DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and Abca8a

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_001268753.1	Gene:	Abca8a / 303638	RGDID:	1307333	Length:	1615	Species:	Rattus norvegicus

Alignment Length:	1821	Identity:	479/1821 - (26%)
Similarity:	823/1821 - (45%)	Gaps:	344/1821 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KVTNWDKFVLLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDL 67
            ::..|.:...||.||...:...|...:.||:..|...|.|.|...|.|.       |...:|:|:
  Rat     5 EINVWQQTWALLCKNLLRKKRLKRDTLWELLYTAFILLCLSLFFELHDV-------YEFSSLSDV 62

  Fly    68 NLLQHSLHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSL-----GK 127
            :           ||::            ..|:...|.:.|:||.|..::::...  ||     |:
  Rat    63 D-----------LGRV------------DSFNDSTFAIAYTPVTPTTQEIMNRV--SLVSYMTGR 102

  Fly   128 NKIC--ESENATQLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIA- 189
            ..:.  ..||.|:.    :||:      :|||...:     ....:.:.|:|   ::...|.|.
  Rat   103 EILAFPNKENMTEF----ISKH------YDDAVGII-----FSTAYSYHLKF---MKGTRIPIIK 149

  Fly   190 ----NTWLTMRLFPTI--DLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLR---QKSGEQD 245
                :|....|..|.|  ||:              .:.|.||:.||.:::.|.:.   ..|..::
  Rat   150 EHQDHTAHCFRYEPAISCDLS--------------AFWRHGFVALQAAINSAIIEVTTNHSVMEE 200

  Fly   246 LPNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITA---EKEKQLKEVMKIMG 307
            :.::..|.....::|..   ||.::...|.:.:....|.||   ||:|   .:.|::|..|.:||
  Rat   201 MMSLTGKYIKIDSFIAQ---EGTTTDYFLFLCIIAFSPLTY---YISAGVTRERKKMKAFMTVMG 259

  Fly   308 LSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFM 372
            |.:...|.:|.:...:::.|..:.:..:|   :|.....:|  .|..:......|.:|.|...|:
  Rat   260 LRDSAFWLSWGLLYGVIVFIVTLFLTFVV---YSVQFVFMT--GFMMIFSLFFFYGLSLISLSFL 319

  Fly   373 MATFFSRASTAAAVT-------GLIWFIA---YIPYSFTINSYDDLSLSSKLGW--SLISNTAMG 425
            |:....::.....|.       |.:.|.|   |:|.|              |.|  ||:|..|..
  Rat   320 MSVLLKKSFLTDLVVFFLTVSCGSLGFAALYRYLPVS--------------LEWLLSLLSPFAFM 370

  Fly   426 FG----IKLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGS 486
            .|    ::|....|.:|.         |....:.:.  |.:.::....|.|:::..|.|:|:||.
  Rat   371 LGMTQLLRLDYDLESSGH---------PTGNPNVVI--ATVFLLFFDGVFYLMLTFYFEKVLPGE 424

  Fly   487 FGVPRPWNFPFTREFWCG-----------EREYTGVEDIPNGHVEQRDPKAFE---TEPEGKHIG 537
            :|...|..|.....||.|           ||:|...:|            :||   |:..||.:
  Rat   425 YGRRHPPLFFLKSSFWTGQNPADRTVLDNERDYEFPDD------------SFEPVSTDFHGKEV- 476

  Fly   538 LQMRHLKKRFGNKM----VVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIING 598
            :::|:|.|.:..:.    .:|.|::::::.:||.:|||:||||:|.:::|:|:..||.|...|:.
  Rat   477 IRIRNLTKEYIQRSKRTEALKDLTLDVYKGQITAILGHSGAGKSTLLNVLSGLCVPTKGWVTIHD 541

  Fly   599 SDI--RTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDK 661
            :.:  .|::|......|:|||.||.||.::|..::|.|:::||:  :.|:.||.:.|..:|:::.
  Rat   542 NKLSEMTDLESISKLTGVCPQCNVQFDFLTVRENLRLFAKIKGI--QEVDNEVQRVLLALEMKNI 604

  Fly   662 ANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHF 726
            .|.....||||.||||:...|:.||.::.|.|||::|:||.:|.::|:||::.|..|.:|.:|.|
  Rat   605 QNTLVQNLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHRVWNLLKERKADRVVLFSTQF 669

  Fly   727 MDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPE 791
            |||||:|.||...:..|:|:|.|:|.||||::|.||.|.....:.|....:|:|:.::||..|..
  Rat   670 MDEADILADRKVFISQGKLRCAGSSLFLKKKWGIGYHLSLQLSETCVHERITSLVKQHIPDSKLS 734

  Fly   792 CDIGAELSYQLPDSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQ 856
            .:...:|:|.||...:.||.:::..||...| |.:..|||.:|::.|||:|:..:.....:|.:.
  Rat   735 AESEGKLNYILPLERTNKFPDLYRDLERCPD-LGIENYGVSVTTLTEVFLKLEGKSAIDSDIGET 798

  Fly   857 HEIMNGGSGFRGEDDNESVQSDGIFSENRRLLQGLQLLSNQWKAMLLKKFL-YTWRNK---LLLL 917
            .::..||:...|..|.|...|  :.:|..:...|:.|...|..|:...:|| ..:|.|   :|:|
  Rat   799 EDVQAGGTRGPGRLDGEQFVS--LLNEMSKTKGGMALWWQQLCAVTRLRFLKLKYRRKSIVILIL 861

  Fly   918 IQNIMPVFFVVVTILIIKTQGTF-QELKPITISLT-----QYPLAVTVLDRSNVQNGTGYEIANK 976
            |..|..:..:...:..:..|..: .||.|.|..||     |.||...:     :.|.||.:|.:.
  Rat   862 ILGIGLLHILSANVHRLVNQSDYCWELSPHTYFLTPGQRPQMPLTNLL-----IINKTGEKIDDF 921

  Fly   977 YEDLARSYGSNYGLELT--GTQ-GFEDYILDLGKTIQVRINSRYLVAATITESKITAWLNNQALH 1038
            ...|.:   .|..||:.  ||: |.||          .:.|...:||........|...|.:.|:
  Rat   922 LHSLEQ---QNIALEVDAFGTRNGTED----------SQYNGAIIVAGGEKNYNFTLACNTKRLN 973

  Fly  1039 TAPLTVNMVHNAIADKLFGSSVKIQVTNAPLPYTTS-----TLLSQLSTGNNLGTQLASNLCFCM 1098
            ..|:.|::|.||:.. ||..||.||...:..|..|.     .||...|            ....|
  Rat   974 CFPVLVDIVSNALLG-LFTPSVHIQTDRSSFPEDTGYTQFYHLLYMFS------------WILLM 1025

  Fly  1099 CFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLS 1163
            ..|.....:..|.:.::||:...::.|:....:|....:.:...|  :|||:.:.|.
  Rat  1026 ACVPPYISMTSIDDYKNRAQFQLWISGLSPSAYWFGHALFEIPVY--SALILSVYIA-------- 1080

  Fly  1164 TFGELGRYYLLLLLFGFAVLP-------FIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVM 1221
                          |.|:..|       .::|..|:    |.|:|          |::..::.|:
  Rat  1081 --------------FYFSAPPESMITTRDLFIQILY----AGGYA----------MSVIFMMYVI 1117

  Fly  1222 SSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLK 1286
            |......:..:.|....|.|....||.:.|.|.:.:|...::.|   .:|.:.|..     |.|.
  Rat  1118 SFICRKGRKNSGIWSLCFYIVSFISLCLMLFKFFEDTFLFSSIA---LIPVVTLVG-----CTLL 1174

  Fly  1287 PYFAWEEP--GVLPETVYMAV-------TGVVFFLIIIVLEFRLINELM-----FKIR----QLI 1333
            .:...|.|  .:.||..|..:       ..::|..|:..||.:...:.|     |:|.    ::.
  Rat  1175 HFQNHEFPEISLYPERYYTYLFFLAPFFHFLIFLFILRCLERKFGMKTMRMDPVFRISSRSDRVF 1239

  Fly  1334 SKPPPPPTEGQLDDDVANERERILQ-MSSNELATKNLVLDRVTK--YYG----------QFMAVN 1385
            :.|..|  ||: |:||:.||.|... ::|.:...|.:::....:  |.|          :.:|..
  Rat  1240 NNPEEP--EGE-DEDVSLERVRTANALTSADFQEKPVIIASCLRKEYKGKKKCFVLKGKKKIATR 1301

  Fly  1386 QVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFD 1450
            .:||||::.|..||||.|||||:|:.||:||:.:.|:|...::|    ::.....:.:|||||.:
  Rat  1302 NISLCVRKGEVVGLLGHNGAGKSTSIKMITGEIKPSAGQVQLKG----NSTGDTPEFLGYCPQEN 1362

  Fly  1451 ALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVI 1515
            ||...:|.||.|.||..::|:.:|........||.:......:.......|.|.||||...::::
  Rat  1363 ALWQHMTVREHLEIFAAIKGMSKSDAAVAIARLADALKLQDQLKSPVKTLSEGVKRKLCFVLSIL 1427

  Fly  1516 GSPSVIYLDEPTTGMDPAARRQLWNMV-CRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKC 1579
            |:|||:.||||:|||||..::|:|..: ....::.:..:||:|.|.|.||:|.|:||||:|:.:|
  Rat  1428 GNPSVVLLDEPSTGMDPEGQQQMWQAIQATFANTERGALLTTHYMAEAEAVCDRVAIMVSGKLRC 1492

  Fly  1580 IGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETE 1644
            |||.||||:||.|..:|::||:                       .|.|:...:::.::.|
  Rat  1493 IGSIQHLKSKFGKEYLLEMKVK-----------------------TPTQVEPLNMEIMRLF---- 1530

  Fly  1645 YPNSILQEEYQGILTFYIPLTGVK-WSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQRE 1708
             |.:..||.|..::.:.:|...|: .|:.|..:|:.:...::|:||:||:|||::|||.:|.|..
  Rat  1531 -PQAARQERYSSLMVYKLPREDVQPLSQAFFKLETVKQSFDLEEYSLSQSTLEQVFLELSKEQEL 1594

  Fly  1709 D 1709
            |
  Rat  1595 D 1595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	43/198 (22%)
		ABC2_membrane_3	<269..475	CDD:289468	46/224 (21%)
		CcmA	538..843	CDD:224054	113/310 (36%)
		ABC_subfamily_A	538..755	CDD:213230	83/222 (37%)
		ABC2_membrane_3	913..1316	CDD:289468	93/435 (21%)
		ABC_subfamily_A	1369..1587	CDD:213230	83/230 (36%)
		drrA	1376..1702	CDD:130256	113/339 (33%)
Abca8a	NP_001268753.1	ABC2_membrane_3	27..416	CDD:289468	98/488 (20%)
		DUF4149	267..354	CDD:290390	16/91 (18%)
		ABC_subfamily_A	477..698	CDD:213230	83/222 (37%)
		drrA	493..787	CDD:130256	111/296 (38%)
		ABC2_membrane_3	<1005..1155	CDD:289468	34/199 (17%)
		CcmA	1272..1591	CDD:224054	114/350 (33%)
		ABC_subfamily_A	1279..1500	CDD:213230	83/224 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342194
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750