DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and Abca8

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_038943365.1 Gene:Abca8 / 303637 RGDID:1307069 Length:1620 Species:Rattus norvegicus


Alignment Length:1790 Identity:468/1790 - (26%)
Similarity:805/1790 - (44%) Gaps:297/1790 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRS 77
            ||.||..    .||::..|.::..:.||||:|....         |.:....||.:.:.     :
  Rat    15 LLQKNLL----KKWRLRRETLMEWMSSLLLLLFLCW---------YPHGHEATDFSSVP-----T 61

  Fly    78 SYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEE--AWQSLGKNKI---CESENAT 137
            ..||::            ..|::..|::.|:||....::::|:  |...:...|:   .:.||..
  Rat    62 KDLGRV------------DSFTQSGFMIGYTPVTSTTRQIMEKVAAVPFMAGRKVLGLLDEENIR 114

  Fly   138 QLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLFPTID 202
            :|   |.|......|.|.|.::...:       |.|..|.|..                      
  Rat   115 EL---TESHQEVIRVIFSDTFSYHLK-------FQFGQRIPKS---------------------- 147

  Fly   203 LTGPRNEGDDDGGIPPGY----------LREGFLPLQHSLSMAYLRQKSGEQDLPNVV------M 251
                |..||.:......|          .::||:.||.:::.|.:...:....:..::      |
  Rat   148 ----REHGDHEAHCFEMYEDVDCLISIFWKKGFVALQAAINAAIIETTTNHSVMEKLLSVSGKFM 208

  Fly   252 KRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTA 316
            |.:||...      ||:.:...:...:....|.||......|.:.|::|.:|.:|||.:...|.:
  Rat   209 KIHPFVRQ------EGILTDFFIFTCIVSFSPITYFVSISVARERKKMKGLMMMMGLRDSAFWLS 267

  Fly   317 W------FVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMAT 375
            |      ||  |:|    |:.:|:::|   |....:||  :||.:....::|.:|.|...|:|:.
  Rat   268 WGLLYAGFV--FVM----ALSLALVIK---SVQFLILT--SFTVVFSLFLLYGLSMISLAFLMSV 321

  Fly   376 FFSRASTAAAVTGLIWFIAYI---PYSFT-INSYDDLSLSSKLGW--SLISNTAMGFGIKLILGF 434
            ...:    :.:|||..|:..|   ...|| :..|    |.:.|.|  ||.|..|...|:..:|..
  Rat   322 LVRK----SVLTGLTVFLLTIFWGSLGFTALYRY----LPAPLEWTLSLFSPFAFTLGMAQLLRV 378

  Fly   435 EGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTR 499
            :     ...::...|.....:..:.|...|:....::|:.:.:|.|:|:|..:|..|...|....
  Rat   379 D-----YDLNSNAPPDPAGSSNLIAATNFMLAFDALLYLALTMYFEKVLPNEYGHQRSPLFFLKP 438

  Fly   500 EFWCGERE------YTGVEDIP--NGHVEQRDPKAFETEPEGKHIGLQMRHLKKRFGNK----MV 552
            .||...|:      ..|::..|  .|..|...|     |..||. .:::|::.|.:..|    ..
  Rat   439 SFWVQPRKPAHVILEDGIDPAPLSGGSFEPVSP-----EFHGKE-SIRIRNISKEYKGKPSKIEA 497

  Fly   553 VKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAII--NGSDIRTNIEGARMSLGIC 615
            :|.|:::::|.:||.||||:||||:|.:::|:|:..||.|:..|  |......::|......|:|
  Rat   498 LKDLTLDIYEGQITALLGHSGAGKSTLLNILSGLSVPTKGSVTIYNNRLSEMADLESVFRISGVC 562

  Fly   616 PQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVC 680
            ||.||.||.::|..::|.|::::|:..:.||:||.:.|..:|:::..::.:..||||.||||:..
  Rat   563 PQSNVQFDFLTVRENLRLFAKIRGVPPQEVEKEVQRVLLELEMKNIQDILARNLSGGQKRKLTFG 627

  Fly   681 CALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGEL 745
            .|:.||:::.|.|||::|:||.:|.::|:||::.|..|.:|.:|.||||||:|.||...:..|:|
  Rat   628 TAILGDSQIFLLDEPTAGLDPFSRHRVWNLLKERKADRVVLFSTQFMDEADILADRKVFISRGKL 692

  Fly   746 KCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKF 810
            ||.|:|.||||::|.||.|....::.|....:|:|:.::||..|...:....|.|.||...:.:|
  Rat   693 KCAGSSLFLKKKWGVGYHLSLQLKEVCVPENITSLVKQHIPEAKLSAERERTLVYTLPLETTYRF 757

  Fly   811 EEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKD-QHEIMNGGSGFRGEDDN-- 872
            .|:...| :....|.::.|||.:|::.|||:|:    :....|:: :.:|:..|...|..|..  
  Rat   758 PELCQSL-DSCPGLGIDSYGVSMTTLNEVFLKL----EGKSAIEEPEVDIVGEGQTERSGDTERL 817

  Fly   873 -ESVQSDGIFSENRRLLQGLQLLSNQW----KAMLLKKFLYTWRNKLL--LLIQNI--MPVFFVV 928
             |..|:....:|.::....|.|...|.    ||.|||  |...|..||  ||:..:  .|:.|..
  Rat   818 MEMEQTLSTLTETKKKTGSLALWRQQTCAIAKARLLK--LKHERKTLLSVLLVLGVALCPLLFES 880

  Fly   929 VTILIIKTQGTFQELKPITISLTQYPLAVTVLDRSNVQNGTGYEIANKYEDLARSYGSNYGLELT 993
            :.:.|:::..|: :|.|.:..|........:|.:..:.|.|...|.:..:.:.|   .|..||:.
  Rat   881 IKMKILQSAYTW-DLSPHSYFLAPGQQPHGMLTQLLIINKTEASIDDFIQSVER---QNIALEVD 941

  Fly   994 GTQGFEDYILDLGKTIQVRINSRYLVAATITESKITAWLNNQALHTAPLTVNMVHNAIADKLFGS 1058
            .: |..|      .|.....|....|:........:...|.:.|:..|:.::::.|.:.. :...
  Rat   942 AS-GARD------GTDDPSFNGALTVSGGEKNHSFSLACNTKRLNCFPVLMDVLSNGLLG-MVKP 998

  Fly  1059 SVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSI--YI-LFLIKERESRAKLL 1120
            |.:|:...:  .|....:.:.|        |......|.:...|:.  || :..:.:.:::....
  Rat   999 SARIRTDRS--TYFVDEITNPL--------QQLGKTTFWLTLTSACPPYIAMSSVTDYKNKVWFQ 1053

  Fly  1121 QFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPF 1185
            ..|.|:....:|..|.:.|            |.:.||....:|         |:..|.||.....
  Rat  1054 LRVSGLFPSAYWFGQALVD------------IPLYCFVFLFMS---------LMDYLLGFPDATL 1097

  Fly  1186 IYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKDTADILGWIFRIFPHFS-LAM 1249
            |.|..:.....:.|:|          ::|..:..|:|......|..:.|....|.|...|| :||
  Rat  1098 IVITHVLQIPCSVGYA----------ISLIFLTYVISFISRKGKKNSGIWSLCFYIITMFSVVAM 1152

  Fly  1250 SLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPY-FAWEEPGVLPETVYMAVTGVVFFLI 1313
            .|:   .|......|. ...|||..|...:....:|..| .:.||..|.|..|::.....||..|
  Rat  1153 LLD---FNVDAILYCI-IFLLPPSTLIGCLILSMHLFIYRISREESIVEPFLVFLIPLLHVFIFI 1213

  Fly  1314 IIV--LEFRLINELM-----FKI---RQLISKPPPPPTEGQLDDDVANERERILQ-MSSNELATK 1367
            ..:  ||::...:.|     |:|   ...:.:.|..| ||: |:||..||.|... ::|.....|
  Rat  1214 FTLRCLEWKFGKKTMRKDPIFRISPRNNDVHQNPEEP-EGE-DEDVQMERMRTASALASTSFDEK 1276

  Fly  1368 NLVLDRVTK--YYGQF----------MAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERI 1420
            .:::....:  |.|::          :|...||.||::.|..||||.|||||:|:.||::||.:.
  Rat  1277 PVIVASCLRKEYAGKWKHCLSKKKAKIATRNVSFCVRKGEILGLLGHNGAGKSTSLKMISGDTKS 1341

  Fly  1421 SSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAK 1485
            ::|...::|    |........:|||||.:||..:||.:|.|.:|..:.|:.:|........||.
  Rat  1342 TAGQVLLKG----SREGDALGFLGYCPQENALWPNLTVKEHLEVFATVLGLSKSHAAVTITRLAD 1402

  Fly  1486 SFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMV-CRIRDSG 1549
            :......:.......|.|.||||...::::|:||::.||||:||:||..::|:|..: ..|:::.
  Rat  1403 ALQLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSILLLDEPSTGLDPEGQQQIWQAIRAIIKNTD 1467

  Fly  1550 KSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSG 1614
            :..:||:|.|.|.||||.|:||:|:|..:||||.||||:||.|..:|::||:    .|.|.    
  Rat  1468 RGALLTTHYMAEAEALCDRVAILVSGRLRCIGSIQHLKSKFGKDYLLEMKVK----TLEQV---- 1524

  Fly  1615 GYARNPDEQTVPAQMSQRDIDAVKEFVETE----YPNSILQEEYQGILTFYIPLTGVK-WSRIFG 1674
                                    |.:.||    :|.:..||.|..::.:.:|:..|: .|:.|.
  Rat  1525 ------------------------ELLNTEVLRLFPQAARQERYSPLMVYKLPVEDVQPLSQAFF 1565

  Fly  1675 LMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQRED 1709
            .:|..:...::|:||:||:|||::|||.:|.|..|
  Rat  1566 KLEKVKQTFDLEEYSLSQSTLEQVFLELSKEQEMD 1600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 50/191 (26%)
ABC2_membrane_3 <269..475 CDD:289468 50/217 (23%)
CcmA 538..843 CDD:224054 113/310 (36%)
ABC_subfamily_A 538..755 CDD:213230 85/222 (38%)
ABC2_membrane_3 913..1316 CDD:289468 82/411 (20%)
ABC_subfamily_A 1369..1587 CDD:213230 81/230 (35%)
drrA 1376..1702 CDD:130256 113/343 (33%)
Abca8XP_038943365.1 rim_protein <261..1597 CDD:130324 404/1467 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166342197
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.750

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