DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and Abca7

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:NP_997481.1 Gene:Abca7 / 299609 RGDID:1303134 Length:2170 Species:Rattus norvegicus


Alignment Length:1951 Identity:591/1951 - (30%)
Similarity:900/1951 - (46%) Gaps:424/1951 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 PAIFSLL-----LVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSL--HRSSY--------LGKLI 84
            |.||:.:     :.:::.|:|.|..|.:....:....|..::..|  .|..|        :|:|.
  Rat   330 PQIFNFMNDSTNVAMLQKLLDVEGTGWQQQTPKGQKQLEAIRDFLDPSRGRYNWQEAHADMGRLA 394

  Fly    85 ALIAPNRRRKNGGFSKFEFILCYS----PVNPVLKKLVEEAWQSLGKNKICESENATQLELDTVS 145
            .::.             :.:.|.|    ...|..:.||..|.:.||:.::               
  Rat   395 EILG-------------QILECVSLDKLEAVPSEEALVSRALELLGERRL--------------- 431

  Fly   146 KNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLFPTIDLTGP---- 206
               :||:.|......|..::|                                |:...|||    
  Rat   432 ---WAGIVFLSPEHPLDSSEP--------------------------------PSPTTTGPGHLR 461

  Fly   207 ---RNEGDD--------DGGIPPG----------YLREGFLPLQHSLSMAYLRQKSGEQDLPNVV 250
               |.:.||        |....||          |:..||:.||..|..|.:|..||......:.
  Rat   462 VKIRMDIDDVTRTNKIRDKFWDPGPSADPLMDLRYVWGGFVYLQDLLEQAAVRVLSGRDSRAGLY 526

  Fly   251 MKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWT 315
            :::.|.|.|:.|..|..:|..:.|.:.|::||......|.:..|||.:|:|.|:.||||..:.|.
  Rat   527 LQQMPHPCYVDDVFLRVLSRSLPLFLTLAWIYSVALTVKAVVREKETRLRETMRAMGLSRAVLWL 591

  Fly   316 AWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRA 380
            .||:.......:||.|:.:::|:.     .:|.:::...:..||..:.|:::...|:::.|||||
  Rat   592 GWFLSCLGPFLVSAALLVLVLKLG-----NILPYSHPVVVFLFLAAFAVATVAQSFLLSAFFSRA 651

  Fly   381 STAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSN 445
            :.|||..||.:|..|:||...:...:.|.|...|..||:|..|.|||.:.:...|..|:|.||.|
  Rat   652 NLAAACGGLAYFALYLPYVLCVAWRERLPLGGLLAVSLLSPVAFGFGCESLALLEEQGDGAQWHN 716

  Fly   446 FFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTG 510
            ..|. ..:|..:|..|...:|:..|||.:...|:|.|.||.:|:|.||||||.|.:|||...   
  Rat   717 LGTG-PAEDVFSLAQVSAFLLLDAVIYGLALWYLEAVCPGQYGIPEPWNFPFRRSYWCGPGP--- 777

  Fly   511 VEDIPNGHV---EQRDPKAF-ETEPEGKHIGLQMRHLKKRF--GNKMVVKGLSMNMFEDEITVLL 569
                |...|   ..:|||.. |..|.|...|:.:|.|||.|  ..:..::||:::.:|..||..|
  Rat   778 ----PKSSVLAPAPQDPKVLVEEPPPGLVPGVSIRGLKKHFRGSPQPALRGLNLDFYEGHITAFL 838

  Fly   570 GHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFF 634
            ||||||||||:|:|:|:|||:||:|.|.|.|::||:...|..||||||:|||||.::|..|:.|:
  Rat   839 GHNGAGKTTTLSILSGLFPPSSGSASILGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFY 903

  Fly   635 SRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGM 699
            .|:||:...|::.|....::.:.|..|.:..:..|||||:|||||..|..|.::||:.|||::|:
  Rat   904 GRLKGVSAAAIDSEQEHLIRDVGLIPKRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGV 968

  Fly   700 DPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRL 764
            ||::||.:|:||.:.:.||||:|:||.:|||::||||:|::..|.|.|.|:..||::..|.||.|
  Rat   969 DPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAMVASGSLCCCGSPLFLRRHLGCGYYL 1033

  Fly   765 ICVK----------RDDCE--------------------------TNEVTA-------------- 779
            ..||          :.|.|                          :::|.|              
  Rat  1034 TLVKSSQSLVTHDLKGDTEDPRREKKSGSEGKTADTVLTRDGPHRSSQVPAPDAVPVTPSAALIL 1098

  Fly   780 -LLNKYIPGLKPECDIGAELSYQLP--DSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFM 841
             |:.:::||.:...::..||...||  .:....|..:|.:|::|.:.|.|.|||:..|::||:|:
  Rat  1099 ELVQRHVPGAQLVEELPHELVLALPYAGALDGSFATVFQELDQQLERLGLTGYGISDTNLEEIFL 1163

  Fly   842 KVGAEKDNTGNIKD----QHEIMNGGSGFRGEDDNESVQSDGIFSE-------------NRRLLQ 889
            ||..|....|...|    ||.:........|.:  .||..:|..::             ....:|
  Rat  1164 KVVEEAHAHGEGGDPRQQQHLLTATPQPHTGPE--ASVLENGELAKLVLDPQAPKGSAPTTAQVQ 1226

  Fly   890 GLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQY- 953
            |..|...|.:|:|.|:||...|::..|..|.::|..||.:.:........|.:..|:.:|...| 
  Rat  1227 GWTLTCQQLRALLHKRFLLARRSRRGLFAQIVLPALFVGLALFFTLIVPPFGQYPPLQLSPAMYG 1291

  Fly   954 ----------------------------------------------------------PLAVTVL 960
                                                                      |...::|
  Rat  1292 PQVSFFSEDAPADPNRMKLLEALLGEAGLQDPSVQGKGSRGSECTHSLACYFTVPEVPPDVASIL 1356

  Fly   961 DRSN-------------------------------------------VQNGTGYEIAN----KYE 978
            ...|                                           |||.||..:::    .|.
  Rat  1357 ASGNWTPDSPSPACQCSQPGARRLLPDCPAGAGGPPPPQAMAGFGEVVQNLTGRNVSDFLVKTYP 1421

  Fly   979 DLAR------------SYGSNYGLELTGTQGFEDYILDLGKTI-----QVRI-------NSRYLV 1019
            .|.|            .||   |..|.|    .|..|..|:.:     ::|.       |:...:
  Rat  1422 SLVRRGLKTKKWVDEVRYG---GFSLGG----RDPDLPSGREVVRTVAEMRALLSPQPGNTLDRI 1479

  Fly  1020 AATITE--------SKITAWLNNQALHTAPLTVNMVHNAIADKLFGS-SVK----IQVTNAPLPY 1071
            ...:|:        :.:..|.||:..|.....||..:|.:......| ||:    |...|.||..
  Rat  1480 LNNLTQWALGLDARNSLKIWFNNKGWHAMVAFVNRANNGLLRAFLPSGSVRHAHSITTLNHPLNL 1544

  Fly  1072 TTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQF 1136
            |...|.......:::...::..:.|.|.||.:.:.|.||:||.:|||.||.|.|:....:||..|
  Rat  1545 TKEQLSEATLIASSVDVLVSICVVFAMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNF 1609

  Fly  1137 ICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFA 1201
            :.|..:|:|...|||:..:.||:........|....|||||:|:::.|.:|..|.||..|:|.:.
  Rat  1610 LWDMCNYLVAVCIVVLIFLAFQQKAYVAPENLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYV 1674

  Fly  1202 RVSIVNIFCG----MALFIVVVVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTNTATRN 1262
            .::.:|:|.|    ||.|::.::....|   ::.:.||..:|.|||||.|...|..:..|.|..:
  Rat  1675 VLTCINLFIGINSSMATFVLELLSDQNL---QEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMAD 1736

  Fly  1263 ACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMF 1327
            |..:.|..             ..:....|:..|  ...:.|...|.:|.||.::|:.|  |.|: 
  Rat  1737 AFERLGDK-------------QFQSPLRWDIIG--KNLLAMVAQGPLFLLITLLLQHR--NRLL- 1783

  Fly  1328 KIRQLISKPPP----PPTEGQLDDDVANERERILQMSSNELATKN--LVLDRVTKYY-GQ-FMAV 1384
                    |.|    ||..|:.|:||..||||:     .:.||:.  |||..:||.| || ..||
  Rat  1784 --------PQPKSRLPPPLGEEDEDVVRERERV-----TKGATQGDVLVLRDLTKVYRGQRSPAV 1835

  Fly  1385 NQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQF 1449
            :.:.|.:...||||||||||||||:||:|:|||...|||.|.:.|.::....::.::.:|||||.
  Rat  1836 DHLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLPSSGEAVLAGHNVAQEPSAAHRSMGYCPQS 1900

  Fly  1450 DALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAV 1514
            ||:.|.|||||.|.:|..||||.|:::.|.:.......|...:.|:....|||||||||:||:|:
  Rat  1901 DAIFDLLTGREHLELFARLRGVPEAQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRKLATALAL 1965

  Fly  1515 IGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKC 1579
            :|.|:|::||||||||||:|||.|||.:..:...|:|:|||||||||||||||||||||||.|:|
  Rat  1966 VGDPAVVFLDEPTTGMDPSARRFLWNNLLSVVREGRSVVLTSHSMEECEALCTRLAIMVNGRFRC 2030

  Fly  1580 IGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETE 1644
            :||.||||::|..|..|.::|                   |.:|..||          ..|:.|.
  Rat  2031 LGSAQHLKSRFGAGHTLTLRV-------------------PPDQPEPA----------IAFIVTT 2066

  Fly  1645 YPNSILQEEYQGILTFYIPL-TGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQRE 1708
            :|::.|:|.:...|.|.:|. .|...:|:|..:.:......|||:|||||||||:||.|:|.|.|
  Rat  2067 FPDAELREVHGSRLRFQLPPGGGCTLARVFRELAAQGKAHGVEDFSVSQTTLEEVFLYFSKDQGE 2131

  Fly  1709 D 1709
            :
  Rat  2132 E 2132

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 57/179 (32%)
ABC2_membrane_3 <269..475 CDD:289468 66/205 (32%)
CcmA 538..843 CDD:224054 133/359 (37%)
ABC_subfamily_A 538..755 CDD:213230 102/218 (47%)
ABC2_membrane_3 913..1316 CDD:289468 116/549 (21%)
ABC_subfamily_A 1369..1587 CDD:213230 121/219 (55%)
drrA 1376..1702 CDD:130256 152/328 (46%)
Abca7NP_997481.1 rim_protein 1..2127 CDD:130324 588/1944 (30%)
ABC2_membrane <557..742 CDD:304374 61/190 (32%)
ABC_subfamily_A 805..1024 CDD:213230 102/218 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1044..1086 4/41 (10%)
ABC_subfamily_A 1818..2038 CDD:213230 121/219 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2129..2170 2/4 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166342221
Domainoid 1 1.000 158 1.000 Domainoid score I4008
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X215
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.660

Return to query results.
Submit another query.