DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and Abca3

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_001034670.1	Gene:	Abca3 / 27410	MGIID:	1351617	Length:	1704	Species:	Mus musculus

Alignment Length:	1784	Identity:	666/1784 - (37%)
Similarity:	1009/1784 - (56%)	Gaps:	166/1784 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KFVLLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQ-KGVRYYNEQNLTDLNLLQH 72
            :..||||||:||:.......|:||.||.:||.:|:.:|..:.:|. .....|.:|::.:|.|
Mouse     6 QLTLLLWKNYTLKKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATVYPDQSIQELPL--- 67

  Fly    73 SLHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKI----CES 133
                      ..:...|      ||..:..::..:|.....:.:.|:.  :.:.|.::    .|.
Mouse    68 ----------FFSFPPP------GGTWELAYVPSHSDAARTITETVKR--EFMIKMRVHGFSSEK 114

  Fly   134 ENATQLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELR------TATIAIANT- 191
            :....:..|..|.:..|.|.|:.::.:  ..||||....:.|||....|      |..|.:..|
Mouse   115 DFEDYIRYDNHSSSVLAAVVFEHSFNH--SQDPLPLAVKYHLRFSYTRRNYMWTQTGNIFLKETE 177

  Fly   192 -WLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLR---QKSGEQDLPN--VV 250
             |.|..|||.....|||.....||| .|||:|||||.:||::..|.:|   ..|.:|....  |:
Mouse   178 GWHTTSLFPLFPSPGPREPSSPDGG-EPGYIREGFLAMQHAVDKAIMRYHANTSAQQLFQKLMVI 241

  Fly   251 MKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWT 315
            .||:|||.||.||.|..:...:.|:::|||.|....|.:.:..||||:|||.|::|||::||||:
Mouse   242 TKRFPFPPYISDPFLIAIQYQLPLLLMLSFTYTSLTIIRAVVQEKEKKLKEYMRMMGLNSWLHWS 306

  Fly   316 AWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRA 380
            |||:..|:...|....:.:|..:...:|:|||::::.:.::.||:.:.:|||.|.||::||||:|
Mouse   307 AWFLMFFLFFLIVVSFMTLLFCVKVKKDIAVLSNSDPSLVLAFLLCFAISSISFSFMVSTFFSKA 371

  Fly   381 STAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSN 445
            :.||||.|.::|..|.||.|....|:.::||.||...|:||.||..|.:||..||..|.|:||.:
Mouse   372 NIAAAVGGFLYFFTYTPYFFVAPRYNWMTLSQKLLSCLLSNVAMAMGAQLIGKFEAKGTGIQWRD 436

  Fly   446 FFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGE-REYT 509
            ...||:|||....|.|:.|:|:...:|.::..|||.|.||.||||:||:|.....:|||. |...
Mouse   437 LLNPVNVDDNFCFGQVLGMLLLDSALYGLVTWYVEAVFPGQFGVPQPWHFFLMPSYWCGNPRTVV 501

  Fly   510 GVEDIPNGHVEQRDPKA------FETEPEGKHIGLQMRHLKKRF--GN--KMVVKGLSMNMFEDE 564
            |.|:      |..||:.      ||.|||....|::::||.|.|  ||  ||.::.|::|::|.:
Mouse   502 GKEE------EGSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFQVGNKDKMGIRDLTLNLYEGQ 560

  Fly   565 ITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSN 629
            |||||||||||||||:|:|||:||||||.|.|:|.:|..::...|.|||:||||:||||.::|:.
Mouse   561 ITVLLGHNGAGKTTTMSLLTGLFPPTSGHAYIHGYEISQDMAQIRKSLGLCPQHDVLFDNLTVAE 625

  Fly   630 HIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDE 694
            |:.|::::|||..:...:||.:.|.::.||||.::.|..||||||||||:..||...:||::.||
Mouse   626 HLYFYAQLKGLSLQKCPEEVKQMLHILSLEDKRDLRSKFLSGGMKRKLSIGIALIAGSKVLMLDE 690

  Fly   695 PSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYG 759
            |:||||..:||.:||||||:|..||:|||||||||||:|||||||:..|||:|.|:|.|||::||
Mouse   691 PTSGMDAVSRRAIWDLLQQQKSDRTVLLTTHFMDEADLLGDRIAILAKGELQCCGSSLFLKQKYG 755

  Fly   760 SGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQSDEL 824
            :||.:..||...|....::.|::.::|....|...|||||:.||..::.:||.:|.:||::..||
Mouse   756 AGYHMTLVKEPHCNPEGISQLVHHHVPNAMLESHAGAELSFILPKESTHRFESLFAKLEKKQKEL 820

  Fly   825 HLNGYGVGITSMEEVFMKVGAEKDNTGNIKD--------QHE--------------IMNGGSGFR 867
            .:..:|..:|:|||||::||...|.:.:|:.        |||              :|:..:|..
Mouse   821 GIASFGASVTTMEEVFLRVGKLVDTSMDIQAIQLPALQYQHERRASDWALDSNLCGVMDPTNGIG 885

  Fly   868 GEDDNESVQSDGIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTIL 932
            ...:.|.|..        :|..||.|...|:.||.|||..|:||...::..|.::|:..:.:.:|
Mouse   886 ALIEEEEVLV--------KLNTGLALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCLTLALL 942

  Fly   933 IIKTQGTFQELKPITISLTQY-----PLAVTVLDRSNVQNGTGYEIANKYEDLARSYGSNYGLEL 992
            .|.......:...:.:||.:|     |.:|....|      ...:::....|:.::.... ..|:
Mouse   943 AIHYTSEIFDDPLLKLSLNEYGRTVVPFSVPGTSR------LAQQLSENLRDMLQAERQE-PREV 1000

  Fly   993 TGTQGFEDYILDLGKTIQVRINSRYLVAATITE----SKITAWLNNQALHTAPLTVNMVHNAIAD 1053
            .|  ..|::::..........|.|.|||.:..:    :.:||..||||.|:....:.:|.|.:..
Mouse  1001 LG--DLEEFLVFRASVEGGGFNERCLVATSFKDRGELTVVTALFNNQAYHSPATALAIVDNLLFK 1063

  Fly  1054 KLFGSSVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRAK 1118
            .|.|....|:::|.|.|..|..:..........|..:|.||...|.|::|.:.:..:.||..:||
Mouse  1064 LLCGPQASIEISNYPQPRNTLQVAKDHFNEGRKGFDIALNLLIAMAFLASTFSILAVSERAVQAK 1128

  Fly  1119 LLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVL 1183
            .:|||.||.|.|||.|..:.|..|::|.:|::::....|.....:..|.:....|||:|:|:|::
Mouse  1129 HVQFVSGVHVATFWFSALLWDLISFLVPSLLLLVVFQAFNVHAFTRDGHMADLLLLLMLYGWAII 1193

  Fly  1184 PFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKDTADILGWIFRIFPHFSLA 1248
            |.:|:||.||...:|.:.|::|.||..|:|.||:|.:|.......::.:..|..:|.:.|:..|.
Mouse  1194 PLMYLMSFFFSAASTAYTRLTIFNILSGIATFIMVTIMRIPAVKLEELSRTLDHVFLVLPNHCLG 1258

  Fly  1249 MSLNKVYTNTATRNACAKAGALPPILLCELVPQCC---NL---KPYFAWEEPGVLPETVYMAVTG 1307
            |:::..|.|..||..|..:         ||....|   |:   :.::||..|||......||.:|
Mouse  1259 MAVSNFYENYETRRYCTSS---------ELAAHYCKKYNIQYQESFYAWSTPGVGKFVTSMAASG 1314

  Fly  1308 VVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQL---------DDDVANERERILQMSSNE 1363
            .::..::.::|    ..|::::|..|.......|..:|         |.|||.||.|||..|.:.
Mouse  1315 GIYLTLLFLIE----TNLLWRLRTFICAFRRRWTLAELQNRTSVLPEDQDVAEERSRILVPSLDS 1375

  Fly  1364 LATKNLVLDRVTKYYGQ---FMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAA 1425
            :....|:::.::|.|.|   .:||:::||.||:.|||||||.|||||||||||:||:|.|:||.|
Mouse  1376 MLDTPLIINELSKVYDQRAPLLAVDRISLAVQKGECFGLLGFNGAGKTTTFKMLTGEETITSGDA 1440

  Fly  1426 YVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFM 1490
            :|.|.|:.|::..:.:.:|||||||||||.:||||:|.::..|||:.|..|....|:..:.....
Mouse  1441 FVGGYSISSDIGKVRQRMGYCPQFDALLDHMTGREMLVMYARLRGIPERLINACVENTLRGLLLE 1505

  Fly  1491 KHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLT 1555
            .|.:|....|||||||||||.||:||.|:||:||||:|||||.|||.||:.|.|.|:|||:||:|
Mouse  1506 PHANKLVKTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIVIT 1570

  Fly  1556 SHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNP 1620
            ||||||||||||||||||.|:|||:||.||||:||..|..|:.|||
Mouse  1571 SHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLQAKVR------------------- 1616

  Fly  1621 DEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNV 1685
                  ::..|..::..|.||:..:|.|||::|:|.::.:::|...:.|:::||::|..:::..|
Mouse  1617 ------SEGKQDALEEFKAFVDLTFPGSILEDEHQDMVHYHLPGCDLSWAKVFGILEKAKEKYGV 1675

  Fly  1686 EDYSVSQTTLEEIFLEFAKYQ---REDTR 1711
            :||||||.:||::||.||..|   .||.|
Mouse  1676 DDYSVSQISLEQVFLSFAHLQPPTTEDGR 1704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	75/179 (42%)
		ABC2_membrane_3	<269..475	CDD:289468	83/205 (40%)
		CcmA	538..843	CDD:224054	156/308 (51%)
		ABC_subfamily_A	538..755	CDD:213230	123/220 (56%)
		ABC2_membrane_3	913..1316	CDD:289468	107/417 (26%)
		ABC_subfamily_A	1369..1587	CDD:213230	130/220 (59%)
		drrA	1376..1702	CDD:130256	164/328 (50%)
Abca3	NP_001034670.1	rim_protein	1..>43	CDD:130324	16/36 (44%)
Abca3	NP_001034670.1	rim_protein	<206..1699	CDD:130324	605/1553 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838423
Domainoid	1	1.000	180	1.000	Domainoid score	I3485
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37437
Inparanoid	1	1.050	1133	1.000	Inparanoid score	I220
Isobase	1	0.950	-	0	Normalized mean entropy	S3774
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		mtm8719
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	LDO	PTHR19229
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4336
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750