DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and Abca8b

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:NP_038879.2 Gene:Abca8b / 27404 MGIID:1351668 Length:1620 Species:Mus musculus


Alignment Length:1819 Identity:472/1819 - (25%)
Similarity:815/1819 - (44%) Gaps:356/1819 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRS 77
            ||.||...:|..|.:.::|.|    .||||:|..         ..|.:....|||:.:.     :
Mouse    15 LLQKNLLKKWRLKRESLMEWV----SSLLLLLFL---------YWYPHGHGATDLSSVP-----T 61

  Fly    78 SYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEE--AWQSLGKNKI---CESENAT 137
            ..||::.:.      |::|      |::.|:||..:.::::|:  |...:...|:   .:.||..
Mouse    62 KDLGRVDSF------RQSG------FMIGYTPVTSMTQQIMEKVAATPFMADKKVLGLLDEENIK 114

  Fly   138 QLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPA--ELR-----------TATIAIA 189
            :|   |.|......|.|.|.::...:       |.|..|.|.  |||           .....||
Mouse   115 EL---TESHAEIIRVIFSDTFSYHLK-------FQFDQRIPTSRELRDHNAHCDGLYEDVNCLIA 169

  Fly   190 NTWLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQDLPNVV---- 250
            ..|                             :|||:.||.:::.|.:...:....:..::    
Mouse   170 IFW-----------------------------KEGFVALQAAINAAIIETTTNHSVMEELLSVSG 205

  Fly   251 --MKRYPFPAYIFDPLLEGMSS---IMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSN 310
              ||.:||...      ||:.:   |.:.||..|   |.||......|.:.|::|.:|.:|||.:
Mouse   206 KFMKIHPFVRQ------EGILTDFFIFTCIISFS---PITYYVSINVARERKRMKGLMMMMGLRD 261

  Fly   311 WLHWTAW------FVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICF 369
            ...|.:|      ||  |||    |:.:|:::|   |....:||  :|..:....::|.:|.|..
Mouse   262 PAFWLSWGLLYAGFV--FIM----ALSLALVIK---SVQFFILT--SFMVVFSLFLLYGLSMITL 315

  Fly   370 CFMMATFFSRASTAAAVTGLIWFIAYI---PYSFT-INSYDDLSLSSKLGW--SLISNTAMGFGI 428
            .|:|:....:    :.:|||..|:..|   ...|| :..|    |.:.:.|  ||.|..|...|:
Mouse   316 AFLMSALVRK----SVLTGLSVFLLTIFWGSLGFTSLYRY----LPAPVEWTLSLFSPFAFTLGM 372

  Fly   429 KLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPW 493
            ..:|..:     ...::...|.....:..:.|...|::....:|:.:.:|.|:|:|..:|.....
Mouse   373 AQLLRVD-----YDLNSNAPPDPASGSNLIIATNFMLVFDAFLYLALMMYFEKVLPNEYGHQHSP 432

  Fly   494 NFPFTREFWCGERE------YTGVEDIPNGHVEQRDPKAFE-TEPE--GKHIGLQMRHLKKRFGN 549
            .|.....||...|:      ..|::.:|:      ...:|| ..||  ||. .:::|::.|.:..
Mouse   433 LFFLKSSFWLQTRKPAHVILEDGIDPVPS------SGDSFEPVSPEFHGKE-SIRIRNISKEYKG 490

  Fly   550 K----MVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDI--RTNIEGA 608
            |    ..:|.|:::::|.:||.:|||:||||:|.:::|:|:..||.|:..|..:::  ..::|..
Mouse   491 KPNKIEALKDLTLDIYEGQITAVLGHSGAGKSTLLNILSGLSVPTKGSVTIYNNNLSEMADLENI 555

  Fly   609 RMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGM 673
            ....|:|||.||.||.::|..::|.|::::|:..:.||:||.:.|..:|:::..|:.:..||||.
Mouse   556 LRIAGVCPQANVQFDFLTVRENLRLFAKIRGIPPQDVEKEVQRVLLELEMKNIQNILAQNLSGGQ 620

  Fly   674 KRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIA 738
            ||||:...|:.||:::.|.|||::|:||.:|.::|:||::.:..|.:|.:|.||||||:|.||..
Mouse   621 KRKLTFGIAILGDSQIFLLDEPTAGLDPFSRHRVWNLLKERRADRVVLFSTQFMDEADILADRKV 685

  Fly   739 IMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLP 803
            .:.:|.|||.|:|.||||::|.||.|....::.|....:|:|:.::||..|...:...:|.|.||
Mouse   686 FISNGRLKCAGSSLFLKKKWGVGYHLSLQLKEVCVPENITSLVKQHIPAAKLSAEGEGKLLYTLP 750

  Fly   804 DSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKD-QHEIMNGGSGFR 867
            ...:.:|.|:...| :....|.:..|||.:|::.|||:|:    :...:|.: :.:|:..|...|
Mouse   751 LETTYRFPELCQSL-DSCPGLGIENYGVSMTTLNEVFLKL----EGKASIDEPEVDIVGEGQTER 810

  Fly   868 GEDDNESVQSDGIFSENRRL--LQGLQLLSNQW------KAMLLKKFLYTWRNKLLLLIQNIMPV 924
            ..|....::.:...|..|..  ..|:.|...|.      :.:.||....|..:.||:|:..|.|.
Mouse   811 SGDTERLMEMEQTLSSLRETEKTDGMALWRQQTCAIAKVRLLKLKHERKTLLSVLLILVVGICPF 875

  Fly   925 FFVVVTILIIKTQGTFQELKPITISLTQYPLAVTVLDRSNVQNGTGYEIANKYEDLARSYGSNYG 989
            .|..::..|.::..|: ||.|....|........:|.:..:.|.|...|.:....:.|   .|..
Mouse   876 LFENISTKIRQSSYTW-ELSPHDYFLAPGQQPQGMLTQLLIINKTEASIDDFIHSVER---QNIA 936

  Fly   990 LEL--TGTQ-GFEDYILDLGKTIQVRINSRYLVAATITESKITAWLNNQALHTAPLTVNMVHNAI 1051
            ||:  :||: |.:|          ...|...:|:........:...|.:.|:..|:.::::.|.:
Mouse   937 LEVDASGTRDGTDD----------PSYNGALIVSGNEKNHSFSFACNTKRLNCFPVLMDILSNGL 991

  Fly  1052 ADKLFGSSVKIQV---------TNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYIL 1107
            .. :...|.:||.         |..||.....|....:.|.            .|..:::    :
Mouse   992 LG-MVKPSARIQTDRSTYLMDETIHPLEDLWKTAFWLILTS------------ACPPYIA----M 1039

  Fly  1108 FLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYY 1172
            ..:.:.::||.....|.|:....:|:.|.:.|            |.:.||               
Mouse  1040 SSVTDYKNRAWFQLRVSGLFPSAYWVGQAMVD------------IPLYCF--------------- 1077

  Fly  1173 LLLLLFGFAVLPFIYIMSLFFREPATGFARVS-IVNIFC----GMALFIVVVVMSSELFDTKDTA 1232
                     |..|:.:|...||.|.|.|:.:| ::.|.|    .::|..:..|:|......|..:
Mouse  1078 ---------VFLFMSLMDYLFRFPDTMFSIISHVIQIPCSVGYAISLIFLTYVISFISRKGKKNS 1133

  Fly  1233 DILGWIFRIFPHFSLAMSL-------NKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFA 1290
            .|....|.|...||:|:.|       .:.|.          ...:||..|...:....:|.....
Mouse  1134 GIWSLSFYIITVFSVAVILLAFDVDGTQYYI----------IFLIPPSTLVGCLILSLHLFIGQI 1188

  Fly  1291 WEEPGVL-PETVYMAVTGVVFFLIIIV--LEFRLINELM-----FKI----RQLISKPPPPPTEG 1343
            :||..|: |..|::.....||..|..:  ||::...:.|     |:|    ..:...|..|..| 
Mouse  1189 FEEGQVIEPFLVFLIPFLHVFIFIFTLRCLEWKFGKKTMRKDPIFRISPRNNDVYQNPEEPEDE- 1252

  Fly  1344 QLDDDVANERERILQMSSNELATKN------LVLDRVTKYYG-----------QFMAVNQVSLCV 1391
              |:||..||.|    ::|.|.:.:      ::...:.|.|.           ..:|...||.||
Mouse  1253 --DEDVQMERMR----TANALVSTSFDEKPVIIASCLRKEYAGKQKHCLSKKKAKIATRNVSFCV 1311

  Fly  1392 QEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDL 1456
            ::.|..||||.|||||:|:.||::||.::::|...::|    |........:|||||.:||..:|
Mouse  1312 RKGEILGLLGHNGAGKSTSLKMISGDTKVTAGQVLLKG----SREGDTPGFLGYCPQENALWPNL 1372

  Fly  1457 TGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVI 1521
            |.:|.|.||..:||:::|........||.:......:.......|.|.||||...::::|:||::
Mouse  1373 TVKEHLEIFAAVRGLRKSHAAVAITRLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSIL 1437

  Fly  1522 YLDEPTTGMDPAARRQLWNMV-CRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQH 1585
            .||||:||:||..::|:|..: ..|:::.:..:||:|.|.|.||||.|:||:|:|..:||||.||
Mouse  1438 LLDEPSTGLDPEGQQQIWQAIRAIIKNTDRGALLTTHYMAEAEALCDRVAILVSGRLRCIGSIQH 1502

  Fly  1586 LKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETE----YP 1646
            ||:||.|..:|::||:..                  ||..|              :.||    :|
Mouse  1503 LKSKFGKDYLLEMKVKTL------------------EQVEP--------------LNTEILRLFP 1535

  Fly  1647 NSILQEEYQGILTFYIPLTGVK-WSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQRED 1709
            .:..||.|..::.:.:|:..|: .|:.|..:|..:...::|:||:||:|||::|||.:|.|..|
Mouse  1536 QASRQERYSSLMAYKLPVEAVQPLSQAFFKLEKVKQTFDLEEYSLSQSTLEQVFLELSKEQELD 1599

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 53/194 (27%)
ABC2_membrane_3 <269..475 CDD:289468 53/220 (24%)
CcmA 538..843 CDD:224054 111/310 (36%)
ABC_subfamily_A 538..755 CDD:213230 83/222 (37%)
ABC2_membrane_3 913..1316 CDD:289468 84/427 (20%)
ABC_subfamily_A 1369..1587 CDD:213230 83/229 (36%)
drrA 1376..1702 CDD:130256 115/342 (34%)
Abca8bNP_038879.2 rim_protein <265..1596 CDD:130324 398/1486 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838407
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.650

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