DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and Abca16

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	XP_006507746.1	Gene:	Abca16 / 233810	MGIID:	2388711	Length:	1679	Species:	Mus musculus

Alignment Length:	1776	Identity:	586/1776 - (32%)
Similarity:	926/1776 - (52%)	Gaps:	183/1776 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DKFVLLLWKNWTLQWNHKWQMV---IELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNL 69
            ::..:|||||:||:   |.|::   .||:...:|.::|::.|.|.|....|..::..|.:.
Mouse     7 NQLTVLLWKNFTLK---KRQIISTSAELLAALLFVIMLLIFRALTDMNIAGPYHFTAQPIA---- 64

  Fly    70 LQHSLHRSSYLGKLIALIAPNRRRKNGGFSK--FEFILCYSPVN-PVLKKLVEEAWQSLGKN-KI 130
                             |.|:       |.|  .|:.|.|.|.. .|:::::|:..::|... |:
Mouse    65 -----------------IMPS-------FIKDAQEWELVYIPSEIDVVREIIEDVKRNLNTTIKV 105

  Fly   131 ----CESENATQLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANT 191
                .|:|....:..|.:|:...|.:.||..:.|  ::||||....:.|||....||........
Mouse   106 RGFPSEAEFEEYILFDNMSQKVLAAIVFDCGFKN--KSDPLPLQVKYHLRFVGAQRTIWWPDKLG 168

  Fly   192 WLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLS---MAYLRQKSGEQ--DLPNVVM 251
            |.|..|||......|||....||| .|||::||||.:||:|.   |.|....:|::  |..:.|:
Mouse   169 WKTRLLFPNHPSIRPRNPNYLDGG-SPGYIKEGFLAVQHALDKSIMLYHESSAGKKLFDEIDTVI 232

  Fly   252 KRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTA 316
            :|:|:|::..|.||...|..:.|:.:|.|......|.:.|..||||:|||...||||.||:.|..
Mouse   233 QRFPYPSHPQDKLLWISSPFIPLMFILMFSSIVLSIMRSIVFEKEKRLKEYQLIMGLRNWIIWIG 297

  Fly   317 WFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRAS 381
            :|...|.:..|..:||.||:.:...|: .:|.:::.:.:..||..|.::||||.||::||||:..
Mouse   298 YFFTFFPLYVIIILLICILLFVQIVEE-PILRYSDCSFIFVFLTCYAIASICFAFMVSTFFSKTR 361

  Fly   382 TAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNF 446
            .||:...|::|.::.||:|....|..|:|::|:...|.:|.|:..||.:::..|....|::|.|.
Mouse   362 LAASAGNLLFFASFFPYNFISEYYGMLNLTTKITACLSANVALALGINILIKLEIQEIGVKWHNL 426

  Fly   447 FTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTGV 511
            :||.:::|.|..|.::.|:|....:|.::..|||.|.||..|||:||.|...|.:|.|:.:....
Mouse   427 WTPANLEDNLNFGYMLGMLLFDAFLYSLVTWYVEAVFPGQCGVPQPWYFFLMRSYWFGKPKIRKT 491

  Fly   512 ED----IPNGHVEQRDPKAFETEPEGKHIGLQMRHLKKRFGNKMVVKGLSMNMFEDEITVLLGHN 572
            .:    .|..|      ..:|.||.....|:.:.||.|.|.||..|..||:|::|.::|||||||
Mouse   492 TEEAKCTPIVH------NCYEAEPPNLEAGIHIMHLHKEFKNKPAVNNLSLNIYEGQVTVLLGHN 550

  Fly   573 GAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRM 637
            |||||||:|:|||.|..|.|.|.|||.:|..|:...|..||.||||::|||::::|.|:.|:..:
Mouse   551 GAGKTTTLSVLTGRFAATRGEAYINGYNISDNMIEVRKDLGFCPQHDLLFDDLTLSEHLFFYCMV 615

  Fly   638 KGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPS 702
            ||:......:|:.:.|....|::..:..|...|||::||||:..||...:|||:.|||||||||.
Mouse   616 KGIPQNINCEEIDRMLSAFNLQENYHTLSGSASGGVRRKLSIVLALMAGSKVVILDEPSSGMDPV 680

  Fly   703 ARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICV 767
            :||..||:||..|..||:|||||:||||||||||:|||..|.|.|.|:|.|||:.||:||.::..
Mouse   681 SRRATWDILQHYKHNRTILLTTHYMDEADVLGDRVAIMVRGTLHCCGSSVFLKQIYGAGYHIVME 745

  Fly   768 KRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQSDELHLNGYGVG 832
            |:..|:.:.:.|::.:::||...|.:|..|||:.||....::||.:|.:||.:...|.:..:|..
Mouse   746 KQQYCDVDNIIAMIQQHVPGAVLENNIENELSFILPKKYVSRFETLFTELEMRQKALGIASFGAS 810

  Fly   833 ITSMEEVFMKVGAEKDNTGNIKDQHEIMNGGSGFRGEDDNESVQSDGIFSENR----------RL 887
            ||:|||||:||........:|:............| :|:.::|.....:|:..          :.
Mouse   811 ITTMEEVFVKVNKLATPQKSIQTIQPYYLAYRKMR-QDEQQNVNMPINYSKPNFPYLSEIATVKF 874

  Fly   888 LQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQ 952
            ..|:.|...|:.::.:|:.|:..||...:|:|.|  |..||.|.|::.......::....::|:.
Mouse   875 NTGVPLYRQQFYSLFIKRALFISRNWKFMLLQII--VVMVVTTYLLLALHLNNNDIPERELNLSH 937

  Fly   953 YPLAVTVLDRS-------NVQNGTGYEIANKYEDLARSYGSNYGLELTGTQGFEDYILDLGKTIQ 1010
            |...:.....|       |:.......:.:|.::|.:..|.           ..||||.     .
Mouse   938 YGRTIVPYSTSGNSDLALNLTKNLNIFLKSKNQNLRKIRGD-----------MNDYILK-----N 986

  Fly  1011 VRINSRYLVAATI----TESKITAWLNNQALHTAPLTVNMVHNAIADKLFGSSVKIQVTNAPLPY 1071
            ...::..|||.:|    .::.:|.:.||:|.|:..::::::.|.:...|.|....|.|.|.|.|.
Mouse   987 KDCHTFCLVALSIKVERNKTVLTIFFNNEAYHSPAISLSILDNILFMTLSGPDASITVFNKPQPL 1051

  Fly  1072 TTSTLLSQLSTGNNL----GTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFW 1132
            .        ..|:|:    |.|:...|.|.:..|...:.:..:.||.|:||.:||:.||.|.|:|
Mouse  1052 P--------HYGSNIVPVNGLQIVQCLAFGISVVVGSFSIQTVTERTSQAKHIQFLTGVCVHTYW 1108

  Fly  1133 LSQFICD-----FASYIVTALIVVITIVCF--QETGLSTFGELGRYYLLLLLFGFAVLPFIYIMS 1190
            ||..:||     ||..::.|:.....:..|  ....|.|.       |:.:|:|:.|:|..||.|
Mouse  1109 LSALLCDLIFFFFACCVLLAIFKFCQLEAFVVHYNFLDTI-------LIFMLYGWCVVPLTYIAS 1166

  Fly  1191 LFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKDTADIL-GWIFRIFPHFSLAMSLNKV 1254
            ..|......:.::::.|.|..|...|:..::.....|..:...|| ..|....|.::||||::|.
Mouse  1167 FLFNSSTAAYIKITLFNYFSTMFSIIIYTIIQFYGNDFPNFVHILIRAILMALPSYNLAMSISKY 1231

  Fly  1255 YTNTATRNACAKAGALPPILLCELVPQCCNLKPY-----FAWEEPGVLPETVYMAVTGVVFFLII 1314
            :.:...:..||:  ....|.|     .|.:  ||     :.:.|.|:....:.:|..|:||.|::
Mouse  1232 FDDYEVKRLCAR--EFKSIYL-----DCSD--PYTQNNVYGFGEHGIGKFLITLATIGLVFLLLL 1287

  Fly  1315 IVLEFRLINELMFKIRQLI------------SKPPPPPTEGQLDDDVANERERILQMSSNELATK 1367
            :.||....:...|..|.:|            :.|....|:...|:|:..|:.::..:.. .|...
Mouse  1288 LSLESVSCSLKSFVFRNIIFYFYNKLRKGRNAIPSNQRTKEDEDEDIKKEKGKVFTLLL-RLQNT 1351

  Fly  1368 NLVLDRVTKYYGQ---FMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQG 1429
            .|:|:.|||.|.:   ..||..:||.|::.|||||||:|||||||||||:||:|.|:||.|::.|
Mouse  1352 PLLLNEVTKIYFKCPVVKAVKNISLVVKKSECFGLLGLNGAGKTTTFKMLTGEETITSGIAFIDG 1416

  Fly  1430 LSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHID 1494
            .|:......|...||||||.:::|:.:||||.|.::..|.||.|..|.:..|....|.......|
Mouse  1417 NSVTRTPRKIRSRIGYCPQTESVLNHMTGRESLVMYARLWGVLEQDINEYVEAFLHSVHLEPIAD 1481

  Fly  1495 KQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSM 1559
            :..|.||.|:||:||||||::|..||::||||:.||||.|:..||..:..|..:||:|::|||.|
Mouse  1482 QFIHTYSAGSKRRLSTAIALMGKSSVVFLDEPSIGMDPVAQHLLWETITWICKTGKAIIITSHRM 1546

  Fly  1560 EECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQT 1624
            ||||||||||||||.|.|.|:|:.||::.:|  |.:..:.||.|:            |::.|:
Mouse  1547 EECEALCTRLAIMVKGRFTCLGTPQHVRKRF--GHVYTLTVRINI------------AKDEDK-- 1595

  Fly  1625 VPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYS 1689
                     ::..|.|::..:|.:|..:|:.|.:.:|||...:.|.::|.::|..:....:||||
Mouse  1596 ---------VEEFKNFIKVTFPGNIKFQEFHGTIGYYIPSKEIYWGKVFAILEEAKVLFKLEDYS 1651

  Fly  1690 VSQTTLEEIFLEFAKYQREDT 1710
            |.:.|||:|||.||...:..|
Mouse  1652 VKRVTLEQIFLTFANTDKMRT 1672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	63/179 (35%)
		ABC2_membrane_3	<269..475	CDD:289468	70/205 (34%)
		CcmA	538..843	CDD:224054	143/304 (47%)
		ABC_subfamily_A	538..755	CDD:213230	111/216 (51%)
		ABC2_membrane_3	913..1316	CDD:289468	102/430 (24%)
		ABC_subfamily_A	1369..1587	CDD:213230	113/220 (51%)
		drrA	1376..1702	CDD:130256	139/328 (42%)
Abca16	XP_006507746.1	rim_protein	<196..1665	CDD:130324	523/1544 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838483
Domainoid	1	1.000	180	1.000	Domainoid score	I3485
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1133	1.000	Inparanoid score	I220
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		mtm8719
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770