DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and Abca7

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:NP_001334010.1 Gene:Abca7 / 27403 MGIID:1351646 Length:2167 Species:Mus musculus


Alignment Length:1934 Identity:592/1934 - (30%)
Similarity:905/1934 - (46%) Gaps:383/1934 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 PAIFSLL-----LVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRSSYLGKLIALIAPNRRRK 94
            |.||:.:     :.:::.|:|....|.|             |.:......|..:...:.|:|   
Mouse   330 PQIFNFMNDSTNVAMLQRLLDVGGTGQR-------------QQTPRAQKKLEAIKDFLDPSR--- 378

  Fly    95 NGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICESENA---TQLELDTVSKNAFAGVQFDD 156
             ||:|..|.......:..:|.:::|  ..||.|.:...||.|   ..||| ...:..:||:.|  
Mouse   379 -GGYSWREAHADMGRLAGILGQMME--CVSLDKLEAVPSEEALVSRALEL-LGERRLWAGIVF-- 437

  Fly   157 AWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLFPTIDLTGPRNEGDDDGGIPPG-- 219
                |:...||.         |:||.:..::..:....:|: ...|:|  |.....|....||  
Mouse   438 ----LSPEHPLD---------PSELSSPALSPGHLRFKIRM-DIDDVT--RTNKIRDKFWDPGPS 486

  Fly   220 --------YLREGFLPLQHSLSMAYLRQKSGEQDLPNVVMKRYPFPAYIFDPLLEGMSSIMSLII 276
                    |:..||:.||..|..|.:|...|......:.:::.|.|.|:.|..|..:|..:.|.:
Mouse   487 ADPFMDLRYVWGGFVYLQDLLEQAAVRVLGGGNSRTGLYLQQMPHPCYVDDVFLRVLSRSLPLFL 551

  Fly   277 LLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWS 341
            .|::||......|.:..|||.:|:|.|:.||||..:.|..||:.......:||.|:.:::|:.  
Mouse   552 TLAWIYSVALTVKAVVREKETRLRETMRAMGLSRAVLWLGWFLSCLGPFLVSAALLVLVLKLG-- 614

  Fly   342 EDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTINSYD 406
               .:|.:::...:..||..:.|:::...|:::.|||||:.|||..||.:|..|:||...:...:
Mouse   615 ---NILPYSHPVVIFLFLAAFAVATVAQSFLLSAFFSRANLAAACGGLAYFALYLPYVLCVAWRE 676

  Fly   407 DLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVI 471
            .|.|...|..||:|..|.|||.:.:...|..|:|.||.|..|. ..:|..:|..|...:|:..||
Mouse   677 RLHLGGLLAASLLSPVAFGFGCESLALLEEQGDGAQWHNLGTG-PAEDVFSLAQVSAFLLLDAVI 740

  Fly   472 YMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTGVEDIPNGHV---EQRDPKAFETEPE- 532
            |.:...|:|.|.||.:|:|.||||||.|.:|||...       |...|   ..:|||....||. 
Mouse   741 YGLALWYLEAVCPGQYGIPEPWNFPFRRSYWCGPGP-------PKSSVLAPAPQDPKVLVEEPPL 798

  Fly   533 GKHIGLQMRHLKKRFGN--KMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAI 595
            |...|:.:|.|||.|..  :..::||:::.:|..||..|||||||||||:|:|:|:|||:||:|.
Mouse   799 GLVPGVSIRGLKKHFRGCPQPALQGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLFPPSSGSAS 863

  Fly   596 INGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELED 660
            |.|.|::||:...|..||||||:|||||.::|..|:.|:.|:||:...|:..|..:.::.:.|..
Mouse   864 ILGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLKGVSAAAMGPERERLIRDVGLTL 928

  Fly   661 KANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTH 725
            |.:..:..|||||:|||||..|..|.::||:.|||::|:||::||.:|:||.:.:.||||:|:||
Mouse   929 KRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLLKYREGRTLILSTH 993

  Fly   726 FMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVK----------RDDCE------- 773
            .:|||::||||:|::..|.|.|.|:..||::..|.||.|..||          :.|.|       
Mouse   994 HLDEAELLGDRVAMVAGGSLCCCGSPLFLRRHLGCGYYLTLVKSSQSLVTHDAKGDSEDPRREKK 1058

  Fly   774 ----------------------------------TNEVTALLNKYIPGLKPECDIGAELSYQLP- 803
                                              |..:..|:.:::||.:...|:..||...|| 
Mouse  1059 SDGNGRTSDTAFTRGTSDKSNQAPAPGAVPITPSTARILELVQQHVPGAQLVEDLPHELLLVLPY 1123

  Fly   804 -DSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQH---------- 857
             .:....|..:|.:|::|.:.|.|.|||:..|::||:|:||         ::|.|          
Mouse  1124 AGALDGSFAMVFQELDQQLELLGLTGYGISDTNLEEIFLKV---------VEDAHREGGDSRPQL 1179

  Fly   858 ---------------EIMNGGSGFRGEDDNESVQSDGIFSENRRLLQGLQLLSNQWKAMLLKKFL 907
                           .::..|...:...|.::.|.   .:.|...:||..|...|.:|:|.|:||
Mouse  1180 HLRTCTPQPPTGPEASVLENGELAKLVLDPQAPQG---LAPNAAQVQGWTLTCQQLRALLHKRFL 1241

  Fly   908 YTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQY------------------- 953
            ...|::..|..|.::|..||.:.:........|.:..|:.:|...|                   
Mouse  1242 LARRSRRGLFAQVVLPALFVGLALFFSLIVPPFGQYPPLQLSPAMYGPQVSFFSEDAPGDPNRMK 1306

  Fly   954 ----------------------------------------PLAVTVLDRSN-------------- 964
                                                    |...::|...|              
Mouse  1307 LLEALLGEAGLQEPSMQDKDARGSECTHSLACYFTVPEVPPDVASILASGNWTPESPSPACQCSQ 1371

  Fly   965 -----------------------------VQNGTGYEIAN----KYEDLAR------------SY 984
                                         |||.||..:::    .|..|.|            .|
Mouse  1372 PGARRLLPDCPAGAGGPPPPQAVAGLGEVVQNLTGRNVSDFLVKTYPSLVRRGLKTKKWVDEVRY 1436

  Fly   985 GSNYGLELTGTQGFEDYILDLGKTI-----QVRI-------NSRYLVAATITE--------SKIT 1029
            |   |..|.|    .|..|..|..:     ::|.       |:...:...:|:        :.:.
Mouse  1437 G---GFSLGG----RDPDLPTGHEVVRTLAEIRALLSPQPGNALDRILNNLTQWALGLDARNSLK 1494

  Fly  1030 AWLNNQALHTAPLTVNMVHNAIADKLFGS-----SVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQ 1089
            .|.||:..|.....||..:|.:...|..|     :..|...|.||..|...|.......:::...
Mouse  1495 IWFNNKGWHAMVAFVNRANNGLLHALLPSGPVRHAHSITTLNHPLNLTKEQLSEATLIASSVDVL 1559

  Fly  1090 LASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITI 1154
            ::..:.|.|.||.:.:.|.||:||.:|||.||.|.|:....:||..|:.|..:|:|...|||...
Mouse  1560 VSICVVFAMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNFLWDMCNYLVAVCIVVFIF 1624

  Fly  1155 VCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCG----MALF 1215
            :.||:........|....|||||:|:::.|.:|..|.||..|:|.:..::.:|:|.|    ||.|
Mouse  1625 LAFQQRAYVAPENLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINSSMATF 1689

  Fly  1216 IVVVVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVP 1280
            ::.::....|   ::.:.||..:|.|||||.|...|..:..|.|..:|..:.|..          
Mouse  1690 VLELLSDQNL---QEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDK---------- 1741

  Fly  1281 QCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQL 1345
               ..:....|:..|  ...:.|...|.:|.||.::|:.|  |.|:.:     |||...|..|:.
Mouse  1742 ---QFQSPLRWDIIG--KNLLAMMAQGPLFLLITLLLQHR--NRLLPQ-----SKPRLLPPLGEE 1794

  Fly  1346 DDDVANERERILQMSSNELATKN--LVLDRVTKYY-GQ-FMAVNQVSLCVQEVECFGLLGVNGAG 1406
            |:|||.||||:     .:.||:.  |||..:||.| || ..||:::.|.:...||||||||||||
Mouse  1795 DEDVAQERERV-----TKGATQGDVLVLRDLTKVYRGQRNPAVDRLCLGIPPGECFGLLGVNGAG 1854

  Fly  1407 KTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGV 1471
            ||:||:|:|||...|||.|.:.|.::....::.::.:|||||.||:.|.|||||.|.:|..||||
Mouse  1855 KTSTFRMVTGDTLPSSGEAVLAGHNVAQERSAAHRSMGYCPQSDAIFDLLTGREHLELFARLRGV 1919

  Fly  1472 QESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARR 1536
            .|:::.|.:.......|...:.|:....|||||||||:||:|::|.|:|::||||||||||:|||
Mouse  1920 PEAQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARR 1984

  Fly  1537 QLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVR 1601
            .|||.:..:...|:|:|||||||||||||||||||||||.|:|:||:||||.:|..|..|.::| 
Mouse  1985 FLWNSLLSVVREGRSVVLTSHSMEECEALCTRLAIMVNGRFRCLGSSQHLKGRFGAGHTLTLRV- 2048

  Fly  1602 RNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTG 1666
                              |.:|..||          ..|:...:|.:.|:|.:...|.|.:|..|
Mouse  2049 ------------------PPDQPEPA----------IAFIRITFPGAELREVHGSRLRFQLPPGG 2085

  Fly  1667 -VKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQREDTRANQ 1714
             ...:|:|..:.:......|||:|||||||||:||.|:|.|.|:..:::
Mouse  2086 RCTLTRVFRELAAQGRAHGVEDFSVSQTTLEEVFLYFSKDQGEEEESSR 2134

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 57/179 (32%)
ABC2_membrane_3 <269..475 CDD:289468 66/205 (32%)
CcmA 538..843 CDD:224054 133/359 (37%)
ABC_subfamily_A 538..755 CDD:213230 102/218 (47%)
ABC2_membrane_3 913..1316 CDD:289468 115/549 (21%)
ABC_subfamily_A 1369..1587 CDD:213230 121/219 (55%)
drrA 1376..1702 CDD:130256 151/328 (46%)
Abca7NP_001334010.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1042..1088 2/45 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1172..1192 0/19 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2126..2167 2/9 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838431
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
87.660

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