DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and ABCA12

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_011509253.1 Gene:ABCA12 / 26154 HGNCID:14637 Length:2598 Species:Homo sapiens


Alignment Length:1864 Identity:540/1864 - (28%)
Similarity:887/1864 - (47%) Gaps:350/1864 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   105 LCYSPVNPVLKKLVEEAWQSLGKNKICESENATQLELD--------------------TVSKNAF 149
            :.|:|.|||.|.::|::..:|  .::.|....:|..:|                    ...:|.|
Human   809 ILYAPYNPVTKAIMEKSNVTL--RQLAELREKSQEWMDKSPLFMNSFHLLNQAIPMLQNTLRNPF 871

  Fly   150 AG--VQFD---DAWANLTENDPLPNDFHFALRFPAE-----------LRTATIAIANTWL----- 193
            ..  |:|.   ||...|.:.|.|.     .||...|           |.:.|:.|::..|     
Human   872 VQVFVKFSVGLDAVELLKQIDELD-----ILRLKLENNIDIIDQLNTLSSLTVNISSCVLYDRIQ 931

  Fly   194 -----------TMRLFPTIDLTG------PRN----EGDDDGGI--PP----------------G 219
                       ..||:.:.:|.|      |.|    .|.|.|.:  ||                .
Human   932 AAKTIDEMEREAKRLYKSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTR 996

  Fly   220 YLR-------------------EGFLPLQHSLSMAYLRQKSG--EQDLPNVVMKRYPFPAYIFDP 263
            .||                   ..|:.||.|:..|.:..::|  .|::. |.::..|:|.::.|.
Human   997 SLRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAIIELQTGRNSQEIA-VQVQAIPYPCFMKDN 1060

  Fly   264 LLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTIS 328
            .|..:|..:.::::::::.......|.:..||:.:|.|.||:||:::..|:.||.::|...|.::
Human  1061 FLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVT 1125

  Fly   329 AILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFI 393
            .:::.|::|..     .:|...|...|..:...|..|.|...::::.||:..:.||.:..||:.|
Human  1126 IVILIIILKFG-----NILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYII 1185

  Fly   394 AYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTL 458
            |:.|:...:...::||...|:..||:|.||..:..:.|..:|..|.||||.|.:|....|||.:.
Human  1186 AFFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSF 1250

  Fly   459 GAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTGVEDI----PNG-- 517
            |.:..::|....||.:|..||..|.||::|:..||.||....:|   :|..|..::    .||  
Human  1251 GWLCCLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYW---KERFGCAEVKPEKSNGLM 1312

  Fly   518 ----HVEQRDPKAFET----------EPEGKH--IGLQMRHLKKRFGNKMVVKGLSMNMFEDEIT 566
                .::..:|.|.:|          |||.|.  :|:.:..:.|.:|:|:.|..|::|.:|..||
Human  1313 FTNIMMQNTNPSASKTSPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHIT 1377

  Fly   567 VLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHI 631
            .|||.||||||||||||||:|..::||..:.|.||:|::...|.::|:|.||:|||..::...|:
Human  1378 SLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHL 1442

  Fly   632 RFFSRMK--GLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDE 694
            ..:..:|  ....|.:.:||.:.||...|....:.....||||||||||:..||.|.::||:.||
Human  1443 LLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDE 1507

  Fly   695 PSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYG 759
            ||:|:||.:||.:||::.:.|..||::|:||.:|||:||.||||.:..|.|:|.|:.|:||:.:|
Human  1508 PSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFG 1572

  Fly   760 SGYRLICVKRDD--------CETNEVTALLNKYIPGLKPECDIGAELSYQLP---DSASAKFEEM 813
            .||.|...|:..        |:|..|||::..::|....:.|||.||.|.||   ...|..:..:
Human  1573 DGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSL 1637

  Fly   814 FGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQH----EIMNGGSGFRGEDDNES 874
            ...|:....:|::..||:..|::||||:.:..|......:..:|    :|.|..:......|:.|
Human  1638 LRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGNSNANGISTPDDLS 1702

  Fly   875 VQS-------DGIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTI- 931
            |.|       |.|.:...| |.|..||..:..|:|:|:|.:|.||...|:.|.|:|:.||...: 
Human  1703 VSSSNFTDRDDKILTRGER-LDGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMG 1766

  Fly   932 --LIIKTQGTFQELK-------------------PITISLT----QYP-LAVTVLDRSNVQ---- 966
              .:..:..::.|::                   |.|.:|.    .:| :....|:.|::|    
Human  1767 LGTLRNSSNSYPEIQISPSLYGTSEQTAFYANYHPSTEALVSAMWDFPGIDNMCLNTSDLQCLNK 1831

  Fly   967 ------NGTGYEIAN--------------KYE---DLARSYGSNYGLELTGTQGFEDYI------ 1002
                  |.:|..|.|              |:.   ...|:|.|.....||| |..|:|:      
Human  1832 DSLEKWNTSGEPITNFGVCSCSENVQECPKFNYSPPHRRTYSSQVIYNLTG-QRVENYLISTANE 1895

  Fly  1003 ------------LDLGKTIQVRINSRYLVAATITESKITAWLNNQALHTAPLTVNMVHNAI---- 1051
                        |.|.|.::..|..   |.|..|.:|:  |.:.:..|:.|..:|.::|.:    
Human  1896 FVQKRYGGWSFGLPLTKDLRFDITG---VPANRTLAKV--WYDPEGYHSLPAYLNSLNNFLLRVN 1955

  Fly  1052 ADKLFGSSVKIQVTNAPLP-------YTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFL 1109
            ..|...:...|.:.:.|.|       .|.|:|:..|         :|.::.......::.::.::
Human  1956 MSKYDAARHGIIMYSHPYPGVQDQEQATISSLIDIL---------VALSILMGYSVTTASFVTYV 2011

  Fly  1110 IKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLL 1174
            ::|.:::||.||.:.|:.|..:|::.||.|...|:|.....:..|..|:.....:...||...||
Human  2012 VREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLL 2076

  Fly  1175 LLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKD--------- 1230
            |||||:|...::|:::..|.|....|.....||:|.|:.   .:|.:|...|.:|:         
Human  2077 LLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGIN---SIVSLSVVYFLSKEKPNDPTLEL 2138

  Fly  1231 TADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPG 1295
            .::.|..||.|||.|.....|.::....:..:.....|...|             ...|...:.|
Human  2139 ISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYP-------------NETFEMNKLG 2190

  Fly  1296 VLPETVYMAVTGVVFFLIIIVLEFRLINE--LMFK------IRQLISKPPPPPTEGQLDDDVANE 1352
            .:  .|.:...|.:||.:.:::...||.:  |.|:      :|:.|.:          |:||..|
Human  2191 AM--FVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHVRETIDE----------DEDVRAE 2243

  Fly  1353 RERILQMSSNELATKNLV-LDRVTKYY----GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFK 1412
            |.|:    .:..|..:|| |..:||.|    .:.:|||.:|:.:...|||||||||||||||.||
Human  2244 RLRV----ESGAAEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFK 2304

  Fly  1413 MMTGDERISSGAAYVQGL--SLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESR 1475
            |:|||...|||...::..  || .:::|...::|||||.|||.|.:|..|.|..:..:.|:.|..
Human  2305 MLTGDIIPSSGNILIRNKTGSL-GHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKD 2368

  Fly  1476 IRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWN 1540
            |::....|.:....|...|:.|...|.|.|||||||:|:||.||::.||||::||||.::|.||.
Human  2369 IKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWK 2433

  Fly  1541 MVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLE 1605
            ::.....:..|::||||||||||||||||||||||:|:||||.||:|::|.:|..:|:.::.|  
Human  2434 IISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNN-- 2496

  Fly  1606 ALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWS 1670
                                     :..::.:.:|::..:|.:.|::::..:|.:::|:|....:
Human  2497 -------------------------KVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVA 2536

  Fly  1671 RIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAK----YQREDT 1710
            .||.|:|:|:..||:.::.||||||||:|:.|||    |:..||
Human  2537 NIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADT 2580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 45/179 (25%)
ABC2_membrane_3 <269..475 CDD:289468 56/205 (27%)
CcmA 538..843 CDD:224054 126/317 (40%)
ABC_subfamily_A 538..755 CDD:213230 95/218 (44%)
ABC2_membrane_3 913..1316 CDD:289468 103/494 (21%)
ABC_subfamily_A 1369..1587 CDD:213230 111/224 (50%)
drrA 1376..1702 CDD:130256 134/331 (40%)
ABCA12XP_011509253.1 ABC2_membrane_3 <1026..1270 CDD:289468 66/249 (27%)
ZnuC 1349..1573 CDD:224046 97/223 (43%)
ABC_subfamily_A 1353..1568 CDD:213230 95/214 (44%)
ABC2_membrane_3 <1916..2177 CDD:289468 64/277 (23%)
ABC_subfamily_A 2257..2480 CDD:213230 110/223 (49%)
CcmA 2262..2570 CDD:224054 136/335 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148335
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 1 1.100 - - O PTHR19229
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.750

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