DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and Abca17

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_001026807.1	Gene:	Abca17 / 287112	RGDID:	1560494	Length:	1773	Species:	Rattus norvegicus

Alignment Length:	1770	Identity:	599/1770 - (33%)
Similarity:	946/1770 - (53%)	Gaps:	150/1770 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KFVLLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHS 73
            |..||||||:.|:.......|:|.::|.:||.:::.:|.......|....|   ...|::||...
  Rat     6 KLKLLLWKNFVLKKRKTLVTVLETLMPVLFSAIVLYLRLNSMPRNKANTNY---PAVDVSLLPVY 67

  Fly    74 LHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICESENATQ 138
            .|......|...:..|         ||.|.:   ..|..|:::.....::.||...:...||  .
  Rat    68 FHNYPLKSKFQLVYIP---------SKSETL---KAVTEVVEQTFAVDFEVLGFPSVSLFEN--Y 118

  Fly   139 LELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANT--------WLTM 195
            :..|..|.....|:.|...:.  :.|:|||....:.|||....|.:.....:.        |.|.
  Rat   119 IIKDPKSFYVLVGIVFHHDFN--SSNEPLPLVVKYDLRFSYVQRNSISPPRHLFFQEDIEGWCTA 181

  Fly   196 RLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQDLP-----NVVMKRYP 255
            .|:|......||.....||| .|||.:||||.:||::..|.:...:.:..|.     .|.::|:|
  Rat   182 FLYPPNLSQAPREFSYADGG-HPGYNKEGFLAIQHAVDKAIMLHHAPKAALDMFKNLQVSVQRFP 245

  Fly   256 FPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVK 320
            ..::|.||.|..:.:...|:::||||.....||..|..|||::.||.|.:|||.|||||.|||:.
  Rat   246 SGSHIQDPFLVILQNEFPLLLMLSFICVELIITNSILLEKERKQKEYMYLMGLENWLHWVAWFIT 310

  Fly   321 SFI--MLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTA 383
            .|:  ::|:|.:.:....|:|   .|||..::|.|.:..||:.:.:::|.|.|||:|||.||...
  Rat   311 FFLSALVTVSGMTVLFCTKMN---GVAVFRNSNPTLIFIFLMCFAIATIFFAFMMSTFFQRAHVG 372

  Fly   384 AAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFT 448
            ..:.|:::|..|:||.:...||...:.|.|:...|.||.||..|::.|..||..|.|:||.|.
  Rat   373 TVIGGIVFFFTYLPYMYITFSYHQRTYSQKILSCLFSNVAMAMGVRFISLFEAEGTGIQWRNM-- 435

  Fly   449 PVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFW----------- 502
             .||....:...|::|:|:...:|.::...||.:.|...|:|:.|........|
  Rat   436 -GSVWGDFSFTQVLVMLLLDSFLYCLVAFLVESLFPRKIGMPKSWYIFAKCPLWRKKSFPVIPPL 499

  Fly   503 --CGEREYTG----VEDIPNGHVEQRDPKAFETEPEGKHIGLQMRHLKKRF----GNKMVVKGLS 557
              .|:.|.|.    ::|.|.||:.                .::::||.|.|    ...:.||.||
  Rat   500 LVIGDPEKTSKGDFLQDEPAGHIN----------------AIEIQHLYKVFYTGRSKCIAVKDLS 548

  Fly   558 MNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLF 622
            ||:::.:||||||||||||||..|:|||:.||:.|.|.|:|.:|..::...|.::|.||||::||
  Rat   549 MNLYKGQITVLLGHNGAGKTTVCSVLTGLIPPSKGHAYIHGCEISKDMVRIRKNVGWCPQHDILF 613

  Fly   623 DEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDT 687
            |..:|::|:.|:.::|||..:...:::.:.|..:.||||.|..|..|||||||||::..||...:
  Rat   614 DNFTVTDHLYFYGQLKGLSHQDCHEKIEEMLHTLGLEDKRNSRSKFLSGGMKRKLAIGIALIAGS 678

  Fly   688 KVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSF 752
            ||::.|||:||||.|:||.:||||||:|..||:|||||||||||:|||||||:..|||:|.||..
  Rat   679 KVLILDEPTSGMDSSSRRAIWDLLQQQKGDRTVLLTTHFMDEADLLGDRIAILAKGELQCCGTPS 743

  Fly   753 FLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQL 817
            |||::||:||.:..:|...|:|.::..::..:||....|..||.|:.:.||..|..:||.:|..|
  Rat   744 FLKQKYGAGYYMTIIKTPLCDTEKLAKVIYHHIPNAILESRIGEEMIFTLPKKAMPRFEALFADL 808

  Fly   818 EEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQHEIMNGGSGFRGEDDNESVQSD---- 878
            |::..||.::.:|..:|:|||||::|....|.:.|:..:..     ...|....|..|..|
  Rat   809 EQRQTELGISTFGASVTTMEEVFIRVCKLADPSTNVLTEKR-----PSLRHLPRNHRVPVDRIKC 868

  Fly   879 ---GIFS----ENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLL-IQNIMPVFFVVVTILIIK 935
               .|||    :..||..|..||..|:.||||||..::.||.:|:| :|.::|:..:::::....
  Rat   869 LHSRIFSLSSDQPIRLNTGFSLLCQQFYAMLLKKVAFSRRNWMLVLSVQILLPLVIIMLSLSFFN 933

  Fly   936 TQGTFQELKPITISLTQYPLAVTVLDRSNVQNG-TGYEIANKYEDLARSYGSNYGLELTGTQGFE 999
            .:  .::|..:.:.||......|::.....:|. ...::::.:..:..:.| ...|.:.|:  .|
  Rat   934 FK--LRKLDNVPLELTLQTYGQTIVPFFIAENSRLDPQLSDNFVKMLVAAG-QVPLRIQGS--VE 993

  Fly  1000 DYILDLGKTIQVRINSRYLVAATITE----SKITAWLNNQALHTAPLTVNMVHNAIADKLFGSSV 1060
            :::|...|......:..|:|||:..:    :.:.|..||||.|:..|.:.:|.|.:...|.|::.
  Rat   994 NFLLKKAKEAPEDFDKLYVVAASFEDVNDHTTVKALFNNQAYHSPSLALALVDNVLFKLLSGANA 1058

  Fly  1061 KIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGG 1125
            .|..||.|.|.|...|...:......|..|..|..|.:.|:||.:.:..:.|:..::|.|||:.|
  Rat  1059 SITTTNYPQPQTAMELSETILYQGPKGHYLVVNFLFGIAFLSSSFSILTVGEKSIKSKNLQFLSG 1123

  Fly  1126 VKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMS 1190
            |.:..||||..:.|..|::|..|::|:....::|...:....:....|:::|:|:|::|.:|.:|
  Rat  1124 VSMAAFWLSALLWDLISFLVPTLLLVLVFFWYKEEAFAHPQSIPAVVLIMMLYGWAIIPLVYTVS 1188

  Fly  1191 LFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVY 1255
            ..|:.|.:|..::..:..|..::..::|.|.|.......:.:|.|..||.|||...|.|:.:.:|
  Rat  1189 FSFKTPGSGCVKLVAMLTFLSISPVVLVTVTSEIDLGYTELSDTLDHIFLIFPGHCLGMAFSNLY 1253

  Fly  1256 TNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFR 1320
            .|...:..| .|..|..|...:::......|..:|||..|:......:|:.|.|:..::.:.|..
  Rat  1254 YNFEIKKFC-NAKNLSDIDCNDVLEGYVVQKNIYAWESLGIGKYLTALAILGPVYITLLFLTEAN 1317

  Fly  1321 LINELMF---------KIRQLISKPPPPPTEGQLDDDVANERERILQMSSNELATKNLVLDRVTK 1376
            ....|..         |:|.|::      ..|..|:||..|.|.|.......:....||:..::|
  Rat  1318 AFCALKARLSGFFCKQKLRMLLN------VTGAEDEDVLEEAENIKYHLDTLIKKSPLVVKELSK 1376

  Fly  1377 YYGQ---FMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNS 1438
            .|.:   .:|||:||..|:|.|||||||:||||||:.|.|:|.::.|:||.|:|:|.::.::|..
  Rat  1377 VYKEKVPLLAVNKVSFVVKEKECFGLLGLNGAGKTSIFNMLTREQPITSGDAFVKGFNIRTDMAK 1441

  Fly  1439 IYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGG 1503
            :.:.|||||:|||||:.:||||:|.:...:||:.|..|:...:.:.::.....:.||....||.|
  Rat  1442 VQQWIGYCPEFDALLNFMTGREMLVMHARIRGIPECHIKTCVDMILENLLMCVYADKLVKTYSDG 1506

  Fly  1504 NKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTR 1568
            |||.||||||::|.|:||.||||:|||||.|||.:|:.|.|:|:|||:||:||||||||||||||
  Rat  1507 NKRVLSTAIALLGEPTVILLDEPSTGMDPVARRLVWDAVGRVRESGKTIVITSHSMEECEALCTR 1571

  Fly  1569 LAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRD 1633
            |||||.|:|||:||.||||::|..|..|:.||||                         :..|:.
  Rat  1572 LAIMVQGQFKCLGSPQHLKSRFGSGYSLQAKVRR-------------------------KWQQQM 1611

  Fly  1634 IDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEI 1698
            ::..|.||:..:|.|.|::|:|.::.:|:|...:.|:::||:||..:....:||||:||.:||:|
  Rat  1612 LEEFKAFVDLTFPGSSLEDEHQSMVQYYLPGQNLSWAKVFGIMEQAKKDYVLEDYSISQLSLEDI 1676

  Fly  1699 FLEFAKYQREDTRAN 1713
            ||.|.: ...||:.|
  Rat  1677 FLSFTR-PVPDTKEN 1690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	68/181 (38%)
		ABC2_membrane_3	<269..475	CDD:289468	76/207 (37%)
		CcmA	538..843	CDD:224054	146/308 (47%)
		ABC_subfamily_A	538..755	CDD:213230	114/220 (52%)
		ABC2_membrane_3	913..1316	CDD:289468	98/408 (24%)
		ABC_subfamily_A	1369..1587	CDD:213230	119/220 (54%)
		drrA	1376..1702	CDD:130256	153/328 (47%)
Abca17	NP_001026807.1	ABC2_membrane_3	<262..464	CDD:289468	76/207 (37%)
		ABC_subfamily_A	525..746	CDD:213230	114/220 (52%)
		drrA	543..834	CDD:130256	142/290 (49%)
		ABC2_membrane_3	913..1255	CDD:289468	84/346 (24%)
		CcmA	1369..1682	CDD:224054	156/337 (46%)
		ABC_subfamily_A	1369..1590	CDD:213230	119/220 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1690..1773		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342205
Domainoid	1	1.000	176	1.000	Domainoid score	I3511
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1134	1.000	Inparanoid score	I207
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		mtm8956
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770