Protein Alignment Abca3 and ABCA4

DIOPT Version :10

• Sequence 1: NP_608445.2
• Gene: Abca3 / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Sequence 2: NP_000341.2
• Gene: ABCA4 / 24
• HGNCID: 34
• Length: 2273
• Species: Homo sapiens
• Alignment Length: 1922
• Identity: 602/1922 - (31%)
• Similarity: 949/1922 - (49%)
• Gaps: 349/1922 - (18%)

  Fly    45 VRTLVDT-EQKGVR-YYNEQNLTDLNLLQHSLHR-------SSYLGK--------LIALIAPNRR 92
            ||.||.. |:.|.: :|...|.|.:|:::.:|..       :..||:        |..|....|.
Human   424 VRKLVKAWEEVGPQIWYFFDNSTQMNMIRDTLGNPTVKDFLNRQLGEEGITAEAILNFLYKGPRE 488

  Fly    93 RKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICESEN----ATQLELDTVSKNAF-AGV 152
            .:....:.|::...::..:..| :||.:..:.|..:|. ||.|    .||..|..:.:|.| |||
Human   489 SQADDMANFDWRDIFNITDRTL-RLVNQYLECLVLDKF-ESYNDETQLTQRALSLLEENMFWAGV 551

  Fly   153 QFDD--AWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLFPTIDLTGPRNEGDDDGG 215
            .|.|  .|.:     .||....:.:|...::...|..|.:.:..         :|||.:..:|.
Human   552 VFPDMYPWTS-----SLPPHVKYKIRMDIDVVEKTNKIKDRYWD---------SGPRADPVEDF- 601

  Fly   216 IPPGYLREGFLPLQHSLSMAYLRQKSGEQDLPNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSF 280
               .|:..||..||..:.....|.:...:....:.:::.|:|.::.|..:..::....:.::|::
Human   602 ---RYIWGGFAYLQDMVEQGITRSQVQAEAPVGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAW 663

  Fly   281 IYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVA 345
            ||..:...|.|..|||.:|||.:|..|:||.:.|..||:.||.::::|..|:.|.:...     .
Human   664 IYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHG-----R 723

  Fly   346 VLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSL 410
            :|.:::...|..||:.:..::|..||:::||||:||.|||.:|:|:|..|:|:.......|.::.
Human   724 ILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTA 788

  Fly   411 SSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMII 475
            ..|...||:|..|.|||.:.::.||..|.||||||.....:..|..:....|.|||:...:|.::
Human   789 ELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYGLL 853

  Fly   476 CLYVEQVMPGSFGVPRPWNFPFTREFW-----CGEREYTGVEDIPNGHVEQRDPK--------AF 527
            ..|::||.||.:|.|.||.|.....:|     |..||...:|.......|..||:        .|
Human   854 AWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEETEDPEHPEGIHDSFF 918

  Fly   528 ETEPEGKHIGLQMRHLKKRFG--NKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPT 590
            |.|..|...|:.:::|.|.|.  .:..|..|::..:|::||..|||||||||||:|:|||:.|||
Human   919 EREHPGWVPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPT 983

  Fly   591 SGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKM 655
            |||.::.|.||.|:::..|.|||:|||||:||..::|:.|:.|::::||...:..:.|:...|:.
Human   984 SGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLED 1048

  Fly   656 IELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTL 720
            ..|..|.|..:..|||||:|||||..|..||.|||:.|||:||:||.:||.:||||.:.:.|||:
Human  1049 TGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTI 1113

  Fly   721 LLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKR---------------- 769
            :::||.|||||:|||||||:..|.|.|.||..|||..:|:|..|..|::
Human  1114 IMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCS 1178

  Fly   770 --------------DDC--------ETNEVTALLNKYIPGLK-PECDIGAELSYQLPDS--ASAK 809
                          ||.        :.||:..::..::|..| .|| ||.||.:.||:.  ....
Human  1179 CSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVEC-IGQELIFLLPNKNFKHRA 1242

  Fly   810 FEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDN----TGNIKDQHEIMNGGSGFRG-- 868
            :..:|.:|||...:|.|:.:|:..|.:||:|:||..:.|:    .|..:.:.|.:|......|
Human  1243 YASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPR 1307

  Fly   869 EDDNESVQSDGIFSENR------------------RLLQGLQLLSNQWKAMLLKKFLYTWRNKLL 915
            |...::.|...:.|...                  :|..|.||:....:|:|:|:|.:|.|:...
Human  1308 EKAGQTPQDSNVCSPGAPAAHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHKD 1372

  Fly   916 LLIQNIMPVFFVVVTILIIKTQGTFQELKPITIS------------------------------- 949
            .|.|.::|..||.:.:::......|.|...:|:.
Human  1373 FLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLNK 1437

  Fly   950 ------------LTQYPLA---------------------------------------VTVL--- 960
                        |.:||..                                       :|:|
Human  1438 PGFGNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPEC 1502

  Fly   961 -------------DRSN--VQNGTGYEIAN----KYEDLARS------------YGSNYGLELTG 994
                         .||.  :|:.|...|::    .|..|.||            ||   |:.:.|
Human  1503 PEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYG---GISIGG 1564

  Fly   995 T--------QGFEDYILDLGKTIQV------RINSRYL---VAATITESKITAWLNNQALHTAPL 1042
            .        :....::.|||:.:.|      |..|:.:   :....||..|..|.||:..|....
Human  1565 KLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVS 1629

  Fly  1043 TVNMVHNAIADKLFGSSVK--------IQVTNAPLPYTTSTL--LSQLSTGNNLGTQLASNLCFC 1097
            .:|:.||||   |..|..|        |.|.:.||..|...|  ::.|:|  ::...:|..:.|.
Human  1630 FLNVAHNAI---LRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTT--SVDAVVAICVIFS 1689

  Fly  1098 MCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGL 1162
            |.||.:.::|:||:||.:::|.|||:.||...|:|::.|:.|..:|.|:|.:||...:.||:...
Human  1690 MSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAY 1754

  Fly  1163 STFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFD 1227
            ::...|.....||||:|:||:|.:|..|..|..|:|.:..:|..|:|.|:....:..::  |||:
Human  1755 TSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFIL--ELFE 1817

  Fly  1228 TKDTA----DILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAG----ALPPILLCELVPQCCN 1284
            ...|.    .:|..:..:||||.|...|..:..:.|..:..|:.|    |.|
Human  1818 NNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANP------------- 1869

  Fly  1285 LKPYFAWEEPGVLPETVY-MAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQLDDD 1348
                |.|:   ::.:.:: |.|.|||:||:.::::..      |.:.|.|::|...|...: |||
Human  1870 ----FHWD---LIGKNLFAMVVEGVVYFLLTLLVQRH------FFLSQWIAEPTKEPIVDE-DDD 1920

  Fly  1349 VANERERILQMSSNELATKNLVLDRVTKYY--GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTF 1411
            ||.||:||:...:.   |..|.|..:||.|  ....||:::.:.|:..|||||||||||||||||
Human  1921 VAEERQRIITGGNK---TDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTF 1982

  Fly  1412 KMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRI 1476
            ||:|||..::||.|.|.|.|:.:|::.:::.:||||||||:.:.|||||.|.::..||||....|
Human  1983 KMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEI 2047

  Fly  1477 RQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNM 1541
            .:::....||.|...:.|.....||||||||||||||:||.|.::.||||||||||.|||.|||:
Human  2048 EKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNV 2112

  Fly  1542 VCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEA 1606
            :..|...|:::|||||||||||||||||||||.|.|:|:|:.||||:||..|.|:.:|:
Human  2113 IVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKI------ 2171

  Fly  1607 LRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSR 1671
                       ::|.:..:|      |::.|::|.:..:|.|:.:|.:..:|.|.:..:.:  :|
Human  2172 -----------KSPKDDLLP------DLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSL--AR 2217

  Fly  1672 IFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQRE 1708
            ||.|:.|::|.|.:|:|||:||||:::|:.|||.|.|
Human  2218 IFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQTE 2254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abca3	NP_608445.2	rim_protein	<137..1708	CDD:130324	576/1807 (32%)
ABCA4	NP_000341.2	rim_protein	1..2272	CDD:130324	602/1922 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	891..911		4/19 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1284..1345		7/60 (12%)
		Essential for ATP binding and ATPase activity. /evidence=ECO:0000269|PubMed:31481235	2244..2249		1/4 (25%)