|      |.:||.:   :....|:..|..|.
  Rat  1535 G---GISIGGKLPDIPISGEALVGFLSDLGQMMNVSGGPVTRESSREMLDFLKHLETKDNIKVWF 1596

  Fly  1033 NNQALHTAPLTVNMVHNAIADKLFGSSVK--------IQVTNAPLPYTTSTL--LSQLSTGNNLG 1087
            ||:..|.....:|:.||||   |..|..|        |.|.:.||..|...|  ::.|:|  ::.
  Rat  1597 NNKGWHALVSFLNVAHNAI---LRASLPKDRDPEEYGITVISQPLNLTKEQLSEITVLTT--SID 1656

  Fly  1088 TQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVI 1152
            ..:|..:.|.|.||.:.::|:||:||.::||.|||:.||...|:|::.|:.|..:|.|:|.:||.
  Rat  1657 AVVAICVIFAMSFVPASFVLYLIQERVTKAKHLQFISGVSPTTYWMTNFLWDIMNYAVSAGLVVG 1721

  Fly  1153 TIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIV 1217
            ..:.||:...::...|.....||:|:|:||:|.:|..|..|..|:|.:..:|..|:|.|:....:
  Rat  1722 IFIGFQKKAYTSTDNLPALVTLLMLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAI 1786

  Fly  1218 VVVMSSELFDTKDT----ADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAG----ALPPIL 1274
            ..|:  |||:....    :..|..:..:||||.|...|..:..:.|..:..|:.|    |.|
  Rat  1787 TFVL--ELFENNRMLLRFSATLRELLIVFPHFCLGRGLIDLALSQAVTDIYAQFGEEYSANP--- 1846

  Fly  1275 LCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPP 1339
                          |.|:..|  ...|.||:.|||:||:.::::..      |.:.:.|::|...
  Rat  1847 --------------FQWDLIG--KNLVAMAIEGVVYFLLTLLIQHH------FFLTRWIAEPARE 1889

  Fly  1340 PTEGQLDDDVANERERILQMSSNELATKNLVLDRVTKYY--GQFMAVNQVSLCVQEVECFGLLGV 1402
            |...: |||||.||:|::...|.   :..|.|:.:||.|  ....||:::.:.|...||||||||
  Rat  1890 PVFDE-DDDVAEERQRVMSGGSK---SDILKLNELTKVYSGSSSPAVDRLCVGVHPGECFGLLGV 1950

  Fly  1403 NGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCM 1467
            |||||||||||:|||..::||.|.:.|.|:.:|::.:::.:||||||||:.|.|||||.|.::..
  Rat  1951 NGAGKTTTFKMLTGDTTVTSGDATIAGKSILTNISDVHQNMGYCPQFDAIDDLLTGREHLYLYAR 2015

  Fly  1468 LRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDP 1532
            ||||....|.:::....:|.|...:.|:....||||||||||||||:.|.|.::.||||||||||
  Rat  2016 LRGVPSKEIEKVANWGIQSLGLSLYADRLAGTYSGGNKRKLSTAIALTGCPPLLLLDEPTTGMDP 2080

  Fly  1533 AARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILK 1597
            .|||.|||.:..|...|:::|||||||||||||||||||||.|.|:|:|:.||||.||..|.|:.
  Rat  2081 QARRMLWNTIVNIIRQGRAVVLTSHSMEECEALCTRLAIMVKGTFQCMGTIQHLKYKFGDGYIVT 2145

  Fly  1598 IKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYI 1662
            :|:                 ::|.:..:|      |::.|::|.:..:|.|:.:|.:..:|.|.:
  Rat  2146 MKI-----------------KSPKDDLLP------DLNPVEQFFQGNFPGSVQRERHHSMLQFQV 2187

  Fly  1663 PLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQRE 1708
            |.:.:  :|||.|:.|::|.|.:|:|||:||||:::|:.|||.|.|
  Rat  2188 PSSSL--ARIFQLLISHKDSLLIEEYSVTQTTLDQVFVNFAKQQTE 2231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	55/179 (31%)
		ABC2_membrane_3	<269..475	CDD:289468	67/205 (33%)
		CcmA	538..843	CDD:224054	141/347 (41%)
		ABC_subfamily_A	538..755	CDD:213230	108/218 (50%)
		ABC2_membrane_3	913..1316	CDD:289468	125/553 (23%)
		ABC_subfamily_A	1369..1587	CDD:213230	120/219 (55%)
		drrA	1376..1702	CDD:130256	151/327 (46%)
Abca4	NP_001101191.1	rim_protein	1..2249	CDD:130324	601/1931 (31%)
		ABC_subfamily_A	907..1126	CDD:213230	108/218 (50%)
		ABC_subfamily_A	1915..2135	CDD:213230	120/219 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342278
Domainoid	1	1.000	163	1.000	Domainoid score	I3872
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.660