DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and Abca12

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_237242.6 Gene:Abca12 / 301482 RGDID:1304586 Length:2595 Species:Rattus norvegicus


Alignment Length:1700 Identity:514/1700 - (30%)
Similarity:840/1700 - (49%) Gaps:242/1700 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 TENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLFPT-IDLTGPRNEGDDDGGIPPGYLR--- 222
            :|...||....:.:|.  .|:||.        |.|...| |...||.|.        |.:.:   
  Rat   969 SERVSLPPIVRYTIRM--SLKTAQ--------TTRSIRTKIWAPGPHNS--------PSHNQIYG 1015

  Fly   223 EGFLPLQHSLSMAYLRQKSG--EQDLPNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCT 285
            ..|:.||.|:..|.:..::|  .|::. |.::..|:|.::.|..|..:|..:.::::::::....
  Rat  1016 RAFIYLQDSIERAIIELQTGRNSQEVA-VQVQAVPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIA 1079

  Fly   286 YITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKS--FIMLTISAILIAILVKINWSEDVAVLT 348
            ...|.:..||:.:|.|.||:||:::..|:.||.::|  |:::|| ||||.||...|      :|.
  Rat  1080 AFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESIGFLLVTI-AILIVILKFGN------ILP 1137

  Fly   349 HANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSK 413
            ..|...|..:...|..|.|...::::.||:..:.||.:..||:.||:.|:...:...|:||...|
  Rat  1138 KTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYVIAFFPFIVLVTVEDELSYVIK 1202

  Fly   414 LGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLY 478
            :..||:|.||..:..:.|..:|..|.||||.|.:.....|||.:.|.:..::|....||..|..|
  Rat  1203 VFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYKSPVQDDTTSFGWLCCLILADSFIYFFIAWY 1267

  Fly   479 VEQVMPGSFGVPRPWNFPFTREFW-----CGEREYTGVEDI-----------PNGHVEQRD---P 524
            |..|.||::|:..||.||....:|     |.|.::.....:           |:.:....|   |
  Rat  1268 VRNVFPGTYGMAAPWYFPVLPSYWKERFGCAEVKHEKSNGLMFTNIMMQSTNPSANKTSPDCAFP 1332

  Fly   525 KAFETEPEGKHIGLQMRHLKKRFGNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPP 589
            ...|.||:...:|:.:..:.|.:|:|..|..|::|.:|..||.|||.||||||||||||||:|..
  Rat  1333 SNIEPEPKDLQVGVALHGVTKSYGSKTAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGA 1397

  Fly   590 TSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMK--GLRGKAVEQEVAKY 652
            |:||..:.|.||:|::...|.::|:|.||:|||..::...|:..:..:|  ....|.:.:||.:.
  Rat  1398 TAGTIFVYGKDIKTDLNTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRT 1462

  Fly   653 LKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVG 717
            ||...|....:.....||||||||||:..||.|.::||:.||||:|:||.:||.:||::.:.|..
  Rat  1463 LKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTA 1527

  Fly   718 RTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDD--------CET 774
            ||::|:||.:|||:||.||||.:..|.|:|.|:.|:||:.:|.||.|...|:..        |:|
  Rat  1528 RTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLDTNAICDT 1592

  Fly   775 NEVTALLNKYIPGLKPECDIGAELSYQLP---DSASAKFEEMFGQLEEQSDELHLNGYGVGITSM 836
            ..|||::..::|....:.|||.||.|.||   ...|..:..:...|::...:|::..||:..|::
  Rat  1593 VAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDKGMGKLNIGCYGISDTTV 1657

  Fly   837 EEVFMKVGAEKDNTGNIKDQH----EIMNGGSGFRGEDDNESVQS-------DGIFSENRRLLQG 890
            ||||:.:..:....||:..:|    ::.|..:......|:.||.|       |.:.:.:.| |.|
  Rat  1658 EEVFLNLTKDSQKCGNMSLEHLTQRKVGNPSANGTSTPDDLSVSSSNFTDRDDKVLTRSER-LDG 1721

  Fly   891 LQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTI---LIIKTQGTFQEL--------- 943
            ..||..:..|:|:|:|.:|.||...|:.|.::|:.||...:   .:..:..::.||         
  Rat  1722 FGLLLKKIMAILIKRFHHTRRNWKGLIAQVVLPIVFVATAMGLGTLRDSSNSYPELLISPSIYGN 1786

  Fly   944 --------------KPITISLTQYP-LAVTVLDRSNVQ----------NGTGYEIAN-------- 975
                          ..:..:|..:| :....|:.|:.|          |.:|..|.|        
  Rat  1787 SEQTAFYANFDPSTNALVSALWNFPGIDNVCLNTSDSQCLKKDNLGKWNTSGEAIDNFGVCSCSD 1851

  Fly   976 ------KYE---DLARSYGSNYGLELTGTQGFEDYILDLGKTIQVRINSRY-------------- 1017
                  |:.   ...|:|.|.....||| :..|:|::   .|....:..||              
  Rat  1852 NVQECPKFNYSPPHRRTYSSQVIYNLTG-KHMENYLI---STANHFVQKRYGGWSFGMKLTNDLR 1912

  Fly  1018 --LVAATITESKITAWLNNQALHTAPLTVNMVHNAI----ADKLFGSSVKIQVTNAPLP------ 1070
              :.|..:..:....|.:.:..|:.|..:|.::|.:    ..:...:...|.:.:.|.|      
  Rat  1913 FDVTAVPVNRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSEYDAARHGIIMYSHPYPGVQDQE 1977

  Fly  1071 -YTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLS 1134
             .|.|:|:..|         :|.::.......::.::.::::|.:::||.||.:.|:.|..:|::
  Rat  1978 QATISSLIDIL---------VALSILMGYSVTTASFVTYIVREHQTKAKQLQHISGIGVTCYWVT 2033

  Fly  1135 QFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATG 1199
            .||.|...|:|.....:..|..|:.....:...||...|||||||:|...::|:::..|.|....
  Rat  2034 NFIYDMVFYLVPVAFSIGVIAIFKLPAFYSGNNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMA 2098

  Fly  1200 FARVSIVNIFCGMALFIVVVVMSSELFDTKD---------TADILGWIFRIFPHFSLAMSLNKVY 1255
            |.....||:|.|:.   .:|.:|...|.:|:         .::.|..||.|||.|.....|.::.
  Rat  2099 FITYVCVNLFFGIN---SIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELS 2160

  Fly  1256 TNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFR 1320
            ...|..:.....|...|             ...|..::.|.:  .|.:...|.:|||:.:::...
  Rat  2161 QQQAVLDFLKAYGVDYP-------------SETFEMDKLGAM--FVALVSQGTMFFLLRLLINEW 2210

  Fly  1321 LINELMFKIRQLISKPPPPPTEGQLDDDVANERERILQMSSNELATKNLV-LDRVTKYY----GQ 1380
            ||.:|....|:..|.|.....:.  |:||..||.|:    .:..|..:|| |.|:||.|    .:
  Rat  2211 LIKKLRLFFRKFTSSPVMETVDE--DEDVHTERLRV----ESGAAEFDLVQLHRLTKTYQLIHKK 2269

  Fly  1381 FMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLE-SNMNSIYKMIG 1444
            .:|||.:||.:...|||||||||||||||.|||:|||...|||...::..|.. .:::|...::|
  Rat  2270 IIAVNNISLGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKSGSLGHVDSHSSLVG 2334

  Fly  1445 YCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLS 1509
            ||||.|||.|.:|..|.|..:..:.|:.|..|::....|.:....|.:.|:.|...|.|.|||||
  Rat  2335 YCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMAYKDRSTSMCSYGTKRKLS 2399

  Fly  1510 TAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVN 1574
            ||:|:||.||::.||||::||||.::|.||.::.....:..|::|||||||||||||||||||||
  Rat  2400 TALALIGKPSILLLDEPSSGMDPKSKRHLWRIISEEVQNKCSVILTSHSMEECEALCTRLAIMVN 2464

  Fly  1575 GEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKE 1639
            |.|:||||.||:|::|.:|..:|:.::.|                           :..::.:.:
  Rat  2465 GRFQCIGSLQHIKSRFGRGFTVKVHLKNN---------------------------KVSMENLTK 2502

  Fly  1640 FVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAK 1704
            |::..:|.:.|::::..:|.:::|:|....:.||.|:|:|:..||:.::.||||||||:|:.|||
  Rat  2503 FMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAK 2567

  Fly  1705 ----YQREDT 1710
                |:..||
  Rat  2568 DQKSYENVDT 2577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 53/181 (29%)
ABC2_membrane_3 <269..475 CDD:289468 63/207 (30%)
CcmA 538..843 CDD:224054 127/317 (40%)
ABC_subfamily_A 538..755 CDD:213230 96/218 (44%)
ABC2_membrane_3 913..1316 CDD:289468 97/492 (20%)
ABC_subfamily_A 1369..1587 CDD:213230 112/223 (50%)
drrA 1376..1702 CDD:130256 134/330 (41%)
Abca12XP_237242.6 ABC2_membrane_3 <1006..1267 CDD:289468 78/276 (28%)
NosY <1108..1269 CDD:224196 54/167 (32%)
ZnuC 1346..1570 CDD:224046 98/223 (44%)
ABC_subfamily_A 1350..1565 CDD:213230 96/214 (45%)
ABC2_membrane_3 <1913..2174 CDD:289468 60/272 (22%)
CcmA 2253..2567 CDD:224054 140/340 (41%)
ABC_subfamily_A 2254..2477 CDD:213230 111/222 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166342229
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 1 1.100 - - O PTHR19229
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
87.750

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