Protein Alignment Abca3 and Abca7

DIOPT Version :10

• Sequence 1: NP_608445.2
• Gene: Abca3 / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Sequence 2: NP_997481.2
• Gene: Abca7 / 299609
• RGDID: 1303134
• Length: 2170
• Species: Rattus norvegicus
• Alignment Length: 1951
• Identity: 591/1951 - (30%)
• Similarity: 899/1951 - (46%)
• Gaps: 424/1951 - (21%)

  Fly    35 PAIFSLL-----LVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSL--HRSSY--------LGKLI 84
            |.||:.:     :.:::.|:|.|..|.:....:....|..::..|  .|..|        :|:|.
  Rat   330 PQIFNFMNDSTNVAMLQKLLDVEGTGWQQQTPKGQKQLEAIRDFLDPSRGRYNWQEAHADMGRLA 394

  Fly    85 ALIAPNRRRKNGGFSKFEFILCYS----PVNPVLKKLVEEAWQSLGKNKICESENATQLELDTVS 145
            .::.             :.:.|.|    ...|..:.||..|.:.||:.::
  Rat   395 EILG-------------QILECVSLDKLEAVPSEEALVSRALELLGERRL--------------- 431

  Fly   146 KNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLFPTIDLTGP---- 206
               :||:.|......|..::|                                |:...|||
  Rat   432 ---WAGIVFLSPEHPLDSSEP--------------------------------PSPTTTGPGHLR 461

  Fly   207 ---RNEGDD--------DGGIPPG----------YLREGFLPLQHSLSMAYLRQKSGEQDLPNVV 250
               |.:.||        |....||          |:..||:.||..|..|.:|..||......:.
  Rat   462 VKIRMDIDDVTRTNKIRDKFWDPGPSADPLMDLRYVWGGFVYLQDLLEQAAVRVLSGRDSRAGLY 526

  Fly   251 MKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWT 315
            :::.|.|.|:.|..|..:|..:.|.:.|::||......|.:..|||.:|:|.|:.||||..:.|.
  Rat   527 LQQMPHPCYVDDVFLRVLSRSLPLFLTLAWIYSVALTVKAVVREKETRLRETMRAMGLSRAVLWL 591

  Fly   316 AWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRA 380
            .||:.......:||.|:.:::|:.     .:|.:::...:..||..:.|:::...|:::.|||||
  Rat   592 GWFLSCLGPFLVSAALLVLVLKLG-----NILPYSHPVVVFLFLAAFAVATVAQSFLLSAFFSRA 651

  Fly   381 STAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSN 445
            :.|||..||.:|..|:||...:...:.|.|...|..||:|..|.|||.:.:...|..|:|.||.|
  Rat   652 NLAAACGGLAYFALYLPYVLCVAWRERLPLGGLLAVSLLSPVAFGFGCESLALLEEQGDGAQWHN 716

  Fly   446 FFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTG 510
            ..|. ..:|..:|..|...:|:..|||.:...|:|.|.||.:|:|.||||||.|.:|||...
  Rat   717 LGTG-PAEDVFSLAQVSAFLLLDAVIYGLALWYLEAVCPGQYGIPEPWNFPFRRSYWCGPGP--- 777

  Fly   511 VEDIPNGHV---EQRDPKAF-ETEPEGKHIGLQMRHLKKRF--GNKMVVKGLSMNMFEDEITVLL 569
                |...|   ..:|||.. |..|.|...|:.:|.|||.|  ..:..::||:::.:|..||..|
  Rat   778 ----PKSSVLAPAPQDPKVLVEEPPPGLVPGVSIRGLKKHFRGSPQPALRGLNLDFYEGHITAFL 838

  Fly   570 GHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFF 634
            ||||||||||:|:|:|:|||:||:|.|.|.|::||:...|..||||||:|||||.::|..|:.|:
  Rat   839 GHNGAGKTTTLSILSGLFPPSSGSASILGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFY 903

  Fly   635 SRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGM 699
            .|:||:...|::.|....::.:.|..|.:..:..|||||:|||||..|..|.::||:.|||::|:
  Rat   904 GRLKGVSAAAIDSEQEHLIRDVGLIPKRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGV 968

  Fly   700 DPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRL 764
            ||::||.:|:||.:.:.||||:|:||.:|||::||||:|::..|.|.|.|:..||::..|.||.|
  Rat   969 DPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAMVASGSLCCCGSPLFLRRHLGCGYYL 1033

  Fly   765 ICVK----------RDDCE-------------------TNE----------------------VT 778
            ..||          :.|.|                   |.:                      :.
  Rat  1034 TLVKSSQSLVTHDLKGDTEDPRREKKSGSEGKTADTVLTRDGPHRSSQAPAPDAVPVTPSAALIL 1098

  Fly   779 ALLNKYIPGLKPECDIGAELSYQLP--DSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFM 841
            .|:.:::||.:...::..||...||  .:....|..:|.:|::|.:.|.|.|||:..|::||:|:
  Rat  1099 ELVQRHVPGAQLVEELPHELVLALPYAGALDGSFATVFQELDQQLERLGLTGYGISDTNLEEIFL 1163

  Fly   842 KVGAEKDNTGNIKD----QHEIMNGGSGFRGEDDNESVQSDGIFSE-------------NRRLLQ 889
            ||..|....|...|    ||.:........|.:  .||..:|..::             ....:|
  Rat  1164 KVVEEAHAHGEGGDPRQQQHLLTATPQPHTGPE--ASVLENGELAKLVLDPQAPKGSAPTTAQVQ 1226

  Fly   890 GLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQY- 953
            |..|...|.:|:|.|:||...|::..|..|.::|..||.:.:........|.:..|:.:|...|
  Rat  1227 GWTLTCQQLRALLHKRFLLARRSRRGLFAQIVLPALFVGLALFFTLIVPPFGQYPPLQLSPAMYG 1291

  Fly   954 ----------------------------------------------------------PLAVTVL 960
                                                                      |...::|
  Rat  1292 PQVSFFSEDAPADPNRMKLLEALLGEAGLQDPSVQGKGSRGSECTHSLACYFTVPEVPPDVASIL 1356

  Fly   961 DRSN-------------------------------------------VQNGTGYEIAN----KYE 978
            ...|                                           |||.||..:::    .|.
  Rat  1357 ASGNWTPDSPSPACQCSQPGARRLLPDCPAGAGGPPPPQAMAGFGEVVQNLTGRNVSDFLVKTYP 1421

  Fly   979 DLAR------------SYGSNYGLELTGTQGFEDYILDLGKTI-----QVRI-------NSRYLV 1019
            .|.|            .||   |..|.|    .|..|..|:.:     ::|.       |:...:
  Rat  1422 SLVRRGLKTKKWVDEVRYG---GFSLGG----RDPDLPSGREVVRTVAEMRALLSPQPGNTLDRI 1479

  Fly  1020 AATITE--------SKITAWLNNQALHTAPLTVNMVHNAIADKLFGS-SVK----IQVTNAPLPY 1071
            ...:|:        :.:..|.||:..|.....||..:|.:......| ||:    |...|.||..
  Rat  1480 LNNLTQWALGLDARNSLKIWFNNKGWHAMVAFVNRANNGLLRAFLPSGSVRHAHSITTLNHPLNL 1544

  Fly  1072 TTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQF 1136
            |...|.......:::...::..:.|.|.||.:.:.|.||:||.:|||.||.|.|:....:||..|
  Rat  1545 TKEQLSEATLIASSVDVLVSICVVFAMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNF 1609

  Fly  1137 ICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFA 1201
            :.|..:|:|...|||:..:.||:........|....|||||:|:::.|.:|..|.||..|:|.:.
  Rat  1610 LWDMCNYLVAVCIVVLIFLAFQQKAYVAPENLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYV 1674

  Fly  1202 RVSIVNIFCG----MALFIVVVVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTNTATRN 1262
            .::.:|:|.|    ||.|::.::....|   ::.:.||..:|.|||||.|...|..:..|.|..:
  Rat  1675 VLTCINLFIGINSSMATFVLELLSDQNL---QEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMAD 1736

  Fly  1263 ACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMF 1327
            |..:.|..             ..:....|:..|  ...:.|...|.:|.||.::|:.|  |.|:
  Rat  1737 AFERLGDK-------------QFQSPLRWDIIG--KNLLAMVAQGPLFLLITLLLQHR--NRLL- 1783

  Fly  1328 KIRQLISKPPP----PPTEGQLDDDVANERERILQMSSNELATKN--LVLDRVTKYY-GQ-FMAV 1384
                    |.|    ||..|:.|:||..||||:     .:.||:.  |||..:||.| || ..||
  Rat  1784 --------PQPKSRLPPPLGEEDEDVVRERERV-----TKGATQGDVLVLRDLTKVYRGQRSPAV 1835

  Fly  1385 NQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQF 1449
            :.:.|.:...||||||||||||||:||:|:|||...|||.|.:.|.::....::.::.:|||||.
  Rat  1836 DHLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLPSSGEAVLAGHNVAQEPSAAHRSMGYCPQS 1900

  Fly  1450 DALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAV 1514
            ||:.|.|||||.|.:|..||||.|:::.|.:.......|...:.|:....|||||||||:||:|:
  Rat  1901 DAIFDLLTGREHLELFARLRGVPEAQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRKLATALAL 1965

  Fly  1515 IGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKC 1579
            :|.|:|::||||||||||:|||.|||.:..:...|:|:|||||||||||||||||||||||.|:|
  Rat  1966 VGDPAVVFLDEPTTGMDPSARRFLWNNLLSVVREGRSVVLTSHSMEECEALCTRLAIMVNGRFRC 2030

  Fly  1580 IGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETE 1644
            :||.||||::|..|..|.::|                   |.:|..||          ..|:.|.
  Rat  2031 LGSAQHLKSRFGAGHTLTLRV-------------------PPDQPEPA----------IAFIVTT 2066

  Fly  1645 YPNSILQEEYQGILTFYIPL-TGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQRE 1708
            :|::.|:|.:...|.|.:|. .|.|.:|:|..:.:......|||:|||||||||:||.|:|.|.|
  Rat  2067 FPDAELREVHGSRLRFQLPPGGGCKLARVFRELAAQGKAHGVEDFSVSQTTLEEVFLYFSKDQGE 2131

  Fly  1709 D 1709
            :
  Rat  2132 E 2132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abca3	NP_608445.2	rim_protein	<137..1708	CDD:130324	569/1827 (31%)
Abca7	NP_997481.2	rim_protein	1..2127	CDD:130324	588/1944 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1044..1086		3/41 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2129..2170		2/4 (50%)