Protein Alignment Abca3 and Abca7

DIOPT Version :10

• Sequence 1: NP_608445.2
• Gene: Abca3 / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Sequence 2: NP_001334010.1
• Gene: Abca7 / 27403
• MGIID: 1351646
• Length: 2167
• Species: Mus musculus
• Alignment Length: 1934
• Identity: 592/1934 - (30%)
• Similarity: 905/1934 - (46%)
• Gaps: 383/1934 - (19%)

  Fly    35 PAIFSLL-----LVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRSSYLGKLIALIAPNRRRK 94
            |.||:.:     :.:::.|:|....|.|             |.:......|..:...:.|:|
Mouse   330 PQIFNFMNDSTNVAMLQRLLDVGGTGQR-------------QQTPRAQKKLEAIKDFLDPSR--- 378

  Fly    95 NGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICESENA---TQLELDTVSKNAFAGVQFDD 156
             ||:|..|.......:..:|.:::|  ..||.|.:...||.|   ..||| ...:..:||:.|
Mouse   379 -GGYSWREAHADMGRLAGILGQMME--CVSLDKLEAVPSEEALVSRALEL-LGERRLWAGIVF-- 437

  Fly   157 AWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLFPTIDLTGPRNEGDDDGGIPPG-- 219
                |:...||.         |:||.:..::..:....:|: ...|:|  |.....|....||
Mouse   438 ----LSPEHPLD---------PSELSSPALSPGHLRFKIRM-DIDDVT--RTNKIRDKFWDPGPS 486

  Fly   220 --------YLREGFLPLQHSLSMAYLRQKSGEQDLPNVVMKRYPFPAYIFDPLLEGMSSIMSLII 276
                    |:..||:.||..|..|.:|...|......:.:::.|.|.|:.|..|..:|..:.|.:
Mouse   487 ADPFMDLRYVWGGFVYLQDLLEQAAVRVLGGGNSRTGLYLQQMPHPCYVDDVFLRVLSRSLPLFL 551

  Fly   277 LLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWS 341
            .|::||......|.:..|||.:|:|.|:.||||..:.|..||:.......:||.|:.:::|:.
Mouse   552 TLAWIYSVALTVKAVVREKETRLRETMRAMGLSRAVLWLGWFLSCLGPFLVSAALLVLVLKLG-- 614

  Fly   342 EDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTINSYD 406
               .:|.:::...:..||..:.|:::...|:::.|||||:.|||..||.:|..|:||...:...:
Mouse   615 ---NILPYSHPVVIFLFLAAFAVATVAQSFLLSAFFSRANLAAACGGLAYFALYLPYVLCVAWRE 676

  Fly   407 DLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVI 471
            .|.|...|..||:|..|.|||.:.:...|..|:|.||.|..|. ..:|..:|..|...:|:..||
Mouse   677 RLHLGGLLAASLLSPVAFGFGCESLALLEEQGDGAQWHNLGTG-PAEDVFSLAQVSAFLLLDAVI 740

  Fly   472 YMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTGVEDIPNGHV---EQRDPKAFETEPE- 532
            |.:...|:|.|.||.:|:|.||||||.|.:|||...       |...|   ..:|||....||.
Mouse   741 YGLALWYLEAVCPGQYGIPEPWNFPFRRSYWCGPGP-------PKSSVLAPAPQDPKVLVEEPPL 798

  Fly   533 GKHIGLQMRHLKKRFGN--KMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAI 595
            |...|:.:|.|||.|..  :..::||:::.:|..||..|||||||||||:|:|:|:|||:||:|.
Mouse   799 GLVPGVSIRGLKKHFRGCPQPALQGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLFPPSSGSAS 863

  Fly   596 INGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELED 660
            |.|.|::||:...|..||||||:|||||.::|..|:.|:.|:||:...|:..|..:.::.:.|..
Mouse   864 ILGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLKGVSAAAMGPERERLIRDVGLTL 928

  Fly   661 KANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTH 725
            |.:..:..|||||:|||||..|..|.::||:.|||::|:||::||.:|:||.:.:.||||:|:||
Mouse   929 KRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLLKYREGRTLILSTH 993

  Fly   726 FMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVK----------RDDCE------- 773
            .:|||::||||:|::..|.|.|.|:..||::..|.||.|..||          :.|.|
Mouse   994 HLDEAELLGDRVAMVAGGSLCCCGSPLFLRRHLGCGYYLTLVKSSQSLVTHDAKGDSEDPRREKK 1058

  Fly   774 ----------------------------------TNEVTALLNKYIPGLKPECDIGAELSYQLP- 803
                                              |..:..|:.:::||.:...|:..||...||
Mouse  1059 SDGNGRTSDTAFTRGTSDKSNQAPAPGAVPITPSTARILELVQQHVPGAQLVEDLPHELLLVLPY 1123

  Fly   804 -DSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQH---------- 857
             .:....|..:|.:|::|.:.|.|.|||:..|::||:|:||         ::|.|
Mouse  1124 AGALDGSFAMVFQELDQQLELLGLTGYGISDTNLEEIFLKV---------VEDAHREGGDSRPQL 1179

  Fly   858 ---------------EIMNGGSGFRGEDDNESVQSDGIFSENRRLLQGLQLLSNQWKAMLLKKFL 907
                           .::..|...:...|.::.|.   .:.|...:||..|...|.:|:|.|:||
Mouse  1180 HLRTCTPQPPTGPEASVLENGELAKLVLDPQAPQG---LAPNAAQVQGWTLTCQQLRALLHKRFL 1241

  Fly   908 YTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQY------------------- 953
            ...|::..|..|.::|..||.:.:........|.:..|:.:|...|
Mouse  1242 LARRSRRGLFAQVVLPALFVGLALFFSLIVPPFGQYPPLQLSPAMYGPQVSFFSEDAPGDPNRMK 1306

  Fly   954 ----------------------------------------PLAVTVLDRSN-------------- 964
                                                    |...::|...|
Mouse  1307 LLEALLGEAGLQEPSMQDKDARGSECTHSLACYFTVPEVPPDVASILASGNWTPESPSPACQCSQ 1371

  Fly   965 -----------------------------VQNGTGYEIAN----KYEDLAR------------SY 984
                                         |||.||..:::    .|..|.|            .|
Mouse  1372 PGARRLLPDCPAGAGGPPPPQAVAGLGEVVQNLTGRNVSDFLVKTYPSLVRRGLKTKKWVDEVRY 1436

  Fly   985 GSNYGLELTGTQGFEDYILDLGKTI-----QVRI-------NSRYLVAATITE--------SKIT 1029
            |   |..|.|    .|..|..|..:     ::|.       |:...:...:|:        :.:.
Mouse  1437 G---GFSLGG----RDPDLPTGHEVVRTLAEIRALLSPQPGNALDRILNNLTQWALGLDARNSLK 1494

  Fly  1030 AWLNNQALHTAPLTVNMVHNAIADKLFGS-----SVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQ 1089
            .|.||:..|.....||..:|.:...|..|     :..|...|.||..|...|.......:::...
Mouse  1495 IWFNNKGWHAMVAFVNRANNGLLHALLPSGPVRHAHSITTLNHPLNLTKEQLSEATLIASSVDVL 1559

  Fly  1090 LASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITI 1154
            ::..:.|.|.||.:.:.|.||:||.:|||.||.|.|:....:||..|:.|..:|:|...|||...
Mouse  1560 VSICVVFAMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNFLWDMCNYLVAVCIVVFIF 1624

  Fly  1155 VCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCG----MALF 1215
            :.||:........|....|||||:|:::.|.:|..|.||..|:|.:..::.:|:|.|    ||.|
Mouse  1625 LAFQQRAYVAPENLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINSSMATF 1689

  Fly  1216 IVVVVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVP 1280
            ::.::....|   ::.:.||..:|.|||||.|...|..:..|.|..:|..:.|..
Mouse  1690 VLELLSDQNL---QEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDK---------- 1741

  Fly  1281 QCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQL 1345
               ..:....|:..|  ...:.|...|.:|.||.::|:.|  |.|:.:     |||...|..|:.
Mouse  1742 ---QFQSPLRWDIIG--KNLLAMMAQGPLFLLITLLLQHR--NRLLPQ-----SKPRLLPPLGEE 1794

  Fly  1346 DDDVANERERILQMSSNELATKN--LVLDRVTKYY-GQ-FMAVNQVSLCVQEVECFGLLGVNGAG 1406
            |:|||.||||:     .:.||:.  |||..:||.| || ..||:::.|.:...||||||||||||
Mouse  1795 DEDVAQERERV-----TKGATQGDVLVLRDLTKVYRGQRNPAVDRLCLGIPPGECFGLLGVNGAG 1854

  Fly  1407 KTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGV 1471
            ||:||:|:|||...|||.|.:.|.::....::.::.:|||||.||:.|.|||||.|.:|..||||
Mouse  1855 KTSTFRMVTGDTLPSSGEAVLAGHNVAQERSAAHRSMGYCPQSDAIFDLLTGREHLELFARLRGV 1919

  Fly  1472 QESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARR 1536
            .|:::.|.:.......|...:.|:....|||||||||:||:|::|.|:|::||||||||||:|||
Mouse  1920 PEAQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARR 1984

  Fly  1537 QLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVR 1601
            .|||.:..:...|:|:|||||||||||||||||||||||.|:|:||:||||.:|..|..|.::|
Mouse  1985 FLWNSLLSVVREGRSVVLTSHSMEECEALCTRLAIMVNGRFRCLGSSQHLKGRFGAGHTLTLRV- 2048

  Fly  1602 RNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTG 1666
                              |.:|..||          ..|:...:|.:.|:|.:...|.|.:|..|
Mouse  2049 ------------------PPDQPEPA----------IAFIRITFPGAELREVHGSRLRFQLPPGG 2085

  Fly  1667 -VKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQREDTRANQ 1714
             ...:|:|..:.:......|||:|||||||||:||.|:|.|.|:..:::
Mouse  2086 RCTLTRVFRELAAQGRAHGVEDFSVSQTTLEEVFLYFSKDQGEEEESSR 2134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abca3	NP_608445.2	rim_protein	<137..1708	CDD:130324	568/1816 (31%)
Abca7	NP_001334010.1	rim_protein	1..2128	CDD:130324	591/1926 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1042..1088		2/45 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1172..1192		0/19 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2126..2167		2/9 (22%)