DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and Abca3

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	XP_006246101.1	Gene:	Abca3 / 302973	RGDID:	1307174	Length:	1704	Species:	Rattus norvegicus

Alignment Length:	1787	Identity:	672/1787 - (37%)
Similarity:	1009/1787 - (56%)	Gaps:	178/1787 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQ-KGVRYYNEQNLTDLNLLQHSLH 75
            ||||||:||:.......|:||.||.:||.:|:.:|..:.:|. .....|.:|::.:|.|
  Rat     9 LLLWKNYTLKKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATVYPDQHIQELPL------ 67

  Fly    76 RSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEA--WQSLGKNKI----CESE 134
                   ..:...|      ||    .:.|.|.|.:....:.:.||  .:.:.|.::    .|.:
  Rat    68 -------FFSFPPP------GG----SWELAYVPSHSDAARTITEAVRREFMIKMRVHGFSSEKD 115

  Fly   135 NATQLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELR------TATIAIANT-- 191
            ....:..|..|.|..|.|.|:..:.:  ..||||....:.|||....|      |..:.:..|
  Rat   116 FEDYVRYDNHSSNVLAAVVFEHTFNH--SKDPLPLAVRYHLRFSYTRRNYMWTQTGNLFLKETEG 178

  Fly   192 WLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLS---MAYLRQKSGEQ--DLPNVVM 251
            |.|..|||.....|||.....||| .|||:|||||.:||::.   |.|....|..|  ....|:.
  Rat   179 WHTASLFPLFPSPGPREPSSPDGG-EPGYIREGFLAVQHAVDKAIMHYHANASAHQLFQKLTVIT 242

  Fly   252 KRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTA 316
            ||:|||.||.||.|..:...:.|:::|||.|....|.:.:..||||:|||.|::||||:||||:|
  Rat   243 KRFPFPPYISDPFLIAIQYQLPLLLMLSFTYTSLTIIRAVVQEKEKKLKEYMRMMGLSSWLHWSA 307

  Fly   317 WFVK----SFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFF 377
            ||:.    |.|:::...:|..:.||    :|:|||::::.:.::.||:.:.:|||.|.||::|||
  Rat   308 WFLMFLLFSLIVVSFMTLLFCVKVK----KDIAVLSNSDPSLVLAFLLCFAISSISFSFMVSTFF 368

  Fly   378 SRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQ 442
            |:|:.||.|.|.::|..|.||.|....|:.::||.||...|:||.||..|.:||..||..|.|:|
  Rat   369 SKANMAATVGGFLYFFTYTPYFFVAPRYNWMTLSQKLLSCLLSNVAMAMGAQLIGKFEAKGTGIQ 433

  Fly   443 WSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGE-R 506
            |.:...||:|||....|.|:.|:|:..|:|.::..|||.|.||.||||:||.|.....:|||. |
  Rat   434 WCDLLNPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYVEAVFPGQFGVPQPWYFFLMPSYWCGNPR 498

  Fly   507 EYTGVEDIPNGHVEQRDPKA------FETEPEGKHIGLQMRHLKKRF--GN--KMVVKGLSMNMF 561
            ...|.|:      |..||:.      ||.|||....|::::||.|.|  ||  ||.::.|::|::
  Rat   499 TVVGKEE------EGGDPEKAFRTEYFEAEPEDLAAGIKIKHLSKVFQVGNKDKMGIRDLTLNLY 557

  Fly   562 EDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMS 626
            |.:|||||||||||||||:|||||:||||||.|.|.|.:|..::...|.|||:||||:||||.::
  Rat   558 EGQITVLLGHNGAGKTTTMSMLTGLFPPTSGHAYIRGYEISQDMVQIRKSLGLCPQHDVLFDNLT 622

  Fly   627 VSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVL 691
            |:.|:.|::::|||..:...:||.:.|..:.||||.:..|..|||||||||::..||...:||::
  Rat   623 VAEHLYFYAQLKGLSVQKCPEEVKQMLHTLGLEDKRDSRSKFLSGGMKRKLAIGIALIAGSKVLM 687

  Fly   692 CDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKK 756
            .|||:||||..:||.:||||||:|..||:|||||||||||:|||||||:..|||:|.|:|.|||:
  Rat   688 LDEPTSGMDAVSRRAIWDLLQQQKSDRTVLLTTHFMDEADLLGDRIAILAKGELQCCGSSLFLKQ 752

  Fly   757 QYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQS 821
            :||:||.:..||...|....::.|::.::|....|...|||||:.||..::.:||.:|.:||::.
  Rat   753 KYGAGYHMTLVKEPHCNPEGISQLVHHHVPNAMLESHAGAELSFILPKESTHRFESLFAKLEKKQ 817

  Fly   822 DELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKD--------QHE--------------IMNGGS 864
            .||.:..:|..:|:|||||::||...|.:.:|:.        |||              :|:..:
  Rat   818 KELGIASFGASVTTMEEVFLRVGKLVDTSMDIQAIQLPALQYQHERRASDWALDSNLCGVMDPTN 882

  Fly   865 GFRGEDDNESVQSDGIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVV 929
            |.....:.|.|..        :|..||.|...|:.||.|||..|:||...::..|.::||..:.:
  Rat   883 GIGALIEEEEVLV--------KLNTGLALHCQQFWAMFLKKAAYSWREWRMVAAQILVPVTCLTL 939

  Fly   930 TILIIKTQGTFQELKPITISLTQY-----PLAVTVLDRSNVQNGTGYEIANKYEDLARSYGSNYG 989
            .:|.|.......:..|:.:||.:|     |.:|....|      .|.:::....|:.::.... .
  Rat   940 ALLAINYTSEIFDDPPLKLSLNEYGTTVVPFSVPGTSR------LGQQLSEHLRDMLQAERQE-P 997

  Fly   990 LELTGTQGFEDYILDLGKTIQVRINSRYLVAATITES----KITAWLNNQALHTAPLTVNMVHNA 1050
            .|:.|  ..|::::..........|.|.|||.:..:|    .:||..||||.|:....:.:|.|.
  Rat   998 REVLG--DLEEFLVFRASVEGGGFNERCLVATSFKDSGERTVVTALFNNQAYHSPATALAIVDNL 1060

  Fly  1051 IADKLFGSSVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKERES 1115
            :...|.|....|:::|.|.|.:|..:..........|..:|.||...|.|::|.:.:..:.||..
  Rat  1061 LFKLLCGPRASIEISNYPQPRSTLQVAKDQFNEGRKGFDIALNLLIAMAFLASTFSILAVSERAV 1125

  Fly  1116 RAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGF 1180
            :||.:|||.||.|.|||||..:.|..|::|.:|::::....|.....:..|.:....|||:|:|:
  Rat  1126 QAKHVQFVSGVHVATFWLSALLWDLISFLVPSLLLLVVFRAFDVHAFTRDGHMADLLLLLMLYGW 1190

  Fly  1181 AVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKDTADILGWIFRIFPHF 1245
            |::|.:|::|.||...:|.:.|::|.||..|:|.||||.:|.......::.:..|..:|.:.|:.
  Rat  1191 AIIPLMYLLSFFFSAASTAYTRLTIFNILSGIATFIVVTIMRIPAVKLEELSRTLDHVFLVLPNH 1255

  Fly  1246 SLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCC---NL---KPYFAWEEPGVLPETVYMA 1304
            .|.|:::..|.|..||..|..:         |:....|   |:   :.::||..||:......||
  Rat  1256 CLGMAVSNFYENYETRRYCTSS---------EVATHYCKKYNIQYQENFYAWSTPGIGKFVTSMA 1311

  Fly  1305 VTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQL---------DDDVANERERILQMS 1360
            .:|.::..::.::|    ..|::::|..:.......|..:|         |.|||:||.|:|..|
  Rat  1312 ASGGIYLTLLFLIE----TNLLWRLRTFVCAFRRRWTLAELQNRTSVLPEDQDVADERSRVLVPS 1372

  Fly  1361 SNELATKNLVLDRVTKYYGQ---FMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISS 1422
            .:.:....|:::.::|.|.|   .:||:::||.||:.|||||||.|||||||||||:||:|.|:|
  Rat  1373 LDSMLDTPLIINELSKVYDQRAPLLAVDRISLAVQKGECFGLLGFNGAGKTTTFKMLTGEETITS 1437

  Fly  1423 GAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSF 1487
            |.|:|.|.|:.|::..:.:.:|||||||||||.:||||:|.::..|||:.|..|....|:..:..
  Rat  1438 GDAFVGGYSISSDIGKVRQRMGYCPQFDALLDHMTGREMLVMYARLRGIPERLIDACVENTLRGL 1502

  Fly  1488 GFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSI 1552
            ....|.:|....|||||||||||.||:||.|:||:||||:|||||.|||.||:.|.|.|:|||:|
  Rat  1503 LLEPHANKLVKTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAI 1567

  Fly  1553 VLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYA 1617
            |:|||||||||||||||||||.|:|||:||.||||:||..|..|:.|||
  Rat  1568 VITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLQAKVR---------------- 1616

  Fly  1618 RNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQ 1682
                     ::..|..::..|.||:..:|.|:|::|:|.::.:::|...:.|:::||::|..:::
  Rat  1617 ---------SEGKQEVLEEFKAFVDLTFPGSVLEDEHQDMVHYHLPGCDLSWAKVFGILEKAKEK 1672

  Fly  1683 LNVEDYSVSQTTLEEIFLEFAKYQ---REDTR 1711
            ..|:||||||.:||::||.||..|   .||.|
  Rat  1673 YGVDDYSVSQISLEQVFLSFAHLQPPTTEDGR 1704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	77/183 (42%)
		ABC2_membrane_3	<269..475	CDD:289468	86/209 (41%)
		CcmA	538..843	CDD:224054	156/308 (51%)
		ABC_subfamily_A	538..755	CDD:213230	123/220 (56%)
		ABC2_membrane_3	913..1316	CDD:289468	110/417 (26%)
		ABC_subfamily_A	1369..1587	CDD:213230	130/220 (59%)
		drrA	1376..1702	CDD:130256	163/328 (50%)
Abca3	XP_006246101.1	rim_protein	<206..1699	CDD:130324	608/1557 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342213
Domainoid	1	1.000	176	1.000	Domainoid score	I3511
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37437
Inparanoid	1	1.050	1134	1.000	Inparanoid score	I207
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		mtm8956
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	LDO	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910