DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and Abca6

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_006247716.1 Gene:Abca6 / 303639 RGDID:1308998 Length:1630 Species:Rattus norvegicus


Alignment Length:1817 Identity:453/1817 - (24%)
Similarity:822/1817 - (45%) Gaps:350/1817 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHR 76
            :||.||...:|..|.:.::|..:|.:..|.:.|           ..|:.|.|             
  Rat    18 VLLHKNLLKKWRMKRESLLEWSIPVVIGLYMGL-----------FSYFKENN------------- 58

  Fly    77 SSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVE--------EAWQSLGKNKICES 133
                  .:..:.|........|:....::.|:|::.|.::::.        :..:.:|   :...
  Rat    59 ------QVPEVPPQDLGSIDEFNGSSIMVVYTPISNVTQQIMNKTITAPTMKGTRIVG---VPSE 114

  Fly   134 ENATQLELDTVSKNAFAGVQFDDAW-----ANLTENDP-LPNDFHFALRFPAELRTATIAIANTW 192
            ::..::.||.|.: || |:.|:|.:     ..|...:| |..|.                :|:.|
  Rat   115 KDLDEMLLDHVPR-AF-GIVFNDTFFYKLKVYLMYGNPFLKEDL----------------LAHCW 161

  Fly   193 LTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQDLPNVV------M 251
            .|   :|.:..:..|            |.:.||:.||.:::.|.:...:....:..::      |
  Rat   162 DT---YPHVFCSLTR------------YWKRGFVALQTAINAAIIEVTTKHPVMEELMSVNAFNM 211

  Fly   252 KRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTA 316
            |..||.:.  |.....:..:..|:...||||   :.::.:|.|: |..||.||:|||.:...|.:
  Rat   212 KTLPFISK--DIFQYEIFILFCLLYFSSFIY---FASRSVTKER-KHSKEFMKVMGLQDSAFWLS 270

  Fly   317 WFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRAS 381
            |.:.....:.|.::.||:::.   |..:.|:|  .|..:.....:|.:|.|...|:||....:  
  Rat   271 WGLIYVGFIFIFSVFIAVIIT---STRIIVMT--GFLVIFTLFFLYGLSVIAVTFLMAVLLQK-- 328

  Fly   382 TAAAVTGLIWFIAYIPY---SFTINSYDDLSLSSKLGW--SLISNTAMGFGIKLILGFEGTGEGL 441
              |.:|.|..|:..:.:   .||:...:   |.|.|.|  |:.|..|...|:..|:..|....|:
  Rat   329 --AIITNLFVFLFNLFWGCVGFTVLHKE---LPSSLEWVLSICSPFAFTSGMTKIIFLEYNLNGV 388

  Fly   442 QWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGE- 505
            .:     |....::..:.||..::....::|:::.||.::::|                  ||. 
  Rat   389 VF-----PDPSGESYVMIAVFFILAFDGLLYLVLALYFDKILP------------------CGAD 430

  Fly   506 ---------------REYTGVEDIPNGHVEQRDPKAFETEP-----EGKHIGLQMRHLKKRF--- 547
                           |:.|....:....::...|.....||     :||. .:::|:::|.:   
  Rat   431 RRAAPLFFLNPVSCFRKRTSRNKVTERDIDPELPSDEYFEPVDPEYQGKE-AIRIRNIRKEYKGK 494

  Fly   548 -GNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAII---NGSDIRTNIEGA 608
             |....:|||..:::|.:||.:|||.||||::.:::|.|:..||||.|.:   |.|::: :::..
  Rat   495 SGKVEALKGLFFDVYESQITAVLGHGGAGKSSLLNILNGLSVPTSGLATVYNKNLSEMQ-DLKEI 558

  Fly   609 RMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGM 673
            |..:|:||||||.||.::|..::..|:.:||:..::|.|||.:.|..::::...:..:..||.|.
  Rat   559 RKMIGVCPQHNVQFDALTVKENLTLFANIKGIVPQSVAQEVQQILSELDMQTIQDELAEHLSEGQ 623

  Fly   674 KRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIA 738
            ||||:...|:.||.:::|.|||::|:||.:|:::|..|::.:..|.:|.:|.|.||||:|.||..
  Rat   624 KRKLTFGVAILGDPRILLLDEPTAGLDPFSRQRVWGFLKERRADRVILFSTQFTDEADILADRKV 688

  Fly   739 IMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLP 803
            |:.:|.|||.|:|.|||:::|.||.|.....:.|::.::|:.:|.:|||.|.:.....:|.|.||
  Rat   689 ILSNGALKCTGSSVFLKRKWGLGYHLSLFMNETCDSEQLTSFINHHIPGAKLKAKTKEKLVYTLP 753

  Fly   804 DSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQHEIMNGGSGFRG 868
            ...::||.|.|..|::.|.:..:| |.|.::::.||||.:..|...|.:.:....:.:..|    
  Rat   754 LEKTSKFPEFFSDLDKYSGQGLMN-YEVSMSTLNEVFMNLEGEPSTTQDFEKGETLTDSDS---- 813

  Fly   869 EDDNESVQSDGIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNK------LLLLIQNIMPVF-- 925
              .||...:....|:.::.:..:.|...|..|:...:.|...|.:      |.||..:::|:.  
  Rat   814 --LNEMEVAPPSLSKAQKTMSAMSLWRMQVCAIARLRVLKLRRERKAFLTFLPLLGISLIPLITE 876

  Fly   926 FVVVTILIIKTQGTFQE----LKPITISLTQYP--LAVTVLDRSNVQNGTGYEIANKYEDLARSY 984
            ::...::.:||...|:.    |.|     .|.|  |..::|..:|.:        :..||..:|.
  Rat   877 YMANALIEVKTNWEFKTDLYFLSP-----GQLPQGLRTSLLVINNTE--------SNIEDFVQSL 928

  Fly   985 -GSNYGLELTGTQGFEDYILDLGKTIQVRINSRYLVAATITESKITAWLNNQALHTAPLTVNMVH 1048
             ..|..||:   ..||    :...|..:..|...:|:....:.:.:|..|.:.||..|:.:|::.
  Rat   929 KHQNIVLEV---DDFE----NRNATESLSYNGAIIVSGRQKDYRFSAVCNTKRLHCFPILMNVIS 986

  Fly  1049 NAIADKLFGSSVKIQVTNAPLPYTTSTLLSQ--LSTGNNL---GTQLAS-NLCFCMCFVSSIYIL 1107
            |.|          :::.|    :|....|.:  ||:|..:   |...|| ::.|.:|.||....:
  Rat   987 NGI----------LRMLN----HTQHIRLEEDVLSSGIVVVWFGILEASLSILFIVCSVSPHIAM 1037

  Fly  1108 FLIKERESRAKLLQFVGGVKVWTFWLSQFICD---FASYIVTALIVVIT-----IVCFQETGLST 1164
            ..|.:.:.:|....::.|:....:|..|.:.|   .:..::|..|.:.|     |....|..|| 
  Rat  1038 SSISDFKKKADSQLWISGLYPSAYWCGQALVDITLLSGILLTGYITLYTTKLMHIYLTGEIVLS- 1101

  Fly  1165 FGELGRYYLLLLLFGFAV-LPFI-YIMSLFFREPATGFARVSIVNIFCGMALFIVVVVM-SSELF 1226
                    ::||.||.|. |.|: |::|..|.:........||       ..|||:.:| .:.|.
  Rat  1102 --------IVLLAFGCAASLVFLTYVISFVFGKKRKNSGLWSI-------CFFIVITIMFDTVLM 1151

  Fly  1227 DTKDTADILGWIFRIFPHFSLAMSLNKV------YTNTATRNACAKAGALPPILLCELVPQCCNL 1285
            |..:.|.::. ...:.|.|||...|..:      |......:....:|.  .:|||        |
  Rat  1152 DPFNEALLIS-AMMLVPSFSLNALLIVLEMRAYQYYREFGESKYGLSGV--DLLLC--------L 1205

  Fly  1286 KPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFR-----LINELMFKIR-QLISKPPPPPTEGQ 1344
            .|||                ..::|..::..||.:     :..:.:|:|. |.:...|.|.....
  Rat  1206 IPYF----------------HTLLFIFVLRCLELKYGKNVVRKDPLFRIAPQSLHVQPNPEEPVD 1254

  Fly  1345 LDDDVANERERILQMSSNELATKNL---------VLDRVTKYYGQ----------FMAVNQVSLC 1390
            .|:||..||.|    :|:.|:|.||         .|.:  :|.||          .:||..:|.|
  Rat  1255 EDEDVQAERMR----TSDALSTVNLDEKPAIIASCLHK--EYTGQKKWCCSKRRKKIAVRNISFC 1313

  Fly  1391 VQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSL----ESNMNSIYKMIGYCPQFDA 1451
            |.:.|..||||..||||:::.:|:.|..:.::|...::.||.    :...:...| :|||||.:.
  Rat  1314 VNKGEILGLLGPEGAGKSSSLRMIAGIMKPTAGEVELKELSSAVAHQGEGHGAAK-LGYCPQENV 1377

  Fly  1452 LLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIG 1516
            |...||.:|.|.::..::|:::.........|..:|.....::.|......|..|||..|::::|
  Rat  1378 LWPILTVKEHLEVYAAVKGLRKKDAVIAISRLVNAFKLHDQLNVQARNLVVGLTRKLCFALSILG 1442

  Fly  1517 SPSVIYLDEPTTGMDPAARRQLWNMV-CRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCI 1580
            :..|:.||||:||:|.:.::|:|..: ..::|:.|.::|::|.:.|.||||.|.||||:|..:.|
  Rat  1443 NSPVLILDEPSTGLDVSGKQQMWQAIQAAVKDNKKGVLLSTHDLAEAEALCDRAAIMVSGRLRLI 1507

  Fly  1581 GSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEY 1645
            ||.||||.:|.|..||:::|:                          ::||..: ..||.:.. :
  Rat  1508 GSIQHLKRRFGKDYILELRVK--------------------------EISQEPL-VHKEILRL-F 1544

  Fly  1646 PNSILQEEYQGILTFYIPLTGV-KWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQ 1706
            |.:..|:....:||:.:|:|.| ..|:.|..:|:.:...|::|||:||.||:.:|||.:|.|
  Rat  1545 PQAARQDRCFSLLTYKLPVTDVHPLSQAFHKLEAVKRGFNLDDYSLSQCTLDRVFLELSKEQ 1606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 48/184 (26%)
ABC2_membrane_3 <269..475 CDD:289468 51/210 (24%)
CcmA 538..843 CDD:224054 113/311 (36%)
ABC_subfamily_A 538..755 CDD:213230 83/223 (37%)
ABC2_membrane_3 913..1316 CDD:289468 93/440 (21%)
ABC_subfamily_A 1369..1587 CDD:213230 75/241 (31%)
drrA 1376..1702 CDD:130256 104/341 (30%)
Abca6XP_006247716.1 ABC2_membrane_3 35..420 CDD:289468 92/473 (19%)
ABC2_membrane_4 220..409 CDD:289500 51/209 (24%)
CcmA 480..795 CDD:224054 113/317 (36%)
ABC_subfamily_A 482..705 CDD:213230 83/223 (37%)
ABC2_membrane_3 859..1171 CDD:289468 80/362 (22%)
ABC2_membrane_4 1007..1178 CDD:289500 46/187 (25%)
CcmA 1279..1605 CDD:224054 106/356 (30%)
ABC_subfamily_A 1300..1514 CDD:213230 70/214 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166342237
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.650

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