DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abca3 and ABCA12

DIOPT Version :10

Sequence 1:NP_608445.2 Gene:Abca3 / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_011509253.1 Gene:ABCA12 / 26154 HGNCID:14637 Length:2598 Species:Homo sapiens


Alignment Length:1864 Identity:540/1864 - (28%)
Similarity:887/1864 - (47%) Gaps:350/1864 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   105 LCYSPVNPVLKKLVEEAWQSLGKNKICESENATQLELD--------------------TVSKNAF 149
            :.|:|.|||.|.::|::..:|  .::.|....:|..:|                    ...:|.|
Human   809 ILYAPYNPVTKAIMEKSNVTL--RQLAELREKSQEWMDKSPLFMNSFHLLNQAIPMLQNTLRNPF 871

  Fly   150 AG--VQFD---DAWANLTENDPLPNDFHFALRFPAE-----------LRTATIAIANTWL----- 193
            ..  |:|.   ||...|.:.|.|.     .||...|           |.:.|:.|::..|     
Human   872 VQVFVKFSVGLDAVELLKQIDELD-----ILRLKLENNIDIIDQLNTLSSLTVNISSCVLYDRIQ 931

  Fly   194 -----------TMRLFPTIDLTG------PRN----EGDDDGGI--PP----------------G 219
                       ..||:.:.:|.|      |.|    .|.|.|.:  ||                .
Human   932 AAKTIDEMEREAKRLYKSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTR 996

  Fly   220 YLR-------------------EGFLPLQHSLSMAYLRQKSG--EQDLPNVVMKRYPFPAYIFDP 263
            .||                   ..|:.||.|:..|.:..::|  .|::. |.::..|:|.::.|.
Human   997 SLRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAIIELQTGRNSQEIA-VQVQAIPYPCFMKDN 1060

  Fly   264 LLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTIS 328
            .|..:|..:.::::::::.......|.:..||:.:|.|.||:||:::..|:.||.::|...|.::
Human  1061 FLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVT 1125

  Fly   329 AILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFI 393
            .:::.|::|..     .:|...|...|..:...|..|.|...::::.||:..:.||.:..||:.|
Human  1126 IVILIIILKFG-----NILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYII 1185

  Fly   394 AYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTL 458
            |:.|:...:...::||...|:..||:|.||..:..:.|..:|..|.||||.|.:|....|||.:.
Human  1186 AFFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSF 1250

  Fly   459 GAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTGVEDI----PNG-- 517
            |.:..::|....||.:|..||..|.||::|:..||.||....:|   :|..|..::    .||  
Human  1251 GWLCCLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYW---KERFGCAEVKPEKSNGLM 1312

  Fly   518 ----HVEQRDPKAFET----------EPEGKH--IGLQMRHLKKRFGNKMVVKGLSMNMFEDEIT 566
                .::..:|.|.:|          |||.|.  :|:.:..:.|.:|:|:.|..|::|.:|..||
Human  1313 FTNIMMQNTNPSASKTSPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHIT 1377

  Fly   567 VLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHI 631
            .|||.||||||||||||||:|..::||..:.|.||:|::...|.::|:|.||:|||..::...|:
Human  1378 SLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHL 1442

  Fly   632 RFFSRMK--GLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDE 694
            ..:..:|  ....|.:.:||.:.||...|....:.....||||||||||:..||.|.::||:.||
Human  1443 LLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDE 1507

  Fly   695 PSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYG 759
            ||:|:||.:||.:||::.:.|..||::|:||.:|||:||.||||.:..|.|:|.|:.|:||:.:|
Human  1508 PSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFG 1572

  Fly   760 SGYRLICVKRDD--------CETNEVTALLNKYIPGLKPECDIGAELSYQLP---DSASAKFEEM 813
            .||.|...|:..        |:|..|||::..::|....:.|||.||.|.||   ...|..:..:
Human  1573 DGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSL 1637

  Fly   814 FGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQH----EIMNGGSGFRGEDDNES 874
            ...|:....:|::..||:..|::||||:.:..|......:..:|    :|.|..:......|:.|
Human  1638 LRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGNSNANGISTPDDLS 1702

  Fly   875 VQS-------DGIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTI- 931
            |.|       |.|.:...| |.|..||..:..|:|:|:|.:|.||...|:.|.|:|:.||...: 
Human  1703 VSSSNFTDRDDKILTRGER-LDGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMG 1766

  Fly   932 --LIIKTQGTFQELK-------------------PITISLT----QYP-LAVTVLDRSNVQ---- 966
              .:..:..::.|::                   |.|.:|.    .:| :....|:.|::|    
Human  1767 LGTLRNSSNSYPEIQISPSLYGTSEQTAFYANYHPSTEALVSAMWDFPGIDNMCLNTSDLQCLNK 1831

  Fly   967 ------NGTGYEIAN--------------KYE---DLARSYGSNYGLELTGTQGFEDYI------ 1002
                  |.:|..|.|              |:.   ...|:|.|.....||| |..|:|:      
Human  1832 DSLEKWNTSGEPITNFGVCSCSENVQECPKFNYSPPHRRTYSSQVIYNLTG-QRVENYLISTANE 1895

  Fly  1003 ------------LDLGKTIQVRINSRYLVAATITESKITAWLNNQALHTAPLTVNMVHNAI---- 1051
                        |.|.|.::..|..   |.|..|.:|:  |.:.:..|:.|..:|.::|.:    
Human  1896 FVQKRYGGWSFGLPLTKDLRFDITG---VPANRTLAKV--WYDPEGYHSLPAYLNSLNNFLLRVN 1955

  Fly  1052 ADKLFGSSVKIQVTNAPLP-------YTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFL 1109
            ..|...:...|.:.:.|.|       .|.|:|:..|         :|.::.......::.::.::
Human  1956 MSKYDAARHGIIMYSHPYPGVQDQEQATISSLIDIL---------VALSILMGYSVTTASFVTYV 2011

  Fly  1110 IKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLL 1174
            ::|.:::||.||.:.|:.|..:|::.||.|...|:|.....:..|..|:.....:...||...||
Human  2012 VREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLL 2076

  Fly  1175 LLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKD--------- 1230
            |||||:|...::|:::..|.|....|.....||:|.|:.   .:|.:|...|.:|:         
Human  2077 LLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGIN---SIVSLSVVYFLSKEKPNDPTLEL 2138

  Fly  1231 TADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPG 1295
            .::.|..||.|||.|.....|.::....:..:.....|...|             ...|...:.|
Human  2139 ISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYP-------------NETFEMNKLG 2190

  Fly  1296 VLPETVYMAVTGVVFFLIIIVLEFRLINE--LMFK------IRQLISKPPPPPTEGQLDDDVANE 1352
            .:  .|.:...|.:||.:.:::...||.:  |.|:      :|:.|.:          |:||..|
Human  2191 AM--FVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHVRETIDE----------DEDVRAE 2243

  Fly  1353 RERILQMSSNELATKNLV-LDRVTKYY----GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFK 1412
            |.|:    .:..|..:|| |..:||.|    .:.:|||.:|:.:...|||||||||||||||.||
Human  2244 RLRV----ESGAAEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFK 2304

  Fly  1413 MMTGDERISSGAAYVQGL--SLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESR 1475
            |:|||...|||...::..  || .:::|...::|||||.|||.|.:|..|.|..:..:.|:.|..
Human  2305 MLTGDIIPSSGNILIRNKTGSL-GHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKD 2368

  Fly  1476 IRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWN 1540
            |::....|.:....|...|:.|...|.|.|||||||:|:||.||::.||||::||||.::|.||.
Human  2369 IKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWK 2433

  Fly  1541 MVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLE 1605
            ::.....:..|::||||||||||||||||||||||:|:||||.||:|::|.:|..:|:.::.|  
Human  2434 IISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNN-- 2496

  Fly  1606 ALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWS 1670
                                     :..::.:.:|::..:|.:.|::::..:|.:::|:|....:
Human  2497 -------------------------KVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVA 2536

  Fly  1671 RIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAK----YQREDT 1710
            .||.|:|:|:..||:.::.||||||||:|:.|||    |:..||
Human  2537 NIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADT 2580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Abca3NP_608445.2 rim_protein <137..1708 CDD:130324 529/1828 (29%)
ABCA12XP_011509253.1 rim_protein 7..>86 CDD:130324
rim_protein 752..2579 CDD:130324 538/1861 (29%)
Blue background indicates that the domain is not in the aligned region.

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