DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and Abca15

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_001099763.2	Gene:	Abca15 / 293442	RGDID:	1305981	Length:	1668	Species:	Rattus norvegicus

Alignment Length:	1765	Identity:	603/1765 - (34%)
Similarity:	953/1765 - (53%)	Gaps:	169/1765 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KFVLLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHS 73
            |.:||||||:||:......:|.|::|...||::|:..|                :|..:|.:: |
  Rat     8 KLLLLLWKNFTLKRRKFGALVTEIILMLAFSIVLLTTR----------------HLLSINKME-S 55

  Fly    74 LHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVN-PVLKKLVEEAWQSLGKNKI-----CE 132
            ||   :..:.:..: |...|.:...|: .:.|.|.|.| .|:..:||...:.|.....     .|
  Rat    56 LH---FPDQPVGAV-PFFFRVSANSSR-PWELAYVPSNITVVHNIVENVKKDLNFPMAVIGFPSE 115

  Fly   133 SENATQLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIA----NTWL 193
            |:..........|:|..|.:.||..:||  ..||||....:.||| ::::.....:|    :|||
  Rat   116 SDFEDYARSSVNSRNILAAIVFDHNFAN--SRDPLPKKIKYNLRF-SDIKKNIHGMAYYQGHTWL 177

  Fly   194 TMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGE------QDLPNVVMK 252
            |..|||.:.:.||||..:.||| .|||:.||||.:||:|..|.:....|.      .|: ::.::
  Rat   178 TKFLFPPLRIVGPRNPQEADGG-SPGYITEGFLAVQHALDKAIMLHHGGAAATALFNDV-SLFIQ 240

  Fly   253 RYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAW 317
            |:|:|||..|......::.:.|.:...|......:...|..|||.:|||...::||.||:.|.|:
  Rat   241 RFPYPAYYHDHFYLFANTFVPLTVASIFFLNHLILVWSIVWEKENRLKEYQLMIGLRNWMFWIAY 305

  Fly   318 FVKSFIMLTISAIL--IAILVKINWSEDVAVLTHANFTALVFFLII-YIVSSICFCFMMATFFSR 379
            |...|.:..|:.|.  |.:.|||    |.|.:...|...|||.|:: |.:|||.|.||::|.|:|
  Rat   306 FFTFFCLYFINIIFMCIVLFVKI----DPAPIFQYNDPILVFILLLFYAISSIFFSFMISTLFNR 366

  Fly   380 ASTAAAVTGLIWFIAYIPYSFTIN-SYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQW 443
            .|.|.::...::|:.|:| :.|:| |::.:....||.||...|..|.||.:.::..|....|::|
  Rat   367 VSFAVSLGSFLFFLTYLP-AITMNQSFEHMPPRQKLIWSFDFNVGMAFGFRFLVNAETRKTGMKW 430

  Fly   444 SNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREY 508
            :|.|.|.. .|:|....|:.|:||...||.::..|:|.|.||.:|||:||||.....:|.||...
  Rat   431 NNIFLPTD-SDSLLFTYVLGMLLVDAFIYGLVAWYIEAVFPGEYGVPKPWNFFLMHSYWFGESRQ 494

  Fly   509 TGVEDIPNGHVEQRDPKAFETEPEGKHIGLQMRHLKKRFG----NKMVVKGLSMNMFEDEITVLL 569
            ...|  .....::.:.|.||.||.....|:|::||.|.|.    .|:.:..||:|::|.:|||||
  Rat   495 QKPE--ITQFCKRVESKYFEVEPTDLTAGIQIKHLHKVFQENNITKVAINDLSLNVYEGQITVLL 557

  Fly   570 GHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFF 634
            |||||||:||:|:|:|::|||||.|.::|.||..:::..|..||:|||.|:|||.::||.|:.|:
  Rat   558 GHNGAGKSTTLSILSGLYPPTSGEAYVHGEDISQHMDQIRNFLGLCPQQNLLFDHLTVSEHLYFY 622

  Fly   635 SRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGM 699
            .|:||:......:|....|....|.:|.:..|..|||||||||::..||.|.:|||:.|||:|||
  Rat   623 CRVKGVPQNMCLEETNNMLSAFNLTEKRDAFSKSLSGGMKRKLAIIIALIGGSKVVILDEPTSGM 687

  Fly   700 DPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRL 764
            ||::||..||::|..|..||:|||||:|||||:||||||||..|.|:|.|:|.|||:.||.|..:
  Rat   688 DPASRRSTWDVVQTYKQNRTILLTTHYMDEADMLGDRIAIMVQGTLRCCGSSVFLKRLYGVGSHI 752

  Fly   765 ICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQSDELHLNGY 829
            :.||...|:.:|::.|::.|||....:.::|.|||:.||...:.|||.:...|||..:.|.::.:
  Rat   753 VMVKEPVCDVDEISKLIHYYIPTATLKTNVGNELSFILPKEYTHKFEALLTALEENQENLGISSF 817

  Fly   830 GVGITSMEEVFMKVGAEKDNTGNIKDQHEIMNGGSGFRGEDDNESVQSDGIF---SENRRLL--Q 889
            |:.||:|||||::|...:|:..:::.......|..|.|..|...|:::.  |   ||::.::  .
  Rat   818 GMSITTMEEVFLRVSKMEDSKPDMEATQSPSAGSKGNRNRDVESSMRAG--FPTQSEDQTIVFNT 880

  Fly   890 GLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQYP 954
            |..|...|:.||.:|:.:|.|||..:|.:|.:   ..|:.|.|::|:. .|:..:...::|..|.
  Rat   881 GCPLYLQQFHAMFMKRLMYNWRNWRVLSVQIL---GLVISTFLLLKSH-EFRHKRIRQMNLDDYG 941

  Fly   955 LAV---TVLDRSNVQNGTGYEIANKYEDLARSYGSNYGLELTGTQGFEDYILDLGKTIQVRINSR 1016
            ..:   ::|.:||:.......:.|..:.      .|:  :|...||      ||.|.::......
  Rat   942 QTIVPFSILGKSNLTTSLLIHLENMLKP------GNH--QLKEVQG------DLLKYLEGNEECI 992

  Fly  1017 YL--VAATIT----ESKITAWLNNQALHTAPLTVNMVHNAIADKLFGSSVKIQVTNAPLPYTTST 1075
            :|  ||.:|.    .:|:|...||:|.|:..|::.::.|.:...|.|::..|.|.:.|.|..||.
  Rat   993 HLCIVALSIKVAAGRAKLTVLFNNEAYHSPSLSLAVLDNILFMSLSGANASITVFHKPQPRPTSK 1057

  Fly  1076 LLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDF 1140
            ...:    :..|..:|..:...|..:.|.:.:..:.||.::||.:||:.|..|..:|||..:.||
  Rat  1058 EWPR----STYGKIVAFKIQLGMALLVSGFCILTVTERITKAKHMQFLSGASVLVYWLSALVFDF 1118

  Fly  1141 ASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSI 1205
            ..:.::...:::....::.....|...:....|:|:|||::.:|..|:||..|.:....:.::.:
  Rat  1119 IIFFISCCFLLVMFKYYKIDIYVTDYHILETMLILILFGWSAIPLTYLMSFLFSKSIPAYIQLLV 1183

  Fly  1206 VNIFCGMA-LFIVVVV---MSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTNTATRN-ACA 1265
            .....|.: |.|..::   :|:.:.::..|..:...:|  ||.::|...::: ||....|. .|.
  Rat  1184 FYYLSGTSGLLIDTIIEAGLSTIISNSTQTFLLSSLLF--FPTYNLGKCISE-YTVIYQRKILCI 1245

  Fly  1266 KAGALPPILLCELVPQCCNLKPY-----FAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINEL 1325
            :...:...|.|.        |.|     ::.::|.:....:.|::.|.|:.|.|...|     .:
  Rat  1246 QQKNVLKYLNCS--------KEYTKKNIYSLKKPMIGKYLIAMSIAGFVYLLFIFFWE-----NI 1297

  Fly  1326 MFKIRQLI---------SKPPPPPTEGQL-----DDDVANERERILQMSSNELATKNLVLDRVTK 1376
            .:|:|.||         .|........:|     |:||.|||..||......|... :::.::||
  Rat  1298 SWKLRMLIHQHIYFGVCKKYKSDIISNELSGTSEDNDVENERREILYQPEKFLNCP-VLIKQLTK 1361

  Fly  1377 YYGQ---FMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNS 1438
            .|.:   .:||..:||.:||.|||||||.|||||||||:::||:...::|..::.|:|:..::..
  Rat  1362 IYFKSPLILAVKNISLAIQERECFGLLGFNGAGKTTTFQILTGEITPTAGDVFIDGISITKDVLK 1426

  Fly  1439 IYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGG 1503
            :...|||||||||||:.|||.|::.::..:.|:.|.:||........|.....|.:.....||.|
  Rat  1427 VRSKIGYCPQFDALLEYLTGWEIMVMYARIWGISERQIRPYVNTYLNSLELEPHANSLISTYSEG 1491

  Fly  1504 NKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTR 1568
            |||:||||||::|.||||:||||:|||||.|||.||:.|.:||:|||:|::||||||||||||||
  Rat  1492 NKRRLSTAIAMMGKPSVIFLDEPSTGMDPRARRLLWDAVIKIRESGKAIIITSHSMEECEALCTR 1556

  Fly  1569 LAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRD 1633
            |:|||:|:..|:||.|:|||||....|||.||:.. |.|::
  Rat  1557 LSIMVHGKLTCLGSPQYLKNKFGDIYILKTKVKSG-ETLKE------------------------ 1596

  Fly  1634 IDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEI 1698
               .|.|:...:|.|.|::|.||||.:|||.....|.::||::|..::|.::||||:||.||:::
  Rat  1597 ---FKNFITLTFPGSELKQENQGILNYYIPSKDNSWGKVFGILEKAKEQYDLEDYSISQITLDQV 1658

  Fly  1699 FLEFAKYQRE 1708
            ||.||...|:
  Rat  1659 FLAFADQDRK 1668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	61/183 (33%)
		ABC2_membrane_3	<269..475	CDD:289468	70/209 (33%)
		CcmA	538..843	CDD:224054	147/308 (48%)
		ABC_subfamily_A	538..755	CDD:213230	113/220 (51%)
		ABC2_membrane_3	913..1316	CDD:289468	91/421 (22%)
		ABC_subfamily_A	1369..1587	CDD:213230	112/220 (51%)
		drrA	1376..1702	CDD:130256	151/328 (46%)
Abca15	NP_001099763.2	ABC2_membrane_3	<255..464	CDD:289468	70/214 (33%)
		CcmA	522..834	CDD:224054	148/311 (48%)
		ABC_subfamily_A	522..743	CDD:213230	113/220 (51%)
		ABC2_membrane_3	<1007..1195	CDD:289468	46/191 (24%)
		ABC_subfamily_A	1354..1575	CDD:213230	112/220 (51%)
		drrA	1369..1662	CDD:130256	149/320 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342268
Domainoid	1	1.000	176	1.000	Domainoid score	I3511
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1134	1.000	Inparanoid score	I207
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		mtm8956
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770