DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and ABCA5

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_061142.2	Gene:	ABCA5 / 23461	HGNCID:	35	Length:	1642	Species:	Homo sapiens

Alignment Length:	1830	Identity:	474/1830 - (25%)
Similarity:	813/1830 - (44%)	Gaps:	348/1830 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WDKFVLLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQ 71
            |.:...||.||:.::...|...|.|::.|..|...|:|: :::...:|    |.|....:||.:.
Human    11 WRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILI-SMMHPNKK----YEEVPNIELNPMD 70

  Fly    72 HSLHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICESENA 136
            .                         |:....||.|:||..:...::::.......:.|...|..
Human    71 K-------------------------FTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYT 110

  Fly   137 TQLELDTVS---KNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLF 198
            .:.|:.|.|   .:.|.||.|.|:.:             :.|||..::    |.:::.::..|
Human   111 NEKEMLTSSLSKPSNFVGVVFKDSMS-------------YELRFFPDM----IPVSSIYMDSR-- 156

  Fly   199 PTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKS----------------GEQDLP 247
                      .|.........|...||..||.|:..|.::.|:                ||
Human   157 ----------AGCSKSCEAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGE---- 207

  Fly   248 NVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWL 312
            ..|::...||        .|:..|..:|....|.|   ::..:|.|||||::||.:|||||.:..
Human   208 TAVVEIDTFP--------RGVILIYLVIAFSPFGY---FLAIHIVAEKEKKIKEFLKIMGLHDTA 261

  Fly   313 HWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLI--IYIVSSICFCFMMAT 375
            .|.:|.:....::.:.::|:|::.       .|.|.....:::|.||:  :|.:||:.|..|:..
Human   262 FWLSWVLLYTSLIFLMSLLMAVIA-------TASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTP 319

  Fly   376 FFSRASTAAAVTGLIWFIAYIPYSF------TINSYDDLSLSSKLGW--SLISNTAMGFGIKLIL 432
            .|.::..    .|::.|...:.:.|      .|.|:     ...|.|  |...:.....||..::
Human   320 LFKKSKH----VGIVEFFVTVAFGFIGLMIILIESF-----PKSLVWLFSPFCHCTFVIGIAQVM 375

  Fly   433 GFEGTGEGLQWSNFFTPVSVDDTLTLG-----AVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRP 492
            ..|...||..:||          ||.|     ..:||:.::.:.|:::.:|::||:||.||:.|.
Human   376 HLEDFNEGASFSN----------LTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRS 430

  Fly   493 WNFPFTREFWC-GEREYTGVEDIPNGHV-------EQRDPKAFETEPEGKHI----GLQMRHLKK 545
            ..:.....:|. .:|.|   |::..|:|       |..:|  ..:|..||..    |:|..: :|
Human   431 SLYFLKPSYWSKSKRNY---EELSEGNVNGNISFSEIIEP--VSSEFVGKEAIRISGIQKTY-RK 489

  Fly   546 RFGNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIING---SDIRTNIEG 607
            :..|...::.||.:::|.:||.||||:|.||:|.:::|.|:.||:.|.|.|.|   |:|....|
Human   490 KGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFE- 553

  Fly   608 ARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGG 672
            ||..:|||||.::.||.::|..::...:.:||:....:.|||.|.|..::::...:..:.|||||
Human   554 ARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGG 618

  Fly   673 MKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRI 737
            .|||||:..|:.|:.|::|.|||::||||.:|..:|:||:..|..|..:.:||||||||:|.||.
Human   619 QKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRK 683

  Fly   738 AIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQL 802
            |::..|.|||.|:|.|||.::|.||||.......|.|..:::|:.::|||.........:|.|.|
Human   684 AVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLVKQHIPGATLLQQNDQQLVYSL 748

  Fly   803 PDSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMK--VGAEKDNTGNIKDQHEIMNGGSG 865
            |.....||..:|..|:..|: |.:..|||.:|::|:||:|  |.||.|.........:.:.....
Human   749 PFKDMDKFSGLFSALDSHSN-LGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMD 812

  Fly   866 FRGEDDNESVQSDGIFSENRRLLQGLQLLSNQWKAML----------LKKFLYTWRNKLLLLIQN 920
            .:..|:.|  ||..|.||.:..|.....|   ||..:          ||:...:.|:.||||:
Human   813 SKSFDEME--QSLLILSETKAALVSTMSL---WKQQMYTIAKFHFFTLKRESKSVRSVLLLLL-- 870

  Fly   921 IMPVFFVVVTILIIKTQGTFQELKPITISLTQYPLAVTVLDRSNVQNGTGYEIANKYEDLARSYG 985
               :||.|...:.:........:.||.:....|.|                    |..|....|.
Human   871 ---IFFTVQIFMFLVHHSFKNAVVPIKLVPDLYFL--------------------KPGDKPHKYK 912

  Fly   986 SNYGLELTGTQGFEDYI-LDLGKTIQVRI--NSRYL------VAATITESK----ITAWLNNQAL 1037
            ::..|:.:......|.| ....:.|.|.:  :|.|:      .|..:..|:    ..|..|:..:
Human   913 TSLLLQNSADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTMV 977

  Fly  1038 HTAPLTVNMVHNAIADKLFGSSV--KIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCF 1100
            ::.|:.||::.|..   |:..:|  .||:.:.|.....:.::.::        :|..........
Human   978 YSLPILVNIISNYY---LYHLNVTETIQIWSTPFFQEITDIVFKI--------ELYFQAALLGII 1031

  Fly  1101 VSSIYILFLIKERESRAKLLQF----VGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETG 1161
            |:::...|.::..|:. |:..:    :.|:....:|:.|.:.|...:.:..::::.:::.|
Human  1032 VTAMPPYFAMENAENH-KIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAF---- 1091

  Fly  1162 LSTFGELGRYY-------LLLLLFGF--AVLPFIYIMSLFFREPATGFARVSIVN------IFCG 1211
                 ..|.|:       ::..|.|:  :|:.|.||.|..|::         |:|      ....
Human  1092 -----HYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKK---------ILNTKEFWSFIYS 1142

  Fly  1212 MALFIVVVVMSSELFDTKDTADILGWIF----RIFPHFSLAMSLNKVYTNTATRNACAKAGALPP 1272
            :|....:.:.....|.....|.||.:.|    .|:|.....:|..|:......:
Human  1143 VAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRK----------- 1196

  Fly  1273 ILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEF--RLINELMFKIRQLISK 1335
                       |:..|..|:...|...:.|:.....:|.|.....::  |.|.:..| .|.|.:|
Human  1197 -----------NVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPF-FRNLSTK 1249

  Fly  1336 ------PPPPPTEGQLDDDVANERERILQMSSNELA-----------------TKNLVLDRVTKY 1377
                  |.||..|.: |:||..||.::.::...:..                 .|:.:|.|..|.
Human  1250 SKNRKLPEPPDNEDE-DEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKK 1313

  Fly  1378 YGQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLE-SNMNSIYK 1441
                :|...:|.||::.|..||||.|||||:|...::.||...:||..::...|.| |..:...|
Human  1314 ----VATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLK 1374

  Fly  1442 MIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKR 1506
            .:|||||.:.|..|.|.:|...|:..::|:..|.::::...:..:....:|:.|.......|.||
Human  1375 CMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKR 1439

  Fly  1507 KLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMV-CRIRDSGKSIVLTSHSMEECEALCTRLA 1570
            ||..|::::|:|.:..||||:|||||.|::.:|..: ...::..::.:||:|.|||.||:|.|:|
Human  1440 KLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVA 1504

  Fly  1571 IMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDID 1635
            |||:|:.:|||:.||||:||.||..|:||::..:|.|...||                  ||:|.
Human  1505 IMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRL------------------QREIQ 1551

  Fly  1636 AVKEFVETEYPNSILQEEYQGILTFYIPLTGVK-WSRIFGLMESNRDQLNVEDYSVSQTTLEEIF 1699
            .:       :||:..||.:..||.:.||...|: .|:.|..:|..:....:|:||.||.|||::|
Human  1552 YI-------FPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVF 1609

  Fly  1700 LEFAKYQRED 1709
            :|..|.|.|:
Human  1610 VELTKEQEEE 1619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	45/189 (24%)
		ABC2_membrane_3	<269..475	CDD:289468	53/220 (24%)
		CcmA	538..843	CDD:224054	121/309 (39%)
		ABC_subfamily_A	538..755	CDD:213230	90/219 (41%)
		ABC2_membrane_3	913..1316	CDD:289468	73/440 (17%)
		ABC_subfamily_A	1369..1587	CDD:213230	79/219 (36%)
		drrA	1376..1702	CDD:130256	114/328 (35%)
ABCA5	NP_061142.2	ABC2_membrane_4	202..403	CDD:289500	57/241 (24%)
		ABC2_membrane_3	<214..416	CDD:289468	56/238 (24%)
		CcmA	476..788	CDD:224054	121/314 (39%)
		ABC_subfamily_A	478..701	CDD:213230	91/224 (41%)
		ABC2_membrane_3	<943..1224	CDD:289468	52/332 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1249..1268		6/19 (32%)
		CcmA	1290..1615	CDD:224054	118/353 (33%)
		ABC_subfamily_A	1290..1521	CDD:213230	80/234 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720