DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Abca3 and Abca13

DIOPT Version :10

Sequence 1:NP_608445.2 Gene:Abca3 / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:NP_839990.2 Gene:Abca13 / 268379 MGIID:2388707 Length:5034 Species:Mus musculus


Alignment Length:2013 Identity:562/2013 - (27%)
Similarity:917/2013 - (45%) Gaps:440/2013 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 WQMVIELV-LPA--IFSLLL----------VLVRTLVDTEQKGVRYYNEQNLTDL-----NLLQH 72
            |.:..||. ||.  :||||:          ::.:||:.:|..|:.    ::|.|:     ::|..
Mouse  3107 WFVTRELCSLPGSQVFSLLVMMGQNLNLRNLIYKTLIPSEANGLL----KSLLDVVASLSSILAR 3167

  Fly    73 SLHRSSYLG------KLIAL--------IAPNRRRKNGGFSKFEFI---LCYSP----------- 109
            :.|...||.      |:.||        ::...:.::..|:.|:.:   ||...           
Mouse  3168 AQHALEYLPEFLHTFKITALLDMPDFQQVSSKGQTRSSAFASFQSVMKLLCKDQESFLSNSNMFI 3232

  Fly   110 ----VNPVLK-----------------KLVEE---------AWQSL-----GK----------NK 129
                ||.:|:                 ||.:|         .|..|     ||          |:
Mouse  3233 NLPRVNELLEDNKEKFNIPHDSTPFCLKLYQEILQSPNGALVWSFLKPVLHGKILYTPNSPEINE 3297

  Fly   130 ICESENATQLELDTVS---------KNAFAGV-------QFDDAWAN-----------------L 161
            :.:..|.|...:|.:.         ...|.|.       |..||..|                 |
Mouse  3298 VIQKANYTFYFVDKIKVLSETFLKISKLFQGSGNGQMFNQLQDALRNKFIRNFVESQLHIDMDKL 3362

  Fly   162 TEN--------DPLPNDF---HFAL---------------RFPA-------ELRTATIAIANTWL 193
            ||:        |.:.|..   ||..               ||.|       |.:...:...|::|
Mouse  3363 TEDLQTYGRMLDKMFNHVEAGHFRFLGGMLANLSSCVVLDRFQAVETVDTLETKAHELMQQNSFL 3427

  Fly   194 TMRLF-----------------PTIDLT---------------------GPRNEGDDDGGIPPGY 220
            ...:|                 |.:..|                     .|:|.  ..||....|
Mouse  3428 ASIIFNSSLRHRHIRSAPHKLPPHVTYTIRTNVLYSMRTDMIKNPSWKFHPQNL--PAGGFKYNY 3490

  Fly   221 LREGFLPLQHSLSMAYLRQKSGEQDL-PNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPC 284
            :   |:|||..:..|.:..::|::.| |....:..|:|.:..|..|..:.....||::|:::...
Mouse  3491 I---FVPLQDMIERAIIVVQTGQESLEPTTQAQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVAV 3552

  Fly   285 TYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTH 349
            ..:.:.:..|:|.|::|.|::|||...:|:.:||:::...|.:|:..:|:::|::     .:..|
Mouse  3553 ASMVRKLVYEREIQIEEYMRMMGLHPTIHFLSWFLENMATLALSSAALAVILKMS-----GIFMH 3612

  Fly   350 ANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKL 414
            ::...:..:|:.:.||::...:.::.||::|:|||..|.|.:.|:::||...:..::.||.:.:.
Mouse  3613 SDAFIIFLYLLDFGVSAVMMSYFLSVFFNQANTAALCTSLGYMISFLPYVVLLVLHNQLSFAIQT 3677

  Fly   415 GWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYV 479
            ...|:|.||.|.|:..|...||..||:||.|.:. ......:|.|.|..|:|...::|.:...|.
Mouse  3678 LLCLLSTTAFGQGVFFITFLEGQEEGIQWGNMYR-APEPGGMTFGWVCWMILFDAILYFLGGWYF 3741

  Fly   480 EQVMPGSFGVPRPWNFPFTREFW---CG--EREYTGV--------EDIPN-GHVEQRDPKAFETE 530
            ..::||:||:.:||.||||..:|   ||  ||....:        ||..| |..:|..|    .|
Mouse  3742 SNLVPGTFGLGKPWYFPFTASYWKSICGLMERRRCSLSSGLFFFNEDFGNKGLSQQNGP----GE 3802

  Fly   531 PEGKHIGLQMRHLKKRF-GNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTA 594
            .||.:.|:.:..:.|.: .:|:.|:.|::....|:||.|||.|||||||.||||.|:|||||||.
Mouse  3803 MEGGNPGVALISVTKEYEDHKVAVQELTLTFHRDQITALLGTNGAGKTTIISMLMGLFPPTSGTI 3867

  Fly   595 IINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKG--LRGKAVEQEVAKYLKMIE 657
            .|||.:::|::...|..||:|||.:||.|.::|..|:..|:.:|.  ...|.::|:|.|.|..:|
Mouse  3868 TINGKNLQTDLSKVREELGVCPQQDVLLDNLTVREHLMLFASIKAPWWTTKELQQQVNKTLDEVE 3932

  Fly   658 LEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLL 722
            |....:..:..||||||||||:..|..|.:|.|:.||||||:||.:||.|||:|.:.:.|||::.
Mouse  3933 LTQHQHKPAGVLSGGMKRKLSIGIAFMGMSKTVVLDEPSSGVDPCSRRSLWDILLKYREGRTIIF 3997

  Fly   723 TTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDD-CETNE------VTAL 780
            |||.:|||::|.|.:|::..|.|:|......||:.||.|..|...|:.. .||.|      ||:|
Mouse  3998 TTHHLDEAEMLSDHVAVLQQGRLRCYAPPADLKETYGQGLTLTLSKQPSILETQEPKDVARVTSL 4062

  Fly   781 LNKYIPG--LKPECDIGAELSYQLP-DSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMK 842
            :..|||.  ||..|  |.||:|.:| |:....|:.:...|::....|||.|||:..|::||||:.
Mouse  4063 IQIYIPQAFLKDSC--GGELTYTIPKDADRTCFKGLCQALDQNLQHLHLTGYGISDTTLEEVFLM 4125

  Fly   843 VGAEKDNTGNIKDQHEIMNGGSGFRGEDDNE--------------SVQSDGIFSENRRLLQGLQL 893
            :..:.:....|...:::         |..||              |...:|...|.   :.|.||
Mouse  4126 LLQDTNKKSYITPDNKV---------EPQNERPVGPLSPHNVSPLSTPPEGALPEP---IGGCQL 4178

  Fly   894 LSNQWKAMLLKKFLYT---WRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQYPL 955
            |..|..|:|.|:.|:|   |::....|   ::||.||.:.:.:...|.......|:.::...|..
Mouse  4179 LLGQAVALLRKRLLHTLRAWKSTTSDL---LLPVLFVALAMGLFMVQPLAITYPPLKLTPGHYET 4240

  Fly   956 AVTVLDRS-NVQNGTGYEIANKYEDL--------------------------------------- 980
            |.|....| |......:.:..|:.|.                                       
Mouse  4241 AETYFFSSGNHGPDLTHVLLRKFRDQDPVCADAFRMNSSSWHRDPYSGPESQDSCGCLKCPNKSA 4305

  Fly   981 -ARSYGSNYGLELTGTQGF--EDYIL-----------DLGKTI-----QVRINSRYLVAATITES 1026
             |.|..:..|..|....|:  |:|:|           ..|..|     .|:.|:    :...|.:
Mouse  4306 GAPSLTNCLGHTLLNLSGYDVEEYLLVPSAKPRLGGWSFGGQIPNDAEDVKTNT----SKPRTLA 4366

  Fly  1027 KITAWLNNQALHTAPLTVNMVHNAIA-DKLFGSSV---KIQVTNAPLPYTTSTLLSQLSTGNNLG 1087
            |:  |.|.:..|:.|..:|.::|.|. ..|..::|   :..:|....|| ...||::        
Mouse  4367 KV--WYNQKGFHSLPSYLNHLNNLILWHHLPANAVDWRQYGITLYSHPY-GGALLNE-------- 4420

  Fly  1088 TQLASNLCFC---MCFVSSIYIL------FLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASY 1143
            .::..::..|   :|.|....||      .::::|.:.||.||.:.|:...|:||..|:.|...|
Mouse  4421 DRILESIRQCGVALCIVLGFSILSASIGSSVVRDRVTGAKRLQHISGLGHRTYWLINFLYDMLFY 4485

  Fly  1144 IVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNI 1208
            :|:..:.|..|..||.|..:....|....|||.|||:|::|::|:||..|......|.....:|.
Mouse  4486 LVSVCLCVAVIGAFQLTAFTFRENLAATALLLALFGYAMIPWMYLMSRIFSSSDVAFISYISLNF 4550

  Fly  1209 FCGMALFIV-----VVVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAG 1268
            ..|:...::     ::.:.|:..:.:...::|.|.|.|||.|.|...|.::..|....:.....|
Mouse  4551 IFGLCTMLMTTMPRLLAIISKAQNLQKIYNVLKWAFTIFPQFCLGQGLIELCYNQIKYDLTHNFG 4615

  Fly  1269 ALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELM-----FK 1328
            ....:...|:        .:..|         :::.:|....||::  |...|..:|:     ..
Mouse  4616 IDSYVSPFEM--------NFLGW---------IFVELTLQGTFLLL--LRLMLHGDLLRWPRDHS 4661

  Fly  1329 IRQLISKPPPPPTEGQLDDDVANERERILQMSSNELATKNLVLDRVTKYY-----GQFMAVNQVS 1388
            :.|.|.||..       |.||..|:.|:|:   .......:||..::|.|     |:..||:.:|
Mouse  4662 VLQDIVKPAK-------DIDVETEQMRVLE---GRTGGDMMVLCNLSKSYRSVFGGKTTAVHGIS 4716

  Fly  1389 LCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYV---QGLSLE-SNMNSIYKMIGYCPQF 1449
            |.:...|||||||||||||:||||::.|:...|||...:   ||..:: ::......:||||||.
Mouse  4717 LGIPRGECFGLLGVNGAGKSTTFKILNGETPPSSGYTVIRTPQGDMVDLASAGKAGILIGYCPQQ 4781

  Fly  1450 DALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAV 1514
            |||.:.|||.|.|:.:|.|||:.:..|.:::.||.:......|:||....||||.:||||||:|:
Mouse  4782 DALDELLTGWEHLQYYCRLRGIPKQYIPEVAADLVRRLHLESHVDKPVATYSGGTRRKLSTALAL 4846

  Fly  1515 IGSPSVIYLDEPTTGMDPAARRQLWNMVCR-IRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFK 1578
            :|.|.::.||||::||||.::|.||..:.: :|| |.:.|||||||||||||||||||||:|.|:
Mouse  4847 VGKPDILLLDEPSSGMDPCSKRYLWQTITQEVRD-GCAAVLTSHSMEECEALCTRLAIMVDGSFR 4910

  Fly  1579 CIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVET 1643
            |:|..||:||:|..|..:|:.:.:                   |.:.|:        ||.:.::.
Mouse  4911 CLGPPQHIKNRFGDGYTVKVWLHK-------------------EGSQPS--------AVSDCLKL 4948

  Fly  1644 EYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQ 1706
            .:|....:.:...:|.:::..:....:.:|.::|:|:..||:|.||:||||||::|:.||..|
Mouse  4949 HFPGIQFKGQRLNLLEYHVQKSWECLADLFKVLENNKSLLNIEHYSISQTTLEQVFVNFATEQ 5011

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Abca3NP_608445.2 rim_protein <137..1708 CDD:130324 524/1811 (29%)
Abca13NP_839990.2 rim_protein 1..>82 CDD:130324
rim_protein 3036..5019 CDD:130324 562/2013 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4135..4165 5/38 (13%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.