DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and Abca13

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:NP_839990.2 Gene:Abca13 / 268379 MGIID:2388707 Length:5034 Species:Mus musculus


Alignment Length:2013 Identity:562/2013 - (27%)
Similarity:917/2013 - (45%) Gaps:440/2013 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 WQMVIELV-LPA--IFSLLL----------VLVRTLVDTEQKGVRYYNEQNLTDL-----NLLQH 72
            |.:..||. ||.  :||||:          ::.:||:.:|..|:.    ::|.|:     ::|..
Mouse  3107 WFVTRELCSLPGSQVFSLLVMMGQNLNLRNLIYKTLIPSEANGLL----KSLLDVVASLSSILAR 3167

  Fly    73 SLHRSSYLG------KLIAL--------IAPNRRRKNGGFSKFEFI---LCYSP----------- 109
            :.|...||.      |:.||        ::...:.::..|:.|:.:   ||...           
Mouse  3168 AQHALEYLPEFLHTFKITALLDMPDFQQVSSKGQTRSSAFASFQSVMKLLCKDQESFLSNSNMFI 3232

  Fly   110 ----VNPVLK-----------------KLVEE---------AWQSL-----GK----------NK 129
                ||.:|:                 ||.:|         .|..|     ||          |:
Mouse  3233 NLPRVNELLEDNKEKFNIPHDSTPFCLKLYQEILQSPNGALVWSFLKPVLHGKILYTPNSPEINE 3297

  Fly   130 ICESENATQLELDTVS---------KNAFAGV-------QFDDAWAN-----------------L 161
            :.:..|.|...:|.:.         ...|.|.       |..||..|                 |
Mouse  3298 VIQKANYTFYFVDKIKVLSETFLKISKLFQGSGNGQMFNQLQDALRNKFIRNFVESQLHIDMDKL 3362

  Fly   162 TEN--------DPLPNDF---HFAL---------------RFPA-------ELRTATIAIANTWL 193
            ||:        |.:.|..   ||..               ||.|       |.:...:...|::|
Mouse  3363 TEDLQTYGRMLDKMFNHVEAGHFRFLGGMLANLSSCVVLDRFQAVETVDTLETKAHELMQQNSFL 3427

  Fly   194 TMRLF-----------------PTIDLT---------------------GPRNEGDDDGGIPPGY 220
            ...:|                 |.:..|                     .|:|.  ..||....|
Mouse  3428 ASIIFNSSLRHRHIRSAPHKLPPHVTYTIRTNVLYSMRTDMIKNPSWKFHPQNL--PAGGFKYNY 3490

  Fly   221 LREGFLPLQHSLSMAYLRQKSGEQDL-PNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPC 284
            :   |:|||..:..|.:..::|::.| |....:..|:|.:..|..|..:.....||::|:::...
Mouse  3491 I---FVPLQDMIERAIIVVQTGQESLEPTTQAQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVAV 3552

  Fly   285 TYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTH 349
            ..:.:.:..|:|.|::|.|::|||...:|:.:||:::...|.:|:..:|:::|::     .:..|
Mouse  3553 ASMVRKLVYEREIQIEEYMRMMGLHPTIHFLSWFLENMATLALSSAALAVILKMS-----GIFMH 3612

  Fly   350 ANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKL 414
            ::...:..:|:.:.||::...:.::.||::|:|||..|.|.:.|:::||...:..::.||.:.:.
Mouse  3613 SDAFIIFLYLLDFGVSAVMMSYFLSVFFNQANTAALCTSLGYMISFLPYVVLLVLHNQLSFAIQT 3677

  Fly   415 GWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYV 479
            ...|:|.||.|.|:..|...||..||:||.|.:. ......:|.|.|..|:|...::|.:...|.
Mouse  3678 LLCLLSTTAFGQGVFFITFLEGQEEGIQWGNMYR-APEPGGMTFGWVCWMILFDAILYFLGGWYF 3741

  Fly   480 EQVMPGSFGVPRPWNFPFTREFW---CG--EREYTGV--------EDIPN-GHVEQRDPKAFETE 530
            ..::||:||:.:||.||||..:|   ||  ||....:        ||..| |..:|..|    .|
Mouse  3742 SNLVPGTFGLGKPWYFPFTASYWKSICGLMERRRCSLSSGLFFFNEDFGNKGLSQQNGP----GE 3802

  Fly   531 PEGKHIGLQMRHLKKRF-GNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTA 594
            .||.:.|:.:..:.|.: .:|:.|:.|::....|:||.|||.|||||||.||||.|:|||||||.
Mouse  3803 MEGGNPGVALISVTKEYEDHKVAVQELTLTFHRDQITALLGTNGAGKTTIISMLMGLFPPTSGTI 3867

  Fly   595 IINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKG--LRGKAVEQEVAKYLKMIE 657
            .|||.:::|::...|..||:|||.:||.|.::|..|:..|:.:|.  ...|.::|:|.|.|..:|
Mouse  3868 TINGKNLQTDLSKVREELGVCPQQDVLLDNLTVREHLMLFASIKAPWWTTKELQQQVNKTLDEVE 3932

  Fly   658 LEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLL 722
            |....:..:..||||||||||:..|..|.:|.|:.||||||:||.:||.|||:|.:.:.|||::.
Mouse  3933 LTQHQHKPAGVLSGGMKRKLSIGIAFMGMSKTVVLDEPSSGVDPCSRRSLWDILLKYREGRTIIF 3997

  Fly   723 TTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDD-CETNE------VTAL 780
            |||.:|||::|.|.:|::..|.|:|......||:.||.|..|...|:.. .||.|      ||:|
Mouse  3998 TTHHLDEAEMLSDHVAVLQQGRLRCYAPPADLKETYGQGLTLTLSKQPSILETQEPKDVARVTSL 4062

  Fly   781 LNKYIPG--LKPECDIGAELSYQLP-DSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMK 842
            :..|||.  ||..|  |.||:|.:| |:....|:.:...|::....|||.|||:..|::||||:.
Mouse  4063 IQIYIPQAFLKDSC--GGELTYTIPKDADRTCFKGLCQALDQNLQHLHLTGYGISDTTLEEVFLM 4125

  Fly   843 VGAEKDNTGNIKDQHEIMNGGSGFRGEDDNE--------------SVQSDGIFSENRRLLQGLQL 893
            :..:.:....|...:::         |..||              |...:|...|.   :.|.||
Mouse  4126 LLQDTNKKSYITPDNKV---------EPQNERPVGPLSPHNVSPLSTPPEGALPEP---IGGCQL 4178

  Fly   894 LSNQWKAMLLKKFLYT---WRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQYPL 955
            |..|..|:|.|:.|:|   |::....|   ::||.||.:.:.:...|.......|:.::...|..
Mouse  4179 LLGQAVALLRKRLLHTLRAWKSTTSDL---LLPVLFVALAMGLFMVQPLAITYPPLKLTPGHYET 4240

  Fly   956 AVTVLDRS-NVQNGTGYEIANKYEDL--------------------------------------- 980
            |.|....| |......:.:..|:.|.                                       
Mouse  4241 AETYFFSSGNHGPDLTHVLLRKFRDQDPVCADAFRMNSSSWHRDPYSGPESQDSCGCLKCPNKSA 4305

  Fly   981 -ARSYGSNYGLELTGTQGF--EDYIL-----------DLGKTI-----QVRINSRYLVAATITES 1026
             |.|..:..|..|....|:  |:|:|           ..|..|     .|:.|:    :...|.:
Mouse  4306 GAPSLTNCLGHTLLNLSGYDVEEYLLVPSAKPRLGGWSFGGQIPNDAEDVKTNT----SKPRTLA 4366

  Fly  1027 KITAWLNNQALHTAPLTVNMVHNAIA-DKLFGSSV---KIQVTNAPLPYTTSTLLSQLSTGNNLG 1087
            |:  |.|.:..|:.|..:|.::|.|. ..|..::|   :..:|....|| ...||::        
Mouse  4367 KV--WYNQKGFHSLPSYLNHLNNLILWHHLPANAVDWRQYGITLYSHPY-GGALLNE-------- 4420

  Fly  1088 TQLASNLCFC---MCFVSSIYIL------FLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASY 1143
            .::..::..|   :|.|....||      .::::|.:.||.||.:.|:...|:||..|:.|...|
Mouse  4421 DRILESIRQCGVALCIVLGFSILSASIGSSVVRDRVTGAKRLQHISGLGHRTYWLINFLYDMLFY 4485

  Fly  1144 IVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNI 1208
            :|:..:.|..|..||.|..:....|....|||.|||:|::|::|:||..|......|.....:|.
Mouse  4486 LVSVCLCVAVIGAFQLTAFTFRENLAATALLLALFGYAMIPWMYLMSRIFSSSDVAFISYISLNF 4550

  Fly  1209 FCGMALFIV-----VVVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAG 1268
            ..|:...::     ::.:.|:..:.:...::|.|.|.|||.|.|...|.::..|....:.....|
Mouse  4551 IFGLCTMLMTTMPRLLAIISKAQNLQKIYNVLKWAFTIFPQFCLGQGLIELCYNQIKYDLTHNFG 4615

  Fly  1269 ALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELM-----FK 1328
            ....:...|:        .:..|         :::.:|....||::  |...|..:|:     ..
Mouse  4616 IDSYVSPFEM--------NFLGW---------IFVELTLQGTFLLL--LRLMLHGDLLRWPRDHS 4661

  Fly  1329 IRQLISKPPPPPTEGQLDDDVANERERILQMSSNELATKNLVLDRVTKYY-----GQFMAVNQVS 1388
            :.|.|.||..       |.||..|:.|:|:   .......:||..::|.|     |:..||:.:|
Mouse  4662 VLQDIVKPAK-------DIDVETEQMRVLE---GRTGGDMMVLCNLSKSYRSVFGGKTTAVHGIS 4716

  Fly  1389 LCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYV---QGLSLE-SNMNSIYKMIGYCPQF 1449
            |.:...|||||||||||||:||||::.|:...|||...:   ||..:: ::......:||||||.
Mouse  4717 LGIPRGECFGLLGVNGAGKSTTFKILNGETPPSSGYTVIRTPQGDMVDLASAGKAGILIGYCPQQ 4781

  Fly  1450 DALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAV 1514
            |||.:.|||.|.|:.:|.|||:.:..|.:::.||.:......|:||....||||.:||||||:|:
Mouse  4782 DALDELLTGWEHLQYYCRLRGIPKQYIPEVAADLVRRLHLESHVDKPVATYSGGTRRKLSTALAL 4846

  Fly  1515 IGSPSVIYLDEPTTGMDPAARRQLWNMVCR-IRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFK 1578
            :|.|.::.||||::||||.::|.||..:.: :|| |.:.|||||||||||||||||||||:|.|:
Mouse  4847 VGKPDILLLDEPSSGMDPCSKRYLWQTITQEVRD-GCAAVLTSHSMEECEALCTRLAIMVDGSFR 4910

  Fly  1579 CIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVET 1643
            |:|..||:||:|..|..:|:.:.:                   |.:.|:        ||.:.::.
Mouse  4911 CLGPPQHIKNRFGDGYTVKVWLHK-------------------EGSQPS--------AVSDCLKL 4948

  Fly  1644 EYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQ 1706
            .:|....:.:...:|.:::..:....:.:|.::|:|:..||:|.||:||||||::|:.||..|
Mouse  4949 HFPGIQFKGQRLNLLEYHVQKSWECLADLFKVLENNKSLLNIEHYSISQTTLEQVFVNFATEQ 5011

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 46/179 (26%)
ABC2_membrane_3 <269..475 CDD:289468 55/205 (27%)
CcmA 538..843 CDD:224054 134/317 (42%)
ABC_subfamily_A 538..755 CDD:213230 96/219 (44%)
ABC2_membrane_3 913..1316 CDD:289468 98/479 (20%)
ABC_subfamily_A 1369..1587 CDD:213230 110/227 (48%)
drrA 1376..1702 CDD:130256 134/335 (40%)
Abca13NP_839990.2 rim_protein 3036..5019 CDD:130324 562/2013 (28%)
ABC_subfamily_A 3815..4030 CDD:213230 96/214 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4135..4165 5/38 (13%)
ABC_subfamily_A 4692..4919 CDD:213230 110/227 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838504
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 1 1.100 - - O PTHR19229
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.750

Return to query results.
Submit another query.