DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and ABCA6

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_525023.2	Gene:	ABCA6 / 23460	HGNCID:	36	Length:	1617	Species:	Homo sapiens

Alignment Length:	1813	Identity:	456/1813 - (25%)
Similarity:	825/1813 - (45%)	Gaps:	353/1813 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRS 77
            ||.||:..:|..|.:.::|..|    |:||.|...|..:..:.|::..
Human    15 LLCKNFLKKWRMKRESLLEWGL----SILLGLCIALFSSSMRNVQFPG----------------- 58

  Fly    78 SYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQS--LGKNKICESENATQLE 140
                     :||....:...|:....::.|:|::.:.::::.:...:  |....:..:.|.|.::
Human    59 ---------MAPQNLGRVDKFNSSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPNKTHMD 114

  Fly   141 LDTVSKNAFA-GVQFDDAWANLT-----ENDPL-PNDFHFALRFPAELRTATIAIANTWLTMRLF 198
            ...:....:| |:.|::.::...     .|.|| ..||.                |:.|.....|
Human   115 EILLENLPYAMGIIFNETFSYKLIFFQGYNSPLWKEDFS----------------AHCWDGYGEF 163

  Fly   199 PTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGE---QDLPNV---VMKRYPFP 257
             :..||              .|...||:.||.:::.|.:...:..   ::|.:|   .||..||
Human   164 -SCTLT--------------KYWNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPF- 212

  Fly   258 AYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSF 322
              |...||.  :.:..|..||.|.....:|:..:|.|::|. |.:||:|||.:...|.:|.:...
Human   213 --ITKNLLH--NEMFILFFLLHFSPLVYFISLNVTKERKKS-KNLMKMMGLQDSAFWLSWGLIYA 272

  Fly   323 IMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVT 387
            ..:.|.:|.:.|::...   .:.|:|......::|||  |.:|.:...|:|:....:    |.:|
Human   273 GFIFIISIFVTIIITFT---QIIVMTGFMVIFILFFL--YGLSLVALVFLMSVLLKK----AVLT 328

  Fly   388 GLIWFIAYIPY---SFTINSYDDLSLSSKLGW--SLISNTAMGFGIKLILGFEGTGEGLQWSNFF 447
            .|:.|:..:.:   .||: .|:  .|.|.|.|  ::.|..|...|:..|:..:....|:     .
Human   329 NLVVFLLTLFWGCLGFTV-FYE--QLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGV-----I 385

  Fly   448 TPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFP--FTREFWCGEREYTG 510
            .|....|:.|:.|...|:|:..:||:::.||.::::|  :|..|.:: |  |.....|.:.:.|.
Human   386 FPDPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILP--YGDERHYS-PLFFLNSSSCFQHQRTN 447

  Fly   511 VEDIPNGHVEQRDPKAFETEP-----EGKHIGLQMRHLKKRF----GNKMVVKGLSMNMFEDEIT 566
            .:.|.. .::...|.....||     :||. .:::|::||.:    |....:|||..:::|.:||
Human   448 AKVIEK-EIDAEHPSDDYFEPVAPEFQGKE-AIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQIT 510

  Fly   567 VLLGHNGAGKTTTISMLTGMFPPTSGTAII---NGSDIRTNIEGARMSLGICPQHNVLFDEMSVS 628
            .:|||:||||::.:::|.|:..||.|:..|   |.|::: ::|..|...|:|||.||.||.::|.
Human   511 AILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQ-DLEEIRKITGVCPQFNVQFDILTVK 574

  Fly   629 NHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCD 693
            .::..|:::||:..|.|||||.:.|..:::::..:..:..||.|.||||:....:.||.:::|.|
Human   575 ENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLD 639

  Fly   694 EPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQY 758
            ||::|:||.:|.|:|.||::.:....:|.:|..|||||:|.||..||.:|.|||.|:|.|||:::
Human   640 EPTTGLDPFSRDQVWSLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRW 704

  Fly   759 GSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQSDE 823
            |.||.|...:.:.|...::|:.:..:||..|.:.:...:|.|.||...:..|.::|..|::.||:
Human   705 GLGYHLSLHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQ 769

  Fly   824 LHLNGYGVGITSMEEVFMKVGAEK------DNTGNIKDQHEIMNGGSGFRGEDDNESVQSDGIFS 882
             .:.||.:.::::.|||||:..:.      :....|:|...:            ||...:...||
Human   770 -GVTGYDISMSTLNEVFMKLEGQSTIEQDFEQVEMIRDSESL------------NEMELAHSSFS 821

  Fly   883 ENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILII----------KTQ 937
            |.:..:..:.|...|..||...:||...|...:||  .::.||.:.:..||:          |..
Human   822 EMQTAVSDMGLWRMQVFAMARLRFLKLKRQTKVLL--TLLLVFGIAIFPLIVENIMYAMLNEKID 884

  Fly   938 GTFQE----LKPITISLTQYPLAVTVLDRSNVQNGTGYEIANKYEDLARSY-GSNYGLEL----- 992
            ..|:.    |.|  ..|.|.|....::..:...|         .||..:|. ..|..||:
Human   885 WEFKNELYFLSP--GQLPQEPRTSLLIINNTESN---------IEDFIKSLKHQNILLEVDDFEN 938

  Fly   993 -TGTQGFEDYILDLGKTIQVRINSRYLVAATITESKITAWLNNQALHTAPLTVNMVHNAIADKLF 1056
             .||.|             :..|...:|:....:.:.:...|.:.||..|:.:|::.|.:. ::|
Human   939 RNGTDG-------------LSYNGAIIVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLL-QMF 989

  Fly  1057 GSSVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQ 1121
            ..:..|::.::|.|.:...|.:.|..|:..       |...:|.:|....:..|.:.:..||...
Human   990 NHTQHIRIESSPFPLSHIGLWTGLPDGSFF-------LFLVLCSISPYITMGSISDYKKNAKSQL 1047

  Fly  1122 FVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLL---LLFGFAVL 1183
            ::.|:....:|..|.:.|.:.:|   ||:::..:.|....:.        |||:   ::|...::
Human  1048 WISGLYTSAYWCGQALVDVSFFI---LILLLMYLIFYIENMQ--------YLLITSQIVFALVIV 1101

  Fly  1184 P---------FIYIMSLFFRE--------------PATGFARVSIVNIF-CGMALFIVVVVMSSE 1224
            .         |||::|..||:              .:|....::::|.| ..:.:..:|:|.|..
Human  1102 TPGYAASLVFFIYMISFIFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITTMVLVPSYT 1166

  Fly  1225 LFDTKDTADILGW-IFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPY 1288
            |...|...::... .:|.||..:..:|        ||           ..|:|.:        ||
Human  1167 LLGFKTFLEVRDQEHYREFPEANFELS--------AT-----------DFLVCFI--------PY 1204

  Fly  1289 FAWEEPGVLPETVYMAVTGVVFFLIIIVLEF-----RLINELMFKIRQLISKPPPPPTEGQLDDD 1348
            |         :|       ::|..::..:|.     |:..:.:|:|... |:...|..|..:|:|
Human  1205 F---------QT-------LLFVFVLRCMELKCGKKRMRKDPVFRISPQ-SRDAKPNPEEPIDED 1252

  Fly  1349 VANERERILQMSSNELATKNLVLDRV---------TKYYGQ----------FMAVNQVSLCVQEV 1394
            ...:.|||  .::..|.|.  :||..         .:|.||          .:|...:|.||||.
Human  1253 EDIQTERI--RTATALTTS--ILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNISFCVQEG 1313

  Fly  1395 ECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGR 1459
            |..||||.|||||:::.:|::|..:.::|...::|.|      |:...:|||||.:.|...||.|
Human  1314 EILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCS------SVLGHLGYCPQENVLWPMLTLR 1372

  Fly  1460 EVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLD 1524
            |.|.::..::|::::..|.....|..:|...:.::......:.|..|||...::::|:..|:.||
Human  1373 EHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLD 1437

  Fly  1525 EPTTGMDPAARRQLWNMV-CRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKN 1588
            ||:||:||..::|:|..: ..::::.:.::||:|::.|.||||.|:||||:|..:||||.|||||
Human  1438 EPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKN 1502

  Fly  1589 KFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETE----YPNSI 1649
            |..|..||::||:...:.                                ..|.||    :|.:.
Human  1503 KLGKDYILELKVKETSQV--------------------------------TLVHTEILKLFPQAA 1535

  Fly  1650 LQEEYQGILTFYIPLTGV-KWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQ 1706
            .||.|..:||:.:|:..| ..|:.|..:|:.:...|:|:||:||.|||::|||.:|.|
Human  1536 GQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQ 1593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	48/184 (26%)
		ABC2_membrane_3	<269..475	CDD:289468	52/210 (25%)
		CcmA	538..843	CDD:224054	112/311 (36%)
		ABC_subfamily_A	538..755	CDD:213230	86/223 (39%)
		ABC2_membrane_3	913..1316	CDD:289468	83/451 (18%)
		ABC_subfamily_A	1369..1587	CDD:213230	78/237 (33%)
		drrA	1376..1702	CDD:130256	110/341 (32%)
ABCA6	NP_525023.2	ABC2_membrane_3	34..375	CDD:289468	85/419 (20%)
		CcmA	476..788	CDD:224054	112/314 (36%)
		ABC_subfamily_A	478..701	CDD:213230	86/223 (39%)
		ABC2_membrane_3	866..1167	CDD:289468	64/343 (19%)
		CcmA	1275..1592	CDD:224054	111/354 (31%)
		ABC_subfamily_A	1296..1501	CDD:213230	73/210 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148351
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.650